3UX0A

Crystal structure of human 14-3-3 sigma in complex with task-3 peptide and stabilizer fusicoccin h
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
235
structure length
227
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of k(+) channels at the cell surface.
pubmed doi rcsb
molecule tags Peptide binding protein
source organism Homo sapiens
molecule keywords 14-3-3 protein sigma
total genus 100
structure length 227
sequence length 235
ec nomenclature
pdb deposition date 2011-12-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 3ux0A00
4IEAA 3M51A 4WRQA 4JDDA 1A37A 5BTVA 2O8PA 2O02A 3SMNA 3UZDA 3EFZA 5F74A 2C1JA 5LHOA 4DATA 4DHMA 4DX0A 2BR9A 4Y5IA 3P1SA 4J6SA 5LU1A 3LW1A 5EWZA 5LU2A 4O46A 3IQJA 4HKCA 2BQ0A 4DHQA 4DNKA 3M50A 3P1QA 1A38A 4ZQ0A 4DHPA 2V7DA 1YWTA 4IHLA 4DAUA 3P1OA 4FR3A 3UALA 3SMMA 5IQPA 3U9XA 4QLIA 3T0LA 2C1NA 5HF3A 4E2EA 4Y32A 3O8IA 4GNTA 3P1RA 1QJBA 4N7YA 3UBWA 4BG6A 5EXAA 2C63A 3SMOA 1A4OA 3AXYC 3IQVA 4N7GA 2C74A 3MHRA 2C23A 4JC3A 4N84A 1YZ5A 4Y3BA 3SMKA 3P1NA 3RDHA 3SP5A 2WH0A 4FJ3A 4DHOA 4F7RA 5J31A 4DHTA 4FL5A 1QJAA 2O98A 4DHRA 3UX0A 3T0MA 5BY9A 5LVZA 4ZDRA 2B05A 5D2DA 3E6YA 1O9EA 4DHSA 4DHUA 2BTPA 3P1PA 5D3EA 2NPMA 3CU8A 4DHNA 1O9DA 1O9CA 5LX2A 3SPRA 3SMLA 5D3FA 3IQUA 3NKXA 1O9FA 1IB1A
chains in the Genus database with same CATH superfamily
4IEAA 4ARXA 3M51A 4WRQA 4JDDA 1A37A 4W8JA 4MOAA 2O8PA 2O02A 3SMNA 5BTVA 4ARYA 3UZDA 1W99A 4QX3A 1URJA 3EFZA 5F74A 2C1JA 5LHOA 4DATA 4DHMA 4DX0A 2BR9A 4Y5IA 3P1SA 4J6SA 5LU1A 3LW1A 5EWZA 5LU2A 4O46A 1I5PA 3IQJA 3EB7A 4HKCA 2BQ0A 4DHQA 4DNKA 3M50A 3P1QA 1A38A 4ZQ0A 4DHPA 2V7DA 4QX2A 1YWTA 4IHLA 4DAUA 1JI6A 3CQGA 3P1OA 4FR3A 3UALA 3SMMA 5IQPA 3U9XA 4QLIA 3T0LA 2C1NA 5HF3A 4E2EA 4Y32A 3O8IA 4GNTA 3P1RA 4D8MA 1QJBA 1CIYA 4N7YA 3UBWA 4BG6A 5EXAA 2C63A 4QX1A 3SMOA 1A4OA 3AXYC 3IQVA 4N7GA 2C74A 4QX0A 3ZHEB 3MHRA 2C23A 4JC3A 4N84A 1YZ5A 3X0UA 4Y3BA 3SMKA 3P1NA 3RDHA 3SP5A 2WH0A 4FJ3A 4DHOA 4F7RA 5J31A 4DHTA 4FL5A 1QJAA 2O98A 4DHRA 3UX0A 3T0MA 5BY9A 1DLCA 5LVZA 4ZDRA 2B05A 5D2DA 3E6YA 1O9EA 4DHSA 4DHUA 2BTPA 3P1PA 1S2XA 5D3EA 2NPMA 3CU8A 4DHNA 1O9DA 1O9CA 5LX2A 3SPRA 3SMLA 5D3FA 3IQUA 3CQCA 2C9KA 3NKXA 1O9FA 3I4RA 1IB1A
chains in the Genus database with same CATH topology
4IEAA 3M51A 4WRQA 4JDDA 1A37A 5BTVA 2O8PA 2O02A 3SMNA 3UZDA 3EFZA 5F74A 2C1JA 5LHOA 4DATA 4DHMA 4DX0A 2BR9A 4Y5IA 3P1SA 4J6SA 5LU1A 3LW1A 5EWZA 5LU2A 4O46A 3IQJA 4HKCA 2BQ0A 4DHQA 4DNKA 3M50A 3P1QA 1A38A 4ZQ0A 4DHPA 2V7DA 1YWTA 4IHLA 4DAUA 3P1OA 4FR3A 3UALA 3SMMA 5IQPA 3U9XA 4QLIA 3T0LA 2C1NA 5HF3A 4E2EA 4Y32A 3O8IA 4GNTA 3P1RA 1QJBA 4N7YA 3UBWA 4BG6A 5EXAA 2C63A 3SMOA 1A4OA 3AXYC 3IQVA 4N7GA 2C74A 3MHRA 2C23A 4JC3A 4N84A 1YZ5A 4Y3BA 3SMKA 3P1NA 3RDHA 3SP5A 2WH0A 4FJ3A 4DHOA 4F7RA 5J31A 4DHTA 4FL5A 1QJAA 2O98A 4DHRA 3UX0A 3T0MA 5BY9A 5LVZA 4ZDRA 2B05A 5D2DA 3E6YA 1O9EA 4DHSA 4DHUA 2BTPA 3P1PA 5D3EA 2NPMA 3CU8A 4DHNA 1O9DA 1O9CA 5LX2A 3SPRA 3SMLA 5D3FA 3IQUA 3NKXA 1O9FA 1IB1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IEA A;  3M51 A;  4WRQ A;  4JDD A;  1A37 A;  5BTV A;  2O8P A;  2O02 A;  3SMN A;  3UZD A;  3EFZ A;  5F74 A;  2C1J A;  5LHO A;  4DAT A;  4DHM A;  4DX0 A;  2BR9 A;  4Y5I A;  3P1S A;  4J6S A;  5LU1 A;  3LW1 A;  5EWZ A;  5LU2 A;  4O46 A;  3IQJ A;  4HKC A;  2BQ0 A;  4DHQ A;  4DNK A;  3M50 A;  3P1Q A;  1A38 A;  4ZQ0 A;  4DHP A;  2V7D A;  1YWT A;  4IHL A;  4DAU A;  3P1O A;  4FR3 A;  3UAL A;  3SMM A;  5IQP A;  3U9X A;  4QLI A;  3T0L A;  2C1N A;  5HF3 A;  4E2E A;  4Y32 A;  3O8I A;  4GNT A;  3P1R A;  1QJB A;  4N7Y A;  3UBW A;  4BG6 A;  5EXA A;  2C63 A;  3SMO A;  1A4O A;  3AXY C;  3IQV A;  4N7G A;  2C74 A;  3MHR A;  2C23 A;  4JC3 A;  4N84 A;  1YZ5 A;  4Y3B A;  3SMK A;  3P1N A;  3RDH A;  3SP5 A;  2WH0 A;  4FJ3 A;  4DHO A;  4F7R A;  5J31 A;  4DHT A;  4FL5 A;  1QJA A;  2O98 A;  4DHR A;  3UX0 A;  3T0M A;  5BY9 A;  5LVZ A;  4ZDR A;  2B05 A;  5D2D A;  3E6Y A;  1O9E A;  4DHS A;  4DHU A;  2BTP A;  3P1P A;  5D3E A;  2NPM A;  3CU8 A;  4DHN A;  1O9D A;  1O9C A;  5LX2 A;  3SPR A;  3SML A;  5D3F A;  3IQU A;  3NKX A;  1O9F A;  1IB1 A; 
#chains in the Genus database with same CATH topology
 4IEA A;  4ARX A;  3M51 A;  4WRQ A;  4JDD A;  1A37 A;  4W8J A;  4MOA A;  2O8P A;  2O02 A;  3SMN A;  5BTV A;  4ARY A;  3UZD A;  1W99 A;  4QX3 A;  1URJ A;  3EFZ A;  5F74 A;  2C1J A;  5LHO A;  4DAT A;  4DHM A;  4DX0 A;  2BR9 A;  4Y5I A;  3P1S A;  4J6S A;  5LU1 A;  3LW1 A;  5EWZ A;  5LU2 A;  4O46 A;  1I5P A;  3IQJ A;  3EB7 A;  4HKC A;  2BQ0 A;  4DHQ A;  4DNK A;  3M50 A;  3P1Q A;  1A38 A;  4ZQ0 A;  4DHP A;  2V7D A;  4QX2 A;  1YWT A;  4IHL A;  4DAU A;  1JI6 A;  3CQG A;  3P1O A;  4FR3 A;  3UAL A;  3SMM A;  5IQP A;  3U9X A;  4QLI A;  3T0L A;  2C1N A;  5HF3 A;  4E2E A;  4Y32 A;  3O8I A;  4GNT A;  3P1R A;  4D8M A;  1QJB A;  1CIY A;  4N7Y A;  3UBW A;  4BG6 A;  5EXA A;  2C63 A;  4QX1 A;  3SMO A;  1A4O A;  3AXY C;  3IQV A;  4N7G A;  2C74 A;  4QX0 A;  3ZHE B;  3MHR A;  2C23 A;  4JC3 A;  4N84 A;  1YZ5 A;  3X0U A;  4Y3B A;  3SMK A;  3P1N A;  3RDH A;  3SP5 A;  2WH0 A;  4FJ3 A;  4DHO A;  4F7R A;  5J31 A;  4DHT A;  4FL5 A;  1QJA A;  2O98 A;  4DHR A;  3UX0 A;  3T0M A;  5BY9 A;  1DLC A;  5LVZ A;  4ZDR A;  2B05 A;  5D2D A;  3E6Y A;  1O9E A;  4DHS A;  4DHU A;  2BTP A;  3P1P A;  1S2X A;  5D3E A;  2NPM A;  3CU8 A;  4DHN A;  1O9D A;  1O9C A;  5LX2 A;  3SPR A;  3SML A;  5D3F A;  3IQU A;  3CQC A;  2C9K A;  3NKX A;  1O9F A;  3I4R A;  1IB1 A; 
#chains in the Genus database with same CATH homology
 4IEA A;  3M51 A;  4WRQ A;  4JDD A;  1A37 A;  5BTV A;  2O8P A;  2O02 A;  3SMN A;  3UZD A;  3EFZ A;  5F74 A;  2C1J A;  5LHO A;  4DAT A;  4DHM A;  4DX0 A;  2BR9 A;  4Y5I A;  3P1S A;  4J6S A;  5LU1 A;  3LW1 A;  5EWZ A;  5LU2 A;  4O46 A;  3IQJ A;  4HKC A;  2BQ0 A;  4DHQ A;  4DNK A;  3M50 A;  3P1Q A;  1A38 A;  4ZQ0 A;  4DHP A;  2V7D A;  1YWT A;  4IHL A;  4DAU A;  3P1O A;  4FR3 A;  3UAL A;  3SMM A;  5IQP A;  3U9X A;  4QLI A;  3T0L A;  2C1N A;  5HF3 A;  4E2E A;  4Y32 A;  3O8I A;  4GNT A;  3P1R A;  1QJB A;  4N7Y A;  3UBW A;  4BG6 A;  5EXA A;  2C63 A;  3SMO A;  1A4O A;  3AXY C;  3IQV A;  4N7G A;  2C74 A;  3MHR A;  2C23 A;  4JC3 A;  4N84 A;  1YZ5 A;  4Y3B A;  3SMK A;  3P1N A;  3RDH A;  3SP5 A;  2WH0 A;  4FJ3 A;  4DHO A;  4F7R A;  5J31 A;  4DHT A;  4FL5 A;  1QJA A;  2O98 A;  4DHR A;  3UX0 A;  3T0M A;  5BY9 A;  5LVZ A;  4ZDR A;  2B05 A;  5D2D A;  3E6Y A;  1O9E A;  4DHS A;  4DHU A;  2BTP A;  3P1P A;  5D3E A;  2NPM A;  3CU8 A;  4DHN A;  1O9D A;  1O9C A;  5LX2 A;  3SPR A;  3SML A;  5D3F A;  3IQU A;  3NKX A;  1O9F A;  1IB1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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