3T0MA

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Total Genus 102

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
235
structure length
229
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH4 (79-104)AH5 (114-134)3H1 (107-110)TIV1 (104-107)EMPTYTI2 (163-166)AH7 (167-183)AH6 (139-161)AH8 (187-203)AH9 (210-230)AH1 (3-16)AH3 (38-69)AH2 (19-32)3H2 (205-207)Updating...
connected with : NaN
molecule tags Protein binding/inhibitor
source organism Homo sapiens
publication title Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb
molecule keywords 14-3-3 protein sigma
total genus 102
structure length 229
sequence length 235
ec nomenclature
pdb deposition date 2011-07-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 3t0mA00
1A37A 4DHRA 4QLIA 4Y5IA 4ZDRA 4DHNA 3E6YA 5D3FA 1IB1A 3T0LA 3SMKA 4DHUA 2C74A 4DAUA 3UX0A 5BY9A 3IQJA 4HKCA 3T0MA 4E2EA 3SMMA 2C23A 5HF3A 2O98A 4ZQ0A 3P1PA 4WRQA 2BTPA 5BTVA 5D2DA 3SP5A 3SMOA 3SPRA 4N7GA 4Y3BA 5LX2A 3IQUA 5LU2A 1QJBA 2V7DA 4O46A 1O9DA 3IQVA 3EFZA 4IHLA 4DATA 4DHPA 3RDHA 4Y32A 3MHRA 2BQ0A 4IEAA 4DNKA 4GNTA 3P1SA 4FJ3A 2C1NA 2NPMA 3P1NA 3U9XA 5F74A 4FR3A 5LHOA 2C1JA 4F7RA 3M51A 4DX0A 2BR9A 5EXAA 4DHSA 5J31A 2WH0A 4DHOA 3P1RA 4DHQA 1YWTA 2O8PA 4JDDA 3M50A 5EWZA 1A38A 5D3EA 1O9CA 1O9FA 5LU1A 3NKXA 3SMLA 1YZ5A 2B05A 1O9EA 2C63A 3UALA 4N84A 1QJAA 3O8IA 3CU8A 3LW1A 4BG6A 5LVZA 5IQPA 3AXYC 1A4OA 3SMNA 3UBWA 4N7YA 4J6SA 4FL5A 3UZDA 4JC3A 2O02A 3P1OA 3P1QA 4DHTA 4DHMA
chains in the Genus database with same CATH superfamily
1I5PA 1A37A 3CQCA 4QX1A 4DHRA 3ZHEB 4QLIA 4Y5IA 4ZDRA 4DHNA 1JI6A 3E6YA 5D3FA 1IB1A 3T0LA 3SMKA 4DHUA 4QX2A 2C74A 4DAUA 4QX3A 3UX0A 5BY9A 4W8JA 3IQJA 4HKCA 3T0MA 4ARXA 4E2EA 3SMMA 2C23A 5HF3A 4ARYA 2O98A 4ZQ0A 2BTPA 3P1PA 4WRQA 5BTVA 5D2DA 3SP5A 1CIYA 3SMOA 3SPRA 4N7GA 4Y3BA 5LX2A 3IQUA 5LU2A 1QJBA 1URJA 2V7DA 4O46A 1O9DA 4D8MA 3IQVA 3EFZA 4IHLA 4DATA 4DHPA 3RDHA 4Y32A 3MHRA 2BQ0A 4IEAA 3EB7A 4DNKA 2C9KA 4GNTA 3P1SA 4FJ3A 2C1NA 2NPMA 3P1NA 3U9XA 5F74A 3X0UA 4FR3A 5LHOA 2C1JA 4F7RA 3CQGA 3M51A 2BR9A 4DX0A 5EXAA 4DHSA 5J31A 2WH0A 4DHOA 3P1RA 4DHQA 1YWTA 2O8PA 4JDDA 3M50A 5EWZA 1A38A 5D3EA 1O9CA 1O9FA 4MOAA 5LU1A 1S2XA 3NKXA 1W99A 3SMLA 1YZ5A 2B05A 1O9EA 2C63A 3UALA 4N84A 1DLCA 3I4RA 1QJAA 3O8IA 3CU8A 3LW1A 4BG6A 5LVZA 5IQPA 3AXYC 1A4OA 3SMNA 3UBWA 4N7YA 4J6SA 4FL5A 3UZDA 4JC3A 4QX0A 2O02A 3P1OA 3P1QA 4DHTA 4DHMA
chains in the Genus database with same CATH topology
1A37A 4DHRA 4QLIA 4Y5IA 4ZDRA 4DHNA 3E6YA 5D3FA 1IB1A 3T0LA 3SMKA 4DHUA 2C74A 4DAUA 3UX0A 5BY9A 3IQJA 4HKCA 3T0MA 4E2EA 3SMMA 2C23A 5HF3A 2O98A 4ZQ0A 3P1PA 4WRQA 2BTPA 5BTVA 5D2DA 3SP5A 3SMOA 3SPRA 4N7GA 4Y3BA 5LX2A 3IQUA 5LU2A 1QJBA 2V7DA 4O46A 1O9DA 3IQVA 3EFZA 4IHLA 4DATA 4DHPA 3RDHA 4Y32A 3MHRA 2BQ0A 4IEAA 4DNKA 4GNTA 3P1SA 4FJ3A 2C1NA 2NPMA 3P1NA 3U9XA 5F74A 4FR3A 5LHOA 2C1JA 4F7RA 3M51A 4DX0A 2BR9A 5EXAA 4DHSA 5J31A 2WH0A 4DHOA 3P1RA 4DHQA 1YWTA 2O8PA 4JDDA 3M50A 5EWZA 1A38A 5D3EA 1O9CA 1O9FA 5LU1A 3NKXA 3SMLA 1YZ5A 2B05A 1O9EA 2C63A 3UALA 4N84A 1QJAA 3O8IA 3CU8A 3LW1A 4BG6A 5LVZA 5IQPA 3AXYC 1A4OA 3SMNA 3UBWA 4N7YA 4J6SA 4FL5A 3UZDA 4JC3A 2O02A 3P1OA 3P1QA 4DHTA 4DHMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A37 A;  4DHR A;  4QLI A;  4Y5I A;  4ZDR A;  4DHN A;  3E6Y A;  5D3F A;  1IB1 A;  3T0L A;  3SMK A;  4DHU A;  2C74 A;  4DAU A;  3UX0 A;  5BY9 A;  3IQJ A;  4HKC A;  3T0M A;  4E2E A;  3SMM A;  2C23 A;  5HF3 A;  2O98 A;  4ZQ0 A;  3P1P A;  4WRQ A;  2BTP A;  5BTV A;  5D2D A;  3SP5 A;  3SMO A;  3SPR A;  4N7G A;  4Y3B A;  5LX2 A;  3IQU A;  5LU2 A;  1QJB A;  2V7D A;  4O46 A;  1O9D A;  3IQV A;  3EFZ A;  4IHL A;  4DAT A;  4DHP A;  3RDH A;  4Y32 A;  3MHR A;  2BQ0 A;  4IEA A;  4DNK A;  4GNT A;  3P1S A;  4FJ3 A;  2C1N A;  2NPM A;  3P1N A;  3U9X A;  5F74 A;  4FR3 A;  5LHO A;  2C1J A;  4F7R A;  3M51 A;  4DX0 A;  2BR9 A;  5EXA A;  4DHS A;  5J31 A;  2WH0 A;  4DHO A;  3P1R A;  4DHQ A;  1YWT A;  2O8P A;  4JDD A;  3M50 A;  5EWZ A;  1A38 A;  5D3E A;  1O9C A;  1O9F A;  5LU1 A;  3NKX A;  3SML A;  1YZ5 A;  2B05 A;  1O9E A;  2C63 A;  3UAL A;  4N84 A;  1QJA A;  3O8I A;  3CU8 A;  3LW1 A;  4BG6 A;  5LVZ A;  5IQP A;  3AXY C;  1A4O A;  3SMN A;  3UBW A;  4N7Y A;  4J6S A;  4FL5 A;  3UZD A;  4JC3 A;  2O02 A;  3P1O A;  3P1Q A;  4DHT A;  4DHM A; 
#chains in the Genus database with same CATH topology
 1I5P A;  1A37 A;  3CQC A;  4QX1 A;  4DHR A;  3ZHE B;  4QLI A;  4Y5I A;  4ZDR A;  4DHN A;  1JI6 A;  3E6Y A;  5D3F A;  1IB1 A;  3T0L A;  3SMK A;  4DHU A;  4QX2 A;  2C74 A;  4DAU A;  4QX3 A;  3UX0 A;  5BY9 A;  4W8J A;  3IQJ A;  4HKC A;  3T0M A;  4ARX A;  4E2E A;  3SMM A;  2C23 A;  5HF3 A;  4ARY A;  2O98 A;  4ZQ0 A;  2BTP A;  3P1P A;  4WRQ A;  5BTV A;  5D2D A;  3SP5 A;  1CIY A;  3SMO A;  3SPR A;  4N7G A;  4Y3B A;  5LX2 A;  3IQU A;  5LU2 A;  1QJB A;  1URJ A;  2V7D A;  4O46 A;  1O9D A;  4D8M A;  3IQV A;  3EFZ A;  4IHL A;  4DAT A;  4DHP A;  3RDH A;  4Y32 A;  3MHR A;  2BQ0 A;  4IEA A;  3EB7 A;  4DNK A;  2C9K A;  4GNT A;  3P1S A;  4FJ3 A;  2C1N A;  2NPM A;  3P1N A;  3U9X A;  5F74 A;  3X0U A;  4FR3 A;  5LHO A;  2C1J A;  4F7R A;  3CQG A;  3M51 A;  2BR9 A;  4DX0 A;  5EXA A;  4DHS A;  5J31 A;  2WH0 A;  4DHO A;  3P1R A;  4DHQ A;  1YWT A;  2O8P A;  4JDD A;  3M50 A;  5EWZ A;  1A38 A;  5D3E A;  1O9C A;  1O9F A;  4MOA A;  5LU1 A;  1S2X A;  3NKX A;  1W99 A;  3SML A;  1YZ5 A;  2B05 A;  1O9E A;  2C63 A;  3UAL A;  4N84 A;  1DLC A;  3I4R A;  1QJA A;  3O8I A;  3CU8 A;  3LW1 A;  4BG6 A;  5LVZ A;  5IQP A;  3AXY C;  1A4O A;  3SMN A;  3UBW A;  4N7Y A;  4J6S A;  4FL5 A;  3UZD A;  4JC3 A;  4QX0 A;  2O02 A;  3P1O A;  3P1Q A;  4DHT A;  4DHM A; 
#chains in the Genus database with same CATH homology
 1A37 A;  4DHR A;  4QLI A;  4Y5I A;  4ZDR A;  4DHN A;  3E6Y A;  5D3F A;  1IB1 A;  3T0L A;  3SMK A;  4DHU A;  2C74 A;  4DAU A;  3UX0 A;  5BY9 A;  3IQJ A;  4HKC A;  3T0M A;  4E2E A;  3SMM A;  2C23 A;  5HF3 A;  2O98 A;  4ZQ0 A;  3P1P A;  4WRQ A;  2BTP A;  5BTV A;  5D2D A;  3SP5 A;  3SMO A;  3SPR A;  4N7G A;  4Y3B A;  5LX2 A;  3IQU A;  5LU2 A;  1QJB A;  2V7D A;  4O46 A;  1O9D A;  3IQV A;  3EFZ A;  4IHL A;  4DAT A;  4DHP A;  3RDH A;  4Y32 A;  3MHR A;  2BQ0 A;  4IEA A;  4DNK A;  4GNT A;  3P1S A;  4FJ3 A;  2C1N A;  2NPM A;  3P1N A;  3U9X A;  5F74 A;  4FR3 A;  5LHO A;  2C1J A;  4F7R A;  3M51 A;  4DX0 A;  2BR9 A;  5EXA A;  4DHS A;  5J31 A;  2WH0 A;  4DHO A;  3P1R A;  4DHQ A;  1YWT A;  2O8P A;  4JDD A;  3M50 A;  5EWZ A;  1A38 A;  5D3E A;  1O9C A;  1O9F A;  5LU1 A;  3NKX A;  3SML A;  1YZ5 A;  2B05 A;  1O9E A;  2C63 A;  3UAL A;  4N84 A;  1QJA A;  3O8I A;  3CU8 A;  3LW1 A;  4BG6 A;  5LVZ A;  5IQP A;  3AXY C;  1A4O A;  3SMN A;  3UBW A;  4N7Y A;  4J6S A;  4FL5 A;  3UZD A;  4JC3 A;  2O02 A;  3P1O A;  3P1Q A;  4DHT A;  4DHM A; 
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