|
43
|
159
|
4p3rA |
Cryogenic wt dhfr, time-averaged ensemble |
|
32
|
162
|
1bzfA |
Nmr solution structure and dynamics of the complex of lactobacillus casei dihydrofolate reductase with the new lipophilic antifolate drug trimetrexate, 22 structures |
|
30
|
162
|
1ao8A |
Dihydrofolate reductase complexed with methotrexate, nmr, 21 structures |
|
41
|
162
|
1diuA |
Dihydrofolate reductase (e.c.1.5.1.3) complex with brodimoprim-4,6-dicarboxylate |
|
44
|
159
|
4pthA |
Ensemble model for escherichia coli dihydrofolate reductase at 100k |
|
38
|
159
|
4p3qA |
Room-temperature wt dhfr, time-averaged ensemble |
|
41
|
159
|
4ptjA |
Ensemble model for escherichia coli dihydrofolate reductase at 277k |
|
169
|
608
|
3um8A |
Wild-type plasmodium falciparum dhfr-ts complexed with cycloguanil and nadph |
|
45
|
165
|
3sa2A |
Bacuills anthracis dihydrofolate reductase bound propargyl-linked tmp analog, ucp1014 |
|
46
|
164
|
3sa1A |
Bacuills anthracis dihydrofolate reductase bound propargyl-linked tmp analog, ucp1021 |
|
43
|
165
|
3s9uA |
Bacillus anthracis dihydrofolate reductase bound to propargyl-linked tmp analog, ucp120j |
|
45
|
165
|
3saiA |
Bacuills anthracis dihydrofolate reductase bound to propargyl-linked tmp analog, ucp1015 |
|
41
|
157
|
5jg0X |
Staphylococcus aureus dihydrofolate reductase complexed with beta-nadph and ucp1191 |
|
43
|
159
|
5ja3A |
Mycobacterium tuberculosis dihydrofolate reductase complexed with beta- nadph and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-b iphenyl]-4-carboxylic acid (ucp1106) |
|
57
|
186
|
5hsrA |
Fluorine substituted 5-methyl-6-(3',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
54
|
186
|
5hvbA |
5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine |
|
60
|
186
|
5hveA |
5-methyl-6-(3'-trifluromethoxyphenylthio)[2,3-d]pyrimidine 2,4-diamine |
|
50
|
186
|
5hpbA |
Human dihydrofolate reductase complex with nadph and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5ht5A |
6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl) |
|
56
|
186
|
5hsuA |
Fluorine substituted 5-methyl-6-(2',4'-difluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5huiA |
6-substituted pyrido[3,2-d]pyrimidine--6-4'-trifluoromethoxyphenyl) |
|
55
|
186
|
5hqzA |
Fluorine substituted 5-methyl-6-(4'-trifluoromethoxyphenythio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
53
|
186
|
5hqyA |
Human dihydrofolate reductase complex with nadph and 5-methyl-6-(2',3',4'-trifluorophenylthio)thieno[2,3-d]pyrimidine-2,4-diamine |
|
54
|
186
|
8dfrA |
Refined crystal structures of chicken liver dihydrofolate reductase. 3 angstroms apo-enzyme and 1.7 angstroms nadph holo-enzyme complex |
|
40
|
159
|
7dfrA |
Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state |
|
40
|
159
|
6dfrA |
Crystal structures of escherichia coli dihydrofolate reductase. the nadp+ holoenzyme and the folate(dot)nadp+ ternary complex. substrate binding and a model for the transition state |
|
44
|
159
|
5cccA |
Wild-type e.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate |
|
45
|
159
|
5cc9A |
L28f e.coli dihydrofolate reductase complexed with 5,10-dideazatetrahydrofolate and oxidized nicotinamide adenine dinucleotide phosphate |
|
42
|
159
|
4qleA |
Crystal structure of i14a dhfr mutant complexed with folate and nadp+ |
|
42
|
166
|
4elfA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
44
|
159
|
4ej1A |
Binding of nb113 camelid antibody fragment with the binary dhfr:folate complex |
|
182
|
606
|
4dp3A |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with p218 and nadph |
|
46
|
159
|
4eizA |
Structure of nb113 bound to apodhfr |
|
108
|
608
|
4eckA |
Crystal structure of the toxoplasma gondii ts-dhfr |
|
171
|
563
|
4eilA |
Crystal structure of the loop truncated toxoplasma gondii ts-dhfr |
|
44
|
166
|
4eleA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
174
|
605
|
4dpdA |
Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts), dhf complex, nadp+, dump |
|
40
|
166
|
4elgA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
42
|
159
|
4eigA |
Ca1698 camel antibody fragment in complex with dhfr |
|
41
|
166
|
4elhA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
173
|
606
|
4dphA |
Quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with p65 and nadph |
|
40
|
166
|
4elbA |
Structure-activity relationship guides enantiomeric preference among potent inhibitors of b. anthracis dihydrofolate reductase |
|
43
|
159
|
4dfrA |
Crystal structures of escherichia coli and lactobacillus casei dihydrofolate reductase refined at 1.7 angstroms resolution. i. general features and binding of methotrexate |
|
56
|
186
|
4ddrA |
Human dihydrofolate reductase complexed with nadph and p218 |
|
56
|
202
|
4cd2A |
Ligand induced conformational changes in the crystal structures of pneumocystis carinii dihydrofolate reductase complexes with folate and nadp+ |
|
110
|
356
|
3zpgA |
Acinetobacter baumannii ribd, form 2 |
|
107
|
357
|
3zpcA |
Acinetobacter baumannii ribd, form 1 |
|
46
|
183
|
3vcoA |
Schistosoma mansoni dihydrofolate reductase |
|
168
|
608
|
3um6A |
Double mutant (a16v+s108t) plasmodium falciparum dhfr-ts (t9/94) complexed with cycloguanil, nadph and dump |
|
177
|
608
|
3um5A |
Double mutant (a16v+s108t) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts-t9/94) complexed with pyrimethamine, nadph, and dump |
