3IQJ | Genus

Total Genus 101

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	101
sequence length	236
structure length	235
Chain Sequence	GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Protein binding, signaling protein
publication title	Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. pubmed doi rcsb
molecule keywords	14-3-3 protein sigma
total genus	101
structure length	235
sequence length	236
ec nomenclature
pdb deposition date	2009-08-20

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00244	14-3-3	14-3-3 protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin; domain 1	14-3-3 domain	3iqjA00

3UBWA 4WRQA 3M50A 4DHPA 5LU1A 5LHOA 5D3FA 5LU2A 5EWZA 1O9DA 4N7YA 3P1QA 3T0LA 2BR9A 5D2DA 3UALA 3SMOA 5HF3A 3MHRA 2BTPA 4E2EA 4DHMA 1A38A 3M51A 3P1RA 3P1NA 5J31A 1YZ5A 4Y3BA 3SPRA 3U9XA 3UX0A 1A37A 3SMMA 5BTVA 2V7DA 3EFZA 1O9FA 4DHQA 4N7GA 2O02A 4Y5IA 3P1OA 1YWTA 2C1JA 4HKCA 3IQUA 1QJAA 3AXYC 3UZDA 4N84A 5BY9A 2C23A 3SMKA 1O9EA 3NKXA 4DAUA 4JDDA 5EXAA 4DHTA 4DHOA 4DHUA 2WH0A 3IQVA 4Y32A 3P1PA 5F74A 1QJBA 1IB1A 3P1SA 4ZDRA 5LVZA 2O98A 4DX0A 4J6SA 3SMNA 2O8PA 3CU8A 4GNTA 3IQJA 4QLIA 4F7RA 2B05A 4DHRA 1A4OA 5D3EA 2C63A 3SP5A 5IQPA 4FL5A 3E6YA 3LW1A 4ZQ0A 5LX2A 4IHLA 2BQ0A 4O46A 2NPMA 4DATA 2C1NA 1O9CA 4DHNA 3SMLA 4DNKA 4IEAA 3O8IA 4FR3A 2C74A 4FJ3A 3RDHA 4BG6A 4JC3A 3T0MA 4DHSA
chains in the Genus database with same CATH superfamily

1W99A 3UBWA 4WRQA 3M50A 4DHPA 5LU1A 5LHOA 5D3FA 5LU2A 5EWZA 1O9DA 4N7YA 3P1QA 1CIYA 3T0LA 2BR9A 5D2DA 3UALA 3SMOA 1JI6A 3EB7A 5HF3A 3MHRA 4D8MA 2BTPA 4E2EA 4QX3A 4DHMA 4QX0A 1A38A 3M51A 3P1RA 3P1NA 5J31A 1YZ5A 3I4RA 4Y3BA 1URJA 3SPRA 3U9XA 3UX0A 1A37A 3SMMA 5BTVA 2V7DA 3EFZA 4ARXA 1O9FA 4DHQA 4N7GA 2O02A 4Y5IA 4HKCA 4QX1A 1YWTA 2C1JA 3IQUA 3P1OA 1QJAA 3AXYC 4W8JA 3UZDA 4N84A 5BY9A 2C23A 3SMKA 1O9EA 1S2XA 3NKXA 4DAUA 3CQCA 4JDDA 5EXAA 4DHTA 4DHOA 3ZHEB 4DHUA 2WH0A 3IQVA 4Y32A 3P1PA 5F74A 1QJBA 2C9KA 1IB1A 3P1SA 4ZDRA 5LVZA 2O98A 4DX0A 4J6SA 3SMNA 2O8PA 3CU8A 4GNTA 3IQJA 4QLIA 4QX2A 3X0UA 2B05A 4F7RA 3CQGA 4DHRA 1A4OA 5D3EA 2C63A 3SP5A 5IQPA 4FL5A 3E6YA 3LW1A 4ZQ0A 5LX2A 1DLCA 4IHLA 2BQ0A 4O46A 2NPMA 4DATA 2C1NA 1O9CA 4DHNA 3SMLA 4DNKA 4IEAA 3O8IA 1I5PA 4FR3A 4MOAA 4ARYA 2C74A 4FJ3A 3RDHA 4BG6A 4JC3A 3T0MA 4DHSA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3UBW A;  4WRQ A;  3M50 A;  4DHP A;  5LU1 A;  5LHO A;  5D3F A;  5LU2 A;  5EWZ A;  1O9D A;  4N7Y A;  3P1Q A;  3T0L A;  2BR9 A;  5D2D A;  3UAL A;  3SMO A;  5HF3 A;  3MHR A;  2BTP A;  4E2E A;  4DHM A;  1A38 A;  3M51 A;  3P1R A;  3P1N A;  5J31 A;  1YZ5 A;  4Y3B A;  3SPR A;  3U9X A;  3UX0 A;  1A37 A;  3SMM A;  5BTV A;  2V7D A;  3EFZ A;  1O9F A;  4DHQ A;  4N7G A;  2O02 A;  4Y5I A;  3P1O A;  1YWT A;  2C1J A;  4HKC A;  3IQU A;  1QJA A;  3AXY C;  3UZD A;  4N84 A;  5BY9 A;  2C23 A;  3SMK A;  1O9E A;  3NKX A;  4DAU A;  4JDD A;  5EXA A;  4DHT A;  4DHO A;  4DHU A;  2WH0 A;  3IQV A;  4Y32 A;  3P1P A;  5F74 A;  1QJB A;  1IB1 A;  3P1S A;  4ZDR A;  5LVZ A;  2O98 A;  4DX0 A;  4J6S A;  3SMN A;  2O8P A;  3CU8 A;  4GNT A;  3IQJ A;  4QLI A;  4F7R A;  2B05 A;  4DHR A;  1A4O A;  5D3E A;  2C63 A;  3SP5 A;  5IQP A;  4FL5 A;  3E6Y A;  3LW1 A;  4ZQ0 A;  5LX2 A;  4IHL A;  2BQ0 A;  4O46 A;  2NPM A;  4DAT A;  2C1N A;  1O9C A;  4DHN A;  3SML A;  4DNK A;  4IEA A;  3O8I A;  4FR3 A;  2C74 A;  4FJ3 A;  3RDH A;  4BG6 A;  4JC3 A;  3T0M A;  4DHS A; 
#chains in the Genus database with same CATH topology
 1W99 A;  3UBW A;  4WRQ A;  3M50 A;  4DHP A;  5LU1 A;  5LHO A;  5D3F A;  5LU2 A;  5EWZ A;  1O9D A;  4N7Y A;  3P1Q A;  1CIY A;  3T0L A;  2BR9 A;  5D2D A;  3UAL A;  3SMO A;  1JI6 A;  3EB7 A;  5HF3 A;  3MHR A;  4D8M A;  2BTP A;  4E2E A;  4QX3 A;  4DHM A;  4QX0 A;  1A38 A;  3M51 A;  3P1R A;  3P1N A;  5J31 A;  1YZ5 A;  3I4R A;  4Y3B A;  1URJ A;  3SPR A;  3U9X A;  3UX0 A;  1A37 A;  3SMM A;  5BTV A;  2V7D A;  3EFZ A;  4ARX A;  1O9F A;  4DHQ A;  4N7G A;  2O02 A;  4Y5I A;  4HKC A;  4QX1 A;  1YWT A;  2C1J A;  3IQU A;  3P1O A;  1QJA A;  3AXY C;  4W8J A;  3UZD A;  4N84 A;  5BY9 A;  2C23 A;  3SMK A;  1O9E A;  1S2X A;  3NKX A;  4DAU A;  3CQC A;  4JDD A;  5EXA A;  4DHT A;  4DHO A;  3ZHE B;  4DHU A;  2WH0 A;  3IQV A;  4Y32 A;  3P1P A;  5F74 A;  1QJB A;  2C9K A;  1IB1 A;  3P1S A;  4ZDR A;  5LVZ A;  2O98 A;  4DX0 A;  4J6S A;  3SMN A;  2O8P A;  3CU8 A;  4GNT A;  3IQJ A;  4QLI A;  4QX2 A;  3X0U A;  2B05 A;  4F7R A;  3CQG A;  4DHR A;  1A4O A;  5D3E A;  2C63 A;  3SP5 A;  5IQP A;  4FL5 A;  3E6Y A;  3LW1 A;  4ZQ0 A;  5LX2 A;  1DLC A;  4IHL A;  2BQ0 A;  4O46 A;  2NPM A;  4DAT A;  2C1N A;  1O9C A;  4DHN A;  3SML A;  4DNK A;  4IEA A;  3O8I A;  1I5P A;  4FR3 A;  4MOA A;  4ARY A;  2C74 A;  4FJ3 A;  3RDH A;  4BG6 A;  4JC3 A;  3T0M A;  4DHS A; 
#chains in the Genus database with same CATH homology
 3UBW A;  4WRQ A;  3M50 A;  4DHP A;  5LU1 A;  5LHO A;  5D3F A;  5LU2 A;  5EWZ A;  1O9D A;  4N7Y A;  3P1Q A;  3T0L A;  2BR9 A;  5D2D A;  3UAL A;  3SMO A;  5HF3 A;  3MHR A;  2BTP A;  4E2E A;  4DHM A;  1A38 A;  3M51 A;  3P1R A;  3P1N A;  5J31 A;  1YZ5 A;  4Y3B A;  3SPR A;  3U9X A;  3UX0 A;  1A37 A;  3SMM A;  5BTV A;  2V7D A;  3EFZ A;  1O9F A;  4DHQ A;  4N7G A;  2O02 A;  4Y5I A;  3P1O A;  1YWT A;  2C1J A;  4HKC A;  3IQU A;  1QJA A;  3AXY C;  3UZD A;  4N84 A;  5BY9 A;  2C23 A;  3SMK A;  1O9E A;  3NKX A;  4DAU A;  4JDD A;  5EXA A;  4DHT A;  4DHO A;  4DHU A;  2WH0 A;  3IQV A;  4Y32 A;  3P1P A;  5F74 A;  1QJB A;  1IB1 A;  3P1S A;  4ZDR A;  5LVZ A;  2O98 A;  4DX0 A;  4J6S A;  3SMN A;  2O8P A;  3CU8 A;  4GNT A;  3IQJ A;  4QLI A;  4F7R A;  2B05 A;  4DHR A;  1A4O A;  5D3E A;  2C63 A;  3SP5 A;  5IQP A;  4FL5 A;  3E6Y A;  3LW1 A;  4ZQ0 A;  5LX2 A;  4IHL A;  2BQ0 A;  4O46 A;  2NPM A;  4DAT A;  2C1N A;  1O9C A;  4DHN A;  3SML A;  4DNK A;  4IEA A;  3O8I A;  4FR3 A;  2C74 A;  4FJ3 A;  3RDH A;  4BG6 A;  4JC3 A;  3T0M A;  4DHS A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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3IQJA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations