3T0LA

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Total Genus 101

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
235
structure length
229
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH4 (79-104)AH5 (114-134)3H1 (108-110)TIV1 (104-107)AH7 (167-183)AH6 (137-161)TI2 (163-166)AH8 (187-203)AH9 (210-230)AH1 (3-16)AH3 (38-70)AH2 (19-32)EMPTY3H2 (205-207)Updating...
connected with : NaN
molecule tags Protein binding/inhibitor
source organism Homo sapiens
publication title Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb
molecule keywords 14-3-3 protein sigma
total genus 101
structure length 229
sequence length 235
ec nomenclature
pdb deposition date 2011-07-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 3t0lA00
4JDDA 3T0MA 1A38A 3UX0A 3P1PA 3RDHA 1YWTA 5LU2A 3SPRA 4DHPA 2NPMA 4O46A 4ZQ0A 5F74A 4IEAA 5LX2A 2O8PA 2B05A 3SMMA 3EFZA 4IHLA 4DHMA 4E2EA 2C74A 4N84A 1A37A 4FL5A 2BQ0A 3P1SA 5BY9A 3MHRA 5LHOA 1O9CA 4DHQA 4FR3A 4FJ3A 5EWZA 4DHNA 2V7DA 1IB1A 4WRQA 5LU1A 1O9DA 4DHRA 5BTVA 4DX0A 5J31A 3IQJA 3LW1A 3UBWA 5HF3A 4DHOA 3SMNA 4Y32A 3M51A 4DNKA 4JC3A 2C1NA 3SMLA 4F7RA 4N7GA 1YZ5A 5D3EA 4GNTA 3NKXA 4DHTA 1QJBA 3SMKA 1O9EA 3E6YA 2BR9A 3U9XA 3O8IA 3IQVA 3T0LA 4DAUA 2O98A 4Y3BA 3P1NA 2WH0A 1QJAA 2BTPA 3SMOA 5D2DA 3AXYC 4DHUA 3M50A 2C23A 4QLIA 4Y5IA 4N7YA 1O9FA 1A4OA 4DHSA 4J6SA 5D3FA 4ZDRA 5EXAA 3UZDA 3P1OA 3SP5A 2C63A 3P1QA 2O02A 5LVZA 2C1JA 3P1RA 3CU8A 4HKCA 4DATA 3UALA 4BG6A 3IQUA 5IQPA
chains in the Genus database with same CATH superfamily
4JDDA 3T0MA 1A38A 3UX0A 3P1PA 3CQCA 3RDHA 1YWTA 5LU2A 3SPRA 4DHPA 2NPMA 4O46A 4ZQ0A 3EB7A 5F74A 4IEAA 5LX2A 2O8PA 2B05A 3SMMA 3EFZA 4IHLA 4DHMA 4E2EA 2C74A 4N84A 3CQGA 4W8JA 1URJA 1A37A 4FL5A 2BQ0A 3P1SA 5BY9A 3MHRA 5LHOA 1O9CA 4DHQA 4FR3A 4FJ3A 5EWZA 4DHNA 2V7DA 1W99A 1IB1A 4WRQA 1CIYA 5LU1A 1O9DA 4DHRA 5BTVA 4DX0A 5J31A 3IQJA 3LW1A 3UBWA 5HF3A 4QX3A 4DHOA 3SMNA 4Y32A 3M51A 4DNKA 4JC3A 2C1NA 3SMLA 3I4RA 4F7RA 4N7GA 1YZ5A 5D3EA 4GNTA 4QX1A 3NKXA 4DHTA 1QJBA 3SMKA 1O9EA 3E6YA 2BR9A 3U9XA 3O8IA 4D8MA 3IQVA 3T0LA 3ZHEB 4DAUA 1DLCA 2O98A 4ARXA 4Y3BA 3P1NA 2WH0A 1QJAA 4QX2A 2BTPA 3SMOA 2C9KA 4MOAA 5D2DA 3AXYC 4DHUA 3M50A 2C23A 4QLIA 4N7YA 4Y5IA 1O9FA 1A4OA 4DHSA 4J6SA 5D3FA 4ZDRA 5EXAA 3UZDA 3P1OA 1JI6A 3SP5A 2C63A 4ARYA 3P1QA 1I5PA 2O02A 5LVZA 2C1JA 4QX0A 3P1RA 1S2XA 3CU8A 4HKCA 4DATA 3UALA 4BG6A 3IQUA 5IQPA 3X0UA
chains in the Genus database with same CATH topology
4JDDA 3T0MA 1A38A 3UX0A 3P1PA 3RDHA 1YWTA 5LU2A 3SPRA 4DHPA 2NPMA 4O46A 4ZQ0A 5F74A 4IEAA 5LX2A 2O8PA 2B05A 3SMMA 3EFZA 4IHLA 4DHMA 4E2EA 2C74A 4N84A 1A37A 4FL5A 2BQ0A 3P1SA 5BY9A 3MHRA 5LHOA 1O9CA 4DHQA 4FR3A 4FJ3A 5EWZA 4DHNA 2V7DA 1IB1A 4WRQA 5LU1A 1O9DA 4DHRA 5BTVA 4DX0A 5J31A 3IQJA 3LW1A 3UBWA 5HF3A 4DHOA 3SMNA 4Y32A 3M51A 4DNKA 4JC3A 2C1NA 3SMLA 4F7RA 4N7GA 1YZ5A 5D3EA 4GNTA 3NKXA 4DHTA 1QJBA 3SMKA 1O9EA 3E6YA 2BR9A 3U9XA 3O8IA 3IQVA 3T0LA 4DAUA 2O98A 4Y3BA 3P1NA 2WH0A 1QJAA 2BTPA 3SMOA 5D2DA 3AXYC 4DHUA 3M50A 2C23A 4QLIA 4Y5IA 4N7YA 1O9FA 1A4OA 4DHSA 4J6SA 5D3FA 4ZDRA 5EXAA 3UZDA 3P1OA 3SP5A 2C63A 3P1QA 2O02A 5LVZA 2C1JA 3P1RA 3CU8A 4HKCA 4DATA 3UALA 4BG6A 3IQUA 5IQPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4JDD A;  3T0M A;  1A38 A;  3UX0 A;  3P1P A;  3RDH A;  1YWT A;  5LU2 A;  3SPR A;  4DHP A;  2NPM A;  4O46 A;  4ZQ0 A;  5F74 A;  4IEA A;  5LX2 A;  2O8P A;  2B05 A;  3SMM A;  3EFZ A;  4IHL A;  4DHM A;  4E2E A;  2C74 A;  4N84 A;  1A37 A;  4FL5 A;  2BQ0 A;  3P1S A;  5BY9 A;  3MHR A;  5LHO A;  1O9C A;  4DHQ A;  4FR3 A;  4FJ3 A;  5EWZ A;  4DHN A;  2V7D A;  1IB1 A;  4WRQ A;  5LU1 A;  1O9D A;  4DHR A;  5BTV A;  4DX0 A;  5J31 A;  3IQJ A;  3LW1 A;  3UBW A;  5HF3 A;  4DHO A;  3SMN A;  4Y32 A;  3M51 A;  4DNK A;  4JC3 A;  2C1N A;  3SML A;  4F7R A;  4N7G A;  1YZ5 A;  5D3E A;  4GNT A;  3NKX A;  4DHT A;  1QJB A;  3SMK A;  1O9E A;  3E6Y A;  2BR9 A;  3U9X A;  3O8I A;  3IQV A;  3T0L A;  4DAU A;  2O98 A;  4Y3B A;  3P1N A;  2WH0 A;  1QJA A;  2BTP A;  3SMO A;  5D2D A;  3AXY C;  4DHU A;  3M50 A;  2C23 A;  4QLI A;  4Y5I A;  4N7Y A;  1O9F A;  1A4O A;  4DHS A;  4J6S A;  5D3F A;  4ZDR A;  5EXA A;  3UZD A;  3P1O A;  3SP5 A;  2C63 A;  3P1Q A;  2O02 A;  5LVZ A;  2C1J A;  3P1R A;  3CU8 A;  4HKC A;  4DAT A;  3UAL A;  4BG6 A;  3IQU A;  5IQP A; 
#chains in the Genus database with same CATH topology
 4JDD A;  3T0M A;  1A38 A;  3UX0 A;  3P1P A;  3CQC A;  3RDH A;  1YWT A;  5LU2 A;  3SPR A;  4DHP A;  2NPM A;  4O46 A;  4ZQ0 A;  3EB7 A;  5F74 A;  4IEA A;  5LX2 A;  2O8P A;  2B05 A;  3SMM A;  3EFZ A;  4IHL A;  4DHM A;  4E2E A;  2C74 A;  4N84 A;  3CQG A;  4W8J A;  1URJ A;  1A37 A;  4FL5 A;  2BQ0 A;  3P1S A;  5BY9 A;  3MHR A;  5LHO A;  1O9C A;  4DHQ A;  4FR3 A;  4FJ3 A;  5EWZ A;  4DHN A;  2V7D A;  1W99 A;  1IB1 A;  4WRQ A;  1CIY A;  5LU1 A;  1O9D A;  4DHR A;  5BTV A;  4DX0 A;  5J31 A;  3IQJ A;  3LW1 A;  3UBW A;  5HF3 A;  4QX3 A;  4DHO A;  3SMN A;  4Y32 A;  3M51 A;  4DNK A;  4JC3 A;  2C1N A;  3SML A;  3I4R A;  4F7R A;  4N7G A;  1YZ5 A;  5D3E A;  4GNT A;  4QX1 A;  3NKX A;  4DHT A;  1QJB A;  3SMK A;  1O9E A;  3E6Y A;  2BR9 A;  3U9X A;  3O8I A;  4D8M A;  3IQV A;  3T0L A;  3ZHE B;  4DAU A;  1DLC A;  2O98 A;  4ARX A;  4Y3B A;  3P1N A;  2WH0 A;  1QJA A;  4QX2 A;  2BTP A;  3SMO A;  2C9K A;  4MOA A;  5D2D A;  3AXY C;  4DHU A;  3M50 A;  2C23 A;  4QLI A;  4N7Y A;  4Y5I A;  1O9F A;  1A4O A;  4DHS A;  4J6S A;  5D3F A;  4ZDR A;  5EXA A;  3UZD A;  3P1O A;  1JI6 A;  3SP5 A;  2C63 A;  4ARY A;  3P1Q A;  1I5P A;  2O02 A;  5LVZ A;  2C1J A;  4QX0 A;  3P1R A;  1S2X A;  3CU8 A;  4HKC A;  4DAT A;  3UAL A;  4BG6 A;  3IQU A;  5IQP A;  3X0U A; 
#chains in the Genus database with same CATH homology
 4JDD A;  3T0M A;  1A38 A;  3UX0 A;  3P1P A;  3RDH A;  1YWT A;  5LU2 A;  3SPR A;  4DHP A;  2NPM A;  4O46 A;  4ZQ0 A;  5F74 A;  4IEA A;  5LX2 A;  2O8P A;  2B05 A;  3SMM A;  3EFZ A;  4IHL A;  4DHM A;  4E2E A;  2C74 A;  4N84 A;  1A37 A;  4FL5 A;  2BQ0 A;  3P1S A;  5BY9 A;  3MHR A;  5LHO A;  1O9C A;  4DHQ A;  4FR3 A;  4FJ3 A;  5EWZ A;  4DHN A;  2V7D A;  1IB1 A;  4WRQ A;  5LU1 A;  1O9D A;  4DHR A;  5BTV A;  4DX0 A;  5J31 A;  3IQJ A;  3LW1 A;  3UBW A;  5HF3 A;  4DHO A;  3SMN A;  4Y32 A;  3M51 A;  4DNK A;  4JC3 A;  2C1N A;  3SML A;  4F7R A;  4N7G A;  1YZ5 A;  5D3E A;  4GNT A;  3NKX A;  4DHT A;  1QJB A;  3SMK A;  1O9E A;  3E6Y A;  2BR9 A;  3U9X A;  3O8I A;  3IQV A;  3T0L A;  4DAU A;  2O98 A;  4Y3B A;  3P1N A;  2WH0 A;  1QJA A;  2BTP A;  3SMO A;  5D2D A;  3AXY C;  4DHU A;  3M50 A;  2C23 A;  4QLI A;  4Y5I A;  4N7Y A;  1O9F A;  1A4O A;  4DHS A;  4J6S A;  5D3F A;  4ZDR A;  5EXA A;  3UZD A;  3P1O A;  3SP5 A;  2C63 A;  3P1Q A;  2O02 A;  5LVZ A;  2C1J A;  3P1R A;  3CU8 A;  4HKC A;  4DAT A;  3UAL A;  4BG6 A;  3IQU A;  5IQP A; 
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