4DHNA

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Total Genus 99

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
235
structure length
228
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH4 (79-104)AH5 (114-134)3H1 (107-110)TIV1 (104-107)EMPTYAH7 (167-183)3H2 (205-207)AH8 (187-203)AH1 (3-16)AH3 (38-69)AH2 (19-32)TIV2 (136-139)AH6 (139-161)TI2 (163-166)AH9 (210-230)Updating...
connected with : NaN
publication title Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb
molecule keywords 14-3-3 protein sigma
molecule tags Protein binding/inhibitor
source organism Homo sapiens
total genus 99
structure length 228
sequence length 235
ec nomenclature
pdb deposition date 2012-01-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4dhnA00
3EFZA 4Y32A 3SPRA 2C23A 3SMKA 3IQUA 3CU8A 4ZDRA 4IHLA 3MHRA 5D2DA 3UX0A 2O98A 1O9EA 2O8PA 3P1NA 5BY9A 5HF3A 1QJAA 3P1SA 5LVZA 5EWZA 4FR3A 3RDHA 3O8IA 4DHRA 5LX2A 4DX0A 4Y5IA 4ZQ0A 5LU2A 3SMOA 1YWTA 4DHOA 1YZ5A 3SP5A 4DHTA 4DHNA 3SMNA 4BG6A 5LU1A 2C1NA 4O46A 2C63A 2C1JA 1QJBA 3UBWA 2C74A 4N7GA 4FL5A 2WH0A 1O9DA 3U9XA 1O9CA 3P1PA 3P1RA 4JDDA 4N7YA 2NPMA 3IQJA 1IB1A 4JC3A 4E2EA 5J31A 4FJ3A 4DHUA 4HKCA 3E6YA 4DHPA 4WRQA 5D3EA 3LW1A 4DHQA 3NKXA 1A38A 4F7RA 5LHOA 3M51A 4QLIA 4Y3BA 3T0LA 3SMLA 1A37A 4N84A 2B05A 5D3FA 3T0MA 5BTVA 3P1QA 5F74A 4J6SA 5IQPA 4DHSA 1O9FA 2BTPA 3UALA 4DHMA 3UZDA 3SMMA 4DAUA 2O02A 3M50A 2BQ0A 3IQVA 3P1OA 4GNTA 3AXYC 1A4OA 5EXAA 2V7DA 4IEAA 4DNKA 4DATA 2BR9A
chains in the Genus database with same CATH superfamily
3EFZA 4Y32A 3SPRA 2C23A 3SMKA 3IQUA 3CU8A 1CIYA 3CQCA 1W99A 3ZHEB 4ZDRA 4IHLA 3MHRA 5D2DA 3I4RA 3UX0A 2O98A 1JI6A 1O9EA 2O8PA 3P1NA 5BY9A 2C9KA 5HF3A 1QJAA 3P1SA 5LVZA 5EWZA 4FR3A 3RDHA 3O8IA 4DHRA 5LX2A 4DX0A 4Y5IA 4ZQ0A 5LU2A 3SMOA 1YWTA 4DHOA 1YZ5A 3SP5A 4DHTA 4DHNA 3SMNA 4BG6A 5LU1A 2C1NA 4O46A 2C63A 2C1JA 1QJBA 3UBWA 4ARXA 2C74A 4N7GA 4FL5A 2WH0A 1O9DA 3U9XA 4QX2A 1O9CA 3P1PA 3P1RA 4ARYA 4JDDA 4N7YA 2NPMA 3IQJA 1IB1A 4JC3A 4E2EA 5J31A 4FJ3A 4DHUA 4HKCA 3E6YA 4DHPA 4WRQA 4QX1A 4QX3A 5D3EA 3LW1A 4DHQA 3NKXA 1A38A 4W8JA 3EB7A 4F7RA 5LHOA 3M51A 4QLIA 4Y3BA 3T0LA 3SMLA 1A37A 4N84A 2B05A 5D3FA 3T0MA 4D8MA 4QX0A 5BTVA 3P1QA 5F74A 4J6SA 5IQPA 1S2XA 4DHSA 1O9FA 2BTPA 4MOAA 3UALA 4DHMA 3UZDA 3SMMA 4DAUA 2O02A 3M50A 2BQ0A 3IQVA 3P1OA 1I5PA 4GNTA 3AXYC 1DLCA 1URJA 1A4OA 5EXAA 2V7DA 3CQGA 4IEAA 4DNKA 3X0UA 4DATA 2BR9A
chains in the Genus database with same CATH topology
3EFZA 4Y32A 3SPRA 2C23A 3SMKA 3IQUA 3CU8A 4ZDRA 4IHLA 3MHRA 5D2DA 3UX0A 2O98A 1O9EA 2O8PA 3P1NA 5BY9A 5HF3A 1QJAA 3P1SA 5LVZA 5EWZA 4FR3A 3RDHA 3O8IA 4DHRA 5LX2A 4DX0A 4Y5IA 4ZQ0A 5LU2A 3SMOA 1YWTA 4DHOA 1YZ5A 3SP5A 4DHTA 4DHNA 3SMNA 4BG6A 5LU1A 2C1NA 4O46A 2C63A 2C1JA 1QJBA 3UBWA 2C74A 4N7GA 4FL5A 2WH0A 1O9DA 3U9XA 1O9CA 3P1PA 3P1RA 4JDDA 4N7YA 2NPMA 3IQJA 1IB1A 4JC3A 4E2EA 5J31A 4FJ3A 4DHUA 4HKCA 3E6YA 4DHPA 4WRQA 5D3EA 3LW1A 4DHQA 3NKXA 1A38A 4F7RA 5LHOA 3M51A 4QLIA 4Y3BA 3T0LA 3SMLA 1A37A 4N84A 2B05A 5D3FA 3T0MA 5BTVA 3P1QA 5F74A 4J6SA 5IQPA 4DHSA 1O9FA 2BTPA 3UALA 4DHMA 3UZDA 3SMMA 4DAUA 2O02A 3M50A 2BQ0A 3IQVA 3P1OA 4GNTA 3AXYC 1A4OA 5EXAA 2V7DA 4IEAA 4DNKA 4DATA 2BR9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EFZ A;  4Y32 A;  3SPR A;  2C23 A;  3SMK A;  3IQU A;  3CU8 A;  4ZDR A;  4IHL A;  3MHR A;  5D2D A;  3UX0 A;  2O98 A;  1O9E A;  2O8P A;  3P1N A;  5BY9 A;  5HF3 A;  1QJA A;  3P1S A;  5LVZ A;  5EWZ A;  4FR3 A;  3RDH A;  3O8I A;  4DHR A;  5LX2 A;  4DX0 A;  4Y5I A;  4ZQ0 A;  5LU2 A;  3SMO A;  1YWT A;  4DHO A;  1YZ5 A;  3SP5 A;  4DHT A;  4DHN A;  3SMN A;  4BG6 A;  5LU1 A;  2C1N A;  4O46 A;  2C63 A;  2C1J A;  1QJB A;  3UBW A;  2C74 A;  4N7G A;  4FL5 A;  2WH0 A;  1O9D A;  3U9X A;  1O9C A;  3P1P A;  3P1R A;  4JDD A;  4N7Y A;  2NPM A;  3IQJ A;  1IB1 A;  4JC3 A;  4E2E A;  5J31 A;  4FJ3 A;  4DHU A;  4HKC A;  3E6Y A;  4DHP A;  4WRQ A;  5D3E A;  3LW1 A;  4DHQ A;  3NKX A;  1A38 A;  4F7R A;  5LHO A;  3M51 A;  4QLI A;  4Y3B A;  3T0L A;  3SML A;  1A37 A;  4N84 A;  2B05 A;  5D3F A;  3T0M A;  5BTV A;  3P1Q A;  5F74 A;  4J6S A;  5IQP A;  4DHS A;  1O9F A;  2BTP A;  3UAL A;  4DHM A;  3UZD A;  3SMM A;  4DAU A;  2O02 A;  3M50 A;  2BQ0 A;  3IQV A;  3P1O A;  4GNT A;  3AXY C;  1A4O A;  5EXA A;  2V7D A;  4IEA A;  4DNK A;  4DAT A;  2BR9 A; 
#chains in the Genus database with same CATH topology
 3EFZ A;  4Y32 A;  3SPR A;  2C23 A;  3SMK A;  3IQU A;  3CU8 A;  1CIY A;  3CQC A;  1W99 A;  3ZHE B;  4ZDR A;  4IHL A;  3MHR A;  5D2D A;  3I4R A;  3UX0 A;  2O98 A;  1JI6 A;  1O9E A;  2O8P A;  3P1N A;  5BY9 A;  2C9K A;  5HF3 A;  1QJA A;  3P1S A;  5LVZ A;  5EWZ A;  4FR3 A;  3RDH A;  3O8I A;  4DHR A;  5LX2 A;  4DX0 A;  4Y5I A;  4ZQ0 A;  5LU2 A;  3SMO A;  1YWT A;  4DHO A;  1YZ5 A;  3SP5 A;  4DHT A;  4DHN A;  3SMN A;  4BG6 A;  5LU1 A;  2C1N A;  4O46 A;  2C63 A;  2C1J A;  1QJB A;  3UBW A;  4ARX A;  2C74 A;  4N7G A;  4FL5 A;  2WH0 A;  1O9D A;  3U9X A;  4QX2 A;  1O9C A;  3P1P A;  3P1R A;  4ARY A;  4JDD A;  4N7Y A;  2NPM A;  3IQJ A;  1IB1 A;  4JC3 A;  4E2E A;  5J31 A;  4FJ3 A;  4DHU A;  4HKC A;  3E6Y A;  4DHP A;  4WRQ A;  4QX1 A;  4QX3 A;  5D3E A;  3LW1 A;  4DHQ A;  3NKX A;  1A38 A;  4W8J A;  3EB7 A;  4F7R A;  5LHO A;  3M51 A;  4QLI A;  4Y3B A;  3T0L A;  3SML A;  1A37 A;  4N84 A;  2B05 A;  5D3F A;  3T0M A;  4D8M A;  4QX0 A;  5BTV A;  3P1Q A;  5F74 A;  4J6S A;  5IQP A;  1S2X A;  4DHS A;  1O9F A;  2BTP A;  4MOA A;  3UAL A;  4DHM A;  3UZD A;  3SMM A;  4DAU A;  2O02 A;  3M50 A;  2BQ0 A;  3IQV A;  3P1O A;  1I5P A;  4GNT A;  3AXY C;  1DLC A;  1URJ A;  1A4O A;  5EXA A;  2V7D A;  3CQG A;  4IEA A;  4DNK A;  3X0U A;  4DAT A;  2BR9 A; 
#chains in the Genus database with same CATH homology
 3EFZ A;  4Y32 A;  3SPR A;  2C23 A;  3SMK A;  3IQU A;  3CU8 A;  4ZDR A;  4IHL A;  3MHR A;  5D2D A;  3UX0 A;  2O98 A;  1O9E A;  2O8P A;  3P1N A;  5BY9 A;  5HF3 A;  1QJA A;  3P1S A;  5LVZ A;  5EWZ A;  4FR3 A;  3RDH A;  3O8I A;  4DHR A;  5LX2 A;  4DX0 A;  4Y5I A;  4ZQ0 A;  5LU2 A;  3SMO A;  1YWT A;  4DHO A;  1YZ5 A;  3SP5 A;  4DHT A;  4DHN A;  3SMN A;  4BG6 A;  5LU1 A;  2C1N A;  4O46 A;  2C63 A;  2C1J A;  1QJB A;  3UBW A;  2C74 A;  4N7G A;  4FL5 A;  2WH0 A;  1O9D A;  3U9X A;  1O9C A;  3P1P A;  3P1R A;  4JDD A;  4N7Y A;  2NPM A;  3IQJ A;  1IB1 A;  4JC3 A;  4E2E A;  5J31 A;  4FJ3 A;  4DHU A;  4HKC A;  3E6Y A;  4DHP A;  4WRQ A;  5D3E A;  3LW1 A;  4DHQ A;  3NKX A;  1A38 A;  4F7R A;  5LHO A;  3M51 A;  4QLI A;  4Y3B A;  3T0L A;  3SML A;  1A37 A;  4N84 A;  2B05 A;  5D3F A;  3T0M A;  5BTV A;  3P1Q A;  5F74 A;  4J6S A;  5IQP A;  4DHS A;  1O9F A;  2BTP A;  3UAL A;  4DHM A;  3UZD A;  3SMM A;  4DAU A;  2O02 A;  3M50 A;  2BQ0 A;  3IQV A;  3P1O A;  4GNT A;  3AXY C;  1A4O A;  5EXA A;  2V7D A;  4IEA A;  4DNK A;  4DAT A;  2BR9 A; 
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