The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
108
|
sequence length |
229
|
structure length |
229
|
Chain Sequence |
DKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling
pubmed doi rcsb |
| molecule keywords |
14-3-3 protein zeta/delta
|
| molecule tags |
Protein binding, signaling protein
|
| source organism |
Homo sapiens
|
| total genus |
108
|
| structure length |
229
|
| sequence length |
229
|
| chains with identical sequence |
B
|
| ec nomenclature | |
| pdb deposition date | 2010-06-21 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00244 | 14-3-3 | 14-3-3 protein |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Up-down Bundle | Delta-Endotoxin; domain 1 | 14-3-3 domain |
#chains in the Genus database with same CATH superfamily 5LX2 A; 5LHO A; 1O9E A; 3IQU A; 4HKC A; 5LVZ A; 4DHR A; 4DHO A; 4E2E A; 3SP5 A; 1O9F A; 4DHU A; 1YZ5 A; 3SMK A; 4JDD A; 2C1N A; 1A4O A; 1O9D A; 2O8P A; 4WRQ A; 4DHT A; 1O9C A; 4FL5 A; 4DHN A; 3UAL A; 4FJ3 A; 3IQJ A; 2C63 A; 2O02 A; 2V7D A; 5LU2 A; 4J6S A; 4N7G A; 2NPM A; 3LW1 A; 3AXY C; 4FR3 A; 3T0L A; 5EWZ A; 1IB1 A; 3E6Y A; 5BY9 A; 4Y3B A; 3P1O A; 2WH0 A; 1QJB A; 5HF3 A; 1A37 A; 3IQV A; 4N84 A; 3SMM A; 3CU8 A; 5LU1 A; 5F74 A; 4Y5I A; 4DAU A; 3M51 A; 4ZDR A; 3T0M A; 1YWT A; 2C23 A; 3O8I A; 4ZQ0 A; 2C1J A; 4DNK A; 4DHQ A; 4N7Y A; 3P1Q A; 1QJA A; 4IHL A; 1A38 A; 5D3E A; 4DHM A; 3SMN A; 5EXA A; 3UX0 A; 5J31 A; 2BR9 A; 4QLI A; 4F7R A; 4BG6 A; 3UZD A; 5IQP A; 3NKX A; 2B05 A; 4IEA A; 3SML A; 2O98 A; 4DAT A; 2BTP A; 3P1N A; 4O46 A; 3SMO A; 4Y32 A; 3P1S A; 3P1R A; 3UBW A; 4DHS A; 4DHP A; 4GNT A; 5D3F A; 3MHR A; 3RDH A; 2C74 A; 3M50 A; 4JC3 A; 3EFZ A; 3P1P A; 5D2D A; 5BTV A; 4DX0 A; 2BQ0 A; 3U9X A; 3SPR A; #chains in the Genus database with same CATH topology 5LX2 A; 5LHO A; 1O9E A; 3IQU A; 4HKC A; 5LVZ A; 4DHR A; 4DHO A; 4E2E A; 3SP5 A; 4D8M A; 1O9F A; 4DHU A; 1YZ5 A; 3SMK A; 1W99 A; 4JDD A; 3CQG A; 2C1N A; 1A4O A; 1O9D A; 1JI6 A; 1S2X A; 2O8P A; 4WRQ A; 4W8J A; 4DHT A; 1O9C A; 4FL5 A; 4DHN A; 3UAL A; 4FJ3 A; 3IQJ A; 3CQC A; 2C63 A; 2O02 A; 2V7D A; 3X0U A; 5LU2 A; 4J6S A; 4N7G A; 2NPM A; 3LW1 A; 3AXY C; 3EB7 A; 4FR3 A; 3T0L A; 5EWZ A; 1IB1 A; 3E6Y A; 5BY9 A; 4Y3B A; 3P1O A; 2WH0 A; 1QJB A; 5HF3 A; 1A37 A; 3IQV A; 4MOA A; 4N84 A; 1DLC A; 4QX3 A; 3SMM A; 2C9K A; 3CU8 A; 5LU1 A; 5F74 A; 4Y5I A; 4DAU A; 3M51 A; 4ZDR A; 4QX2 A; 3T0M A; 4ARX A; 1YWT A; 2C23 A; 3O8I A; 4ZQ0 A; 2C1J A; 3I4R A; 4DNK A; 4DHQ A; 4N7Y A; 3P1Q A; 1QJA A; 4IHL A; 1A38 A; 5D3E A; 4DHM A; 3SMN A; 5EXA A; 3UX0 A; 3ZHE B; 4ARY A; 5J31 A; 2BR9 A; 4QLI A; 4F7R A; 4BG6 A; 3UZD A; 5IQP A; 3NKX A; 2B05 A; 4IEA A; 4QX0 A; 3SML A; 1URJ A; 2O98 A; 4DAT A; 2BTP A; 3P1N A; 4O46 A; 3SMO A; 4Y32 A; 3P1S A; 3P1R A; 3UBW A; 4DHS A; 4DHP A; 4GNT A; 5D3F A; 3MHR A; 3RDH A; 2C74 A; 1I5P A; 3M50 A; 4QX1 A; 4JC3 A; 3EFZ A; 3P1P A; 5D2D A; 5BTV A; 1CIY A; 4DX0 A; 2BQ0 A; 3U9X A; 3SPR A; #chains in the Genus database with same CATH homology 5LX2 A; 5LHO A; 1O9E A; 3IQU A; 4HKC A; 5LVZ A; 4DHR A; 4DHO A; 4E2E A; 3SP5 A; 1O9F A; 4DHU A; 1YZ5 A; 3SMK A; 4JDD A; 2C1N A; 1A4O A; 1O9D A; 2O8P A; 4WRQ A; 4DHT A; 1O9C A; 4FL5 A; 4DHN A; 3UAL A; 4FJ3 A; 3IQJ A; 2C63 A; 2O02 A; 2V7D A; 5LU2 A; 4J6S A; 4N7G A; 2NPM A; 3LW1 A; 3AXY C; 4FR3 A; 3T0L A; 5EWZ A; 1IB1 A; 3E6Y A; 5BY9 A; 4Y3B A; 3P1O A; 2WH0 A; 1QJB A; 5HF3 A; 1A37 A; 3IQV A; 4N84 A; 3SMM A; 3CU8 A; 5LU1 A; 5F74 A; 4Y5I A; 4DAU A; 3M51 A; 4ZDR A; 3T0M A; 1YWT A; 2C23 A; 3O8I A; 4ZQ0 A; 2C1J A; 4DNK A; 4DHQ A; 4N7Y A; 3P1Q A; 1QJA A; 4IHL A; 1A38 A; 5D3E A; 4DHM A; 3SMN A; 5EXA A; 3UX0 A; 5J31 A; 2BR9 A; 4QLI A; 4F7R A; 4BG6 A; 3UZD A; 5IQP A; 3NKX A; 2B05 A; 4IEA A; 3SML A; 2O98 A; 4DAT A; 2BTP A; 3P1N A; 4O46 A; 3SMO A; 4Y32 A; 3P1S A; 3P1R A; 3UBW A; 4DHS A; 4DHP A; 4GNT A; 5D3F A; 3MHR A; 3RDH A; 2C74 A; 3M50 A; 4JC3 A; 3EFZ A; 3P1P A; 5D2D A; 5BTV A; 4DX0 A; 2BQ0 A; 3U9X A; 3SPR A;
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