4DHT | Genus

Total Genus 102

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	102
sequence length	235
structure length	228
Chain Sequence	AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Protein binding/inhibitor
source organism	Homo sapiens
publication title	Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. pubmed doi rcsb
molecule keywords	14-3-3 PROTEIN SIGMA
total genus	102
structure length	228
sequence length	235
ec nomenclature
pdb deposition date	2012-01-30

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00244	14-3-3	14-3-3 protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin; domain 1	14-3-3 domain	4dhtA00

4DAUA 3LW1A 3SMMA 3P1PA 5LU1A 4ZQ0A 5LU2A 5F74A 4O46A 3U9XA 1QJBA 1O9CA 2C74A 2BR9A 4FR3A 5EWZA 3UX0A 2C23A 3CU8A 3NKXA 2O98A 4E2EA 1QJAA 4QLIA 4Y32A 3P1NA 4JC3A 3UZDA 3T0LA 4DHOA 3RDHA 4ZDRA 4DHQA 1YWTA 1O9DA 4HKCA 2C1JA 2C1NA 5IQPA 4IEAA 4DHTA 5LVZA 5LX2A 3P1SA 4N7YA 5D3FA 5J31A 4IHLA 4N84A 2B05A 3T0MA 3O8IA 4WRQA 4JDDA 3MHRA 3M51A 1O9FA 1A37A 4Y5IA 3SPRA 2NPMA 3E6YA 4DHNA 3P1RA 2BQ0A 4DATA 4GNTA 3P1OA 2WH0A 5EXAA 2C63A 3SMOA 4J6SA 1O9EA 4FL5A 3IQVA 5HF3A 3SP5A 5BTVA 4DHRA 4DHUA 4N7GA 1A4OA 4F7RA 5D2DA 3IQUA 4DHSA 3UALA 5BY9A 3EFZA 4DNKA 3P1QA 3SMNA 5LHOA 2O02A 4DX0A 1IB1A 4FJ3A 4Y3BA 4BG6A 3SMKA 3SMLA 2O8PA 3AXYC 3IQJA 2V7DA 1YZ5A 2BTPA 4DHPA 5D3EA 3M50A 3UBWA 4DHMA 1A38A
chains in the Genus database with same CATH superfamily

3EB7A 3LW1A 3SMMA 3I4RA 4DAUA 3P1PA 5LU1A 4ZQ0A 5LU2A 5F74A 4O46A 3U9XA 1QJBA 1O9CA 2C74A 2BR9A 1S2XA 4FR3A 5EWZA 4QX0A 3UX0A 2C23A 3CU8A 3NKXA 4MOAA 2O98A 4E2EA 1QJAA 4QLIA 4Y32A 3P1NA 4JC3A 1I5PA 3UZDA 3T0LA 4DHOA 3RDHA 4ZDRA 4DHQA 1YWTA 1O9DA 4W8JA 4HKCA 2C1NA 2C1JA 5IQPA 4IEAA 4DHTA 5LVZA 5LX2A 3P1SA 4N7YA 5D3FA 5J31A 4IHLA 1JI6A 4ARXA 4N84A 2B05A 3T0MA 3O8IA 4WRQA 4JDDA 3MHRA 3M51A 3CQCA 1O9FA 1A37A 4Y5IA 3SPRA 2NPMA 3E6YA 4DHNA 4D8MA 3P1RA 2BQ0A 4DATA 4GNTA 3P1OA 2WH0A 3CQGA 5EXAA 2C63A 4QX1A 3SMOA 4J6SA 1O9EA 4FL5A 3ZHEB 1DLCA 3IQVA 5HF3A 1W99A 3SP5A 4QX3A 5BTVA 4DHRA 4DHUA 4N7GA 1A4OA 4F7RA 5D2DA 3IQUA 2C9KA 4DHSA 3UALA 5BY9A 3EFZA 1CIYA 4ARYA 4DNKA 3P1QA 3SMNA 5LHOA 3X0UA 2O02A 4DX0A 1IB1A 4FJ3A 1URJA 4Y3BA 4BG6A 3SMKA 3SMLA 2O8PA 3AXYC 3IQJA 2V7DA 1YZ5A 2BTPA 4DHPA 5D3EA 4QX2A 3M50A 3UBWA 4DHMA 1A38A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4DAU A;  3LW1 A;  3SMM A;  3P1P A;  5LU1 A;  4ZQ0 A;  5LU2 A;  5F74 A;  4O46 A;  3U9X A;  1QJB A;  1O9C A;  2C74 A;  2BR9 A;  4FR3 A;  5EWZ A;  3UX0 A;  2C23 A;  3CU8 A;  3NKX A;  2O98 A;  4E2E A;  1QJA A;  4QLI A;  4Y32 A;  3P1N A;  4JC3 A;  3UZD A;  3T0L A;  4DHO A;  3RDH A;  4ZDR A;  4DHQ A;  1YWT A;  1O9D A;  4HKC A;  2C1J A;  2C1N A;  5IQP A;  4IEA A;  4DHT A;  5LVZ A;  5LX2 A;  3P1S A;  4N7Y A;  5D3F A;  5J31 A;  4IHL A;  4N84 A;  2B05 A;  3T0M A;  3O8I A;  4WRQ A;  4JDD A;  3MHR A;  3M51 A;  1O9F A;  1A37 A;  4Y5I A;  3SPR A;  2NPM A;  3E6Y A;  4DHN A;  3P1R A;  2BQ0 A;  4DAT A;  4GNT A;  3P1O A;  2WH0 A;  5EXA A;  2C63 A;  3SMO A;  4J6S A;  1O9E A;  4FL5 A;  3IQV A;  5HF3 A;  3SP5 A;  5BTV A;  4DHR A;  4DHU A;  4N7G A;  1A4O A;  4F7R A;  5D2D A;  3IQU A;  4DHS A;  3UAL A;  5BY9 A;  3EFZ A;  4DNK A;  3P1Q A;  3SMN A;  5LHO A;  2O02 A;  4DX0 A;  1IB1 A;  4FJ3 A;  4Y3B A;  4BG6 A;  3SMK A;  3SML A;  2O8P A;  3AXY C;  3IQJ A;  2V7D A;  1YZ5 A;  2BTP A;  4DHP A;  5D3E A;  3M50 A;  3UBW A;  4DHM A;  1A38 A; 
#chains in the Genus database with same CATH topology
 3EB7 A;  3LW1 A;  3SMM A;  3I4R A;  4DAU A;  3P1P A;  5LU1 A;  4ZQ0 A;  5LU2 A;  5F74 A;  4O46 A;  3U9X A;  1QJB A;  1O9C A;  2C74 A;  2BR9 A;  1S2X A;  4FR3 A;  5EWZ A;  4QX0 A;  3UX0 A;  2C23 A;  3CU8 A;  3NKX A;  4MOA A;  2O98 A;  4E2E A;  1QJA A;  4QLI A;  4Y32 A;  3P1N A;  4JC3 A;  1I5P A;  3UZD A;  3T0L A;  4DHO A;  3RDH A;  4ZDR A;  4DHQ A;  1YWT A;  1O9D A;  4W8J A;  4HKC A;  2C1N A;  2C1J A;  5IQP A;  4IEA A;  4DHT A;  5LVZ A;  5LX2 A;  3P1S A;  4N7Y A;  5D3F A;  5J31 A;  4IHL A;  1JI6 A;  4ARX A;  4N84 A;  2B05 A;  3T0M A;  3O8I A;  4WRQ A;  4JDD A;  3MHR A;  3M51 A;  3CQC A;  1O9F A;  1A37 A;  4Y5I A;  3SPR A;  2NPM A;  3E6Y A;  4DHN A;  4D8M A;  3P1R A;  2BQ0 A;  4DAT A;  4GNT A;  3P1O A;  2WH0 A;  3CQG A;  5EXA A;  2C63 A;  4QX1 A;  3SMO A;  4J6S A;  1O9E A;  4FL5 A;  3ZHE B;  1DLC A;  3IQV A;  5HF3 A;  1W99 A;  3SP5 A;  4QX3 A;  5BTV A;  4DHR A;  4DHU A;  4N7G A;  1A4O A;  4F7R A;  5D2D A;  3IQU A;  2C9K A;  4DHS A;  3UAL A;  5BY9 A;  3EFZ A;  1CIY A;  4ARY A;  4DNK A;  3P1Q A;  3SMN A;  5LHO A;  3X0U A;  2O02 A;  4DX0 A;  1IB1 A;  4FJ3 A;  1URJ A;  4Y3B A;  4BG6 A;  3SMK A;  3SML A;  2O8P A;  3AXY C;  3IQJ A;  2V7D A;  1YZ5 A;  2BTP A;  4DHP A;  5D3E A;  4QX2 A;  3M50 A;  3UBW A;  4DHM A;  1A38 A; 
#chains in the Genus database with same CATH homology
 4DAU A;  3LW1 A;  3SMM A;  3P1P A;  5LU1 A;  4ZQ0 A;  5LU2 A;  5F74 A;  4O46 A;  3U9X A;  1QJB A;  1O9C A;  2C74 A;  2BR9 A;  4FR3 A;  5EWZ A;  3UX0 A;  2C23 A;  3CU8 A;  3NKX A;  2O98 A;  4E2E A;  1QJA A;  4QLI A;  4Y32 A;  3P1N A;  4JC3 A;  3UZD A;  3T0L A;  4DHO A;  3RDH A;  4ZDR A;  4DHQ A;  1YWT A;  1O9D A;  4HKC A;  2C1J A;  2C1N A;  5IQP A;  4IEA A;  4DHT A;  5LVZ A;  5LX2 A;  3P1S A;  4N7Y A;  5D3F A;  5J31 A;  4IHL A;  4N84 A;  2B05 A;  3T0M A;  3O8I A;  4WRQ A;  4JDD A;  3MHR A;  3M51 A;  1O9F A;  1A37 A;  4Y5I A;  3SPR A;  2NPM A;  3E6Y A;  4DHN A;  3P1R A;  2BQ0 A;  4DAT A;  4GNT A;  3P1O A;  2WH0 A;  5EXA A;  2C63 A;  3SMO A;  4J6S A;  1O9E A;  4FL5 A;  3IQV A;  5HF3 A;  3SP5 A;  5BTV A;  4DHR A;  4DHU A;  4N7G A;  1A4O A;  4F7R A;  5D2D A;  3IQU A;  4DHS A;  3UAL A;  5BY9 A;  3EFZ A;  4DNK A;  3P1Q A;  3SMN A;  5LHO A;  2O02 A;  4DX0 A;  1IB1 A;  4FJ3 A;  4Y3B A;  4BG6 A;  3SMK A;  3SML A;  2O8P A;  3AXY C;  3IQJ A;  2V7D A;  1YZ5 A;  2BTP A;  4DHP A;  5D3E A;  3M50 A;  3UBW A;  4DHM A;  1A38 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4DHTA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations