2O02A

Phosphorylation independent interactions between 14-3-3 and exoenzyme s: from structure to pathogenesis
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
230
structure length
224
Chain Sequence
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis
pubmed doi rcsb
molecule tags Protein binding/toxin
source organism Homo sapiens
molecule keywords 14-3-3 protein zeta/delta
total genus 99
structure length 224
sequence length 230
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-11-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 2o02A00
3EFZA 3SPRA 3P1OA 1YWTA 4IEAA 4DHTA 2C1JA 2BR9A 4JC3A 5D3FA 4GNTA 3SMOA 3O8IA 2O98A 3U9XA 3M51A 4FJ3A 3M50A 1YZ5A 5BY9A 4WRQA 4FR3A 2B05A 3SMKA 4IHLA 4DATA 1O9CA 2C23A 2WH0A 1A37A 2BQ0A 3SMMA 4JDDA 1QJAA 4ZQ0A 3CU8A 3SP5A 3P1SA 4DAUA 3SMNA 2O8PA 4DHPA 3P1PA 5LU2A 4E2EA 4QLIA 4O46A 3UBWA 3SMLA 4N7YA 1QJBA 3UX0A 2C63A 4F7RA 1O9FA 4N84A 4DX0A 3P1RA 3UALA 2C1NA 3RDHA 3T0LA 4J6SA 4DHQA 3T0MA 5IQPA 4FL5A 5LU1A 2V7DA 4DHSA 3MHRA 1O9DA 1IB1A 4DHUA 4DHOA 3E6YA 5EXAA 5HF3A 2NPMA 1O9EA 4Y32A 5D3EA 2O02A 5J31A 3NKXA 5LVZA 4DHMA 1A4OA 5D2DA 3P1QA 4Y5IA 1A38A 5BTVA 4N7GA 3P1NA 5LHOA 4BG6A 3IQJA 4DHNA 3AXYC 2BTPA 3LW1A 4Y3BA 5F74A 3UZDA 4ZDRA 4DNKA 3IQVA 2C74A 5EWZA 3IQUA 4DHRA 4HKCA 5LX2A
chains in the Genus database with same CATH superfamily
3ZHEB 3EFZA 3SPRA 4MOAA 3P1OA 1YWTA 4IEAA 4DHTA 2C1JA 2BR9A 3EB7A 4QX1A 4JC3A 5D3FA 4GNTA 3SMOA 3O8IA 1W99A 2O98A 3U9XA 3M51A 4FJ3A 3M50A 1YZ5A 5BY9A 4WRQA 4FR3A 2B05A 3SMKA 3CQGA 4IHLA 4DATA 1O9CA 2C23A 1CIYA 2WH0A 1JI6A 1A37A 2BQ0A 3SMMA 4JDDA 1URJA 1QJAA 4ZQ0A 3CU8A 3SP5A 3P1SA 4DAUA 3SMNA 2O8PA 4DHPA 3P1PA 5LU2A 4E2EA 1DLCA 4QLIA 4O46A 3UBWA 3SMLA 4N7YA 1QJBA 3UX0A 4ARYA 2C63A 4F7RA 1O9FA 4N84A 1I5PA 4DX0A 3P1RA 3UALA 2C1NA 4QX2A 4QX0A 3RDHA 3T0LA 4J6SA 4DHQA 4W8JA 3T0MA 5IQPA 4FL5A 5LU1A 2V7DA 4DHSA 3MHRA 1O9DA 3I4RA 1IB1A 4DHUA 4DHOA 3E6YA 5EXAA 5HF3A 2NPMA 1S2XA 1O9EA 2C9KA 4Y32A 5D3EA 2O02A 3CQCA 5J31A 3NKXA 5LVZA 4DHMA 1A4OA 5D2DA 3P1QA 4Y5IA 1A38A 4ARXA 4D8MA 4N7GA 3P1NA 5BTVA 5LHOA 4BG6A 3X0UA 3IQJA 4DHNA 3AXYC 2BTPA 3LW1A 4Y3BA 5F74A 3UZDA 4ZDRA 4QX3A 4DNKA 3IQVA 2C74A 5EWZA 3IQUA 4DHRA 4HKCA 5LX2A
chains in the Genus database with same CATH topology
3EFZA 3SPRA 3P1OA 1YWTA 4IEAA 4DHTA 2C1JA 2BR9A 4JC3A 5D3FA 4GNTA 3SMOA 3O8IA 2O98A 3U9XA 3M51A 4FJ3A 3M50A 1YZ5A 5BY9A 4WRQA 4FR3A 2B05A 3SMKA 4IHLA 4DATA 1O9CA 2C23A 2WH0A 1A37A 2BQ0A 3SMMA 4JDDA 1QJAA 4ZQ0A 3CU8A 3SP5A 3P1SA 4DAUA 3SMNA 2O8PA 4DHPA 3P1PA 5LU2A 4E2EA 4QLIA 4O46A 3UBWA 3SMLA 4N7YA 1QJBA 3UX0A 2C63A 4F7RA 1O9FA 4N84A 4DX0A 3P1RA 3UALA 2C1NA 3RDHA 3T0LA 4J6SA 4DHQA 3T0MA 5IQPA 4FL5A 5LU1A 2V7DA 4DHSA 3MHRA 1O9DA 1IB1A 4DHUA 4DHOA 3E6YA 5EXAA 5HF3A 2NPMA 1O9EA 4Y32A 5D3EA 2O02A 5J31A 3NKXA 5LVZA 4DHMA 1A4OA 5D2DA 3P1QA 4Y5IA 1A38A 5BTVA 4N7GA 3P1NA 5LHOA 4BG6A 3IQJA 4DHNA 3AXYC 2BTPA 3LW1A 4Y3BA 5F74A 3UZDA 4ZDRA 4DNKA 3IQVA 2C74A 5EWZA 3IQUA 4DHRA 4HKCA 5LX2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EFZ A;  3SPR A;  3P1O A;  1YWT A;  4IEA A;  4DHT A;  2C1J A;  2BR9 A;  4JC3 A;  5D3F A;  4GNT A;  3SMO A;  3O8I A;  2O98 A;  3U9X A;  3M51 A;  4FJ3 A;  3M50 A;  1YZ5 A;  5BY9 A;  4WRQ A;  4FR3 A;  2B05 A;  3SMK A;  4IHL A;  4DAT A;  1O9C A;  2C23 A;  2WH0 A;  1A37 A;  2BQ0 A;  3SMM A;  4JDD A;  1QJA A;  4ZQ0 A;  3CU8 A;  3SP5 A;  3P1S A;  4DAU A;  3SMN A;  2O8P A;  4DHP A;  3P1P A;  5LU2 A;  4E2E A;  4QLI A;  4O46 A;  3UBW A;  3SML A;  4N7Y A;  1QJB A;  3UX0 A;  2C63 A;  4F7R A;  1O9F A;  4N84 A;  4DX0 A;  3P1R A;  3UAL A;  2C1N A;  3RDH A;  3T0L A;  4J6S A;  4DHQ A;  3T0M A;  5IQP A;  4FL5 A;  5LU1 A;  2V7D A;  4DHS A;  3MHR A;  1O9D A;  1IB1 A;  4DHU A;  4DHO A;  3E6Y A;  5EXA A;  5HF3 A;  2NPM A;  1O9E A;  4Y32 A;  5D3E A;  2O02 A;  5J31 A;  3NKX A;  5LVZ A;  4DHM A;  1A4O A;  5D2D A;  3P1Q A;  4Y5I A;  1A38 A;  5BTV A;  4N7G A;  3P1N A;  5LHO A;  4BG6 A;  3IQJ A;  4DHN A;  3AXY C;  2BTP A;  3LW1 A;  4Y3B A;  5F74 A;  3UZD A;  4ZDR A;  4DNK A;  3IQV A;  2C74 A;  5EWZ A;  3IQU A;  4DHR A;  4HKC A;  5LX2 A; 
#chains in the Genus database with same CATH topology
 3ZHE B;  3EFZ A;  3SPR A;  4MOA A;  3P1O A;  1YWT A;  4IEA A;  4DHT A;  2C1J A;  2BR9 A;  3EB7 A;  4QX1 A;  4JC3 A;  5D3F A;  4GNT A;  3SMO A;  3O8I A;  1W99 A;  2O98 A;  3U9X A;  3M51 A;  4FJ3 A;  3M50 A;  1YZ5 A;  5BY9 A;  4WRQ A;  4FR3 A;  2B05 A;  3SMK A;  3CQG A;  4IHL A;  4DAT A;  1O9C A;  2C23 A;  1CIY A;  2WH0 A;  1JI6 A;  1A37 A;  2BQ0 A;  3SMM A;  4JDD A;  1URJ A;  1QJA A;  4ZQ0 A;  3CU8 A;  3SP5 A;  3P1S A;  4DAU A;  3SMN A;  2O8P A;  4DHP A;  3P1P A;  5LU2 A;  4E2E A;  1DLC A;  4QLI A;  4O46 A;  3UBW A;  3SML A;  4N7Y A;  1QJB A;  3UX0 A;  4ARY A;  2C63 A;  4F7R A;  1O9F A;  4N84 A;  1I5P A;  4DX0 A;  3P1R A;  3UAL A;  2C1N A;  4QX2 A;  4QX0 A;  3RDH A;  3T0L A;  4J6S A;  4DHQ A;  4W8J A;  3T0M A;  5IQP A;  4FL5 A;  5LU1 A;  2V7D A;  4DHS A;  3MHR A;  1O9D A;  3I4R A;  1IB1 A;  4DHU A;  4DHO A;  3E6Y A;  5EXA A;  5HF3 A;  2NPM A;  1S2X A;  1O9E A;  2C9K A;  4Y32 A;  5D3E A;  2O02 A;  3CQC A;  5J31 A;  3NKX A;  5LVZ A;  4DHM A;  1A4O A;  5D2D A;  3P1Q A;  4Y5I A;  1A38 A;  4ARX A;  4D8M A;  4N7G A;  3P1N A;  5BTV A;  5LHO A;  4BG6 A;  3X0U A;  3IQJ A;  4DHN A;  3AXY C;  2BTP A;  3LW1 A;  4Y3B A;  5F74 A;  3UZD A;  4ZDR A;  4QX3 A;  4DNK A;  3IQV A;  2C74 A;  5EWZ A;  3IQU A;  4DHR A;  4HKC A;  5LX2 A; 
#chains in the Genus database with same CATH homology
 3EFZ A;  3SPR A;  3P1O A;  1YWT A;  4IEA A;  4DHT A;  2C1J A;  2BR9 A;  4JC3 A;  5D3F A;  4GNT A;  3SMO A;  3O8I A;  2O98 A;  3U9X A;  3M51 A;  4FJ3 A;  3M50 A;  1YZ5 A;  5BY9 A;  4WRQ A;  4FR3 A;  2B05 A;  3SMK A;  4IHL A;  4DAT A;  1O9C A;  2C23 A;  2WH0 A;  1A37 A;  2BQ0 A;  3SMM A;  4JDD A;  1QJA A;  4ZQ0 A;  3CU8 A;  3SP5 A;  3P1S A;  4DAU A;  3SMN A;  2O8P A;  4DHP A;  3P1P A;  5LU2 A;  4E2E A;  4QLI A;  4O46 A;  3UBW A;  3SML A;  4N7Y A;  1QJB A;  3UX0 A;  2C63 A;  4F7R A;  1O9F A;  4N84 A;  4DX0 A;  3P1R A;  3UAL A;  2C1N A;  3RDH A;  3T0L A;  4J6S A;  4DHQ A;  3T0M A;  5IQP A;  4FL5 A;  5LU1 A;  2V7D A;  4DHS A;  3MHR A;  1O9D A;  1IB1 A;  4DHU A;  4DHO A;  3E6Y A;  5EXA A;  5HF3 A;  2NPM A;  1O9E A;  4Y32 A;  5D3E A;  2O02 A;  5J31 A;  3NKX A;  5LVZ A;  4DHM A;  1A4O A;  5D2D A;  3P1Q A;  4Y5I A;  1A38 A;  5BTV A;  4N7G A;  3P1N A;  5LHO A;  4BG6 A;  3IQJ A;  4DHN A;  3AXY C;  2BTP A;  3LW1 A;  4Y3B A;  5F74 A;  3UZD A;  4ZDR A;  4DNK A;  3IQV A;  2C74 A;  5EWZ A;  3IQU A;  4DHR A;  4HKC A;  5LX2 A; 
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similar chains in the Genus database (?% sequence similarity)
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