1GMNA

Crystal structures of nk1-heparin complexes reveal the basis for nk1 activity and enable engineering of potent agonists of the met receptor
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
170
structure length
170
Chain Sequence
TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCADRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone/growth factor
molecule keywords HEPATOCYTE GROWTH FACTOR
publication title Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
pubmed doi rcsb
source organism Homo sapiens
total genus 39
structure length 170
sequence length 170
chains with identical sequence B
ec nomenclature
pdb deposition date 2001-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 1gmnA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 1gmnA01
2YILA 2HPPP 2QJ2A 3ZWZA 5CS9A 1YXEA 2FD6A 1NK1A 1NL2A 4NZQA 2I9BA 5EODA 4UAOA 5I25A 2PF1A 4KIVA 5CT2A 4D3CA 2F83A 2Q8BA 1GMOA 2PK4A 2YIOA 3HMRA 1KIVA 2Z8WA 4O03A 1HPJA 2SPTA 2HPQP 3U73A 2HGFA 2QJ4A 3ZLEA 1HPKA 5COEA 2K51A 2Y8RA 4Z0DA 4Z0FA 3BT1A 3BT2A 3SP8A 2LL3A 1PKRA 1TPKA 3HN4A 1GMNA 4A5TS 1W81A 2FEBA 1KRNA 1JFNA 4BVCA 1I8NA 4R1CA 2J8LA 4APLA 4BV7A 1NL1A 4BVWA 3SRIA 1URKA 4APMA 1A0HA 3LAQA 1Z40A 4BVDA 2L0SA 2DOIA 5CS5A 1PMKA 5CSQA 1CEBA 2KNFA 4UV6A 5CS1A 2Z8VA 1KI0A 4R1BA 3HMSA 4Z0EA 2K13X 1PK4A 1KDUA 2KJ4A 5CP9A 3NXPA 4R1AA 5CT1A 1BHTA 4IUAA 2LL4M 3E6PL 5CT3A 4BV5A 3HMTA 2X2ZA 4CIKA 2J8JA 1GP9A 5CS3A 4R19A 1HKYA 1B2IA 1PMLA 4HZHA 2PF2A 4Z09A 1W8KA 3MKPA 3K65A 3KIVA 2YIPA 2Q8AA 4DURA 1CEAA 5HPGA 1I5KA 1PK2A 2K4RA 2DOHX 5EOKA 1I71A 3SRJA 4BVVA 2I9AA
chains in the Genus database with same CATH superfamily
2YILA 2HPPP 2QJ2A 3ZWZA 5CS9A 1YXEA 2FD6A 1NK1A 1NL2A 4NZQA 2I9BA 5EODA 4YIZA 4UAOA 5I25A 2PF1A 4KIVA 5CT2A 4D3CA 2F83A 2Q8BA 1GMOA 2PK4A 2YIOA 3HMRA 1KIVA 2Z8WA 4O03A 1HPJA 2SPTA 2HPQP 2KL5A 3U73A 2HGFA 2QJ4A 3ZLEA 1HPKA 5COEA 2K51A 2Y8RA 4Z0DA 4Z0FA 3BT1A 3BT2A 3SP8A 2LL3A 1PKRA 1TPKA 3HN4A 1GMNA 4A5TS 1W81A 2FEBA 1KRNA 1JFNA 4BVCA 1I8NA 4R1CA 2J8LA 4APLA 4BV7A 1NL1A 4BVWA 3SRIA 1URKA 4APMA 1A0HA 3LAQA 1Z40A 4BVDA 4YIVA 2L0SA 2DOIA 5CS5A 1PMKA 5CSQA 1CEBA 2KNFA 4UV6A 5CS1A 2Z8VA 1KI0A 4R1BA 3HMSA 4Z0EA 2K13X 1PK4A 1KDUA 2KJ4A 5CP9A 3NXPA 4R1AA 5CT1A 1BHTA 4IUAA 2LL4M 3E6PL 5CT3A 4BV5A 3HMTA 2X2ZA 4CIKA 2J8JA 1GP9A 5CS3A 4R19A 1HKYA 1B2IA 1PMLA 4HZHA 2PF2A 4Z09A 1W8KA 3MKPA 3K65A 3KIVA 2YIPA 2Q8AA 4DURA 1CEAA 5HPGA 1I5KA 1PK2A 2K4RA 2DOHX 5EOKA 1I71A 3SRJA 4BVVA 2I9AA
chains in the Genus database with same CATH topology
2YILA 2HPPP 2QJ2A 3ZWZA 5CS9A 1YXEA 2FD6A 1NK1A 1NL2A 4NZQA 2I9BA 5EODA 4YIZA 4UAOA 5I25A 2PF1A 4KIVA 5CT2A 4D3CA 2F83A 2Q8BA 1GMOA 2PK4A 2YIOA 3HMRA 1KIVA 2Z8WA 4O03A 1HPJA 2SPTA 2HPQP 2KL5A 3U73A 2HGFA 2QJ4A 3ZLEA 1HPKA 5COEA 2K51A 2Y8RA 4Z0DA 4Z0FA 3BT1A 3BT2A 3SP8A 2LL3A 1PKRA 1TPKA 3HN4A 1GMNA 4A5TS 1W81A 2FEBA 1KRNA 1JFNA 4BVCA 1I8NA 4R1CA 2J8LA 4APLA 4BV7A 1NL1A 4BVWA 3SRIA 1URKA 4APMA 1A0HA 3LAQA 1Z40A 4BVDA 4YIVA 2L0SA 2DOIA 5CS5A 1PMKA 5CSQA 1CEBA 2KNFA 4UV6A 5CS1A 2Z8VA 1KI0A 4R1BA 3HMSA 4Z0EA 2K13X 1PK4A 1KDUA 2KJ4A 5CP9A 3NXPA 4R1AA 5CT1A 1BHTA 4IUAA 2LL4M 3E6PL 5CT3A 4BV5A 3HMTA 2X2ZA 4CIKA 2J8JA 1GP9A 5CS3A 4R19A 1HKYA 1B2IA 1PMLA 4HZHA 2PF2A 4Z09A 1W8KA 3MKPA 3K65A 3KIVA 2YIPA 2Q8AA 4DURA 1CEAA 5HPGA 1I5KA 1PK2A 2K4RA 2DOHX 5EOKA 1I71A 3SRJA 4BVVA 2I9AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2YIL A;  2HPP P;  2QJ2 A;  3ZWZ A;  5CS9 A;  1YXE A;  2FD6 A;  1NK1 A;  1NL2 A;  4NZQ A;  2I9B A;  5EOD A;  4UAO A;  5I25 A;  2PF1 A;  4KIV A;  5CT2 A;  4D3C A;  2F83 A;  2Q8B A;  1GMO A;  2PK4 A;  2YIO A;  3HMR A;  1KIV A;  2Z8W A;  4O03 A;  1HPJ A;  2SPT A;  2HPQ P;  3U73 A;  2HGF A;  2QJ4 A;  3ZLE A;  1HPK A;  5COE A;  2K51 A;  2Y8R A;  4Z0D A;  4Z0F A;  3BT1 A;  3BT2 A;  3SP8 A;  2LL3 A;  1PKR A;  1TPK A;  3HN4 A;  1GMN A;  4A5T S;  1W81 A;  2FEB A;  1KRN A;  1JFN A;  4BVC A;  1I8N A;  4R1C A;  2J8L A;  4APL A;  4BV7 A;  1NL1 A;  4BVW A;  3SRI A;  1URK A;  4APM A;  1A0H A;  3LAQ A;  1Z40 A;  4BVD A;  2L0S A;  2DOI A;  5CS5 A;  1PMK A;  5CSQ A;  1CEB A;  2KNF A;  4UV6 A;  5CS1 A;  2Z8V A;  1KI0 A;  4R1B A;  3HMS A;  4Z0E A;  2K13 X;  1PK4 A;  1KDU A;  2KJ4 A;  5CP9 A;  3NXP A;  4R1A A;  5CT1 A;  1BHT A;  4IUA A;  2LL4 M;  3E6P L;  5CT3 A;  4BV5 A;  3HMT A;  2X2Z A;  4CIK A;  2J8J A;  1GP9 A;  5CS3 A;  4R19 A;  1HKY A;  1B2I A;  1PML A;  4HZH A;  2PF2 A;  4Z09 A;  1W8K A;  3MKP A;  3K65 A;  3KIV A;  2YIP A;  2Q8A A;  4DUR A;  1CEA A;  5HPG A;  1I5K A;  1PK2 A;  2K4R A;  2DOH X;  5EOK A;  1I71 A;  3SRJ A;  4BVV A;  2I9A A; 
#chains in the Genus database with same CATH topology
 2YIL A;  2HPP P;  2QJ2 A;  3ZWZ A;  5CS9 A;  1YXE A;  2FD6 A;  1NK1 A;  1NL2 A;  4NZQ A;  2I9B A;  5EOD A;  4YIZ A;  4UAO A;  5I25 A;  2PF1 A;  4KIV A;  5CT2 A;  4D3C A;  2F83 A;  2Q8B A;  1GMO A;  2PK4 A;  2YIO A;  3HMR A;  1KIV A;  2Z8W A;  4O03 A;  1HPJ A;  2SPT A;  2HPQ P;  2KL5 A;  3U73 A;  2HGF A;  2QJ4 A;  3ZLE A;  1HPK A;  5COE A;  2K51 A;  2Y8R A;  4Z0D A;  4Z0F A;  3BT1 A;  3BT2 A;  3SP8 A;  2LL3 A;  1PKR A;  1TPK A;  3HN4 A;  1GMN A;  4A5T S;  1W81 A;  2FEB A;  1KRN A;  1JFN A;  4BVC A;  1I8N A;  4R1C A;  2J8L A;  4APL A;  4BV7 A;  1NL1 A;  4BVW A;  3SRI A;  1URK A;  4APM A;  1A0H A;  3LAQ A;  1Z40 A;  4BVD A;  4YIV A;  2L0S A;  2DOI A;  5CS5 A;  1PMK A;  5CSQ A;  1CEB A;  2KNF A;  4UV6 A;  5CS1 A;  2Z8V A;  1KI0 A;  4R1B A;  3HMS A;  4Z0E A;  2K13 X;  1PK4 A;  1KDU A;  2KJ4 A;  5CP9 A;  3NXP A;  4R1A A;  5CT1 A;  1BHT A;  4IUA A;  2LL4 M;  3E6P L;  5CT3 A;  4BV5 A;  3HMT A;  2X2Z A;  4CIK A;  2J8J A;  1GP9 A;  5CS3 A;  4R19 A;  1HKY A;  1B2I A;  1PML A;  4HZH A;  2PF2 A;  4Z09 A;  1W8K A;  3MKP A;  3K65 A;  3KIV A;  2YIP A;  2Q8A A;  4DUR A;  1CEA A;  5HPG A;  1I5K A;  1PK2 A;  2K4R A;  2DOH X;  5EOK A;  1I71 A;  3SRJ A;  4BVV A;  2I9A A; 
#chains in the Genus database with same CATH homology
 2YIL A;  2HPP P;  2QJ2 A;  3ZWZ A;  5CS9 A;  1YXE A;  2FD6 A;  1NK1 A;  1NL2 A;  4NZQ A;  2I9B A;  5EOD A;  4YIZ A;  4UAO A;  5I25 A;  2PF1 A;  4KIV A;  5CT2 A;  4D3C A;  2F83 A;  2Q8B A;  1GMO A;  2PK4 A;  2YIO A;  3HMR A;  1KIV A;  2Z8W A;  4O03 A;  1HPJ A;  2SPT A;  2HPQ P;  2KL5 A;  3U73 A;  2HGF A;  2QJ4 A;  3ZLE A;  1HPK A;  5COE A;  2K51 A;  2Y8R A;  4Z0D A;  4Z0F A;  3BT1 A;  3BT2 A;  3SP8 A;  2LL3 A;  1PKR A;  1TPK A;  3HN4 A;  1GMN A;  4A5T S;  1W81 A;  2FEB A;  1KRN A;  1JFN A;  4BVC A;  1I8N A;  4R1C A;  2J8L A;  4APL A;  4BV7 A;  1NL1 A;  4BVW A;  3SRI A;  1URK A;  4APM A;  1A0H A;  3LAQ A;  1Z40 A;  4BVD A;  4YIV A;  2L0S A;  2DOI A;  5CS5 A;  1PMK A;  5CSQ A;  1CEB A;  2KNF A;  4UV6 A;  5CS1 A;  2Z8V A;  1KI0 A;  4R1B A;  3HMS A;  4Z0E A;  2K13 X;  1PK4 A;  1KDU A;  2KJ4 A;  5CP9 A;  3NXP A;  4R1A A;  5CT1 A;  1BHT A;  4IUA A;  2LL4 M;  3E6P L;  5CT3 A;  4BV5 A;  3HMT A;  2X2Z A;  4CIK A;  2J8J A;  1GP9 A;  5CS3 A;  4R19 A;  1HKY A;  1B2I A;  1PML A;  4HZH A;  2PF2 A;  4Z09 A;  1W8K A;  3MKP A;  3K65 A;  3KIV A;  2YIP A;  2Q8A A;  4DUR A;  1CEA A;  5HPG A;  1I5K A;  1PK2 A;  2K4R A;  2DOH X;  5EOK A;  1I71 A;  3SRJ A;  4BVV A;  2I9A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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