3UBWA

Complex of 14-3-3 isoform epsilon, a mlf1 phosphopeptide and a small fragment hit from a fbdd screen
Total Genus 106
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
106
sequence length
230
structure length
229
Chain Sequence
DREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural insights of the MLF1/14-3-3 interaction.
pubmed doi rcsb
molecule tags Signaling protein/protein binding
source organism Homo sapiens
molecule keywords 14-3-3 protein epsilon
total genus 106
structure length 229
sequence length 230
ec nomenclature
pdb deposition date 2011-10-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 3ubwA00
3O8IA 1IB1A 2O8PA 5D3FA 3P1SA 3MHRA 4N84A 5HF3A 4N7GA 5LU1A 5LVZA 5LX2A 5LHOA 4ZDRA 4WRQA 4O46A 1YZ5A 3T0MA 2WH0A 2B05A 3P1RA 4DHQA 4JDDA 2C1JA 3IQUA 5BTVA 3CU8A 4Y5IA 2NPMA 3SP5A 2BQ0A 3UALA 3P1PA 4FJ3A 1YWTA 4IHLA 3U9XA 3SMOA 4DHPA 3NKXA 2O02A 4FR3A 1O9FA 4GNTA 3P1NA 4DHMA 3UZDA 3AXYC 4J6SA 3LW1A 3T0LA 5IQPA 5D3EA 1O9EA 1A4OA 4IEAA 5D2DA 4N7YA 4DATA 4DAUA 1QJBA 3EFZA 4DHUA 4ZQ0A 1O9DA 3RDHA 3UBWA 2BR9A 3SMNA 2C74A 3SMKA 5LU2A 4E2EA 5EXAA 4Y3BA 3IQJA 5EWZA 2BTPA 4DHOA 4DHSA 5J31A 3UX0A 1A38A 4Y32A 2O98A 4DX0A 3P1QA 4DHRA 2C1NA 2C63A 3SPRA 5BY9A 4BG6A 4DHTA 4FL5A 3M50A 1O9CA 5F74A 1A37A 2C23A 3E6YA 2V7DA 3M51A 3SMLA 4DHNA 4JC3A 3P1OA 1QJAA 3SMMA 4QLIA 4F7RA 4HKCA 3IQVA 4DNKA
chains in the Genus database with same CATH superfamily
3O8IA 1IB1A 2O8PA 5D3FA 3P1SA 3MHRA 4N84A 5HF3A 4N7GA 5LU1A 5LVZA 5LX2A 5LHOA 4ZDRA 4WRQA 4O46A 4QX3A 1YZ5A 3T0MA 2WH0A 2B05A 3P1RA 4DHQA 4JDDA 2C1JA 3IQUA 5BTVA 3CU8A 4Y5IA 2NPMA 3CQCA 3SP5A 3EB7A 2BQ0A 3UALA 3P1PA 4MOAA 4FJ3A 1YWTA 4IHLA 3CQGA 3U9XA 1CIYA 3SMOA 4DHPA 4QX1A 3NKXA 2O02A 4FR3A 1O9FA 4GNTA 3P1NA 4DHMA 3UZDA 3AXYC 1JI6A 1S2XA 4ARXA 3ZHEB 4J6SA 3LW1A 3T0LA 5IQPA 1O9EA 5D3EA 1A4OA 3I4RA 4IEAA 5D2DA 4N7YA 4DATA 4DAUA 1QJBA 3EFZA 4DHUA 4QX0A 4ZQ0A 1O9DA 3RDHA 3UBWA 2BR9A 4W8JA 3SMNA 4QX2A 2C74A 3SMKA 3X0UA 4E2EA 5LU2A 5EXAA 4Y3BA 3IQJA 5EWZA 2BTPA 4DHOA 4D8MA 4DHSA 5J31A 3UX0A 1A38A 4Y32A 2O98A 1W99A 4DX0A 3P1QA 4DHRA 2C1NA 1URJA 2C63A 3SPRA 5BY9A 4BG6A 4DHTA 1DLCA 4FL5A 3M50A 1O9CA 5F74A 1A37A 2C23A 3E6YA 2V7DA 3M51A 3SMLA 2C9KA 4DHNA 4ARYA 4JC3A 3P1OA 1QJAA 3SMMA 4QLIA 4F7RA 4HKCA 3IQVA 4DNKA 1I5PA
chains in the Genus database with same CATH topology
3O8IA 1IB1A 2O8PA 5D3FA 3P1SA 3MHRA 4N84A 5HF3A 4N7GA 5LU1A 5LVZA 5LX2A 5LHOA 4ZDRA 4WRQA 4O46A 1YZ5A 3T0MA 2WH0A 2B05A 3P1RA 4DHQA 4JDDA 2C1JA 3IQUA 5BTVA 3CU8A 4Y5IA 2NPMA 3SP5A 2BQ0A 3UALA 3P1PA 4FJ3A 1YWTA 4IHLA 3U9XA 3SMOA 4DHPA 3NKXA 2O02A 4FR3A 1O9FA 4GNTA 3P1NA 4DHMA 3UZDA 3AXYC 4J6SA 3LW1A 3T0LA 5IQPA 5D3EA 1O9EA 1A4OA 4IEAA 5D2DA 4N7YA 4DATA 4DAUA 1QJBA 3EFZA 4DHUA 4ZQ0A 1O9DA 3RDHA 3UBWA 2BR9A 3SMNA 2C74A 3SMKA 5LU2A 4E2EA 5EXAA 4Y3BA 3IQJA 5EWZA 2BTPA 4DHOA 4DHSA 5J31A 3UX0A 1A38A 4Y32A 2O98A 4DX0A 3P1QA 4DHRA 2C1NA 2C63A 3SPRA 5BY9A 4BG6A 4DHTA 4FL5A 3M50A 1O9CA 5F74A 1A37A 2C23A 3E6YA 2V7DA 3M51A 3SMLA 4DHNA 4JC3A 3P1OA 1QJAA 3SMMA 4QLIA 4F7RA 4HKCA 3IQVA 4DNKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3O8I A;  1IB1 A;  2O8P A;  5D3F A;  3P1S A;  3MHR A;  4N84 A;  5HF3 A;  4N7G A;  5LU1 A;  5LVZ A;  5LX2 A;  5LHO A;  4ZDR A;  4WRQ A;  4O46 A;  1YZ5 A;  3T0M A;  2WH0 A;  2B05 A;  3P1R A;  4DHQ A;  4JDD A;  2C1J A;  3IQU A;  5BTV A;  3CU8 A;  4Y5I A;  2NPM A;  3SP5 A;  2BQ0 A;  3UAL A;  3P1P A;  4FJ3 A;  1YWT A;  4IHL A;  3U9X A;  3SMO A;  4DHP A;  3NKX A;  2O02 A;  4FR3 A;  1O9F A;  4GNT A;  3P1N A;  4DHM A;  3UZD A;  3AXY C;  4J6S A;  3LW1 A;  3T0L A;  5IQP A;  5D3E A;  1O9E A;  1A4O A;  4IEA A;  5D2D A;  4N7Y A;  4DAT A;  4DAU A;  1QJB A;  3EFZ A;  4DHU A;  4ZQ0 A;  1O9D A;  3RDH A;  3UBW A;  2BR9 A;  3SMN A;  2C74 A;  3SMK A;  5LU2 A;  4E2E A;  5EXA A;  4Y3B A;  3IQJ A;  5EWZ A;  2BTP A;  4DHO A;  4DHS A;  5J31 A;  3UX0 A;  1A38 A;  4Y32 A;  2O98 A;  4DX0 A;  3P1Q A;  4DHR A;  2C1N A;  2C63 A;  3SPR A;  5BY9 A;  4BG6 A;  4DHT A;  4FL5 A;  3M50 A;  1O9C A;  5F74 A;  1A37 A;  2C23 A;  3E6Y A;  2V7D A;  3M51 A;  3SML A;  4DHN A;  4JC3 A;  3P1O A;  1QJA A;  3SMM A;  4QLI A;  4F7R A;  4HKC A;  3IQV A;  4DNK A; 
#chains in the Genus database with same CATH topology
 3O8I A;  1IB1 A;  2O8P A;  5D3F A;  3P1S A;  3MHR A;  4N84 A;  5HF3 A;  4N7G A;  5LU1 A;  5LVZ A;  5LX2 A;  5LHO A;  4ZDR A;  4WRQ A;  4O46 A;  4QX3 A;  1YZ5 A;  3T0M A;  2WH0 A;  2B05 A;  3P1R A;  4DHQ A;  4JDD A;  2C1J A;  3IQU A;  5BTV A;  3CU8 A;  4Y5I A;  2NPM A;  3CQC A;  3SP5 A;  3EB7 A;  2BQ0 A;  3UAL A;  3P1P A;  4MOA A;  4FJ3 A;  1YWT A;  4IHL A;  3CQG A;  3U9X A;  1CIY A;  3SMO A;  4DHP A;  4QX1 A;  3NKX A;  2O02 A;  4FR3 A;  1O9F A;  4GNT A;  3P1N A;  4DHM A;  3UZD A;  3AXY C;  1JI6 A;  1S2X A;  4ARX A;  3ZHE B;  4J6S A;  3LW1 A;  3T0L A;  5IQP A;  1O9E A;  5D3E A;  1A4O A;  3I4R A;  4IEA A;  5D2D A;  4N7Y A;  4DAT A;  4DAU A;  1QJB A;  3EFZ A;  4DHU A;  4QX0 A;  4ZQ0 A;  1O9D A;  3RDH A;  3UBW A;  2BR9 A;  4W8J A;  3SMN A;  4QX2 A;  2C74 A;  3SMK A;  3X0U A;  4E2E A;  5LU2 A;  5EXA A;  4Y3B A;  3IQJ A;  5EWZ A;  2BTP A;  4DHO A;  4D8M A;  4DHS A;  5J31 A;  3UX0 A;  1A38 A;  4Y32 A;  2O98 A;  1W99 A;  4DX0 A;  3P1Q A;  4DHR A;  2C1N A;  1URJ A;  2C63 A;  3SPR A;  5BY9 A;  4BG6 A;  4DHT A;  1DLC A;  4FL5 A;  3M50 A;  1O9C A;  5F74 A;  1A37 A;  2C23 A;  3E6Y A;  2V7D A;  3M51 A;  3SML A;  2C9K A;  4DHN A;  4ARY A;  4JC3 A;  3P1O A;  1QJA A;  3SMM A;  4QLI A;  4F7R A;  4HKC A;  3IQV A;  4DNK A;  1I5P A; 
#chains in the Genus database with same CATH homology
 3O8I A;  1IB1 A;  2O8P A;  5D3F A;  3P1S A;  3MHR A;  4N84 A;  5HF3 A;  4N7G A;  5LU1 A;  5LVZ A;  5LX2 A;  5LHO A;  4ZDR A;  4WRQ A;  4O46 A;  1YZ5 A;  3T0M A;  2WH0 A;  2B05 A;  3P1R A;  4DHQ A;  4JDD A;  2C1J A;  3IQU A;  5BTV A;  3CU8 A;  4Y5I A;  2NPM A;  3SP5 A;  2BQ0 A;  3UAL A;  3P1P A;  4FJ3 A;  1YWT A;  4IHL A;  3U9X A;  3SMO A;  4DHP A;  3NKX A;  2O02 A;  4FR3 A;  1O9F A;  4GNT A;  3P1N A;  4DHM A;  3UZD A;  3AXY C;  4J6S A;  3LW1 A;  3T0L A;  5IQP A;  5D3E A;  1O9E A;  1A4O A;  4IEA A;  5D2D A;  4N7Y A;  4DAT A;  4DAU A;  1QJB A;  3EFZ A;  4DHU A;  4ZQ0 A;  1O9D A;  3RDH A;  3UBW A;  2BR9 A;  3SMN A;  2C74 A;  3SMK A;  5LU2 A;  4E2E A;  5EXA A;  4Y3B A;  3IQJ A;  5EWZ A;  2BTP A;  4DHO A;  4DHS A;  5J31 A;  3UX0 A;  1A38 A;  4Y32 A;  2O98 A;  4DX0 A;  3P1Q A;  4DHR A;  2C1N A;  2C63 A;  3SPR A;  5BY9 A;  4BG6 A;  4DHT A;  4FL5 A;  3M50 A;  1O9C A;  5F74 A;  1A37 A;  2C23 A;  3E6Y A;  2V7D A;  3M51 A;  3SML A;  4DHN A;  4JC3 A;  3P1O A;  1QJA A;  3SMM A;  4QLI A;  4F7R A;  4HKC A;  3IQV A;  4DNK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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