4D3CA

Crystal structure of the nk1 domain of hgf in complex with anti-hgf monoclonal antibody sfn68.
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
172
structure length
137
Chain Sequence
NTIHEFKKSAKTADQCANRCTRNKGLPFTCKAFVFCLWFPFNSMSDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords HEPATOCYTE GROWTH FACTOR
total genus 27
structure length 137
sequence length 172
ec nomenclature
pdb deposition date 2014-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4d3cA02
2KJ4A 3KIVA 1TPKA 1KRNA 2FEBA 5COEA 4BVVA 3SP8A 4BVWA 2HPQP 2PF2A 2K4RA 2L0SA 1NL2A 3LAQA 2I9BA 4BVCA 1CEBA 1PMKA 1I71A 5CS5A 3U73A 2QJ2A 1PMLA 1GMOA 1HPKA 2PF1A 1JFNA 1NL1A 4NZQA 2I9AA 1PK2A 2DOIA 5CT1A 4KIVA 4CIKA 3K65A 1HPJA 3HN4A 4O03A 2QJ4A 1KDUA 1GMNA 5CP9A 1B2IA 1KIVA 1BHTA 4A5TS 1CEAA 3NXPA 2FD6A 5HPGA 5CS3A 1A0HA 2PK4A 1NK1A 4IUAA 4HZHA 4BV7A 4DURA 5CT3A 5CS9A 2DOHX 1KI0A 1PK4A 4BV5A 2SPTA 3BT2A 3E6PL 3MKPA 1I5KA 1URKA 5CT2A 4D3CA 2K51A 3BT1A 4BVDA 5CS1A 1GP9A 2KNFA 1PKRA 5CSQA 2HPPP
chains in the Genus database with same CATH superfamily
2KJ4A 3KIVA 1TPKA 1KRNA 2FEBA 5COEA 4BVVA 3SP8A 4BVWA 2HPQP 2PF2A 2K4RA 2L0SA 1NL2A 3LAQA 2I9BA 4BVCA 1CEBA 1PMKA 1I71A 5CS5A 3U73A 2QJ2A 1PMLA 1GMOA 1HPKA 2PF1A 1JFNA 1NL1A 4NZQA 2I9AA 1PK2A 2DOIA 5CT1A 4KIVA 4CIKA 3K65A 1HPJA 3HN4A 4O03A 2QJ4A 1KDUA 1GMNA 5CP9A 1B2IA 1KIVA 1BHTA 4A5TS 1CEAA 3NXPA 2FD6A 5HPGA 5CS3A 1A0HA 2PK4A 1NK1A 4IUAA 4HZHA 4BV7A 4DURA 5CT3A 5CS9A 2DOHX 1KI0A 1PK4A 4BV5A 2SPTA 3BT2A 3E6PL 3MKPA 1I5KA 1URKA 5CT2A 4D3CA 2K51A 3BT1A 4BVDA 5CS1A 1GP9A 2KNFA 1PKRA 5CSQA 2HPPP
chains in the Genus database with same CATH topology
2KJ4A 3KIVA 1TPKA 1KRNA 2FEBA 5COEA 4BVVA 3SP8A 4BVWA 2HPQP 2PF2A 2K4RA 2L0SA 1NL2A 3LAQA 2I9BA 4BVCA 1CEBA 1PMKA 1I71A 5CS5A 3U73A 2QJ2A 1PMLA 1GMOA 1HPKA 2PF1A 1JFNA 1NL1A 4NZQA 2I9AA 1PK2A 2DOIA 5CT1A 4KIVA 4CIKA 3K65A 1HPJA 3HN4A 4O03A 2QJ4A 1KDUA 1GMNA 5CP9A 1B2IA 1KIVA 1BHTA 4A5TS 1CEAA 3NXPA 2FD6A 5HPGA 5CS3A 1A0HA 2PK4A 1NK1A 4IUAA 4HZHA 4BV7A 4DURA 5CT3A 5CS9A 2DOHX 1KI0A 1PK4A 4BV5A 2SPTA 3BT2A 3E6PL 3MKPA 1I5KA 1URKA 5CT2A 4D3CA 2K51A 3BT1A 4BVDA 5CS1A 1GP9A 2KNFA 1PKRA 5CSQA 2HPPP
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KJ4 A;  3KIV A;  1TPK A;  1KRN A;  2FEB A;  5COE A;  4BVV A;  3SP8 A;  4BVW A;  2HPQ P;  2PF2 A;  2K4R A;  2L0S A;  1NL2 A;  3LAQ A;  2I9B A;  4BVC A;  1CEB A;  1PMK A;  1I71 A;  5CS5 A;  3U73 A;  2QJ2 A;  1PML A;  1GMO A;  1HPK A;  2PF1 A;  1JFN A;  1NL1 A;  4NZQ A;  2I9A A;  1PK2 A;  2DOI A;  5CT1 A;  4KIV A;  4CIK A;  3K65 A;  1HPJ A;  3HN4 A;  4O03 A;  2QJ4 A;  1KDU A;  1GMN A;  5CP9 A;  1B2I A;  1KIV A;  1BHT A;  4A5T S;  1CEA A;  3NXP A;  2FD6 A;  5HPG A;  5CS3 A;  1A0H A;  2PK4 A;  1NK1 A;  4IUA A;  4HZH A;  4BV7 A;  4DUR A;  5CT3 A;  5CS9 A;  2DOH X;  1KI0 A;  1PK4 A;  4BV5 A;  2SPT A;  3BT2 A;  3E6P L;  3MKP A;  1I5K A;  1URK A;  5CT2 A;  4D3C A;  2K51 A;  3BT1 A;  4BVD A;  5CS1 A;  1GP9 A;  2KNF A;  1PKR A;  5CSQ A;  2HPP P; 
#chains in the Genus database with same CATH topology
 2KJ4 A;  3KIV A;  1TPK A;  1KRN A;  2FEB A;  5COE A;  4BVV A;  3SP8 A;  4BVW A;  2HPQ P;  2PF2 A;  2K4R A;  2L0S A;  1NL2 A;  3LAQ A;  2I9B A;  4BVC A;  1CEB A;  1PMK A;  1I71 A;  5CS5 A;  3U73 A;  2QJ2 A;  1PML A;  1GMO A;  1HPK A;  2PF1 A;  1JFN A;  1NL1 A;  4NZQ A;  2I9A A;  1PK2 A;  2DOI A;  5CT1 A;  4KIV A;  4CIK A;  3K65 A;  1HPJ A;  3HN4 A;  4O03 A;  2QJ4 A;  1KDU A;  1GMN A;  5CP9 A;  1B2I A;  1KIV A;  1BHT A;  4A5T S;  1CEA A;  3NXP A;  2FD6 A;  5HPG A;  5CS3 A;  1A0H A;  2PK4 A;  1NK1 A;  4IUA A;  4HZH A;  4BV7 A;  4DUR A;  5CT3 A;  5CS9 A;  2DOH X;  1KI0 A;  1PK4 A;  4BV5 A;  2SPT A;  3BT2 A;  3E6P L;  3MKP A;  1I5K A;  1URK A;  5CT2 A;  4D3C A;  2K51 A;  3BT1 A;  4BVD A;  5CS1 A;  1GP9 A;  2KNF A;  1PKR A;  5CSQ A;  2HPP P; 
#chains in the Genus database with same CATH homology
 2KJ4 A;  3KIV A;  1TPK A;  1KRN A;  2FEB A;  5COE A;  4BVV A;  3SP8 A;  4BVW A;  2HPQ P;  2PF2 A;  2K4R A;  2L0S A;  1NL2 A;  3LAQ A;  2I9B A;  4BVC A;  1CEB A;  1PMK A;  1I71 A;  5CS5 A;  3U73 A;  2QJ2 A;  1PML A;  1GMO A;  1HPK A;  2PF1 A;  1JFN A;  1NL1 A;  4NZQ A;  2I9A A;  1PK2 A;  2DOI A;  5CT1 A;  4KIV A;  4CIK A;  3K65 A;  1HPJ A;  3HN4 A;  4O03 A;  2QJ4 A;  1KDU A;  1GMN A;  5CP9 A;  1B2I A;  1KIV A;  1BHT A;  4A5T S;  1CEA A;  3NXP A;  2FD6 A;  5HPG A;  5CS3 A;  1A0H A;  2PK4 A;  1NK1 A;  4IUA A;  4HZH A;  4BV7 A;  4DUR A;  5CT3 A;  5CS9 A;  2DOH X;  1KI0 A;  1PK4 A;  4BV5 A;  2SPT A;  3BT2 A;  3E6P L;  3MKP A;  1I5K A;  1URK A;  5CT2 A;  4D3C A;  2K51 A;  3BT1 A;  4BVD A;  5CS1 A;  1GP9 A;  2KNF A;  1PKR A;  5CSQ A;  2HPP P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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