4JDDA

14-3-3 protein interaction with estrogen receptor alpha provides a novel drug target interface
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
236
structure length
236
Chain Sequence
GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/peptide
molecule keywords 14-3-3 protein sigma
publication title Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 236
sequence length 236
ec nomenclature
pdb deposition date 2013-02-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4jddA00
4DHPA 2BR9A 4N84A 4FR3A 4J6SA 2V7DA 3P1SA 4E2EA 3T0LA 4DHMA 3SMOA 4ZQ0A 2O98A 2C74A 4GNTA 1QJBA 5LHOA 1O9DA 4FL5A 3AXYC 4QLIA 3EFZA 3P1RA 4BG6A 3RDHA 4DHTA 5LU2A 2C63A 3P1QA 4IEAA 1A4OA 2BQ0A 5EWZA 4JDDA 5F74A 1YZ5A 5HF3A 3SMMA 4Y3BA 3SMKA 3LW1A 4DHNA 3UX0A 4HKCA 4O46A 5D3EA 3P1NA 4Y32A 2C1JA 3IQVA 2O02A 4N7YA 3SP5A 3MHRA 3UZDA 2C23A 5LVZA 4DHRA 1QJAA 1O9FA 4WRQA 4IHLA 5LX2A 2B05A 3SMLA 4ZDRA 3M50A 1O9CA 5IQPA 4DHSA 5D3FA 5LU1A 1A37A 3P1PA 1A38A 3IQUA 4FJ3A 3UBWA 3M51A 2C1NA 3U9XA 2O8PA 4DAUA 1YWTA 3NKXA 3T0MA 3IQJA 1IB1A 3O8IA 2BTPA 4F7RA 5BY9A 2WH0A 3UALA 4DHQA 5D2DA 3P1OA 4DHUA 1O9EA 5BTVA 2NPMA 5EXAA 4DX0A 4DATA 5J31A 4N7GA 3CU8A 4JC3A 3SMNA 4Y5IA 4DNKA 4DHOA 3E6YA 3SPRA
chains in the Genus database with same CATH superfamily
4DHPA 2BR9A 4MOAA 4N84A 4FR3A 4J6SA 2V7DA 4W8JA 3P1SA 4E2EA 3T0LA 4DHMA 3SMOA 4ZQ0A 2O98A 2C74A 4GNTA 1QJBA 5LHOA 1O9DA 4FL5A 3AXYC 3EB7A 4QLIA 3EFZA 3P1RA 4BG6A 3RDHA 4DHTA 5LU2A 2C63A 3P1QA 4IEAA 1A4OA 2BQ0A 5EWZA 4JDDA 5F74A 1YZ5A 5HF3A 3SMMA 4Y3BA 3SMKA 1CIYA 3LW1A 4DHNA 3UX0A 4HKCA 4O46A 1URJA 3CQCA 5D3EA 3P1NA 4Y32A 2C1JA 3CQGA 3IQVA 2O02A 4N7YA 3SP5A 1JI6A 3MHRA 3UZDA 3I4RA 2C23A 5LVZA 4DHRA 4QX1A 1I5PA 1QJAA 1O9FA 4D8MA 3X0UA 4WRQA 4ARYA 4IHLA 5LX2A 2B05A 2C9KA 3SMLA 4ZDRA 3M50A 1O9CA 1DLCA 5IQPA 4DHSA 5D3FA 5LU1A 1A37A 3P1PA 1A38A 4QX0A 3IQUA 4FJ3A 3UBWA 3M51A 4QX3A 2C1NA 3U9XA 2O8PA 4DAUA 1YWTA 3NKXA 3T0MA 3IQJA 4ARXA 1IB1A 3O8IA 2BTPA 4F7RA 5BY9A 2WH0A 3UALA 1W99A 4DHQA 5D2DA 3ZHEB 3P1OA 4DHUA 1O9EA 5BTVA 2NPMA 4QX2A 5EXAA 4DX0A 4DATA 5J31A 4N7GA 3CU8A 4JC3A 3SMNA 4Y5IA 4DNKA 4DHOA 3E6YA 1S2XA 3SPRA
chains in the Genus database with same CATH topology
4DHPA 2BR9A 4N84A 4FR3A 4J6SA 2V7DA 3P1SA 4E2EA 3T0LA 4DHMA 3SMOA 4ZQ0A 2O98A 2C74A 4GNTA 1QJBA 5LHOA 1O9DA 4FL5A 3AXYC 4QLIA 3EFZA 3P1RA 4BG6A 3RDHA 4DHTA 5LU2A 2C63A 3P1QA 4IEAA 1A4OA 2BQ0A 5EWZA 4JDDA 5F74A 1YZ5A 5HF3A 3SMMA 4Y3BA 3SMKA 3LW1A 4DHNA 3UX0A 4HKCA 4O46A 5D3EA 3P1NA 4Y32A 2C1JA 3IQVA 2O02A 4N7YA 3SP5A 3MHRA 3UZDA 2C23A 5LVZA 4DHRA 1QJAA 1O9FA 4WRQA 4IHLA 5LX2A 2B05A 3SMLA 4ZDRA 3M50A 1O9CA 5IQPA 4DHSA 5D3FA 5LU1A 1A37A 3P1PA 1A38A 3IQUA 4FJ3A 3UBWA 3M51A 2C1NA 3U9XA 2O8PA 4DAUA 1YWTA 3NKXA 3T0MA 3IQJA 1IB1A 3O8IA 2BTPA 4F7RA 5BY9A 2WH0A 3UALA 4DHQA 5D2DA 3P1OA 4DHUA 1O9EA 5BTVA 2NPMA 5EXAA 4DX0A 4DATA 5J31A 4N7GA 3CU8A 4JC3A 3SMNA 4Y5IA 4DNKA 4DHOA 3E6YA 3SPRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DHP A;  2BR9 A;  4N84 A;  4FR3 A;  4J6S A;  2V7D A;  3P1S A;  4E2E A;  3T0L A;  4DHM A;  3SMO A;  4ZQ0 A;  2O98 A;  2C74 A;  4GNT A;  1QJB A;  5LHO A;  1O9D A;  4FL5 A;  3AXY C;  4QLI A;  3EFZ A;  3P1R A;  4BG6 A;  3RDH A;  4DHT A;  5LU2 A;  2C63 A;  3P1Q A;  4IEA A;  1A4O A;  2BQ0 A;  5EWZ A;  4JDD A;  5F74 A;  1YZ5 A;  5HF3 A;  3SMM A;  4Y3B A;  3SMK A;  3LW1 A;  4DHN A;  3UX0 A;  4HKC A;  4O46 A;  5D3E A;  3P1N A;  4Y32 A;  2C1J A;  3IQV A;  2O02 A;  4N7Y A;  3SP5 A;  3MHR A;  3UZD A;  2C23 A;  5LVZ A;  4DHR A;  1QJA A;  1O9F A;  4WRQ A;  4IHL A;  5LX2 A;  2B05 A;  3SML A;  4ZDR A;  3M50 A;  1O9C A;  5IQP A;  4DHS A;  5D3F A;  5LU1 A;  1A37 A;  3P1P A;  1A38 A;  3IQU A;  4FJ3 A;  3UBW A;  3M51 A;  2C1N A;  3U9X A;  2O8P A;  4DAU A;  1YWT A;  3NKX A;  3T0M A;  3IQJ A;  1IB1 A;  3O8I A;  2BTP A;  4F7R A;  5BY9 A;  2WH0 A;  3UAL A;  4DHQ A;  5D2D A;  3P1O A;  4DHU A;  1O9E A;  5BTV A;  2NPM A;  5EXA A;  4DX0 A;  4DAT A;  5J31 A;  4N7G A;  3CU8 A;  4JC3 A;  3SMN A;  4Y5I A;  4DNK A;  4DHO A;  3E6Y A;  3SPR A; 
#chains in the Genus database with same CATH topology
 4DHP A;  2BR9 A;  4MOA A;  4N84 A;  4FR3 A;  4J6S A;  2V7D A;  4W8J A;  3P1S A;  4E2E A;  3T0L A;  4DHM A;  3SMO A;  4ZQ0 A;  2O98 A;  2C74 A;  4GNT A;  1QJB A;  5LHO A;  1O9D A;  4FL5 A;  3AXY C;  3EB7 A;  4QLI A;  3EFZ A;  3P1R A;  4BG6 A;  3RDH A;  4DHT A;  5LU2 A;  2C63 A;  3P1Q A;  4IEA A;  1A4O A;  2BQ0 A;  5EWZ A;  4JDD A;  5F74 A;  1YZ5 A;  5HF3 A;  3SMM A;  4Y3B A;  3SMK A;  1CIY A;  3LW1 A;  4DHN A;  3UX0 A;  4HKC A;  4O46 A;  1URJ A;  3CQC A;  5D3E A;  3P1N A;  4Y32 A;  2C1J A;  3CQG A;  3IQV A;  2O02 A;  4N7Y A;  3SP5 A;  1JI6 A;  3MHR A;  3UZD A;  3I4R A;  2C23 A;  5LVZ A;  4DHR A;  4QX1 A;  1I5P A;  1QJA A;  1O9F A;  4D8M A;  3X0U A;  4WRQ A;  4ARY A;  4IHL A;  5LX2 A;  2B05 A;  2C9K A;  3SML A;  4ZDR A;  3M50 A;  1O9C A;  1DLC A;  5IQP A;  4DHS A;  5D3F A;  5LU1 A;  1A37 A;  3P1P A;  1A38 A;  4QX0 A;  3IQU A;  4FJ3 A;  3UBW A;  3M51 A;  4QX3 A;  2C1N A;  3U9X A;  2O8P A;  4DAU A;  1YWT A;  3NKX A;  3T0M A;  3IQJ A;  4ARX A;  1IB1 A;  3O8I A;  2BTP A;  4F7R A;  5BY9 A;  2WH0 A;  3UAL A;  1W99 A;  4DHQ A;  5D2D A;  3ZHE B;  3P1O A;  4DHU A;  1O9E A;  5BTV A;  2NPM A;  4QX2 A;  5EXA A;  4DX0 A;  4DAT A;  5J31 A;  4N7G A;  3CU8 A;  4JC3 A;  3SMN A;  4Y5I A;  4DNK A;  4DHO A;  3E6Y A;  1S2X A;  3SPR A; 
#chains in the Genus database with same CATH homology
 4DHP A;  2BR9 A;  4N84 A;  4FR3 A;  4J6S A;  2V7D A;  3P1S A;  4E2E A;  3T0L A;  4DHM A;  3SMO A;  4ZQ0 A;  2O98 A;  2C74 A;  4GNT A;  1QJB A;  5LHO A;  1O9D A;  4FL5 A;  3AXY C;  4QLI A;  3EFZ A;  3P1R A;  4BG6 A;  3RDH A;  4DHT A;  5LU2 A;  2C63 A;  3P1Q A;  4IEA A;  1A4O A;  2BQ0 A;  5EWZ A;  4JDD A;  5F74 A;  1YZ5 A;  5HF3 A;  3SMM A;  4Y3B A;  3SMK A;  3LW1 A;  4DHN A;  3UX0 A;  4HKC A;  4O46 A;  5D3E A;  3P1N A;  4Y32 A;  2C1J A;  3IQV A;  2O02 A;  4N7Y A;  3SP5 A;  3MHR A;  3UZD A;  2C23 A;  5LVZ A;  4DHR A;  1QJA A;  1O9F A;  4WRQ A;  4IHL A;  5LX2 A;  2B05 A;  3SML A;  4ZDR A;  3M50 A;  1O9C A;  5IQP A;  4DHS A;  5D3F A;  5LU1 A;  1A37 A;  3P1P A;  1A38 A;  3IQU A;  4FJ3 A;  3UBW A;  3M51 A;  2C1N A;  3U9X A;  2O8P A;  4DAU A;  1YWT A;  3NKX A;  3T0M A;  3IQJ A;  1IB1 A;  3O8I A;  2BTP A;  4F7R A;  5BY9 A;  2WH0 A;  3UAL A;  4DHQ A;  5D2D A;  3P1O A;  4DHU A;  1O9E A;  5BTV A;  2NPM A;  5EXA A;  4DX0 A;  4DAT A;  5J31 A;  4N7G A;  3CU8 A;  4JC3 A;  3SMN A;  4Y5I A;  4DNK A;  4DHO A;  3E6Y A;  3SPR A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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