3CU8 | Genus

Total Genus 104

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	104
sequence length	229
structure length	229
Chain Sequence	DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 229 atoms

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229 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Protein binding, signaling protein
source organism	Homo sapiens
publication title	Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. pubmed doi rcsb
molecule keywords	14-3-3 protein zeta/delta
total genus	104
structure length	229
sequence length	229
chains with identical sequence	B
ec nomenclature
pdb deposition date	2008-04-16

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00244	14-3-3	14-3-3 protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin; domain 1	14-3-3 domain	3cu8A00

3U9XA 3IQUA 1QJAA 3P1QA 4FL5A 3E6YA 4JDDA 2C1NA 3SP5A 2C23A 5LU1A 4WRQA 1A37A 5LHOA 4DHTA 3AXYC 2BTPA 4IHLA 3SPRA 4N7YA 2O98A 3P1PA 3SMNA 2C1JA 2NPMA 2V7DA 3UX0A 4JC3A 3EFZA 3SMOA 3SMMA 4DHSA 4N7GA 3UZDA 5HF3A 4DHRA 2C63A 3SMKA 5LU2A 4FR3A 3CU8A 5J31A 1IB1A 4FJ3A 4DX0A 4BG6A 5D2DA 4DAUA 4DHNA 1O9CA 2BR9A 3RDHA 3P1NA 4Y3BA 2WH0A 5LX2A 4IEAA 4J6SA 5F74A 4HKCA 4DHQA 4DHUA 4ZQ0A 3UALA 4ZDRA 1O9EA 4DHMA 5EXAA 3UBWA 3IQVA 3M50A 3NKXA 1A4OA 1YWTA 1O9DA 3P1OA 2C74A 5EWZA 5IQPA 4DNKA 2BQ0A 3P1SA 4DATA 4F7RA 4N84A 3O8IA 3P1RA 4E2EA 1QJBA 2B05A 3LW1A 3M51A 3T0LA 4DHPA 5LVZA 2O8PA 4DHOA 3T0MA 4GNTA 5D3EA 4O46A 4Y32A 4QLIA 5D3FA 2O02A 5BY9A 3SMLA 4Y5IA 3IQJA 3MHRA 5BTVA 1YZ5A 1A38A 1O9FA
chains in the Genus database with same CATH superfamily

3U9XA 3IQUA 1QJAA 3P1QA 4FL5A 3E6YA 4JDDA 4QX1A 2C1NA 3SP5A 1JI6A 2C23A 5LU1A 4WRQA 3CQGA 1A37A 5LHOA 4DHTA 3AXYC 2BTPA 3X0UA 4W8JA 4IHLA 3SPRA 4N7YA 2O98A 3P1PA 3SMNA 3I4RA 2C1JA 2NPMA 2V7DA 4QX3A 3UX0A 4JC3A 3EFZA 4MOAA 3SMOA 3SMMA 4DHSA 4N7GA 3UZDA 1CIYA 5HF3A 1DLCA 4DHRA 3CQCA 2C63A 3SMKA 5LU2A 4FR3A 3CU8A 5J31A 1IB1A 4QX2A 4FJ3A 4DX0A 4BG6A 5D2DA 4DAUA 4ARYA 4DHNA 1O9CA 2BR9A 3P1NA 3RDHA 4Y3BA 2WH0A 5LX2A 4IEAA 4J6SA 4ARXA 5F74A 4HKCA 4DHQA 4DHUA 4ZQ0A 3UALA 3ZHEB 4ZDRA 1O9EA 4DHMA 5EXAA 3UBWA 3IQVA 3M50A 3NKXA 1A4OA 1W99A 1YWTA 1O9DA 3P1OA 2C74A 5EWZA 5IQPA 4DNKA 2C9KA 2BQ0A 3P1SA 4DATA 1I5PA 4F7RA 4N84A 4QX0A 3O8IA 3P1RA 4E2EA 1QJBA 1URJA 2B05A 3LW1A 3M51A 3T0LA 4DHPA 1S2XA 5LVZA 2O8PA 4DHOA 3T0MA 4GNTA 5D3EA 4O46A 4Y32A 4QLIA 4D8MA 5D3FA 2O02A 5BY9A 3SMLA 4Y5IA 3IQJA 3MHRA 5BTVA 1YZ5A 3EB7A 1A38A 1O9FA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3U9X A;  3IQU A;  1QJA A;  3P1Q A;  4FL5 A;  3E6Y A;  4JDD A;  2C1N A;  3SP5 A;  2C23 A;  5LU1 A;  4WRQ A;  1A37 A;  5LHO A;  4DHT A;  3AXY C;  2BTP A;  4IHL A;  3SPR A;  4N7Y A;  2O98 A;  3P1P A;  3SMN A;  2C1J A;  2NPM A;  2V7D A;  3UX0 A;  4JC3 A;  3EFZ A;  3SMO A;  3SMM A;  4DHS A;  4N7G A;  3UZD A;  5HF3 A;  4DHR A;  2C63 A;  3SMK A;  5LU2 A;  4FR3 A;  3CU8 A;  5J31 A;  1IB1 A;  4FJ3 A;  4DX0 A;  4BG6 A;  5D2D A;  4DAU A;  4DHN A;  1O9C A;  2BR9 A;  3RDH A;  3P1N A;  4Y3B A;  2WH0 A;  5LX2 A;  4IEA A;  4J6S A;  5F74 A;  4HKC A;  4DHQ A;  4DHU A;  4ZQ0 A;  3UAL A;  4ZDR A;  1O9E A;  4DHM A;  5EXA A;  3UBW A;  3IQV A;  3M50 A;  3NKX A;  1A4O A;  1YWT A;  1O9D A;  3P1O A;  2C74 A;  5EWZ A;  5IQP A;  4DNK A;  2BQ0 A;  3P1S A;  4DAT A;  4F7R A;  4N84 A;  3O8I A;  3P1R A;  4E2E A;  1QJB A;  2B05 A;  3LW1 A;  3M51 A;  3T0L A;  4DHP A;  5LVZ A;  2O8P A;  4DHO A;  3T0M A;  4GNT A;  5D3E A;  4O46 A;  4Y32 A;  4QLI A;  5D3F A;  2O02 A;  5BY9 A;  3SML A;  4Y5I A;  3IQJ A;  3MHR A;  5BTV A;  1YZ5 A;  1A38 A;  1O9F A; 
#chains in the Genus database with same CATH topology
 3U9X A;  3IQU A;  1QJA A;  3P1Q A;  4FL5 A;  3E6Y A;  4JDD A;  4QX1 A;  2C1N A;  3SP5 A;  1JI6 A;  2C23 A;  5LU1 A;  4WRQ A;  3CQG A;  1A37 A;  5LHO A;  4DHT A;  3AXY C;  2BTP A;  3X0U A;  4W8J A;  4IHL A;  3SPR A;  4N7Y A;  2O98 A;  3P1P A;  3SMN A;  3I4R A;  2C1J A;  2NPM A;  2V7D A;  4QX3 A;  3UX0 A;  4JC3 A;  3EFZ A;  4MOA A;  3SMO A;  3SMM A;  4DHS A;  4N7G A;  3UZD A;  1CIY A;  5HF3 A;  1DLC A;  4DHR A;  3CQC A;  2C63 A;  3SMK A;  5LU2 A;  4FR3 A;  3CU8 A;  5J31 A;  1IB1 A;  4QX2 A;  4FJ3 A;  4DX0 A;  4BG6 A;  5D2D A;  4DAU A;  4ARY A;  4DHN A;  1O9C A;  2BR9 A;  3P1N A;  3RDH A;  4Y3B A;  2WH0 A;  5LX2 A;  4IEA A;  4J6S A;  4ARX A;  5F74 A;  4HKC A;  4DHQ A;  4DHU A;  4ZQ0 A;  3UAL A;  3ZHE B;  4ZDR A;  1O9E A;  4DHM A;  5EXA A;  3UBW A;  3IQV A;  3M50 A;  3NKX A;  1A4O A;  1W99 A;  1YWT A;  1O9D A;  3P1O A;  2C74 A;  5EWZ A;  5IQP A;  4DNK A;  2C9K A;  2BQ0 A;  3P1S A;  4DAT A;  1I5P A;  4F7R A;  4N84 A;  4QX0 A;  3O8I A;  3P1R A;  4E2E A;  1QJB A;  1URJ A;  2B05 A;  3LW1 A;  3M51 A;  3T0L A;  4DHP A;  1S2X A;  5LVZ A;  2O8P A;  4DHO A;  3T0M A;  4GNT A;  5D3E A;  4O46 A;  4Y32 A;  4QLI A;  4D8M A;  5D3F A;  2O02 A;  5BY9 A;  3SML A;  4Y5I A;  3IQJ A;  3MHR A;  5BTV A;  1YZ5 A;  3EB7 A;  1A38 A;  1O9F A; 
#chains in the Genus database with same CATH homology
 3U9X A;  3IQU A;  1QJA A;  3P1Q A;  4FL5 A;  3E6Y A;  4JDD A;  2C1N A;  3SP5 A;  2C23 A;  5LU1 A;  4WRQ A;  1A37 A;  5LHO A;  4DHT A;  3AXY C;  2BTP A;  4IHL A;  3SPR A;  4N7Y A;  2O98 A;  3P1P A;  3SMN A;  2C1J A;  2NPM A;  2V7D A;  3UX0 A;  4JC3 A;  3EFZ A;  3SMO A;  3SMM A;  4DHS A;  4N7G A;  3UZD A;  5HF3 A;  4DHR A;  2C63 A;  3SMK A;  5LU2 A;  4FR3 A;  3CU8 A;  5J31 A;  1IB1 A;  4FJ3 A;  4DX0 A;  4BG6 A;  5D2D A;  4DAU A;  4DHN A;  1O9C A;  2BR9 A;  3RDH A;  3P1N A;  4Y3B A;  2WH0 A;  5LX2 A;  4IEA A;  4J6S A;  5F74 A;  4HKC A;  4DHQ A;  4DHU A;  4ZQ0 A;  3UAL A;  4ZDR A;  1O9E A;  4DHM A;  5EXA A;  3UBW A;  3IQV A;  3M50 A;  3NKX A;  1A4O A;  1YWT A;  1O9D A;  3P1O A;  2C74 A;  5EWZ A;  5IQP A;  4DNK A;  2BQ0 A;  3P1S A;  4DAT A;  4F7R A;  4N84 A;  3O8I A;  3P1R A;  4E2E A;  1QJB A;  2B05 A;  3LW1 A;  3M51 A;  3T0L A;  4DHP A;  5LVZ A;  2O8P A;  4DHO A;  3T0M A;  4GNT A;  5D3E A;  4O46 A;  4Y32 A;  4QLI A;  5D3F A;  2O02 A;  5BY9 A;  3SML A;  4Y5I A;  3IQJ A;  3MHR A;  5BTV A;  1YZ5 A;  1A38 A;  1O9F A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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3CU8A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations