4BVVA

Identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv.
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
81
structure length
81
Chain Sequence
DCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
rcsb
molecule keywords APOLIPOPROTEIN(A)
molecule tags Hydrolase
source organism Homo sapiens
total genus 18
structure length 81
sequence length 81
ec nomenclature ec 3.4.21.-:
pdb deposition date 2013-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4bvvA00
1I5KA 3LAQA 3BT2A 4IUAA 1GP9A 5CT3A 5CS3A 2PF1A 4BV7A 4DURA 3NXPA 1HPKA 1KDUA 2KJ4A 4A5TS 1B2IA 2HPQP 3MKPA 1NL1A 5CT1A 3HN4A 4BVVA 1URKA 2SPTA 4O03A 4KIVA 2KNFA 1PKRA 3K65A 4BVDA 1HPJA 2DOIA 2HPPP 1JFNA 4BV5A 3KIVA 5CP9A 1PMLA 4CIKA 5CS5A 3BT1A 2I9AA 2QJ4A 2L0SA 2QJ2A 1NK1A 3SP8A 5COEA 5CS9A 1PMKA 1A0HA 5CSQA 1TPKA 2DOHX 1KI0A 1GMOA 1NL2A 2K51A 1KRNA 1I71A 4BVCA 4BVWA 3E6PL 2PF2A 2PK4A 5CS1A 2FD6A 2K4RA 2I9BA 1CEAA 1CEBA 5HPGA 3U73A 5CT2A 2FEBA 1GMNA 1BHTA 4NZQA 1PK4A 4D3CA 4HZHA 1PK2A 1KIVA
chains in the Genus database with same CATH superfamily
1I5KA 3LAQA 3BT2A 4IUAA 1GP9A 5CT3A 5CS3A 2PF1A 4BV7A 4DURA 3NXPA 1HPKA 1KDUA 2KJ4A 4A5TS 1B2IA 2HPQP 3MKPA 1NL1A 5CT1A 3HN4A 4BVVA 1URKA 2SPTA 4O03A 4KIVA 2KNFA 1PKRA 3K65A 4BVDA 1HPJA 2DOIA 2HPPP 1JFNA 4BV5A 3KIVA 5CP9A 1PMLA 4CIKA 5CS5A 3BT1A 2I9AA 2QJ4A 2L0SA 2QJ2A 1NK1A 3SP8A 5COEA 5CS9A 1PMKA 1A0HA 5CSQA 1TPKA 2DOHX 1KI0A 1GMOA 1NL2A 2K51A 1KRNA 1I71A 4BVCA 4BVWA 3E6PL 2PF2A 2PK4A 5CS1A 2FD6A 2K4RA 2I9BA 1CEAA 1CEBA 5HPGA 3U73A 5CT2A 2FEBA 1GMNA 1BHTA 4NZQA 1PK4A 4D3CA 4HZHA 1PK2A 1KIVA
chains in the Genus database with same CATH topology
1I5KA 3LAQA 3BT2A 4IUAA 1GP9A 5CT3A 5CS3A 2PF1A 4BV7A 4DURA 3NXPA 1HPKA 1KDUA 2KJ4A 4A5TS 1B2IA 2HPQP 3MKPA 1NL1A 5CT1A 3HN4A 4BVVA 1URKA 2SPTA 4O03A 4KIVA 2KNFA 1PKRA 3K65A 4BVDA 1HPJA 2DOIA 2HPPP 1JFNA 4BV5A 3KIVA 5CP9A 1PMLA 4CIKA 5CS5A 3BT1A 2I9AA 2QJ4A 2L0SA 2QJ2A 1NK1A 3SP8A 5COEA 5CS9A 1PMKA 1A0HA 5CSQA 1TPKA 2DOHX 1KI0A 1GMOA 1NL2A 2K51A 1KRNA 1I71A 4BVCA 4BVWA 3E6PL 2PF2A 2PK4A 5CS1A 2FD6A 2K4RA 2I9BA 1CEAA 1CEBA 5HPGA 3U73A 5CT2A 2FEBA 1GMNA 1BHTA 4NZQA 1PK4A 4D3CA 4HZHA 1PK2A 1KIVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I5K A;  3LAQ A;  3BT2 A;  4IUA A;  1GP9 A;  5CT3 A;  5CS3 A;  2PF1 A;  4BV7 A;  4DUR A;  3NXP A;  1HPK A;  1KDU A;  2KJ4 A;  4A5T S;  1B2I A;  2HPQ P;  3MKP A;  1NL1 A;  5CT1 A;  3HN4 A;  4BVV A;  1URK A;  2SPT A;  4O03 A;  4KIV A;  2KNF A;  1PKR A;  3K65 A;  4BVD A;  1HPJ A;  2DOI A;  2HPP P;  1JFN A;  4BV5 A;  3KIV A;  5CP9 A;  1PML A;  4CIK A;  5CS5 A;  3BT1 A;  2I9A A;  2QJ4 A;  2L0S A;  2QJ2 A;  1NK1 A;  3SP8 A;  5COE A;  5CS9 A;  1PMK A;  1A0H A;  5CSQ A;  1TPK A;  2DOH X;  1KI0 A;  1GMO A;  1NL2 A;  2K51 A;  1KRN A;  1I71 A;  4BVC A;  4BVW A;  3E6P L;  2PF2 A;  2PK4 A;  5CS1 A;  2FD6 A;  2K4R A;  2I9B A;  1CEA A;  1CEB A;  5HPG A;  3U73 A;  5CT2 A;  2FEB A;  1GMN A;  1BHT A;  4NZQ A;  1PK4 A;  4D3C A;  4HZH A;  1PK2 A;  1KIV A; 
#chains in the Genus database with same CATH topology
 1I5K A;  3LAQ A;  3BT2 A;  4IUA A;  1GP9 A;  5CT3 A;  5CS3 A;  2PF1 A;  4BV7 A;  4DUR A;  3NXP A;  1HPK A;  1KDU A;  2KJ4 A;  4A5T S;  1B2I A;  2HPQ P;  3MKP A;  1NL1 A;  5CT1 A;  3HN4 A;  4BVV A;  1URK A;  2SPT A;  4O03 A;  4KIV A;  2KNF A;  1PKR A;  3K65 A;  4BVD A;  1HPJ A;  2DOI A;  2HPP P;  1JFN A;  4BV5 A;  3KIV A;  5CP9 A;  1PML A;  4CIK A;  5CS5 A;  3BT1 A;  2I9A A;  2QJ4 A;  2L0S A;  2QJ2 A;  1NK1 A;  3SP8 A;  5COE A;  5CS9 A;  1PMK A;  1A0H A;  5CSQ A;  1TPK A;  2DOH X;  1KI0 A;  1GMO A;  1NL2 A;  2K51 A;  1KRN A;  1I71 A;  4BVC A;  4BVW A;  3E6P L;  2PF2 A;  2PK4 A;  5CS1 A;  2FD6 A;  2K4R A;  2I9B A;  1CEA A;  1CEB A;  5HPG A;  3U73 A;  5CT2 A;  2FEB A;  1GMN A;  1BHT A;  4NZQ A;  1PK4 A;  4D3C A;  4HZH A;  1PK2 A;  1KIV A; 
#chains in the Genus database with same CATH homology
 1I5K A;  3LAQ A;  3BT2 A;  4IUA A;  1GP9 A;  5CT3 A;  5CS3 A;  2PF1 A;  4BV7 A;  4DUR A;  3NXP A;  1HPK A;  1KDU A;  2KJ4 A;  4A5T S;  1B2I A;  2HPQ P;  3MKP A;  1NL1 A;  5CT1 A;  3HN4 A;  4BVV A;  1URK A;  2SPT A;  4O03 A;  4KIV A;  2KNF A;  1PKR A;  3K65 A;  4BVD A;  1HPJ A;  2DOI A;  2HPP P;  1JFN A;  4BV5 A;  3KIV A;  5CP9 A;  1PML A;  4CIK A;  5CS5 A;  3BT1 A;  2I9A A;  2QJ4 A;  2L0S A;  2QJ2 A;  1NK1 A;  3SP8 A;  5COE A;  5CS9 A;  1PMK A;  1A0H A;  5CSQ A;  1TPK A;  2DOH X;  1KI0 A;  1GMO A;  1NL2 A;  2K51 A;  1KRN A;  1I71 A;  4BVC A;  4BVW A;  3E6P L;  2PF2 A;  2PK4 A;  5CS1 A;  2FD6 A;  2K4R A;  2I9B A;  1CEA A;  1CEB A;  5HPG A;  3U73 A;  5CT2 A;  2FEB A;  1GMN A;  1BHT A;  4NZQ A;  1PK4 A;  4D3C A;  4HZH A;  1PK2 A;  1KIV A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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