3IQU | Genus

Total Genus 101

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	101
sequence length	236
structure length	235
Chain Sequence	GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Protein binding, signaling protein
publication title	Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. pubmed doi rcsb
molecule keywords	14-3-3 protein sigma
total genus	101
structure length	235
sequence length	236
ec nomenclature
pdb deposition date	2009-08-21

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00244	14-3-3	14-3-3 protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin; domain 1	14-3-3 domain	3iquA00

5HF3A 5LX2A 1O9CA 3P1PA 4FJ3A 5J31A 3IQUA 4DATA 2C74A 1QJAA 4N7GA 2O98A 4IHLA 5LU2A 4HKCA 3SMOA 1YZ5A 3RDHA 5BTVA 4DAUA 4DHRA 2NPMA 2WH0A 4JDDA 5D2DA 4DHSA 4N84A 3SMNA 2C1NA 5EXAA 2O8PA 1QJBA 4Y32A 2BTPA 4DHPA 4N7YA 3U9XA 2C63A 3UX0A 5F74A 3SMLA 5BY9A 3CU8A 4ZDRA 3IQVA 5LVZA 5LHOA 3O8IA 1O9FA 5EWZA 1A38A 1A4OA 4DHOA 3P1SA 4QLIA 2BR9A 5D3FA 3UALA 2BQ0A 3AXYC 2O02A 4WRQA 4J6SA 1O9DA 1YWTA 4IEAA 3IQJA 3E6YA 3SMMA 4DHUA 4DNKA 4FL5A 4O46A 3T0MA 3T0LA 3SP5A 1A37A 4DHQA 4FR3A 1IB1A 3LW1A 3P1QA 2C1JA 5D3EA 4F7RA 4Y5IA 2C23A 4E2EA 3P1NA 4JC3A 3UBWA 2V7DA 3P1OA 2B05A 4BG6A 3M50A 3EFZA 5LU1A 3SPRA 3NKXA 4Y3BA 5IQPA 3M51A 4ZQ0A 3MHRA 1O9EA 4DHTA 3UZDA 4DHMA 4DHNA 4DX0A 3SMKA 4GNTA 3P1RA
chains in the Genus database with same CATH superfamily

5HF3A 5LX2A 1O9CA 3P1PA 4FJ3A 5J31A 3IQUA 4DATA 2C74A 1QJAA 4N7GA 2O98A 4QX1A 4IHLA 5LU2A 4HKCA 3SMOA 1YZ5A 3RDHA 5BTVA 4DAUA 4DHRA 2NPMA 2WH0A 3X0UA 4JDDA 1JI6A 5D2DA 4ARXA 4MOAA 4DHSA 4N84A 3SMNA 2C1NA 3ZHEB 1W99A 5EXAA 2O8PA 1QJBA 4Y32A 2BTPA 4DHPA 4N7YA 3U9XA 2C63A 3UX0A 5F74A 3SMLA 5BY9A 3CU8A 4ZDRA 3IQVA 5LVZA 1CIYA 5LHOA 3O8IA 3EB7A 1O9FA 5EWZA 1A38A 1A4OA 4DHOA 3P1SA 4QLIA 2BR9A 5D3FA 4D8MA 3UALA 2BQ0A 4QX2A 3AXYC 1URJA 2O02A 4WRQA 4J6SA 3CQGA 1O9DA 1YWTA 4IEAA 3IQJA 3E6YA 3SMMA 1I5PA 4DHUA 4QX3A 4DNKA 4FL5A 4O46A 3T0MA 2C9KA 3T0LA 4QX0A 3SP5A 1A37A 4DHQA 4FR3A 1IB1A 3LW1A 3P1QA 4W8JA 2C1JA 5D3EA 4F7RA 4Y5IA 2C23A 4E2EA 3P1NA 4JC3A 1DLCA 3UBWA 2V7DA 3P1OA 2B05A 4BG6A 3I4RA 3M50A 4ARYA 3EFZA 5LU1A 3SPRA 1S2XA 3NKXA 4Y3BA 5IQPA 3M51A 4ZQ0A 3MHRA 1O9EA 4DHTA 3CQCA 3UZDA 4DHMA 4DHNA 4DX0A 3SMKA 4GNTA 3P1RA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 5HF3 A;  5LX2 A;  1O9C A;  3P1P A;  4FJ3 A;  5J31 A;  3IQU A;  4DAT A;  2C74 A;  1QJA A;  4N7G A;  2O98 A;  4IHL A;  5LU2 A;  4HKC A;  3SMO A;  1YZ5 A;  3RDH A;  5BTV A;  4DAU A;  4DHR A;  2NPM A;  2WH0 A;  4JDD A;  5D2D A;  4DHS A;  4N84 A;  3SMN A;  2C1N A;  5EXA A;  2O8P A;  1QJB A;  4Y32 A;  2BTP A;  4DHP A;  4N7Y A;  3U9X A;  2C63 A;  3UX0 A;  5F74 A;  3SML A;  5BY9 A;  3CU8 A;  4ZDR A;  3IQV A;  5LVZ A;  5LHO A;  3O8I A;  1O9F A;  5EWZ A;  1A38 A;  1A4O A;  4DHO A;  3P1S A;  4QLI A;  2BR9 A;  5D3F A;  3UAL A;  2BQ0 A;  3AXY C;  2O02 A;  4WRQ A;  4J6S A;  1O9D A;  1YWT A;  4IEA A;  3IQJ A;  3E6Y A;  3SMM A;  4DHU A;  4DNK A;  4FL5 A;  4O46 A;  3T0M A;  3T0L A;  3SP5 A;  1A37 A;  4DHQ A;  4FR3 A;  1IB1 A;  3LW1 A;  3P1Q A;  2C1J A;  5D3E A;  4F7R A;  4Y5I A;  2C23 A;  4E2E A;  3P1N A;  4JC3 A;  3UBW A;  2V7D A;  3P1O A;  2B05 A;  4BG6 A;  3M50 A;  3EFZ A;  5LU1 A;  3SPR A;  3NKX A;  4Y3B A;  5IQP A;  3M51 A;  4ZQ0 A;  3MHR A;  1O9E A;  4DHT A;  3UZD A;  4DHM A;  4DHN A;  4DX0 A;  3SMK A;  4GNT A;  3P1R A; 
#chains in the Genus database with same CATH topology
 5HF3 A;  5LX2 A;  1O9C A;  3P1P A;  4FJ3 A;  5J31 A;  3IQU A;  4DAT A;  2C74 A;  1QJA A;  4N7G A;  2O98 A;  4QX1 A;  4IHL A;  5LU2 A;  4HKC A;  3SMO A;  1YZ5 A;  3RDH A;  5BTV A;  4DAU A;  4DHR A;  2NPM A;  2WH0 A;  3X0U A;  4JDD A;  1JI6 A;  5D2D A;  4ARX A;  4MOA A;  4DHS A;  4N84 A;  3SMN A;  2C1N A;  3ZHE B;  1W99 A;  5EXA A;  2O8P A;  1QJB A;  4Y32 A;  2BTP A;  4DHP A;  4N7Y A;  3U9X A;  2C63 A;  3UX0 A;  5F74 A;  3SML A;  5BY9 A;  3CU8 A;  4ZDR A;  3IQV A;  5LVZ A;  1CIY A;  5LHO A;  3O8I A;  3EB7 A;  1O9F A;  5EWZ A;  1A38 A;  1A4O A;  4DHO A;  3P1S A;  4QLI A;  2BR9 A;  5D3F A;  4D8M A;  3UAL A;  2BQ0 A;  4QX2 A;  3AXY C;  1URJ A;  2O02 A;  4WRQ A;  4J6S A;  3CQG A;  1O9D A;  1YWT A;  4IEA A;  3IQJ A;  3E6Y A;  3SMM A;  1I5P A;  4DHU A;  4QX3 A;  4DNK A;  4FL5 A;  4O46 A;  3T0M A;  2C9K A;  3T0L A;  4QX0 A;  3SP5 A;  1A37 A;  4DHQ A;  4FR3 A;  1IB1 A;  3LW1 A;  3P1Q A;  4W8J A;  2C1J A;  5D3E A;  4F7R A;  4Y5I A;  2C23 A;  4E2E A;  3P1N A;  4JC3 A;  1DLC A;  3UBW A;  2V7D A;  3P1O A;  2B05 A;  4BG6 A;  3I4R A;  3M50 A;  4ARY A;  3EFZ A;  5LU1 A;  3SPR A;  1S2X A;  3NKX A;  4Y3B A;  5IQP A;  3M51 A;  4ZQ0 A;  3MHR A;  1O9E A;  4DHT A;  3CQC A;  3UZD A;  4DHM A;  4DHN A;  4DX0 A;  3SMK A;  4GNT A;  3P1R A; 
#chains in the Genus database with same CATH homology
 5HF3 A;  5LX2 A;  1O9C A;  3P1P A;  4FJ3 A;  5J31 A;  3IQU A;  4DAT A;  2C74 A;  1QJA A;  4N7G A;  2O98 A;  4IHL A;  5LU2 A;  4HKC A;  3SMO A;  1YZ5 A;  3RDH A;  5BTV A;  4DAU A;  4DHR A;  2NPM A;  2WH0 A;  4JDD A;  5D2D A;  4DHS A;  4N84 A;  3SMN A;  2C1N A;  5EXA A;  2O8P A;  1QJB A;  4Y32 A;  2BTP A;  4DHP A;  4N7Y A;  3U9X A;  2C63 A;  3UX0 A;  5F74 A;  3SML A;  5BY9 A;  3CU8 A;  4ZDR A;  3IQV A;  5LVZ A;  5LHO A;  3O8I A;  1O9F A;  5EWZ A;  1A38 A;  1A4O A;  4DHO A;  3P1S A;  4QLI A;  2BR9 A;  5D3F A;  3UAL A;  2BQ0 A;  3AXY C;  2O02 A;  4WRQ A;  4J6S A;  1O9D A;  1YWT A;  4IEA A;  3IQJ A;  3E6Y A;  3SMM A;  4DHU A;  4DNK A;  4FL5 A;  4O46 A;  3T0M A;  3T0L A;  3SP5 A;  1A37 A;  4DHQ A;  4FR3 A;  1IB1 A;  3LW1 A;  3P1Q A;  2C1J A;  5D3E A;  4F7R A;  4Y5I A;  2C23 A;  4E2E A;  3P1N A;  4JC3 A;  3UBW A;  2V7D A;  3P1O A;  2B05 A;  4BG6 A;  3M50 A;  3EFZ A;  5LU1 A;  3SPR A;  3NKX A;  4Y3B A;  5IQP A;  3M51 A;  4ZQ0 A;  3MHR A;  1O9E A;  4DHT A;  3UZD A;  4DHM A;  4DHN A;  4DX0 A;  3SMK A;  4GNT A;  3P1R A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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3IQUA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations