4D10F

Crystal structure of the cop9 signalosome
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
288
structure length
281
Chain Sequence
SVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the Human Cop9 Signalosome
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords COP9 SIGNALOSOME COMPLEX SUBUNIT 1
total genus 89
structure length 281
sequence length 288
chains with identical sequence N
ec nomenclature
pdb deposition date 2014-04-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF01398 JAB JAB1/Mov34/MPN/PAD-1 ubiquitin protease
F PF13012 MitMem_reg Maintenance of mitochondrial structure and function
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.140.10 Alpha Beta 3-Layer(aba) Sandwich Cytidine Deaminase; domain 2 Cytidine Deaminase, domain 2 4d10F01
2HVVA 1R5XA 1OI0A 2B3ZA 2D30A 2Z3IA 4LD2A 3ZEFB 2ZNVA 5DCAJ 1WWRA 1ZABA 4ZFTA 2O7PA 4OWPB 2W4LA 4OCLA 4PQTA 4OCNA 4MSQA 4MSDA 4LCNA 4P9DA 4O8XB 4E0QA 3DMOA 4EG2A 2O95A 1Z3AA 1YSDA 1VQ2A 2ZNRA 4D10F 3E1UA 4G3MA 2Z3HA 1UX0A 4P9EA 2KKSA 4OCMB 5CW6A 2KCQA 1YSBA 3EX8A 2P87A 4BGDC 2O3KA 2G6VA 3RZVA 4WIFA 4HRQA 1TIYA 2HXVA 2D5NA 1WN6A 2Z3JA 4WIGA 1OX7A 4I43B 1UX1A 4KITC 3OJ6A 2O96A 3G8QA 2FR6A 2P8RA 3RZUA 4OWPA 2Z3GA 1WKQA 3OCQA 2QLCA 3IJFX 2OG4A 3MPZA 4O8YB 4O8XA 2A8NA 4F3WA 4LC5A 4MSJA 1ALNA 1AF2A 1UAQA 3ZPGA 1UWZA 5M52C 2OBCA 1CTTA 4HRWA 4NQLA 3B8FA 4MS7A 2G84A 2PW9A 4OCMA 4ZFRA 1R5TA 4P9CA 5M59B 1WN5A 4JXEA 4ZD5A 4LD4A 2B3JA 4OCLB 4OCNB 1RB7A 2NX8A 4MSMA 4QFTA 1MQ0A 4ZD4A 4LCOA 5GAOA 3R2NA 1CTUA 1P6OA 2FR5A 4LCPA 4ILGC 2HVWA 4O8YA 3DH1A 4F7OA 2NYTA 3ZPCA 3SBGA 5C2OA 4K1RA 2RPZA 1JTKA
chains in the Genus database with same CATH superfamily
2HVVA 1R5XA 1OI0A 2B3ZA 2D30A 2Z3IA 4LD2A 3ZEFB 2ZNVA 5DCAJ 1WWRA 1ZABA 1ZCZA 4ZFTA 4J6EA 2O7PA 4OWPB 2W4LA 4OCLA 4PQTA 1THZA 2B1GA 4OCNA 4MSQA 4MSDA 1PL0A 4LCNA 4P9DA 1VK9A 4O8XB 4E0QA 3DMOA 4EG2A 2O95A 1Z3AA 1YSDA 1VQ2A 2ZNRA 4D10F 3E1UA 4G3MA 2Z3HA 1UX0A 4P9EA 2KKSA 4OCMB 5CW6A 2KCQA 1YSBA 3EX8A 2P87A 4BGDC 2O3KA 2G6VA 1OZ0A 3RZVA 4WIFA 4HRQA 1TIYA 2HXVA 2D5NA 1WN6A 2Z3JA 4WIGA 2B1IA 3VX8A 1OX7A 4I43B 1UX1A 4KITC 3OJ6A 2O96A 3G8QA 2FR6A 2P8RA 4GGMX 3RZUA 3ZZMA 4OWPA 2Z3GA 1WKQA 3OCQA 2QLCA 4A1OA 3IJFX 2OG4A 3MPZA 4O8YB 4O8XA 2A8NA 4F3WA 4LC5A 4MSJA 1AF2A 1ALNA 1UAQA 3ZPGA 1UWZA 5M52C 2OBCA 4EHIA 1CTTA 4HRWA 4NQLA 1P4RA 3B8FA 4MS7A 2G84A 2PW9A 2IU3A 4OCMA 4ZFRA 1R5TA 4P9CA 5M59B 1WN5A 4JXEA 4ZD5A 4LD4A 1PKXA 2B3JA 4OCLB 4OCNB 1RB7A 2NX8A 4MSMA 4QFTA 1MQ0A 4ZD4A 4LCOA 5GAOA 3R2NA 1CTUA 1G8MA 2FR5A 4LCPA 1M9NA 4ILGC 1JTKA 2HVWA 4O8YA 3BH1A 3DH1A 4F7OA 2IU0A 2NYTA 3ZPCA 3SBGA 5C2OA 4K1RA 2RPZA 1P6OA
chains in the Genus database with same CATH topology
2HVVA 1R5XA 1OI0A 2B3ZA 2D30A 2Z3IA 4LD2A 3ZEFB 2ZNVA 5DCAJ 1WWRA 1ZABA 4ZFTA 2O7PA 4OWPB 2W4LA 4OCLA 4PQTA 4OCNA 4MSQA 4MSDA 4LCNA 4P9DA 4O8XB 4E0QA 3DMOA 4EG2A 2O95A 1Z3AA 1YSDA 1VQ2A 2ZNRA 4D10F 3E1UA 4G3MA 2Z3HA 1UX0A 4P9EA 2KKSA 4OCMB 5CW6A 2KCQA 1YSBA 3EX8A 2P87A 4BGDC 2O3KA 2G6VA 3RZVA 4WIFA 4HRQA 1TIYA 2HXVA 2D5NA 1WN6A 2Z3JA 4WIGA 1OX7A 4I43B 1UX1A 4KITC 3OJ6A 2O96A 3G8QA 2FR6A 2P8RA 3RZUA 4OWPA 2Z3GA 1WKQA 3OCQA 2QLCA 3IJFX 2OG4A 3MPZA 4O8YB 4O8XA 2A8NA 4F3WA 4LC5A 4MSJA 1ALNA 1AF2A 1UAQA 3ZPGA 1UWZA 5M52C 2OBCA 1CTTA 4HRWA 4NQLA 3B8FA 4MS7A 2G84A 2PW9A 4OCMA 4ZFRA 1R5TA 4P9CA 5M59B 1WN5A 4JXEA 4ZD5A 4LD4A 2B3JA 4OCLB 4OCNB 1RB7A 2NX8A 4MSMA 4QFTA 1MQ0A 4ZD4A 4LCOA 5GAOA 3R2NA 1CTUA 1P6OA 2FR5A 4LCPA 4ILGC 2HVWA 4O8YA 3DH1A 4F7OA 2NYTA 3ZPCA 3SBGA 5C2OA 4K1RA 2RPZA 1JTKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HVV A;  1R5X A;  1OI0 A;  2B3Z A;  2D30 A;  2Z3I A;  4LD2 A;  3ZEF B;  2ZNV A;  5DCA J;  1WWR A;  1ZAB A;  4ZFT A;  2O7P A;  4OWP B;  2W4L A;  4OCL A;  4PQT A;  4OCN A;  4MSQ A;  4MSD A;  4LCN A;  4P9D A;  4O8X B;  4E0Q A;  3DMO A;  4EG2 A;  2O95 A;  1Z3A A;  1YSD A;  1VQ2 A;  2ZNR A;  4D10 F;  3E1U A;  4G3M A;  2Z3H A;  1UX0 A;  4P9E A;  2KKS A;  4OCM B;  5CW6 A;  2KCQ A;  1YSB A;  3EX8 A;  2P87 A;  4BGD C;  2O3K A;  2G6V A;  3RZV A;  4WIF A;  4HRQ A;  1TIY A;  2HXV A;  2D5N A;  1WN6 A;  2Z3J A;  4WIG A;  1OX7 A;  4I43 B;  1UX1 A;  4KIT C;  3OJ6 A;  2O96 A;  3G8Q A;  2FR6 A;  2P8R A;  3RZU A;  4OWP A;  2Z3G A;  1WKQ A;  3OCQ A;  2QLC A;  3IJF X;  2OG4 A;  3MPZ A;  4O8Y B;  4O8X A;  2A8N A;  4F3W A;  4LC5 A;  4MSJ A;  1ALN A;  1AF2 A;  1UAQ A;  3ZPG A;  1UWZ A;  5M52 C;  2OBC A;  1CTT A;  4HRW A;  4NQL A;  3B8F A;  4MS7 A;  2G84 A;  2PW9 A;  4OCM A;  4ZFR A;  1R5T A;  4P9C A;  5M59 B;  1WN5 A;  4JXE A;  4ZD5 A;  4LD4 A;  2B3J A;  4OCL B;  4OCN B;  1RB7 A;  2NX8 A;  4MSM A;  4QFT A;  1MQ0 A;  4ZD4 A;  4LCO A;  5GAO A;  3R2N A;  1CTU A;  1P6O A;  2FR5 A;  4LCP A;  4ILG C;  2HVW A;  4O8Y A;  3DH1 A;  4F7O A;  2NYT A;  3ZPC A;  3SBG A;  5C2O A;  4K1R A;  2RPZ A;  1JTK A; 
#chains in the Genus database with same CATH topology
 2HVV A;  1R5X A;  1OI0 A;  2B3Z A;  2D30 A;  2Z3I A;  4LD2 A;  3ZEF B;  2ZNV A;  5DCA J;  1WWR A;  1ZAB A;  1ZCZ A;  4ZFT A;  4J6E A;  2O7P A;  4OWP B;  2W4L A;  4OCL A;  4PQT A;  1THZ A;  2B1G A;  4OCN A;  4MSQ A;  4MSD A;  1PL0 A;  4LCN A;  4P9D A;  1VK9 A;  4O8X B;  4E0Q A;  3DMO A;  4EG2 A;  2O95 A;  1Z3A A;  1YSD A;  1VQ2 A;  2ZNR A;  4D10 F;  3E1U A;  4G3M A;  2Z3H A;  1UX0 A;  4P9E A;  2KKS A;  4OCM B;  5CW6 A;  2KCQ A;  1YSB A;  3EX8 A;  2P87 A;  4BGD C;  2O3K A;  2G6V A;  1OZ0 A;  3RZV A;  4WIF A;  4HRQ A;  1TIY A;  2HXV A;  2D5N A;  1WN6 A;  2Z3J A;  4WIG A;  2B1I A;  3VX8 A;  1OX7 A;  4I43 B;  1UX1 A;  4KIT C;  3OJ6 A;  2O96 A;  3G8Q A;  2FR6 A;  2P8R A;  4GGM X;  3RZU A;  3ZZM A;  4OWP A;  2Z3G A;  1WKQ A;  3OCQ A;  2QLC A;  4A1O A;  3IJF X;  2OG4 A;  3MPZ A;  4O8Y B;  4O8X A;  2A8N A;  4F3W A;  4LC5 A;  4MSJ A;  1AF2 A;  1ALN A;  1UAQ A;  3ZPG A;  1UWZ A;  5M52 C;  2OBC A;  4EHI A;  1CTT A;  4HRW A;  4NQL A;  1P4R A;  3B8F A;  4MS7 A;  2G84 A;  2PW9 A;  2IU3 A;  4OCM A;  4ZFR A;  1R5T A;  4P9C A;  5M59 B;  1WN5 A;  4JXE A;  4ZD5 A;  4LD4 A;  1PKX A;  2B3J A;  4OCL B;  4OCN B;  1RB7 A;  2NX8 A;  4MSM A;  4QFT A;  1MQ0 A;  4ZD4 A;  4LCO A;  5GAO A;  3R2N A;  1CTU A;  1G8M A;  2FR5 A;  4LCP A;  1M9N A;  4ILG C;  1JTK A;  2HVW A;  4O8Y A;  3BH1 A;  3DH1 A;  4F7O A;  2IU0 A;  2NYT A;  3ZPC A;  3SBG A;  5C2O A;  4K1R A;  2RPZ A;  1P6O A; 
#chains in the Genus database with same CATH homology
 2HVV A;  1R5X A;  1OI0 A;  2B3Z A;  2D30 A;  2Z3I A;  4LD2 A;  3ZEF B;  2ZNV A;  5DCA J;  1WWR A;  1ZAB A;  4ZFT A;  2O7P A;  4OWP B;  2W4L A;  4OCL A;  4PQT A;  4OCN A;  4MSQ A;  4MSD A;  4LCN A;  4P9D A;  4O8X B;  4E0Q A;  3DMO A;  4EG2 A;  2O95 A;  1Z3A A;  1YSD A;  1VQ2 A;  2ZNR A;  4D10 F;  3E1U A;  4G3M A;  2Z3H A;  1UX0 A;  4P9E A;  2KKS A;  4OCM B;  5CW6 A;  2KCQ A;  1YSB A;  3EX8 A;  2P87 A;  4BGD C;  2O3K A;  2G6V A;  3RZV A;  4WIF A;  4HRQ A;  1TIY A;  2HXV A;  2D5N A;  1WN6 A;  2Z3J A;  4WIG A;  1OX7 A;  4I43 B;  1UX1 A;  4KIT C;  3OJ6 A;  2O96 A;  3G8Q A;  2FR6 A;  2P8R A;  3RZU A;  4OWP A;  2Z3G A;  1WKQ A;  3OCQ A;  2QLC A;  3IJF X;  2OG4 A;  3MPZ A;  4O8Y B;  4O8X A;  2A8N A;  4F3W A;  4LC5 A;  4MSJ A;  1ALN A;  1AF2 A;  1UAQ A;  3ZPG A;  1UWZ A;  5M52 C;  2OBC A;  1CTT A;  4HRW A;  4NQL A;  3B8F A;  4MS7 A;  2G84 A;  2PW9 A;  4OCM A;  4ZFR A;  1R5T A;  4P9C A;  5M59 B;  1WN5 A;  4JXE A;  4ZD5 A;  4LD4 A;  2B3J A;  4OCL B;  4OCN B;  1RB7 A;  2NX8 A;  4MSM A;  4QFT A;  1MQ0 A;  4ZD4 A;  4LCO A;  5GAO A;  3R2N A;  1CTU A;  1P6O A;  2FR5 A;  4LCP A;  4ILG C;  2HVW A;  4O8Y A;  3DH1 A;  4F7O A;  2NYT A;  3ZPC A;  3SBG A;  5C2O A;  4K1R A;  2RPZ A;  1JTK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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