4D3CA

Crystal structure of the nk1 domain of hgf in complex with anti-hgf monoclonal antibody sfn68.
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
172
structure length
137
Chain Sequence
NTIHEFKKSAKTADQCANRCTRNKGLPFTCKAFVFCLWFPFNSMSDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.
rcsb
molecule keywords HEPATOCYTE GROWTH FACTOR
molecule tags Protein binding
source organism Homo sapiens
total genus 27
structure length 137
sequence length 172
ec nomenclature
pdb deposition date 2014-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4d3cA02
2FD6A 5CT2A 1BHTA 5CP9A 3K65A 4BVWA 3BT2A 3NXPA 5CSQA 1PK2A 2KNFA 4O03A 5CS9A 4BV7A 4A5TS 3BT1A 1HPJA 1NL2A 2PF2A 2KJ4A 1NL1A 2I9AA 5COEA 2PF1A 1NK1A 1KRNA 2QJ2A 2QJ4A 4HZHA 5CS3A 4KIVA 4CIKA 1I71A 1A0HA 1KDUA 2DOIA 1KIVA 1URKA 2SPTA 4IUAA 4BV5A 1PKRA 1CEAA 4BVVA 2PK4A 1JFNA 4D3CA 2K51A 2DOHX 1B2IA 5CT1A 2FEBA 4DURA 5CS1A 1PMKA 1GMNA 3E6PL 5CS5A 1CEBA 4NZQA 2HPPP 5HPGA 3MKPA 1KI0A 1PK4A 4BVDA 1HPKA 3KIVA 3SP8A 1GMOA 3HN4A 1PMLA 2I9BA 1I5KA 5CT3A 2K4RA 3LAQA 1GP9A 2L0SA 1TPKA 2HPQP 3U73A 4BVCA
chains in the Genus database with same CATH superfamily
2FD6A 5CT2A 1BHTA 5CP9A 3K65A 4BVWA 3BT2A 3NXPA 5CSQA 1PK2A 2KNFA 4O03A 5CS9A 4BV7A 4A5TS 3BT1A 1HPJA 1NL2A 2PF2A 2KJ4A 1NL1A 2I9AA 5COEA 2PF1A 1NK1A 1KRNA 2QJ2A 2QJ4A 4HZHA 5CS3A 4KIVA 4CIKA 1I71A 1A0HA 1KDUA 2DOIA 1KIVA 1URKA 2SPTA 4IUAA 4BV5A 1PKRA 1CEAA 4BVVA 2PK4A 1JFNA 4D3CA 2K51A 2DOHX 1B2IA 5CT1A 2FEBA 4DURA 5CS1A 1PMKA 1GMNA 3E6PL 5CS5A 1CEBA 4NZQA 2HPPP 5HPGA 3MKPA 1KI0A 1PK4A 4BVDA 1HPKA 3KIVA 3SP8A 1GMOA 3HN4A 1PMLA 2I9BA 1I5KA 5CT3A 2K4RA 3LAQA 1GP9A 2L0SA 1TPKA 2HPQP 3U73A 4BVCA
chains in the Genus database with same CATH topology
2FD6A 5CT2A 1BHTA 5CP9A 3K65A 4BVWA 3BT2A 3NXPA 5CSQA 1PK2A 2KNFA 4O03A 5CS9A 4BV7A 4A5TS 3BT1A 1HPJA 1NL2A 2PF2A 2KJ4A 1NL1A 2I9AA 5COEA 2PF1A 1NK1A 1KRNA 2QJ2A 2QJ4A 4HZHA 5CS3A 4KIVA 4CIKA 1I71A 1A0HA 1KDUA 2DOIA 1KIVA 1URKA 2SPTA 4IUAA 4BV5A 1PKRA 1CEAA 4BVVA 2PK4A 1JFNA 4D3CA 2K51A 2DOHX 1B2IA 5CT1A 2FEBA 4DURA 5CS1A 1PMKA 1GMNA 3E6PL 5CS5A 1CEBA 4NZQA 2HPPP 5HPGA 3MKPA 1KI0A 1PK4A 4BVDA 1HPKA 3KIVA 3SP8A 1GMOA 3HN4A 1PMLA 2I9BA 1I5KA 5CT3A 2K4RA 3LAQA 1GP9A 2L0SA 1TPKA 2HPQP 3U73A 4BVCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FD6 A;  5CT2 A;  1BHT A;  5CP9 A;  3K65 A;  4BVW A;  3BT2 A;  3NXP A;  5CSQ A;  1PK2 A;  2KNF A;  4O03 A;  5CS9 A;  4BV7 A;  4A5T S;  3BT1 A;  1HPJ A;  1NL2 A;  2PF2 A;  2KJ4 A;  1NL1 A;  2I9A A;  5COE A;  2PF1 A;  1NK1 A;  1KRN A;  2QJ2 A;  2QJ4 A;  4HZH A;  5CS3 A;  4KIV A;  4CIK A;  1I71 A;  1A0H A;  1KDU A;  2DOI A;  1KIV A;  1URK A;  2SPT A;  4IUA A;  4BV5 A;  1PKR A;  1CEA A;  4BVV A;  2PK4 A;  1JFN A;  4D3C A;  2K51 A;  2DOH X;  1B2I A;  5CT1 A;  2FEB A;  4DUR A;  5CS1 A;  1PMK A;  1GMN A;  3E6P L;  5CS5 A;  1CEB A;  4NZQ A;  2HPP P;  5HPG A;  3MKP A;  1KI0 A;  1PK4 A;  4BVD A;  1HPK A;  3KIV A;  3SP8 A;  1GMO A;  3HN4 A;  1PML A;  2I9B A;  1I5K A;  5CT3 A;  2K4R A;  3LAQ A;  1GP9 A;  2L0S A;  1TPK A;  2HPQ P;  3U73 A;  4BVC A; 
#chains in the Genus database with same CATH topology
 2FD6 A;  5CT2 A;  1BHT A;  5CP9 A;  3K65 A;  4BVW A;  3BT2 A;  3NXP A;  5CSQ A;  1PK2 A;  2KNF A;  4O03 A;  5CS9 A;  4BV7 A;  4A5T S;  3BT1 A;  1HPJ A;  1NL2 A;  2PF2 A;  2KJ4 A;  1NL1 A;  2I9A A;  5COE A;  2PF1 A;  1NK1 A;  1KRN A;  2QJ2 A;  2QJ4 A;  4HZH A;  5CS3 A;  4KIV A;  4CIK A;  1I71 A;  1A0H A;  1KDU A;  2DOI A;  1KIV A;  1URK A;  2SPT A;  4IUA A;  4BV5 A;  1PKR A;  1CEA A;  4BVV A;  2PK4 A;  1JFN A;  4D3C A;  2K51 A;  2DOH X;  1B2I A;  5CT1 A;  2FEB A;  4DUR A;  5CS1 A;  1PMK A;  1GMN A;  3E6P L;  5CS5 A;  1CEB A;  4NZQ A;  2HPP P;  5HPG A;  3MKP A;  1KI0 A;  1PK4 A;  4BVD A;  1HPK A;  3KIV A;  3SP8 A;  1GMO A;  3HN4 A;  1PML A;  2I9B A;  1I5K A;  5CT3 A;  2K4R A;  3LAQ A;  1GP9 A;  2L0S A;  1TPK A;  2HPQ P;  3U73 A;  4BVC A; 
#chains in the Genus database with same CATH homology
 2FD6 A;  5CT2 A;  1BHT A;  5CP9 A;  3K65 A;  4BVW A;  3BT2 A;  3NXP A;  5CSQ A;  1PK2 A;  2KNF A;  4O03 A;  5CS9 A;  4BV7 A;  4A5T S;  3BT1 A;  1HPJ A;  1NL2 A;  2PF2 A;  2KJ4 A;  1NL1 A;  2I9A A;  5COE A;  2PF1 A;  1NK1 A;  1KRN A;  2QJ2 A;  2QJ4 A;  4HZH A;  5CS3 A;  4KIV A;  4CIK A;  1I71 A;  1A0H A;  1KDU A;  2DOI A;  1KIV A;  1URK A;  2SPT A;  4IUA A;  4BV5 A;  1PKR A;  1CEA A;  4BVV A;  2PK4 A;  1JFN A;  4D3C A;  2K51 A;  2DOH X;  1B2I A;  5CT1 A;  2FEB A;  4DUR A;  5CS1 A;  1PMK A;  1GMN A;  3E6P L;  5CS5 A;  1CEB A;  4NZQ A;  2HPP P;  5HPG A;  3MKP A;  1KI0 A;  1PK4 A;  4BVD A;  1HPK A;  3KIV A;  3SP8 A;  1GMO A;  3HN4 A;  1PML A;  2I9B A;  1I5K A;  5CT3 A;  2K4R A;  3LAQ A;  1GP9 A;  2L0S A;  1TPK A;  2HPQ P;  3U73 A;  4BVC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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