3NKX | Genus

Total Genus 108

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	108
sequence length	229
structure length	229
Chain Sequence	DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 229 atoms

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229 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Protein binding, signaling protein
source organism	Homo sapiens
publication title	Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling pubmed doi rcsb
molecule keywords	14-3-3 protein zeta/delta
total genus	108
structure length	229
sequence length	229
chains with identical sequence	B
ec nomenclature
pdb deposition date	2010-06-21

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00244	14-3-3	14-3-3 protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin; domain 1	14-3-3 domain	3nkxA00

3SMKA 5D3EA 3SP5A 4N7YA 1O9CA 1YZ5A 3UBWA 4N7GA 4F7RA 5LU1A 4DHQA 3MHRA 4WRQA 2V7DA 3EFZA 4GNTA 2BR9A 3AXYC 2C23A 1QJAA 2O8PA 3IQJA 3M51A 4JDDA 4DX0A 4DHTA 2B05A 1A4OA 2C1JA 4BG6A 4DATA 5J31A 4DHNA 5EXAA 2WH0A 5F74A 2C1NA 1O9DA 4DHRA 3RDHA 2C63A 3P1SA 3T0MA 3SMLA 5LU2A 3O8IA 5BTVA 5LX2A 3NKXA 3M50A 5LVZA 1A38A 3E6YA 3P1PA 3P1OA 5LHOA 3T0LA 4ZDRA 4ZQ0A 3UALA 1O9EA 3SMMA 5EWZA 3IQVA 4DAUA 2NPMA 3P1QA 1A37A 5BY9A 3SPRA 4DHPA 1O9FA 4Y32A 4DHMA 4DNKA 4JC3A 2O98A 4N84A 3SMOA 4Y5IA 3P1RA 4DHSA 5D2DA 4FR3A 4IHLA 5D3FA 5HF3A 2BTPA 4FJ3A 3UZDA 4O46A 3UX0A 4HKCA 2BQ0A 4FL5A 2O02A 3CU8A 4J6SA 1QJBA 3LW1A 1IB1A 3IQUA 3P1NA 3U9XA 4QLIA 4DHOA 1YWTA 4DHUA 4E2EA 2C74A 5IQPA 3SMNA 4IEAA 4Y3BA
chains in the Genus database with same CATH superfamily

3SMKA 5D3EA 3SP5A 4N7YA 1O9CA 4QX2A 1YZ5A 3UBWA 4N7GA 3EB7A 1DLCA 4F7RA 5LU1A 4DHQA 3MHRA 4WRQA 2V7DA 3EFZA 4GNTA 2BR9A 3AXYC 2C23A 1QJAA 2O8PA 3IQJA 3M51A 4JDDA 4ARYA 4DX0A 4DHTA 2B05A 1A4OA 2C1JA 4BG6A 4MOAA 4DATA 5J31A 4DHNA 2WH0A 5EXAA 5F74A 2C1NA 1O9DA 2C9KA 4DHRA 3RDHA 2C63A 3P1SA 3T0MA 3SMLA 5LU2A 1JI6A 3O8IA 5BTVA 5LX2A 1I5PA 3ZHEB 3NKXA 3M50A 5LVZA 1A38A 3E6YA 3P1PA 3CQGA 3P1OA 5LHOA 3T0LA 4ZDRA 4ZQ0A 3UALA 3CQCA 1O9EA 3SMMA 5EWZA 3IQVA 4DAUA 2NPMA 3P1QA 4W8JA 1A37A 3I4RA 3SPRA 5BY9A 4DHPA 1O9FA 4Y32A 4DHMA 4QX1A 1CIYA 4JC3A 4DNKA 1S2XA 2O98A 4N84A 3SMOA 4Y5IA 3P1RA 4DHSA 5D2DA 4FR3A 4IHLA 5D3FA 5HF3A 4QX3A 2BTPA 3X0UA 4FJ3A 3UZDA 4O46A 3UX0A 4HKCA 2BQ0A 4FL5A 4D8MA 1URJA 2O02A 4ARXA 3CU8A 4J6SA 1QJBA 3LW1A 1IB1A 3IQUA 3P1NA 3U9XA 4QX0A 4QLIA 4DHOA 1YWTA 4DHUA 4E2EA 2C74A 5IQPA 3SMNA 4IEAA 4Y3BA 1W99A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3SMK A;  5D3E A;  3SP5 A;  4N7Y A;  1O9C A;  1YZ5 A;  3UBW A;  4N7G A;  4F7R A;  5LU1 A;  4DHQ A;  3MHR A;  4WRQ A;  2V7D A;  3EFZ A;  4GNT A;  2BR9 A;  3AXY C;  2C23 A;  1QJA A;  2O8P A;  3IQJ A;  3M51 A;  4JDD A;  4DX0 A;  4DHT A;  2B05 A;  1A4O A;  2C1J A;  4BG6 A;  4DAT A;  5J31 A;  4DHN A;  5EXA A;  2WH0 A;  5F74 A;  2C1N A;  1O9D A;  4DHR A;  3RDH A;  2C63 A;  3P1S A;  3T0M A;  3SML A;  5LU2 A;  3O8I A;  5BTV A;  5LX2 A;  3NKX A;  3M50 A;  5LVZ A;  1A38 A;  3E6Y A;  3P1P A;  3P1O A;  5LHO A;  3T0L A;  4ZDR A;  4ZQ0 A;  3UAL A;  1O9E A;  3SMM A;  5EWZ A;  3IQV A;  4DAU A;  2NPM A;  3P1Q A;  1A37 A;  5BY9 A;  3SPR A;  4DHP A;  1O9F A;  4Y32 A;  4DHM A;  4DNK A;  4JC3 A;  2O98 A;  4N84 A;  3SMO A;  4Y5I A;  3P1R A;  4DHS A;  5D2D A;  4FR3 A;  4IHL A;  5D3F A;  5HF3 A;  2BTP A;  4FJ3 A;  3UZD A;  4O46 A;  3UX0 A;  4HKC A;  2BQ0 A;  4FL5 A;  2O02 A;  3CU8 A;  4J6S A;  1QJB A;  3LW1 A;  1IB1 A;  3IQU A;  3P1N A;  3U9X A;  4QLI A;  4DHO A;  1YWT A;  4DHU A;  4E2E A;  2C74 A;  5IQP A;  3SMN A;  4IEA A;  4Y3B A; 
#chains in the Genus database with same CATH topology
 3SMK A;  5D3E A;  3SP5 A;  4N7Y A;  1O9C A;  4QX2 A;  1YZ5 A;  3UBW A;  4N7G A;  3EB7 A;  1DLC A;  4F7R A;  5LU1 A;  4DHQ A;  3MHR A;  4WRQ A;  2V7D A;  3EFZ A;  4GNT A;  2BR9 A;  3AXY C;  2C23 A;  1QJA A;  2O8P A;  3IQJ A;  3M51 A;  4JDD A;  4ARY A;  4DX0 A;  4DHT A;  2B05 A;  1A4O A;  2C1J A;  4BG6 A;  4MOA A;  4DAT A;  5J31 A;  4DHN A;  2WH0 A;  5EXA A;  5F74 A;  2C1N A;  1O9D A;  2C9K A;  4DHR A;  3RDH A;  2C63 A;  3P1S A;  3T0M A;  3SML A;  5LU2 A;  1JI6 A;  3O8I A;  5BTV A;  5LX2 A;  1I5P A;  3ZHE B;  3NKX A;  3M50 A;  5LVZ A;  1A38 A;  3E6Y A;  3P1P A;  3CQG A;  3P1O A;  5LHO A;  3T0L A;  4ZDR A;  4ZQ0 A;  3UAL A;  3CQC A;  1O9E A;  3SMM A;  5EWZ A;  3IQV A;  4DAU A;  2NPM A;  3P1Q A;  4W8J A;  1A37 A;  3I4R A;  3SPR A;  5BY9 A;  4DHP A;  1O9F A;  4Y32 A;  4DHM A;  4QX1 A;  1CIY A;  4JC3 A;  4DNK A;  1S2X A;  2O98 A;  4N84 A;  3SMO A;  4Y5I A;  3P1R A;  4DHS A;  5D2D A;  4FR3 A;  4IHL A;  5D3F A;  5HF3 A;  4QX3 A;  2BTP A;  3X0U A;  4FJ3 A;  3UZD A;  4O46 A;  3UX0 A;  4HKC A;  2BQ0 A;  4FL5 A;  4D8M A;  1URJ A;  2O02 A;  4ARX A;  3CU8 A;  4J6S A;  1QJB A;  3LW1 A;  1IB1 A;  3IQU A;  3P1N A;  3U9X A;  4QX0 A;  4QLI A;  4DHO A;  1YWT A;  4DHU A;  4E2E A;  2C74 A;  5IQP A;  3SMN A;  4IEA A;  4Y3B A;  1W99 A; 
#chains in the Genus database with same CATH homology
 3SMK A;  5D3E A;  3SP5 A;  4N7Y A;  1O9C A;  1YZ5 A;  3UBW A;  4N7G A;  4F7R A;  5LU1 A;  4DHQ A;  3MHR A;  4WRQ A;  2V7D A;  3EFZ A;  4GNT A;  2BR9 A;  3AXY C;  2C23 A;  1QJA A;  2O8P A;  3IQJ A;  3M51 A;  4JDD A;  4DX0 A;  4DHT A;  2B05 A;  1A4O A;  2C1J A;  4BG6 A;  4DAT A;  5J31 A;  4DHN A;  5EXA A;  2WH0 A;  5F74 A;  2C1N A;  1O9D A;  4DHR A;  3RDH A;  2C63 A;  3P1S A;  3T0M A;  3SML A;  5LU2 A;  3O8I A;  5BTV A;  5LX2 A;  3NKX A;  3M50 A;  5LVZ A;  1A38 A;  3E6Y A;  3P1P A;  3P1O A;  5LHO A;  3T0L A;  4ZDR A;  4ZQ0 A;  3UAL A;  1O9E A;  3SMM A;  5EWZ A;  3IQV A;  4DAU A;  2NPM A;  3P1Q A;  1A37 A;  5BY9 A;  3SPR A;  4DHP A;  1O9F A;  4Y32 A;  4DHM A;  4DNK A;  4JC3 A;  2O98 A;  4N84 A;  3SMO A;  4Y5I A;  3P1R A;  4DHS A;  5D2D A;  4FR3 A;  4IHL A;  5D3F A;  5HF3 A;  2BTP A;  4FJ3 A;  3UZD A;  4O46 A;  3UX0 A;  4HKC A;  2BQ0 A;  4FL5 A;  2O02 A;  3CU8 A;  4J6S A;  1QJB A;  3LW1 A;  1IB1 A;  3IQU A;  3P1N A;  3U9X A;  4QLI A;  4DHO A;  1YWT A;  4DHU A;  4E2E A;  2C74 A;  5IQP A;  3SMN A;  4IEA A;  4Y3B A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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3NKXA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations