The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
100
|
sequence length |
235
|
structure length |
230
|
Chain Sequence |
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb |
| molecule tags |
Protein binding/inhibitor
|
| source organism |
Homo sapiens
|
| molecule keywords |
14-3-3 protein sigma
|
| total genus |
100
|
| structure length |
230
|
| sequence length |
235
|
| ec nomenclature | |
| pdb deposition date | 2012-01-30 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00244 | 14-3-3 | 14-3-3 protein |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Up-down Bundle | Delta-Endotoxin; domain 1 | 14-3-3 domain |
#chains in the Genus database with same CATH superfamily 4DX0 A; 2WH0 A; 5IQP A; 1A4O A; 1O9F A; 3IQJ A; 2C74 A; 4JC3 A; 3NKX A; 4FR3 A; 3SMN A; 4F7R A; 4IHL A; 2BR9 A; 4DHU A; 3P1O A; 5F74 A; 3U9X A; 5BTV A; 4O46 A; 4Y3B A; 3IQU A; 2NPM A; 3UAL A; 4BG6 A; 3SP5 A; 4QLI A; 3AXY C; 2BQ0 A; 4FL5 A; 3P1N A; 1IB1 A; 1O9C A; 3MHR A; 4E2E A; 5LHO A; 2O98 A; 1YZ5 A; 3CU8 A; 2O02 A; 3E6Y A; 2C1N A; 4N84 A; 4JDD A; 3O8I A; 2C1J A; 3SPR A; 2V7D A; 5D3F A; 3T0L A; 5D3E A; 3UZD A; 3UX0 A; 3SML A; 4ZDR A; 5LVZ A; 3P1Q A; 3UBW A; 4DAT A; 4N7G A; 3P1S A; 1QJA A; 4WRQ A; 4J6S A; 2C63 A; 1YWT A; 5LU2 A; 4DHQ A; 4N7Y A; 3M51 A; 3LW1 A; 4DHS A; 5HF3 A; 3T0M A; 4DHT A; 3SMM A; 5EWZ A; 4Y5I A; 3P1P A; 1A38 A; 1O9D A; 5J31 A; 4DHM A; 5LU1 A; 3SMO A; 2BTP A; 5BY9 A; 4DHN A; 4GNT A; 2O8P A; 4IEA A; 4DHR A; 4Y32 A; 4DNK A; 4FJ3 A; 4ZQ0 A; 3P1R A; 1QJB A; 4HKC A; 5D2D A; 3RDH A; 1O9E A; 3EFZ A; 1A37 A; 4DHP A; 5EXA A; 3IQV A; 4DAU A; 2B05 A; 2C23 A; 3SMK A; 3M50 A; 5LX2 A; 4DHO A; #chains in the Genus database with same CATH topology 4DX0 A; 3ZHE B; 2WH0 A; 5IQP A; 1A4O A; 1O9F A; 4W8J A; 3IQJ A; 1I5P A; 2C74 A; 4JC3 A; 3NKX A; 4FR3 A; 1JI6 A; 3SMN A; 4F7R A; 4IHL A; 2BR9 A; 4DHU A; 3P1O A; 5F74 A; 1URJ A; 3U9X A; 5BTV A; 4O46 A; 4Y3B A; 3IQU A; 2NPM A; 3UAL A; 4BG6 A; 4D8M A; 3CQC A; 3SP5 A; 4QLI A; 3AXY C; 2BQ0 A; 4FL5 A; 3P1N A; 1IB1 A; 1O9C A; 3MHR A; 4E2E A; 5LHO A; 2O98 A; 1YZ5 A; 4QX2 A; 3CU8 A; 2O02 A; 3E6Y A; 2C1N A; 4N84 A; 4JDD A; 3O8I A; 2C1J A; 3SPR A; 2V7D A; 5D3F A; 3T0L A; 5D3E A; 3UZD A; 4DHO A; 3UX0 A; 3SML A; 4ZDR A; 4ARY A; 5LVZ A; 3P1Q A; 3UBW A; 4DAT A; 4N7G A; 1W99 A; 3P1S A; 1QJA A; 4WRQ A; 4J6S A; 2C63 A; 1YWT A; 5LU2 A; 4DHQ A; 4N7Y A; 3M51 A; 1CIY A; 3LW1 A; 4DHS A; 5HF3 A; 3T0M A; 3I4R A; 1S2X A; 4QX0 A; 4DHT A; 3SMM A; 5EWZ A; 4Y5I A; 3P1P A; 1A38 A; 1O9D A; 5J31 A; 4MOA A; 4DHM A; 5LU1 A; 3SMO A; 2BTP A; 2C9K A; 3CQG A; 5BY9 A; 4ARX A; 4DHN A; 4GNT A; 2O8P A; 4IEA A; 4DHR A; 4Y32 A; 4DNK A; 4FJ3 A; 4ZQ0 A; 1DLC A; 3EB7 A; 3P1R A; 1QJB A; 4HKC A; 5D2D A; 3RDH A; 1O9E A; 4QX3 A; 3EFZ A; 1A37 A; 4DHP A; 5EXA A; 3IQV A; 4DAU A; 2B05 A; 2C23 A; 3SMK A; 3M50 A; 4QX1 A; 5LX2 A; 3X0U A; #chains in the Genus database with same CATH homology 4DX0 A; 2WH0 A; 5IQP A; 1A4O A; 1O9F A; 3IQJ A; 2C74 A; 4JC3 A; 3NKX A; 4FR3 A; 3SMN A; 4F7R A; 4IHL A; 2BR9 A; 4DHU A; 3P1O A; 5F74 A; 3U9X A; 5BTV A; 4O46 A; 4Y3B A; 3IQU A; 2NPM A; 3UAL A; 4BG6 A; 3SP5 A; 4QLI A; 3AXY C; 2BQ0 A; 4FL5 A; 3P1N A; 1IB1 A; 1O9C A; 3MHR A; 4E2E A; 5LHO A; 2O98 A; 1YZ5 A; 3CU8 A; 2O02 A; 3E6Y A; 2C1N A; 4N84 A; 4JDD A; 3O8I A; 2C1J A; 3SPR A; 2V7D A; 5D3F A; 3T0L A; 5D3E A; 3UZD A; 3UX0 A; 3SML A; 4ZDR A; 5LVZ A; 3P1Q A; 3UBW A; 4DAT A; 4N7G A; 3P1S A; 1QJA A; 4WRQ A; 4J6S A; 2C63 A; 1YWT A; 5LU2 A; 4DHQ A; 4N7Y A; 3M51 A; 3LW1 A; 4DHS A; 5HF3 A; 3T0M A; 4DHT A; 3SMM A; 5EWZ A; 4Y5I A; 3P1P A; 1A38 A; 1O9D A; 5J31 A; 4DHM A; 5LU1 A; 3SMO A; 2BTP A; 5BY9 A; 4DHN A; 4GNT A; 2O8P A; 4IEA A; 4DHR A; 4Y32 A; 4DNK A; 4FJ3 A; 4ZQ0 A; 3P1R A; 1QJB A; 4HKC A; 5D2D A; 3RDH A; 1O9E A; 3EFZ A; 1A37 A; 4DHP A; 5EXA A; 3IQV A; 4DAU A; 2B05 A; 2C23 A; 3SMK A; 3M50 A; 5LX2 A; 4DHO A;
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