3G6EW

Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
154
structure length
154
Chain Sequence
MHALVQLRGEVNMHTDIQDTLEMLNIHHVNHCTLVPETDAYRGMVAKVNDFVAFGEPSQETLETVLATRAEPLEGDADVDDEWVAEHTDYDDISGLAFALLSEETTLREQGLSPTLRLHPPRGGHDGVKHPVKEGGQLGKHDTEGIDDLLEAMR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 50
structure length 154
sequence length 154
ec nomenclature
pdb deposition date 2009-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
W PF00327 Ribosomal_L30 Ribosomal protein L30p/L7e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.15.30 Mainly Alpha Orthogonal Bundle 3-methyladenine DNA Glycosylase II; Chain A, domain 3 3-methyladenine DNA Glycosylase II; Chain A, domain 3 3g6eW02
3.30.1390.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein L30; Chain: A, Ribosomal protein L30, ferredoxin-like fold domain 3g6eW01
1M1KX 3CXCV 2OTJW 3CC2W 1NJIX 1Q82X 5DM7W 4IOAW 3PIPW 1VQKW 1VQPW 1VQLW 3CPWV 4WFAW 2ZJPW 1KQSV 4U67W 5GAEa 4WF9W 2ZJRW 1K9MX 5HL7W 3I55W 1K73X 1YITW 5JVHW 3G71W 4WFNW 3CCQW 1VQ7W 1YJNW 3DLLW 5GAHa 2QA4W 3CF5W 1Q81X 1Q86X 1VQ9W 4WFBW 4IO9W 3J7ZZ 3CCRW 1W2BV 3CC7W 3CD6W 3G6EW 1YI2W 3I56W 1QVGV 4UY8Z 1YIJW 3CCEW 1BXYA 1K8AX 1VQ4W 3CCJW 1VQMW 1Q7YX 1VQNW 3CCLW 3G4SW 5DM6W 3CMEW 4WCEW 3CMAW 3OW2V 2ZJQW 3PIOW 1N8RX 4IOCW 5GADa 5JVGW 1YJ9W 1VQOW 3CCVW 3CCSW 1VQ8W 3CCUW 1YHQW 5GAGa 1M90X 1S72W 3CCMW 1YJWW 1KD1X 3CC4W 1KC8X 1VQ5W 2OTLW 1JJ2V 2QEXW 1QVFV 1VQ6W
chains in the Genus database with same CATH superfamily
1M1KX 3CXCV 1MBXC 3W7UA 1MWRA 1VQQA 2OTJW 5M1AA 3O2BA 4DKIA 3CC2W 3G3PA 1RQVA 3GQ1A 1NJIX 1Q82X 1DD4A 4BL2A 1RQUA 2W9RA 4CJNA 5DM7W 4IOAW 5M18A 5CA3A 3PIPW 1VQKW 4C1NA 1VQPW 1VQLW 3CPWV 2WA8A 4WFAW 4YKAA 2ZJPW 1R6QC 1KQSV 4U67W 1MWTA 5GAEa 4WF9W 1MWUA 2ZJRW 3GQ0A 1K9MX 3W7TA 1RQSA 5HL7W 1LZWA 3I55W 1K73X 1YITW 5JVHW 3G71W 3O2HA 4WFNW 3CCQW 1CTFA 1VQ7W 3O1FB 1YJNW 3DLLW 5GAHa 1MBVB 2QA4W 3CF5W 5GW7A 1Q81X 1Q86X 1VQ9W 3G1BA 4WFBW 4IO9W 3J7ZZ 4YJXA 3CCRW 1W2BV 3CC7W 1DD3A 3CD6W 3G6EW 1YI2W 3ZG5A 3I56W 1R6OC 1QVGV 3O1FA 4UY8Z 1YIJW 1MG9A 3CCEW 4BL3A 3G19A 3W7WA 1BXYA 1K8AX 4YJMA 1VQ4W 3CCJW 5M19A 1VQMW 1Q7YX 3DNJA 1VQNW 3CCLW 3G4SW 5DM6W 3CMEW 1MBUC 4WCEW 3CMAW 3OW2V 2ZJQW 3PIOW 2WA9A 1N8RX 3ZG0A 4IOCW 3GW1A 5GADa 5JVGW 1YJ9W 1VQOW 3CCVW 3CCSW 1VQ8W 3CCUW 3W7SA 1YHQW 5GAGa 1M90X 1S72W 3CCMW 3ZFZA 1YJWW 1KD1X 3CC4W 1KC8X 1VQ5W 1MWSA 2OTLW 1JJ2V 2QEXW 4CPKA 3O2OA 1QVFV 1VQ6W 3W7XA 3D3IA
chains in the Genus database with same CATH topology
1M1KX 3CXCV 2OTJW 3CC2W 1NJIX 1Q82X 5DM7W 4IOAW 3PIPW 1VQKW 4C1NA 1VQPW 1VQLW 3CPWV 4WFAW 2ZJPW 1KQSV 4U67W 5GAEa 4WF9W 2ZJRW 1K9MX 5HL7W 3I55W 1K73X 1YITW 5JVHW 3G71W 4WFNW 3CCQW 1VQ7W 1YJNW 3DLLW 5GAHa 2QA4W 3CF5W 1Q81X 1Q86X 1VQ9W 4WFBW 4IO9W 3J7ZZ 3CCRW 1W2BV 3CC7W 3CD6W 3G6EW 1YI2W 3I56W 1QVGV 4UY8Z 1YIJW 3CCEW 1BXYA 1K8AX 1VQ4W 3CCJW 1VQMW 1Q7YX 1VQNW 3CCLW 3G4SW 5DM6W 3CMEW 4WCEW 3CMAW 3OW2V 2ZJQW 3PIOW 1N8RX 4IOCW 5GADa 5JVGW 1YJ9W 1VQOW 3CCVW 3CCSW 1VQ8W 3CCUW 1YHQW 5GAGa 1M90X 1S72W 3CCMW 1YJWW 1KD1X 3CC4W 1KC8X 1VQ5W 2OTLW 1JJ2V 2QEXW 1QVFV 1VQ6W
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M1K X;  3CXC V;  2OTJ W;  3CC2 W;  1NJI X;  1Q82 X;  5DM7 W;  4IOA W;  3PIP W;  1VQK W;  1VQP W;  1VQL W;  3CPW V;  4WFA W;  2ZJP W;  1KQS V;  4U67 W;  5GAE a;  4WF9 W;  2ZJR W;  1K9M X;  5HL7 W;  3I55 W;  1K73 X;  1YIT W;  5JVH W;  3G71 W;  4WFN W;  3CCQ W;  1VQ7 W;  1YJN W;  3DLL W;  5GAH a;  2QA4 W;  3CF5 W;  1Q81 X;  1Q86 X;  1VQ9 W;  4WFB W;  4IO9 W;  3J7Z Z;  3CCR W;  1W2B V;  3CC7 W;  3CD6 W;  3G6E W;  1YI2 W;  3I56 W;  1QVG V;  4UY8 Z;  1YIJ W;  3CCE W;  1BXY A;  1K8A X;  1VQ4 W;  3CCJ W;  1VQM W;  1Q7Y X;  1VQN W;  3CCL W;  3G4S W;  5DM6 W;  3CME W;  4WCE W;  3CMA W;  3OW2 V;  2ZJQ W;  3PIO W;  1N8R X;  4IOC W;  5GAD a;  5JVG W;  1YJ9 W;  1VQO W;  3CCV W;  3CCS W;  1VQ8 W;  3CCU W;  1YHQ W;  5GAG a;  1M90 X;  1S72 W;  3CCM W;  1YJW W;  1KD1 X;  3CC4 W;  1KC8 X;  1VQ5 W;  2OTL W;  1JJ2 V;  2QEX W;  1QVF V;  1VQ6 W; 
#chains in the Genus database with same CATH topology
 1M1K X;  3CXC V;  1MBX C;  3W7U A;  1MWR A;  1VQQ A;  2OTJ W;  5M1A A;  3O2B A;  4DKI A;  3CC2 W;  3G3P A;  1RQV A;  3GQ1 A;  1NJI X;  1Q82 X;  1DD4 A;  4BL2 A;  1RQU A;  2W9R A;  4CJN A;  5DM7 W;  4IOA W;  5M18 A;  5CA3 A;  3PIP W;  1VQK W;  4C1N A;  1VQP W;  1VQL W;  3CPW V;  2WA8 A;  4WFA W;  4YKA A;  2ZJP W;  1R6Q C;  1KQS V;  4U67 W;  1MWT A;  5GAE a;  4WF9 W;  1MWU A;  2ZJR W;  3GQ0 A;  1K9M X;  3W7T A;  1RQS A;  5HL7 W;  1LZW A;  3I55 W;  1K73 X;  1YIT W;  5JVH W;  3G71 W;  3O2H A;  4WFN W;  3CCQ W;  1CTF A;  1VQ7 W;  3O1F B;  1YJN W;  3DLL W;  5GAH a;  1MBV B;  2QA4 W;  3CF5 W;  5GW7 A;  1Q81 X;  1Q86 X;  1VQ9 W;  3G1B A;  4WFB W;  4IO9 W;  3J7Z Z;  4YJX A;  3CCR W;  1W2B V;  3CC7 W;  1DD3 A;  3CD6 W;  3G6E W;  1YI2 W;  3ZG5 A;  3I56 W;  1R6O C;  1QVG V;  3O1F A;  4UY8 Z;  1YIJ W;  1MG9 A;  3CCE W;  4BL3 A;  3G19 A;  3W7W A;  1BXY A;  1K8A X;  4YJM A;  1VQ4 W;  3CCJ W;  5M19 A;  1VQM W;  1Q7Y X;  3DNJ A;  1VQN W;  3CCL W;  3G4S W;  5DM6 W;  3CME W;  1MBU C;  4WCE W;  3CMA W;  3OW2 V;  2ZJQ W;  3PIO W;  2WA9 A;  1N8R X;  3ZG0 A;  4IOC W;  3GW1 A;  5GAD a;  5JVG W;  1YJ9 W;  1VQO W;  3CCV W;  3CCS W;  1VQ8 W;  3CCU W;  3W7S A;  1YHQ W;  5GAG a;  1M90 X;  1S72 W;  3CCM W;  3ZFZ A;  1YJW W;  1KD1 X;  3CC4 W;  1KC8 X;  1VQ5 W;  1MWS A;  2OTL W;  1JJ2 V;  2QEX W;  4CPK A;  3O2O A;  1QVF V;  1VQ6 W;  3W7X A;  3D3I A; 
#chains in the Genus database with same CATH homology
 1M1K X;  3CXC V;  2OTJ W;  3CC2 W;  1NJI X;  1Q82 X;  5DM7 W;  4IOA W;  3PIP W;  1VQK W;  4C1N A;  1VQP W;  1VQL W;  3CPW V;  4WFA W;  2ZJP W;  1KQS V;  4U67 W;  5GAE a;  4WF9 W;  2ZJR W;  1K9M X;  5HL7 W;  3I55 W;  1K73 X;  1YIT W;  5JVH W;  3G71 W;  4WFN W;  3CCQ W;  1VQ7 W;  1YJN W;  3DLL W;  5GAH a;  2QA4 W;  3CF5 W;  1Q81 X;  1Q86 X;  1VQ9 W;  4WFB W;  4IO9 W;  3J7Z Z;  3CCR W;  1W2B V;  3CC7 W;  3CD6 W;  3G6E W;  1YI2 W;  3I56 W;  1QVG V;  4UY8 Z;  1YIJ W;  3CCE W;  1BXY A;  1K8A X;  1VQ4 W;  3CCJ W;  1VQM W;  1Q7Y X;  1VQN W;  3CCL W;  3G4S W;  5DM6 W;  3CME W;  4WCE W;  3CMA W;  3OW2 V;  2ZJQ W;  3PIO W;  1N8R X;  4IOC W;  5GAD a;  5JVG W;  1YJ9 W;  1VQO W;  3CCV W;  3CCS W;  1VQ8 W;  3CCU W;  1YHQ W;  5GAG a;  1M90 X;  1S72 W;  3CCM W;  1YJW W;  1KD1 X;  3CC4 W;  1KC8 X;  1VQ5 W;  2OTL W;  1JJ2 V;  2QEX W;  1QVF V;  1VQ6 W; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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