4BVCA

Identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv.
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
79
structure length
79
Chain Sequence
QCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCALTRC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords APOLIPOPROTEIN(A)
total genus 21
structure length 79
sequence length 79
ec nomenclature ec 3.4.21.-:
pdb deposition date 2013-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4bvcA00
4NZQA 4BV7A 1TPKA 2HPQP 2FD6A 2I9AA 4D3CA 1HPJA 3BT1A 4HZHA 5CT3A 4BVVA 4CIKA 1KRNA 2KNFA 2DOHX 2KJ4A 5CT2A 5CS1A 1B2IA 5CSQA 2PF1A 2K4RA 2QJ4A 1HPKA 1PK4A 5CT1A 2QJ2A 4BVCA 1I5KA 1PKRA 2PK4A 1KI0A 3KIVA 3SP8A 1NL1A 2HPPP 4BVDA 1CEBA 1GMOA 3BT2A 2FEBA 5CS9A 1I71A 1KIVA 5CP9A 5COEA 3MKPA 2SPTA 1GMNA 1BHTA 2I9BA 1URKA 4BV5A 5HPGA 1NL2A 4IUAA 1JFNA 5CS5A 2DOIA 5CS3A 2L0SA 1NK1A 3K65A 3LAQA 3U73A 4KIVA 4BVWA 4O03A 4DURA 1CEAA 1PMKA 1KDUA 1GP9A 1A0HA 4A5TS 3E6PL 1PMLA 1PK2A 2K51A 3NXPA 2PF2A 3HN4A
chains in the Genus database with same CATH superfamily
4NZQA 4BV7A 1TPKA 2HPQP 2FD6A 2I9AA 4D3CA 1HPJA 3BT1A 4HZHA 5CT3A 4BVVA 4CIKA 1KRNA 2KNFA 2DOHX 2KJ4A 5CT2A 5CS1A 1B2IA 5CSQA 2PF1A 2K4RA 2QJ4A 1HPKA 1PK4A 5CT1A 2QJ2A 4BVCA 1I5KA 1PKRA 2PK4A 1KI0A 3KIVA 3SP8A 1NL1A 2HPPP 4BVDA 1CEBA 1GMOA 3BT2A 2FEBA 5CS9A 1I71A 1KIVA 5CP9A 5COEA 3MKPA 2SPTA 1GMNA 1BHTA 2I9BA 1URKA 4BV5A 5HPGA 1NL2A 4IUAA 1JFNA 5CS5A 2DOIA 5CS3A 2L0SA 1NK1A 3K65A 3LAQA 3U73A 4KIVA 4BVWA 4O03A 4DURA 1CEAA 1PMKA 1KDUA 1GP9A 1A0HA 4A5TS 3E6PL 1PMLA 1PK2A 2K51A 3NXPA 2PF2A 3HN4A
chains in the Genus database with same CATH topology
4NZQA 4BV7A 1TPKA 2HPQP 2FD6A 2I9AA 4D3CA 1HPJA 3BT1A 4HZHA 5CT3A 4BVVA 4CIKA 1KRNA 2KNFA 2DOHX 2KJ4A 5CT2A 5CS1A 1B2IA 5CSQA 2PF1A 2K4RA 2QJ4A 1HPKA 1PK4A 5CT1A 2QJ2A 4BVCA 1I5KA 1PKRA 2PK4A 1KI0A 3KIVA 3SP8A 1NL1A 2HPPP 4BVDA 1CEBA 1GMOA 3BT2A 2FEBA 5CS9A 1I71A 1KIVA 5CP9A 5COEA 3MKPA 2SPTA 1GMNA 1BHTA 2I9BA 1URKA 4BV5A 5HPGA 1NL2A 4IUAA 1JFNA 5CS5A 2DOIA 5CS3A 2L0SA 1NK1A 3K65A 3LAQA 3U73A 4KIVA 4BVWA 4O03A 4DURA 1CEAA 1PMKA 1KDUA 1GP9A 1A0HA 4A5TS 3E6PL 1PMLA 1PK2A 2K51A 3NXPA 2PF2A 3HN4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NZQ A;  4BV7 A;  1TPK A;  2HPQ P;  2FD6 A;  2I9A A;  4D3C A;  1HPJ A;  3BT1 A;  4HZH A;  5CT3 A;  4BVV A;  4CIK A;  1KRN A;  2KNF A;  2DOH X;  2KJ4 A;  5CT2 A;  5CS1 A;  1B2I A;  5CSQ A;  2PF1 A;  2K4R A;  2QJ4 A;  1HPK A;  1PK4 A;  5CT1 A;  2QJ2 A;  4BVC A;  1I5K A;  1PKR A;  2PK4 A;  1KI0 A;  3KIV A;  3SP8 A;  1NL1 A;  2HPP P;  4BVD A;  1CEB A;  1GMO A;  3BT2 A;  2FEB A;  5CS9 A;  1I71 A;  1KIV A;  5CP9 A;  5COE A;  3MKP A;  2SPT A;  1GMN A;  1BHT A;  2I9B A;  1URK A;  4BV5 A;  5HPG A;  1NL2 A;  4IUA A;  1JFN A;  5CS5 A;  2DOI A;  5CS3 A;  2L0S A;  1NK1 A;  3K65 A;  3LAQ A;  3U73 A;  4KIV A;  4BVW A;  4O03 A;  4DUR A;  1CEA A;  1PMK A;  1KDU A;  1GP9 A;  1A0H A;  4A5T S;  3E6P L;  1PML A;  1PK2 A;  2K51 A;  3NXP A;  2PF2 A;  3HN4 A; 
#chains in the Genus database with same CATH topology
 4NZQ A;  4BV7 A;  1TPK A;  2HPQ P;  2FD6 A;  2I9A A;  4D3C A;  1HPJ A;  3BT1 A;  4HZH A;  5CT3 A;  4BVV A;  4CIK A;  1KRN A;  2KNF A;  2DOH X;  2KJ4 A;  5CT2 A;  5CS1 A;  1B2I A;  5CSQ A;  2PF1 A;  2K4R A;  2QJ4 A;  1HPK A;  1PK4 A;  5CT1 A;  2QJ2 A;  4BVC A;  1I5K A;  1PKR A;  2PK4 A;  1KI0 A;  3KIV A;  3SP8 A;  1NL1 A;  2HPP P;  4BVD A;  1CEB A;  1GMO A;  3BT2 A;  2FEB A;  5CS9 A;  1I71 A;  1KIV A;  5CP9 A;  5COE A;  3MKP A;  2SPT A;  1GMN A;  1BHT A;  2I9B A;  1URK A;  4BV5 A;  5HPG A;  1NL2 A;  4IUA A;  1JFN A;  5CS5 A;  2DOI A;  5CS3 A;  2L0S A;  1NK1 A;  3K65 A;  3LAQ A;  3U73 A;  4KIV A;  4BVW A;  4O03 A;  4DUR A;  1CEA A;  1PMK A;  1KDU A;  1GP9 A;  1A0H A;  4A5T S;  3E6P L;  1PML A;  1PK2 A;  2K51 A;  3NXP A;  2PF2 A;  3HN4 A; 
#chains in the Genus database with same CATH homology
 4NZQ A;  4BV7 A;  1TPK A;  2HPQ P;  2FD6 A;  2I9A A;  4D3C A;  1HPJ A;  3BT1 A;  4HZH A;  5CT3 A;  4BVV A;  4CIK A;  1KRN A;  2KNF A;  2DOH X;  2KJ4 A;  5CT2 A;  5CS1 A;  1B2I A;  5CSQ A;  2PF1 A;  2K4R A;  2QJ4 A;  1HPK A;  1PK4 A;  5CT1 A;  2QJ2 A;  4BVC A;  1I5K A;  1PKR A;  2PK4 A;  1KI0 A;  3KIV A;  3SP8 A;  1NL1 A;  2HPP P;  4BVD A;  1CEB A;  1GMO A;  3BT2 A;  2FEB A;  5CS9 A;  1I71 A;  1KIV A;  5CP9 A;  5COE A;  3MKP A;  2SPT A;  1GMN A;  1BHT A;  2I9B A;  1URK A;  4BV5 A;  5HPG A;  1NL2 A;  4IUA A;  1JFN A;  5CS5 A;  2DOI A;  5CS3 A;  2L0S A;  1NK1 A;  3K65 A;  3LAQ A;  3U73 A;  4KIV A;  4BVW A;  4O03 A;  4DUR A;  1CEA A;  1PMK A;  1KDU A;  1GP9 A;  1A0H A;  4A5T S;  3E6P L;  1PML A;  1PK2 A;  2K51 A;  3NXP A;  2PF2 A;  3HN4 A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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