1YZ5A

The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution
Total Genus 89
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
89
sequence length
233
structure length
223
Chain Sequence
MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSYKDSTLIMQLLRDNLTLWTAD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords 14-3-3 protein sigma
total genus 89
structure length 223
sequence length 233
chains with identical sequence B
ec nomenclature
pdb deposition date 2005-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 1yz5A00
4F7RA 2BR9A 3P1PA 4IHLA 5D3FA 1YZ5A 4DHSA 2V7DA 3NKXA 5F74A 2C1NA 3SMMA 4N84A 3E6YA 4DHNA 3P1QA 4ZQ0A 1YWTA 1A4OA 3UALA 2C74A 4N7GA 2O02A 5BTVA 3SMLA 2BTPA 3LW1A 3U9XA 4DHQA 4DHOA 4J6SA 4QLIA 3SMKA 5D2DA 4Y32A 1A38A 3SP5A 4ZDRA 3IQVA 4BG6A 2C23A 3O8IA 5EXAA 4JC3A 3M50A 2B05A 5LU2A 3SMOA 1O9EA 2C63A 3SPRA 4DX0A 3CU8A 1A37A 5LX2A 4GNTA 3T0LA 3MHRA 4Y3BA 1O9CA 5D3EA 5LU1A 3P1OA 3UX0A 5LVZA 3T0MA 4FR3A 4DHUA 4DATA 2O8PA 3IQUA 5BY9A 3RDHA 4FL5A 1QJBA 2NPMA 4DHPA 4DAUA 1O9FA 4DHRA 3M51A 4E2EA 3SMNA 3AXYC 3P1SA 5J31A 4DHMA 4FJ3A 2O98A 5EWZA 5HF3A 5IQPA 4IEAA 2C1JA 1IB1A 3P1RA 2WH0A 4DHTA 5LHOA 3UBWA 4DNKA 3EFZA 4HKCA 4O46A 3IQJA 4N7YA 1O9DA 3P1NA 3UZDA 1QJAA 4JDDA 4WRQA 2BQ0A 4Y5IA
chains in the Genus database with same CATH superfamily
3ZHEB 4F7RA 3EB7A 2BR9A 1DLCA 3P1PA 4IHLA 5D3FA 1YZ5A 4DHSA 2V7DA 3NKXA 1CIYA 5F74A 2C1NA 3SMMA 4N84A 3E6YA 4QX3A 4DHNA 1JI6A 3P1QA 4ZQ0A 1YWTA 1A4OA 3UALA 2C74A 3X0UA 4N7GA 2O02A 5BTVA 4QX0A 3SMLA 2BTPA 3LW1A 3U9XA 4DHQA 4DHOA 4J6SA 4QLIA 3SMKA 5D2DA 4Y32A 1S2XA 1A38A 3SP5A 4ZDRA 3IQVA 4BG6A 2C23A 3O8IA 3CQCA 5EXAA 1I5PA 4JC3A 3M50A 2B05A 2C9KA 5LU2A 3SMOA 1O9EA 2C63A 3SPRA 4DX0A 3CU8A 1A37A 4ARXA 5LX2A 4GNTA 3CQGA 4QX1A 3MHRA 4Y3BA 3T0LA 1O9CA 5D3EA 5LU1A 3P1OA 3UX0A 1URJA 5LVZA 3T0MA 4FR3A 4DHUA 3I4RA 4DATA 2O8PA 3IQUA 4ARYA 5BY9A 3RDHA 4FL5A 1QJBA 1W99A 2NPMA 4DHPA 4DAUA 1O9FA 4DHRA 3M51A 4E2EA 3SMNA 3AXYC 3P1SA 5J31A 4DHMA 4FJ3A 2O98A 5EWZA 5HF3A 5IQPA 4IEAA 4W8JA 2C1JA 1IB1A 3P1RA 2WH0A 4DHTA 5LHOA 3UBWA 4DNKA 3EFZA 4HKCA 4O46A 4D8MA 3IQJA 4N7YA 1O9DA 3P1NA 3UZDA 1QJAA 4JDDA 4QX2A 4WRQA 4MOAA 2BQ0A 4Y5IA
chains in the Genus database with same CATH topology
4F7RA 2BR9A 3P1PA 4IHLA 5D3FA 1YZ5A 4DHSA 2V7DA 3NKXA 5F74A 2C1NA 3SMMA 4N84A 3E6YA 4DHNA 3P1QA 4ZQ0A 1YWTA 1A4OA 3UALA 2C74A 4N7GA 2O02A 5BTVA 3SMLA 2BTPA 3LW1A 3U9XA 4DHQA 4DHOA 4J6SA 4QLIA 3SMKA 5D2DA 4Y32A 1A38A 3SP5A 4ZDRA 3IQVA 4BG6A 2C23A 3O8IA 5EXAA 4JC3A 3M50A 2B05A 5LU2A 3SMOA 1O9EA 2C63A 3SPRA 4DX0A 3CU8A 1A37A 5LX2A 4GNTA 3T0LA 3MHRA 4Y3BA 1O9CA 5D3EA 5LU1A 3P1OA 3UX0A 5LVZA 3T0MA 4FR3A 4DHUA 4DATA 2O8PA 3IQUA 5BY9A 3RDHA 4FL5A 1QJBA 2NPMA 4DHPA 4DAUA 1O9FA 4DHRA 3M51A 4E2EA 3SMNA 3AXYC 3P1SA 5J31A 4DHMA 4FJ3A 2O98A 5EWZA 5HF3A 5IQPA 4IEAA 2C1JA 1IB1A 3P1RA 2WH0A 4DHTA 5LHOA 3UBWA 4DNKA 3EFZA 4HKCA 4O46A 3IQJA 4N7YA 1O9DA 3P1NA 3UZDA 1QJAA 4JDDA 4WRQA 2BQ0A 4Y5IA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4F7R A;  2BR9 A;  3P1P A;  4IHL A;  5D3F A;  1YZ5 A;  4DHS A;  2V7D A;  3NKX A;  5F74 A;  2C1N A;  3SMM A;  4N84 A;  3E6Y A;  4DHN A;  3P1Q A;  4ZQ0 A;  1YWT A;  1A4O A;  3UAL A;  2C74 A;  4N7G A;  2O02 A;  5BTV A;  3SML A;  2BTP A;  3LW1 A;  3U9X A;  4DHQ A;  4DHO A;  4J6S A;  4QLI A;  3SMK A;  5D2D A;  4Y32 A;  1A38 A;  3SP5 A;  4ZDR A;  3IQV A;  4BG6 A;  2C23 A;  3O8I A;  5EXA A;  4JC3 A;  3M50 A;  2B05 A;  5LU2 A;  3SMO A;  1O9E A;  2C63 A;  3SPR A;  4DX0 A;  3CU8 A;  1A37 A;  5LX2 A;  4GNT A;  3T0L A;  3MHR A;  4Y3B A;  1O9C A;  5D3E A;  5LU1 A;  3P1O A;  3UX0 A;  5LVZ A;  3T0M A;  4FR3 A;  4DHU A;  4DAT A;  2O8P A;  3IQU A;  5BY9 A;  3RDH A;  4FL5 A;  1QJB A;  2NPM A;  4DHP A;  4DAU A;  1O9F A;  4DHR A;  3M51 A;  4E2E A;  3SMN A;  3AXY C;  3P1S A;  5J31 A;  4DHM A;  4FJ3 A;  2O98 A;  5EWZ A;  5HF3 A;  5IQP A;  4IEA A;  2C1J A;  1IB1 A;  3P1R A;  2WH0 A;  4DHT A;  5LHO A;  3UBW A;  4DNK A;  3EFZ A;  4HKC A;  4O46 A;  3IQJ A;  4N7Y A;  1O9D A;  3P1N A;  3UZD A;  1QJA A;  4JDD A;  4WRQ A;  2BQ0 A;  4Y5I A; 
#chains in the Genus database with same CATH topology
 3ZHE B;  4F7R A;  3EB7 A;  2BR9 A;  1DLC A;  3P1P A;  4IHL A;  5D3F A;  1YZ5 A;  4DHS A;  2V7D A;  3NKX A;  1CIY A;  5F74 A;  2C1N A;  3SMM A;  4N84 A;  3E6Y A;  4QX3 A;  4DHN A;  1JI6 A;  3P1Q A;  4ZQ0 A;  1YWT A;  1A4O A;  3UAL A;  2C74 A;  3X0U A;  4N7G A;  2O02 A;  5BTV A;  4QX0 A;  3SML A;  2BTP A;  3LW1 A;  3U9X A;  4DHQ A;  4DHO A;  4J6S A;  4QLI A;  3SMK A;  5D2D A;  4Y32 A;  1S2X A;  1A38 A;  3SP5 A;  4ZDR A;  3IQV A;  4BG6 A;  2C23 A;  3O8I A;  3CQC A;  5EXA A;  1I5P A;  4JC3 A;  3M50 A;  2B05 A;  2C9K A;  5LU2 A;  3SMO A;  1O9E A;  2C63 A;  3SPR A;  4DX0 A;  3CU8 A;  1A37 A;  4ARX A;  5LX2 A;  4GNT A;  3CQG A;  4QX1 A;  3MHR A;  4Y3B A;  3T0L A;  1O9C A;  5D3E A;  5LU1 A;  3P1O A;  3UX0 A;  1URJ A;  5LVZ A;  3T0M A;  4FR3 A;  4DHU A;  3I4R A;  4DAT A;  2O8P A;  3IQU A;  4ARY A;  5BY9 A;  3RDH A;  4FL5 A;  1QJB A;  1W99 A;  2NPM A;  4DHP A;  4DAU A;  1O9F A;  4DHR A;  3M51 A;  4E2E A;  3SMN A;  3AXY C;  3P1S A;  5J31 A;  4DHM A;  4FJ3 A;  2O98 A;  5EWZ A;  5HF3 A;  5IQP A;  4IEA A;  4W8J A;  2C1J A;  1IB1 A;  3P1R A;  2WH0 A;  4DHT A;  5LHO A;  3UBW A;  4DNK A;  3EFZ A;  4HKC A;  4O46 A;  4D8M A;  3IQJ A;  4N7Y A;  1O9D A;  3P1N A;  3UZD A;  1QJA A;  4JDD A;  4QX2 A;  4WRQ A;  4MOA A;  2BQ0 A;  4Y5I A; 
#chains in the Genus database with same CATH homology
 4F7R A;  2BR9 A;  3P1P A;  4IHL A;  5D3F A;  1YZ5 A;  4DHS A;  2V7D A;  3NKX A;  5F74 A;  2C1N A;  3SMM A;  4N84 A;  3E6Y A;  4DHN A;  3P1Q A;  4ZQ0 A;  1YWT A;  1A4O A;  3UAL A;  2C74 A;  4N7G A;  2O02 A;  5BTV A;  3SML A;  2BTP A;  3LW1 A;  3U9X A;  4DHQ A;  4DHO A;  4J6S A;  4QLI A;  3SMK A;  5D2D A;  4Y32 A;  1A38 A;  3SP5 A;  4ZDR A;  3IQV A;  4BG6 A;  2C23 A;  3O8I A;  5EXA A;  4JC3 A;  3M50 A;  2B05 A;  5LU2 A;  3SMO A;  1O9E A;  2C63 A;  3SPR A;  4DX0 A;  3CU8 A;  1A37 A;  5LX2 A;  4GNT A;  3T0L A;  3MHR A;  4Y3B A;  1O9C A;  5D3E A;  5LU1 A;  3P1O A;  3UX0 A;  5LVZ A;  3T0M A;  4FR3 A;  4DHU A;  4DAT A;  2O8P A;  3IQU A;  5BY9 A;  3RDH A;  4FL5 A;  1QJB A;  2NPM A;  4DHP A;  4DAU A;  1O9F A;  4DHR A;  3M51 A;  4E2E A;  3SMN A;  3AXY C;  3P1S A;  5J31 A;  4DHM A;  4FJ3 A;  2O98 A;  5EWZ A;  5HF3 A;  5IQP A;  4IEA A;  2C1J A;  1IB1 A;  3P1R A;  2WH0 A;  4DHT A;  5LHO A;  3UBW A;  4DNK A;  3EFZ A;  4HKC A;  4O46 A;  3IQJ A;  4N7Y A;  1O9D A;  3P1N A;  3UZD A;  1QJA A;  4JDD A;  4WRQ A;  2BQ0 A;  4Y5I A; 
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