4JC3A

14-3-3 protein interaction with estrogen receptor alpha provides a novel drug target interface
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
236
structure length
236
Chain Sequence
GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/peptide
molecule keywords 14-3-3 protein sigma
publication title Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
pubmed doi rcsb
source organism Homo sapiens
total genus 101
structure length 236
sequence length 236
ec nomenclature
pdb deposition date 2013-02-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4jc3A00
3IQVA 4ZDRA 4N7YA 3P1PA 3E6YA 4WRQA 4DNKA 3UX0A 1QJAA 4DHPA 4QLIA 2O8PA 4O46A 4Y32A 3LW1A 4Y5IA 4DHOA 1YWTA 4BG6A 4FJ3A 2V7DA 4N7GA 3IQJA 3P1QA 4DHQA 3T0LA 4DX0A 4F7RA 2O02A 5D3EA 5HF3A 5J31A 2BQ0A 3P1RA 4DATA 4FR3A 2NPMA 3SMNA 5D3FA 3NKXA 4DHUA 4DHRA 5LHOA 2C63A 1YZ5A 5EWZA 5BTVA 3SMOA 4DHTA 4J6SA 3EFZA 5LX2A 3UBWA 2C74A 5EXAA 1A38A 4DHNA 1QJBA 3AXYC 2BR9A 5LVZA 3SPRA 3O8IA 3SP5A 5IQPA 4ZQ0A 1IB1A 2C1NA 3UALA 4IHLA 3T0MA 1O9DA 2C1JA 4DHMA 4JC3A 3P1NA 3IQUA 3M50A 4DHSA 5LU1A 5LU2A 3SMKA 4JDDA 2C23A 2O98A 3RDHA 3SMLA 4GNTA 1O9CA 3P1SA 2BTPA 2B05A 5D2DA 4FL5A 4DAUA 3UZDA 4Y3BA 2WH0A 3M51A 3SMMA 5BY9A 4E2EA 1O9FA 3CU8A 5F74A 4N84A 1O9EA 4HKCA 3U9XA 3MHRA 1A4OA 1A37A 4IEAA 3P1OA
chains in the Genus database with same CATH superfamily
3IQVA 4ZDRA 4N7YA 3P1PA 3E6YA 4WRQA 4DNKA 3UX0A 1QJAA 4DHPA 4QLIA 2O8PA 4O46A 4Y32A 3CQGA 4ARYA 3LW1A 4Y5IA 4DHOA 1YWTA 1DLCA 3EB7A 4FJ3A 4BG6A 2V7DA 1JI6A 4N7GA 3IQJA 3P1QA 4DHQA 3T0LA 4DX0A 4F7RA 2O02A 5D3EA 4QX0A 5HF3A 3I4RA 5J31A 2BQ0A 3P1RA 4DATA 4FR3A 2NPMA 3SMNA 5D3FA 3NKXA 4DHUA 4W8JA 4DHRA 5LHOA 2C63A 1YZ5A 5EWZA 5BTVA 3SMOA 4DHTA 4J6SA 3EFZA 5LX2A 1W99A 3UBWA 2C74A 3CQCA 5EXAA 1A38A 4DHNA 1QJBA 3AXYC 4MOAA 2BR9A 5LVZA 3SPRA 3O8IA 3SP5A 5IQPA 4ZQ0A 1IB1A 2C1NA 3UALA 4IHLA 1S2XA 3T0MA 1I5PA 1URJA 1O9DA 2C1JA 4ARXA 4DHMA 4JC3A 3P1NA 3IQUA 4QX3A 3M50A 4DHSA 5LU1A 4QX1A 5LU2A 3SMKA 4JDDA 2C23A 2O98A 3RDHA 4D8MA 4GNTA 3SMLA 1O9CA 2C9KA 3P1SA 2BTPA 2B05A 3X0UA 5D2DA 4FL5A 4DAUA 3UZDA 4Y3BA 2WH0A 3M51A 3SMMA 5BY9A 4E2EA 1O9FA 3CU8A 5F74A 4N84A 4QX2A 1O9EA 4HKCA 3U9XA 1CIYA 3MHRA 1A4OA 1A37A 4IEAA 3P1OA 3ZHEB
chains in the Genus database with same CATH topology
3IQVA 4ZDRA 4N7YA 3P1PA 3E6YA 4WRQA 4DNKA 3UX0A 1QJAA 4DHPA 4QLIA 2O8PA 4O46A 4Y32A 3LW1A 4Y5IA 4DHOA 1YWTA 4BG6A 4FJ3A 2V7DA 4N7GA 3IQJA 3P1QA 4DHQA 3T0LA 4DX0A 4F7RA 2O02A 5D3EA 5HF3A 5J31A 2BQ0A 3P1RA 4DATA 4FR3A 2NPMA 3SMNA 5D3FA 3NKXA 4DHUA 4DHRA 5LHOA 2C63A 1YZ5A 5EWZA 5BTVA 3SMOA 4DHTA 4J6SA 3EFZA 5LX2A 3UBWA 2C74A 5EXAA 1A38A 4DHNA 1QJBA 3AXYC 2BR9A 5LVZA 3SPRA 3O8IA 3SP5A 5IQPA 4ZQ0A 1IB1A 2C1NA 3UALA 4IHLA 3T0MA 1O9DA 2C1JA 4DHMA 4JC3A 3P1NA 3IQUA 3M50A 4DHSA 5LU1A 5LU2A 3SMKA 4JDDA 2C23A 2O98A 3RDHA 3SMLA 4GNTA 1O9CA 3P1SA 2BTPA 2B05A 5D2DA 4FL5A 4DAUA 3UZDA 4Y3BA 2WH0A 3M51A 3SMMA 5BY9A 4E2EA 1O9FA 3CU8A 5F74A 4N84A 1O9EA 4HKCA 3U9XA 3MHRA 1A4OA 1A37A 4IEAA 3P1OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IQV A;  4ZDR A;  4N7Y A;  3P1P A;  3E6Y A;  4WRQ A;  4DNK A;  3UX0 A;  1QJA A;  4DHP A;  4QLI A;  2O8P A;  4O46 A;  4Y32 A;  3LW1 A;  4Y5I A;  4DHO A;  1YWT A;  4BG6 A;  4FJ3 A;  2V7D A;  4N7G A;  3IQJ A;  3P1Q A;  4DHQ A;  3T0L A;  4DX0 A;  4F7R A;  2O02 A;  5D3E A;  5HF3 A;  5J31 A;  2BQ0 A;  3P1R A;  4DAT A;  4FR3 A;  2NPM A;  3SMN A;  5D3F A;  3NKX A;  4DHU A;  4DHR A;  5LHO A;  2C63 A;  1YZ5 A;  5EWZ A;  5BTV A;  3SMO A;  4DHT A;  4J6S A;  3EFZ A;  5LX2 A;  3UBW A;  2C74 A;  5EXA A;  1A38 A;  4DHN A;  1QJB A;  3AXY C;  2BR9 A;  5LVZ A;  3SPR A;  3O8I A;  3SP5 A;  5IQP A;  4ZQ0 A;  1IB1 A;  2C1N A;  3UAL A;  4IHL A;  3T0M A;  1O9D A;  2C1J A;  4DHM A;  4JC3 A;  3P1N A;  3IQU A;  3M50 A;  4DHS A;  5LU1 A;  5LU2 A;  3SMK A;  4JDD A;  2C23 A;  2O98 A;  3RDH A;  3SML A;  4GNT A;  1O9C A;  3P1S A;  2BTP A;  2B05 A;  5D2D A;  4FL5 A;  4DAU A;  3UZD A;  4Y3B A;  2WH0 A;  3M51 A;  3SMM A;  5BY9 A;  4E2E A;  1O9F A;  3CU8 A;  5F74 A;  4N84 A;  1O9E A;  4HKC A;  3U9X A;  3MHR A;  1A4O A;  1A37 A;  4IEA A;  3P1O A; 
#chains in the Genus database with same CATH topology
 3IQV A;  4ZDR A;  4N7Y A;  3P1P A;  3E6Y A;  4WRQ A;  4DNK A;  3UX0 A;  1QJA A;  4DHP A;  4QLI A;  2O8P A;  4O46 A;  4Y32 A;  3CQG A;  4ARY A;  3LW1 A;  4Y5I A;  4DHO A;  1YWT A;  1DLC A;  3EB7 A;  4FJ3 A;  4BG6 A;  2V7D A;  1JI6 A;  4N7G A;  3IQJ A;  3P1Q A;  4DHQ A;  3T0L A;  4DX0 A;  4F7R A;  2O02 A;  5D3E A;  4QX0 A;  5HF3 A;  3I4R A;  5J31 A;  2BQ0 A;  3P1R A;  4DAT A;  4FR3 A;  2NPM A;  3SMN A;  5D3F A;  3NKX A;  4DHU A;  4W8J A;  4DHR A;  5LHO A;  2C63 A;  1YZ5 A;  5EWZ A;  5BTV A;  3SMO A;  4DHT A;  4J6S A;  3EFZ A;  5LX2 A;  1W99 A;  3UBW A;  2C74 A;  3CQC A;  5EXA A;  1A38 A;  4DHN A;  1QJB A;  3AXY C;  4MOA A;  2BR9 A;  5LVZ A;  3SPR A;  3O8I A;  3SP5 A;  5IQP A;  4ZQ0 A;  1IB1 A;  2C1N A;  3UAL A;  4IHL A;  1S2X A;  3T0M A;  1I5P A;  1URJ A;  1O9D A;  2C1J A;  4ARX A;  4DHM A;  4JC3 A;  3P1N A;  3IQU A;  4QX3 A;  3M50 A;  4DHS A;  5LU1 A;  4QX1 A;  5LU2 A;  3SMK A;  4JDD A;  2C23 A;  2O98 A;  3RDH A;  4D8M A;  4GNT A;  3SML A;  1O9C A;  2C9K A;  3P1S A;  2BTP A;  2B05 A;  3X0U A;  5D2D A;  4FL5 A;  4DAU A;  3UZD A;  4Y3B A;  2WH0 A;  3M51 A;  3SMM A;  5BY9 A;  4E2E A;  1O9F A;  3CU8 A;  5F74 A;  4N84 A;  4QX2 A;  1O9E A;  4HKC A;  3U9X A;  1CIY A;  3MHR A;  1A4O A;  1A37 A;  4IEA A;  3P1O A;  3ZHE B; 
#chains in the Genus database with same CATH homology
 3IQV A;  4ZDR A;  4N7Y A;  3P1P A;  3E6Y A;  4WRQ A;  4DNK A;  3UX0 A;  1QJA A;  4DHP A;  4QLI A;  2O8P A;  4O46 A;  4Y32 A;  3LW1 A;  4Y5I A;  4DHO A;  1YWT A;  4BG6 A;  4FJ3 A;  2V7D A;  4N7G A;  3IQJ A;  3P1Q A;  4DHQ A;  3T0L A;  4DX0 A;  4F7R A;  2O02 A;  5D3E A;  5HF3 A;  5J31 A;  2BQ0 A;  3P1R A;  4DAT A;  4FR3 A;  2NPM A;  3SMN A;  5D3F A;  3NKX A;  4DHU A;  4DHR A;  5LHO A;  2C63 A;  1YZ5 A;  5EWZ A;  5BTV A;  3SMO A;  4DHT A;  4J6S A;  3EFZ A;  5LX2 A;  3UBW A;  2C74 A;  5EXA A;  1A38 A;  4DHN A;  1QJB A;  3AXY C;  2BR9 A;  5LVZ A;  3SPR A;  3O8I A;  3SP5 A;  5IQP A;  4ZQ0 A;  1IB1 A;  2C1N A;  3UAL A;  4IHL A;  3T0M A;  1O9D A;  2C1J A;  4DHM A;  4JC3 A;  3P1N A;  3IQU A;  3M50 A;  4DHS A;  5LU1 A;  5LU2 A;  3SMK A;  4JDD A;  2C23 A;  2O98 A;  3RDH A;  3SML A;  4GNT A;  1O9C A;  3P1S A;  2BTP A;  2B05 A;  5D2D A;  4FL5 A;  4DAU A;  3UZD A;  4Y3B A;  2WH0 A;  3M51 A;  3SMM A;  5BY9 A;  4E2E A;  1O9F A;  3CU8 A;  5F74 A;  4N84 A;  1O9E A;  4HKC A;  3U9X A;  3MHR A;  1A4O A;  1A37 A;  4IEA A;  3P1O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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