1EMSA

Crystal structure of the c. elegans nitfhit protein
Total Genus 125
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
431
structure length
412
Chain Sequence
MATGRHFIAVCQMTSDNDLEKNFQAAKNMIERAGEKKCEMVFLPECFDFIGLNKNEQIDLAMATDCEYMEKYRELARKHNIWLSLGGLHHKDPSDAAHPWNTHLIIDSDGVTRAEYNKLHLFDLEIPGKVRLMESEFSKAGTEMIPPVDTPIGRLGLSICYDVRFPELSLWNRKRGAQLLSFPSAFTLNTGLAHWETLLRARAIENQCYVVAAAQTGAHNPKRQSYGHSMVVDPWGAVVAQCSERVDMCFAEIDLSYVDTLREMQPVFSHRRSDLYTLHINEKSSETGGLKFARFNIPADHIFYSTPHSFVFVNLKPVTDGHVLVSPKRVVPRLTDLTDAETADLFIVAKKVQAMLEKHHNVTSTTICVQDGKDAGQTVPHVHIHILPRRAGDFPRSNEQMAEEAVVYRNLM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.
pubmed doi rcsb
molecule tags Antitumor protein
source organism Caenorhabditis elegans
molecule keywords NIT-FRAGILE HISTIDINE TRIAD FUSION PROTEIN
total genus 125
structure length 412
sequence length 431
chains with identical sequence B
ec nomenclature ec 3.6.1.29: Bis(5'-adenosyl)-triphosphatase.
pdb deposition date 2000-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00795 CN_hydrolase Carbon-nitrogen hydrolase
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 1emsA02
3.60.110.10 Alpha Beta 4-Layer Sandwich Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase Carbon-nitrogen hydrolase 1emsA01
4XBAA 5ED3A 1XMLA 5H8KA 5CS2A 2E2LA 4EQGA 4NJZA 3N05A 1FITA 5BV3A 1UF4A 1UF5A 4IZTA 3WUYA 3KLCA 4F4HA 1RZYA 5I2FA 3TW2A 1KPAA 6FITA 2GGLA 4NDIA 1HXQA 2OIKA 3SPLA 3BLAA 4YKLB 2DYUA 4EQEA 3HKXA 5I2EA 5JQNA 5IPCA 2VHHA 4IZSA 3KI8A 3R6FA 3ILVA 6RHNA 4GYNA 1J31A 1GUQA 3BL7A 1KPEA 4INCA 1GUPA 2GGKA 4GYLA 5EMTA 4IZUA 2W1VA 2FITA 4FITA 4NJXA 4ZGLA 1FO6A 2VHIA 3O1XA 4LF0A 3SEZA 5IN3A 4EGUA 2E2KA 3QGZA 4NK0A 4NDGA 1KPBA 2PLQA 3SYTA 3I24A 3I4SA 3OHEA 3SP4A 3LB5A 3IW3A 2Q4HA 5H8IA 1UF7A 4QDEA 1F89A 1FHIA 4ZKLA 1ERZA 3SZGA 4CYYA 3SZQA 5IPEA 4INIA 1ST0A 4EQHA 3FITA 4NDFA 3KSVA 4CYGA 5H8JA 5IPBA 4HGDA 4IZVA 3O1ZA 4KZFA 3DLAA 2DYVA 3SDBA 3O0MA 3IMIA 3WO5A 4QEBA 1KPFA 4HG5A 5KHAA 1HXPA 4CYFA 3L7XA 3SEQA 3SPDA 3OXKA 3RHNA 4NDHA 5FITA 5ED6A 3OMFA 1VLRA 1Y23A 4H5UA 1AV5A 4IZWA 3O1CA 3BL9A 1KPCA 1Z84A 2H39A 3ANOA 3IVZA 3N1TA 2E11A 1ST4A 3P0TA 4ZKVA 1ZWJA 2Q4LA 2EO4A 2UXYA 3NRDA 5RHNA 5IPDA 4RHNA 5H8LA 3OJ7A 1XMMA 4HG3A 1EMSA 4QDVA 1UF8A 3N1SA 4NJYA 3P8KA 2FHIA
chains in the Genus database with same CATH superfamily
4XBAA 5ED3A 1XMLA 5H8KA 5CS2A 2E2LA 4EQGA 4NJZA 3N05A 1FITA 5BV3A 1UF4A 4I5WA 1UF5A 4IZTA 3KLCA 3WUYA 4F4HA 1RZYA 5I2FA 3TW2A 1KPAA 6FITA 2GGLA 4NDIA 1HXQA 2OIKA 3SPLA 3BLAA 4YKLB 4G0JA 2DYUA 4EQEA 3HKXA 5I2EA 5JQNA 5IPCA 2VHHA 4IZSA 2R7JA 3KI8A 3R6FA 3ILVA 6RHNA 4GYNA 1J31A 1GUQA 3BL7A 1KPEA 4INCA 1GUPA 2GGKA 4GYLA 5EMTA 2R8FA 4IZUA 2W1VA 2FITA 4FITA 4NJXA 4ZGLA 1FO6A 2VHIA 3O1XA 4LF0A 3SEZA 5IN3A 4EGUA 2E2KA 3QGZA 4NK0A 4NDGA 1KPBA 2PLQA 3SYTA 3I24A 3I4SA 3OHEA 3SP4A 3LB5A 3IW3A 2Q4HA 5H8IA 1UF7A 4QDEA 1F89A 1FHIA 4ZKLA 1ERZA 3SZGA 4CYYA 3SZQA 5IPEA 4INIA 1ST0A 4EQHA 3FITA 4I5VA 4NDFA 3KSVA 4CYGA 5H8JA 2R7PA 5IPBA 4HGDA 4IZVA 3O1ZA 4KZFA 3DLAA 2DYVA 3SDBA 3O0MA 3IMIA 3WO5A 4QEBA 1KPFA 1L9VA 4I5TA 1HXPA 4HG5A 5KHAA 4CYFA 3L7XA 3SEQA 3SPDA 2POFA 3OXKA 3RHNA 4NDHA 5FITA 2GU0A 2LJWA 2R7CA 5ED6A 3OMFA 1VLRA 1Y23A 4H5UA 1AV5A 4IZWA 3O1CA 3BL9A 1KPCA 1Z84A 2H39A 3ANOA 3IVZA 3N1TA 2E11A 1ST4A 3P0TA 4ZKVA 1ZWJA 2Q4LA 2EO4A 2UXYA 3NRDA 5RHNA 5IPDA 4RHNA 5H8LA 3OJ7A 4G0AA 1XMMA 4HG3A 1EMSA 4QDVA 1UF8A 3N1SA 4NJYA 3P8KA 2FHIA
chains in the Genus database with same CATH topology
4XBAA 5ED3A 1XMLA 5H8KA 5CS2A 2E2LA 4EQGA 4NJZA 3N05A 1FITA 5BV3A 1UF4A 1UF5A 4IZTA 3WUYA 3KLCA 4F4HA 1RZYA 5I2FA 3TW2A 1KPAA 6FITA 2GGLA 4NDIA 1HXQA 2OIKA 3SPLA 3BLAA 4YKLB 2DYUA 4EQEA 3HKXA 5I2EA 5JQNA 5IPCA 2VHHA 4IZSA 3KI8A 3R6FA 3ILVA 6RHNA 4GYNA 1J31A 1GUQA 3BL7A 1KPEA 4INCA 1GUPA 2GGKA 4GYLA 5EMTA 4IZUA 2W1VA 2FITA 4FITA 4NJXA 4ZGLA 1FO6A 2VHIA 3O1XA 4LF0A 3SEZA 5IN3A 4EGUA 2E2KA 3QGZA 4NK0A 4NDGA 1KPBA 2PLQA 3SYTA 3I24A 3I4SA 3OHEA 3SP4A 3LB5A 3IW3A 2Q4HA 5H8IA 1UF7A 4QDEA 1F89A 1FHIA 4ZKLA 1ERZA 3SZGA 4CYYA 3SZQA 5IPEA 4INIA 1ST0A 4EQHA 3FITA 4NDFA 3KSVA 4CYGA 5H8JA 5IPBA 4HGDA 4IZVA 3O1ZA 4KZFA 3DLAA 2DYVA 3SDBA 3O0MA 3IMIA 3WO5A 4QEBA 1KPFA 4HG5A 5KHAA 1HXPA 4CYFA 3L7XA 3SEQA 3SPDA 3OXKA 3RHNA 4NDHA 5FITA 5ED6A 3OMFA 1VLRA 1Y23A 4H5UA 1AV5A 4IZWA 3O1CA 3BL9A 1KPCA 1Z84A 2H39A 3ANOA 3IVZA 3N1TA 2E11A 1ST4A 3P0TA 4ZKVA 1ZWJA 2Q4LA 2EO4A 2UXYA 3NRDA 5RHNA 5IPDA 4RHNA 5H8LA 3OJ7A 1XMMA 4HG3A 1EMSA 4QDVA 1UF8A 3N1SA 4NJYA 3P8KA 2FHIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4XBA A;  5ED3 A;  1XML A;  5H8K A;  5CS2 A;  2E2L A;  4EQG A;  4NJZ A;  3N05 A;  1FIT A;  5BV3 A;  1UF4 A;  1UF5 A;  4IZT A;  3WUY A;  3KLC A;  4F4H A;  1RZY A;  5I2F A;  3TW2 A;  1KPA A;  6FIT A;  2GGL A;  4NDI A;  1HXQ A;  2OIK A;  3SPL A;  3BLA A;  4YKL B;  2DYU A;  4EQE A;  3HKX A;  5I2E A;  5JQN A;  5IPC A;  2VHH A;  4IZS A;  3KI8 A;  3R6F A;  3ILV A;  6RHN A;  4GYN A;  1J31 A;  1GUQ A;  3BL7 A;  1KPE A;  4INC A;  1GUP A;  2GGK A;  4GYL A;  5EMT A;  4IZU A;  2W1V A;  2FIT A;  4FIT A;  4NJX A;  4ZGL A;  1FO6 A;  2VHI A;  3O1X A;  4LF0 A;  3SEZ A;  5IN3 A;  4EGU A;  2E2K A;  3QGZ A;  4NK0 A;  4NDG A;  1KPB A;  2PLQ A;  3SYT A;  3I24 A;  3I4S A;  3OHE A;  3SP4 A;  3LB5 A;  3IW3 A;  2Q4H A;  5H8I A;  1UF7 A;  4QDE A;  1F89 A;  1FHI A;  4ZKL A;  1ERZ A;  3SZG A;  4CYY A;  3SZQ A;  5IPE A;  4INI A;  1ST0 A;  4EQH A;  3FIT A;  4NDF A;  3KSV A;  4CYG A;  5H8J A;  5IPB A;  4HGD A;  4IZV A;  3O1Z A;  4KZF A;  3DLA A;  2DYV A;  3SDB A;  3O0M A;  3IMI A;  3WO5 A;  4QEB A;  1KPF A;  4HG5 A;  5KHA A;  1HXP A;  4CYF A;  3L7X A;  3SEQ A;  3SPD A;  3OXK A;  3RHN A;  4NDH A;  5FIT A;  5ED6 A;  3OMF A;  1VLR A;  1Y23 A;  4H5U A;  1AV5 A;  4IZW A;  3O1C A;  3BL9 A;  1KPC A;  1Z84 A;  2H39 A;  3ANO A;  3IVZ A;  3N1T A;  2E11 A;  1ST4 A;  3P0T A;  4ZKV A;  1ZWJ A;  2Q4L A;  2EO4 A;  2UXY A;  3NRD A;  5RHN A;  5IPD A;  4RHN A;  5H8L A;  3OJ7 A;  1XMM A;  4HG3 A;  1EMS A;  4QDV A;  1UF8 A;  3N1S A;  4NJY A;  3P8K A;  2FHI A; 
#chains in the Genus database with same CATH topology
 4XBA A;  5ED3 A;  1XML A;  5H8K A;  5CS2 A;  2E2L A;  4EQG A;  4NJZ A;  3N05 A;  1FIT A;  5BV3 A;  1UF4 A;  4I5W A;  1UF5 A;  4IZT A;  3KLC A;  3WUY A;  4F4H A;  1RZY A;  5I2F A;  3TW2 A;  1KPA A;  6FIT A;  2GGL A;  4NDI A;  1HXQ A;  2OIK A;  3SPL A;  3BLA A;  4YKL B;  4G0J A;  2DYU A;  4EQE A;  3HKX A;  5I2E A;  5JQN A;  5IPC A;  2VHH A;  4IZS A;  2R7J A;  3KI8 A;  3R6F A;  3ILV A;  6RHN A;  4GYN A;  1J31 A;  1GUQ A;  3BL7 A;  1KPE A;  4INC A;  1GUP A;  2GGK A;  4GYL A;  5EMT A;  2R8F A;  4IZU A;  2W1V A;  2FIT A;  4FIT A;  4NJX A;  4ZGL A;  1FO6 A;  2VHI A;  3O1X A;  4LF0 A;  3SEZ A;  5IN3 A;  4EGU A;  2E2K A;  3QGZ A;  4NK0 A;  4NDG A;  1KPB A;  2PLQ A;  3SYT A;  3I24 A;  3I4S A;  3OHE A;  3SP4 A;  3LB5 A;  3IW3 A;  2Q4H A;  5H8I A;  1UF7 A;  4QDE A;  1F89 A;  1FHI A;  4ZKL A;  1ERZ A;  3SZG A;  4CYY A;  3SZQ A;  5IPE A;  4INI A;  1ST0 A;  4EQH A;  3FIT A;  4I5V A;  4NDF A;  3KSV A;  4CYG A;  5H8J A;  2R7P A;  5IPB A;  4HGD A;  4IZV A;  3O1Z A;  4KZF A;  3DLA A;  2DYV A;  3SDB A;  3O0M A;  3IMI A;  3WO5 A;  4QEB A;  1KPF A;  1L9V A;  4I5T A;  1HXP A;  4HG5 A;  5KHA A;  4CYF A;  3L7X A;  3SEQ A;  3SPD A;  2POF A;  3OXK A;  3RHN A;  4NDH A;  5FIT A;  2GU0 A;  2LJW A;  2R7C A;  5ED6 A;  3OMF A;  1VLR A;  1Y23 A;  4H5U A;  1AV5 A;  4IZW A;  3O1C A;  3BL9 A;  1KPC A;  1Z84 A;  2H39 A;  3ANO A;  3IVZ A;  3N1T A;  2E11 A;  1ST4 A;  3P0T A;  4ZKV A;  1ZWJ A;  2Q4L A;  2EO4 A;  2UXY A;  3NRD A;  5RHN A;  5IPD A;  4RHN A;  5H8L A;  3OJ7 A;  4G0A A;  1XMM A;  4HG3 A;  1EMS A;  4QDV A;  1UF8 A;  3N1S A;  4NJY A;  3P8K A;  2FHI A; 
#chains in the Genus database with same CATH homology
 4XBA A;  5ED3 A;  1XML A;  5H8K A;  5CS2 A;  2E2L A;  4EQG A;  4NJZ A;  3N05 A;  1FIT A;  5BV3 A;  1UF4 A;  1UF5 A;  4IZT A;  3WUY A;  3KLC A;  4F4H A;  1RZY A;  5I2F A;  3TW2 A;  1KPA A;  6FIT A;  2GGL A;  4NDI A;  1HXQ A;  2OIK A;  3SPL A;  3BLA A;  4YKL B;  2DYU A;  4EQE A;  3HKX A;  5I2E A;  5JQN A;  5IPC A;  2VHH A;  4IZS A;  3KI8 A;  3R6F A;  3ILV A;  6RHN A;  4GYN A;  1J31 A;  1GUQ A;  3BL7 A;  1KPE A;  4INC A;  1GUP A;  2GGK A;  4GYL A;  5EMT A;  4IZU A;  2W1V A;  2FIT A;  4FIT A;  4NJX A;  4ZGL A;  1FO6 A;  2VHI A;  3O1X A;  4LF0 A;  3SEZ A;  5IN3 A;  4EGU A;  2E2K A;  3QGZ A;  4NK0 A;  4NDG A;  1KPB A;  2PLQ A;  3SYT A;  3I24 A;  3I4S A;  3OHE A;  3SP4 A;  3LB5 A;  3IW3 A;  2Q4H A;  5H8I A;  1UF7 A;  4QDE A;  1F89 A;  1FHI A;  4ZKL A;  1ERZ A;  3SZG A;  4CYY A;  3SZQ A;  5IPE A;  4INI A;  1ST0 A;  4EQH A;  3FIT A;  4NDF A;  3KSV A;  4CYG A;  5H8J A;  5IPB A;  4HGD A;  4IZV A;  3O1Z A;  4KZF A;  3DLA A;  2DYV A;  3SDB A;  3O0M A;  3IMI A;  3WO5 A;  4QEB A;  1KPF A;  4HG5 A;  5KHA A;  1HXP A;  4CYF A;  3L7X A;  3SEQ A;  3SPD A;  3OXK A;  3RHN A;  4NDH A;  5FIT A;  5ED6 A;  3OMF A;  1VLR A;  1Y23 A;  4H5U A;  1AV5 A;  4IZW A;  3O1C A;  3BL9 A;  1KPC A;  1Z84 A;  2H39 A;  3ANO A;  3IVZ A;  3N1T A;  2E11 A;  1ST4 A;  3P0T A;  4ZKV A;  1ZWJ A;  2Q4L A;  2EO4 A;  2UXY A;  3NRD A;  5RHN A;  5IPD A;  4RHN A;  5H8L A;  3OJ7 A;  1XMM A;  4HG3 A;  1EMS A;  4QDV A;  1UF8 A;  3N1S A;  4NJY A;  3P8K A;  2FHI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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