1YZ5A

The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution
Total Genus 89
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
233
structure length
223
Chain Sequence
MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSYKDSTLIMQLLRDNLTLWTAD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords 14-3-3 protein sigma
total genus 89
structure length 223
sequence length 233
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 1yz5A00
4WRQA 3P1SA 2C1NA 3P1RA 4DHMA 1YZ5A 4FL5A 3IQUA 1O9FA 2O02A 4JC3A 5D3FA 2O8PA 4DX0A 1QJAA 1O9EA 3T0LA 3SMNA 1IB1A 3NKXA 3U9XA 4E2EA 3O8IA 4FJ3A 1YWTA 4IHLA 4DNKA 3T0MA 3P1OA 5BTVA 5LVZA 2NPMA 4DHOA 2O98A 3RDHA 4Y3BA 2BR9A 4DHQA 2C1JA 4O46A 4N7GA 2C74A 3P1PA 3SPRA 5LU1A 4DHUA 5HF3A 5F74A 3UALA 4QLIA 3LW1A 5J31A 4N7YA 4F7RA 4DHPA 5LU2A 5IQPA 4HKCA 4DAUA 2V7DA 3UX0A 3SMOA 1O9DA 4BG6A 4DATA 3UBWA 5BY9A 5D2DA 5EWZA 4DHNA 2WH0A 5LHOA 3IQJA 2B05A 5D3EA 3P1QA 4N84A 3CU8A 3EFZA 3IQVA 1A38A 5EXAA 4DHSA 4ZDRA 4DHRA 2C23A 4JDDA 4DHTA 4FR3A 3E6YA 3MHRA 3SMKA 1A4OA 2BQ0A 1QJBA 1A37A 4IEAA 2BTPA 3P1NA 3AXYC 3SMLA 3SMMA 3M50A 1O9CA 3SP5A 4ZQ0A 4Y32A 4GNTA 4J6SA 3UZDA 5LX2A 3M51A 2C63A 4Y5IA
chains in the Genus database with same CATH superfamily
4WRQA 1CIYA 3P1SA 2C1NA 3P1RA 4DHMA 1YZ5A 4FL5A 3IQUA 1O9FA 2O02A 4JC3A 4QX2A 5D3FA 2O8PA 4DX0A 1QJAA 1O9EA 3T0LA 3SMNA 3X0UA 1IB1A 3NKXA 3U9XA 4E2EA 3O8IA 4FJ3A 1YWTA 4IHLA 4DNKA 3I4RA 3T0MA 1W99A 3P1OA 5BTVA 4QX3A 5LVZA 2NPMA 4DHOA 2O98A 3RDHA 4D8MA 4Y3BA 2BR9A 4DHQA 2C1JA 4O46A 4N7GA 2C74A 3P1PA 3SPRA 4ARXA 1I5PA 5LU1A 4DHUA 5HF3A 5F74A 1URJA 3UALA 4QLIA 3LW1A 5J31A 4N7YA 4MOAA 4DHPA 4F7RA 5IQPA 5LU2A 4HKCA 4DAUA 2V7DA 3UX0A 3SMOA 1O9DA 4BG6A 4DATA 3UBWA 5BY9A 4QX1A 5D2DA 5EWZA 4DHNA 2WH0A 5LHOA 3IQJA 2B05A 5D3EA 3P1QA 3CQCA 4N84A 3CU8A 3EFZA 3IQVA 1A38A 5EXAA 4DHSA 4ZDRA 4DHRA 2C23A 4W8JA 3CQGA 4JDDA 4QX0A 4DHTA 1JI6A 4FR3A 3E6YA 3MHRA 3SMKA 1A4OA 2BQ0A 1QJBA 1A37A 2C9KA 4IEAA 3ZHEB 2BTPA 3P1NA 4ARYA 3AXYC 3SMLA 1DLCA 3SMMA 3M50A 1O9CA 3SP5A 4ZQ0A 4Y32A 1S2XA 4GNTA 4J6SA 3UZDA 5LX2A 3M51A 2C63A 4Y5IA 3EB7A
chains in the Genus database with same CATH topology
4WRQA 3P1SA 2C1NA 3P1RA 4DHMA 1YZ5A 4FL5A 3IQUA 1O9FA 2O02A 4JC3A 5D3FA 2O8PA 4DX0A 1QJAA 1O9EA 3T0LA 3SMNA 1IB1A 3NKXA 3U9XA 4E2EA 3O8IA 4FJ3A 1YWTA 4IHLA 4DNKA 3T0MA 3P1OA 5BTVA 5LVZA 2NPMA 4DHOA 2O98A 3RDHA 4Y3BA 2BR9A 4DHQA 2C1JA 4O46A 4N7GA 2C74A 3P1PA 3SPRA 5LU1A 4DHUA 5HF3A 5F74A 3UALA 4QLIA 3LW1A 5J31A 4N7YA 4F7RA 4DHPA 5LU2A 5IQPA 4HKCA 4DAUA 2V7DA 3UX0A 3SMOA 1O9DA 4BG6A 4DATA 3UBWA 5BY9A 5D2DA 5EWZA 4DHNA 2WH0A 5LHOA 3IQJA 2B05A 5D3EA 3P1QA 4N84A 3CU8A 3EFZA 3IQVA 1A38A 5EXAA 4DHSA 4ZDRA 4DHRA 2C23A 4JDDA 4DHTA 4FR3A 3E6YA 3MHRA 3SMKA 1A4OA 2BQ0A 1QJBA 1A37A 4IEAA 2BTPA 3P1NA 3AXYC 3SMLA 3SMMA 3M50A 1O9CA 3SP5A 4ZQ0A 4Y32A 4GNTA 4J6SA 3UZDA 5LX2A 3M51A 2C63A 4Y5IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4WRQ A;  3P1S A;  2C1N A;  3P1R A;  4DHM A;  1YZ5 A;  4FL5 A;  3IQU A;  1O9F A;  2O02 A;  4JC3 A;  5D3F A;  2O8P A;  4DX0 A;  1QJA A;  1O9E A;  3T0L A;  3SMN A;  1IB1 A;  3NKX A;  3U9X A;  4E2E A;  3O8I A;  4FJ3 A;  1YWT A;  4IHL A;  4DNK A;  3T0M A;  3P1O A;  5BTV A;  5LVZ A;  2NPM A;  4DHO A;  2O98 A;  3RDH A;  4Y3B A;  2BR9 A;  4DHQ A;  2C1J A;  4O46 A;  4N7G A;  2C74 A;  3P1P A;  3SPR A;  5LU1 A;  4DHU A;  5HF3 A;  5F74 A;  3UAL A;  4QLI A;  3LW1 A;  5J31 A;  4N7Y A;  4F7R A;  4DHP A;  5LU2 A;  5IQP A;  4HKC A;  4DAU A;  2V7D A;  3UX0 A;  3SMO A;  1O9D A;  4BG6 A;  4DAT A;  3UBW A;  5BY9 A;  5D2D A;  5EWZ A;  4DHN A;  2WH0 A;  5LHO A;  3IQJ A;  2B05 A;  5D3E A;  3P1Q A;  4N84 A;  3CU8 A;  3EFZ A;  3IQV A;  1A38 A;  5EXA A;  4DHS A;  4ZDR A;  4DHR A;  2C23 A;  4JDD A;  4DHT A;  4FR3 A;  3E6Y A;  3MHR A;  3SMK A;  1A4O A;  2BQ0 A;  1QJB A;  1A37 A;  4IEA A;  2BTP A;  3P1N A;  3AXY C;  3SML A;  3SMM A;  3M50 A;  1O9C A;  3SP5 A;  4ZQ0 A;  4Y32 A;  4GNT A;  4J6S A;  3UZD A;  5LX2 A;  3M51 A;  2C63 A;  4Y5I A; 
#chains in the Genus database with same CATH topology
 4WRQ A;  1CIY A;  3P1S A;  2C1N A;  3P1R A;  4DHM A;  1YZ5 A;  4FL5 A;  3IQU A;  1O9F A;  2O02 A;  4JC3 A;  4QX2 A;  5D3F A;  2O8P A;  4DX0 A;  1QJA A;  1O9E A;  3T0L A;  3SMN A;  3X0U A;  1IB1 A;  3NKX A;  3U9X A;  4E2E A;  3O8I A;  4FJ3 A;  1YWT A;  4IHL A;  4DNK A;  3I4R A;  3T0M A;  1W99 A;  3P1O A;  5BTV A;  4QX3 A;  5LVZ A;  2NPM A;  4DHO A;  2O98 A;  3RDH A;  4D8M A;  4Y3B A;  2BR9 A;  4DHQ A;  2C1J A;  4O46 A;  4N7G A;  2C74 A;  3P1P A;  3SPR A;  4ARX A;  1I5P A;  5LU1 A;  4DHU A;  5HF3 A;  5F74 A;  1URJ A;  3UAL A;  4QLI A;  3LW1 A;  5J31 A;  4N7Y A;  4MOA A;  4DHP A;  4F7R A;  5IQP A;  5LU2 A;  4HKC A;  4DAU A;  2V7D A;  3UX0 A;  3SMO A;  1O9D A;  4BG6 A;  4DAT A;  3UBW A;  5BY9 A;  4QX1 A;  5D2D A;  5EWZ A;  4DHN A;  2WH0 A;  5LHO A;  3IQJ A;  2B05 A;  5D3E A;  3P1Q A;  3CQC A;  4N84 A;  3CU8 A;  3EFZ A;  3IQV A;  1A38 A;  5EXA A;  4DHS A;  4ZDR A;  4DHR A;  2C23 A;  4W8J A;  3CQG A;  4JDD A;  4QX0 A;  4DHT A;  1JI6 A;  4FR3 A;  3E6Y A;  3MHR A;  3SMK A;  1A4O A;  2BQ0 A;  1QJB A;  1A37 A;  2C9K A;  4IEA A;  3ZHE B;  2BTP A;  3P1N A;  4ARY A;  3AXY C;  3SML A;  1DLC A;  3SMM A;  3M50 A;  1O9C A;  3SP5 A;  4ZQ0 A;  4Y32 A;  1S2X A;  4GNT A;  4J6S A;  3UZD A;  5LX2 A;  3M51 A;  2C63 A;  4Y5I A;  3EB7 A; 
#chains in the Genus database with same CATH homology
 4WRQ A;  3P1S A;  2C1N A;  3P1R A;  4DHM A;  1YZ5 A;  4FL5 A;  3IQU A;  1O9F A;  2O02 A;  4JC3 A;  5D3F A;  2O8P A;  4DX0 A;  1QJA A;  1O9E A;  3T0L A;  3SMN A;  1IB1 A;  3NKX A;  3U9X A;  4E2E A;  3O8I A;  4FJ3 A;  1YWT A;  4IHL A;  4DNK A;  3T0M A;  3P1O A;  5BTV A;  5LVZ A;  2NPM A;  4DHO A;  2O98 A;  3RDH A;  4Y3B A;  2BR9 A;  4DHQ A;  2C1J A;  4O46 A;  4N7G A;  2C74 A;  3P1P A;  3SPR A;  5LU1 A;  4DHU A;  5HF3 A;  5F74 A;  3UAL A;  4QLI A;  3LW1 A;  5J31 A;  4N7Y A;  4F7R A;  4DHP A;  5LU2 A;  5IQP A;  4HKC A;  4DAU A;  2V7D A;  3UX0 A;  3SMO A;  1O9D A;  4BG6 A;  4DAT A;  3UBW A;  5BY9 A;  5D2D A;  5EWZ A;  4DHN A;  2WH0 A;  5LHO A;  3IQJ A;  2B05 A;  5D3E A;  3P1Q A;  4N84 A;  3CU8 A;  3EFZ A;  3IQV A;  1A38 A;  5EXA A;  4DHS A;  4ZDR A;  4DHR A;  2C23 A;  4JDD A;  4DHT A;  4FR3 A;  3E6Y A;  3MHR A;  3SMK A;  1A4O A;  2BQ0 A;  1QJB A;  1A37 A;  4IEA A;  2BTP A;  3P1N A;  3AXY C;  3SML A;  3SMM A;  3M50 A;  1O9C A;  3SP5 A;  4ZQ0 A;  4Y32 A;  4GNT A;  4J6S A;  3UZD A;  5LX2 A;  3M51 A;  2C63 A;  4Y5I A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...