4DHUA

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Total Genus 102

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
235
structure length
227
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH4 (79-104)AH5 (114-134)3H1 (107-110)AH7 (167-183)AH6 (137-161)TI2 (163-166)AH8 (187-203)AH9 (210-230)AH1 (3-16)AH3 (39-70)AH2 (19-32)TIV1 (104-107)EMPTY3H2 (205-207)Updating...
connected with : NaN
molecule tags Protein binding/inhibitor
source organism Homo sapiens
publication title Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb
molecule keywords 14-3-3 PROTEIN SIGMA
total genus 102
structure length 227
sequence length 235
ec nomenclature
pdb deposition date 2012-01-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4dhuA00
2C63A 5J31A 3EFZA 3P1RA 5LHOA 1QJBA 2BR9A 4DHPA 4HKCA 2O98A 1YWTA 4DHMA 3MHRA 4BG6A 5D3FA 2C74A 3SMLA 1O9DA 4DHTA 5LX2A 4FL5A 4DX0A 2NPMA 4DHNA 4ZQ0A 4FR3A 3UZDA 4DHRA 4N7GA 3SPRA 2O8PA 4F7RA 4DHSA 4N84A 2C23A 3IQJA 1O9CA 4E2EA 5D3EA 3CU8A 5F74A 4QLIA 3UX0A 3SP5A 3P1PA 3UBWA 4GNTA 4N7YA 3AXYC 1A4OA 4IEAA 5LVZA 4Y5IA 4Y3BA 2C1NA 1A37A 3M50A 3SMMA 4Y32A 5EXAA 5EWZA 1O9EA 3T0LA 5LU1A 3U9XA 3SMOA 4O46A 3P1NA 4DHOA 1A38A 5D2DA 5LU2A 3O8IA 1IB1A 4ZDRA 2C1JA 4J6SA 3P1QA 3P1OA 4DAUA 4JC3A 4IHLA 1QJAA 4DNKA 3E6YA 5HF3A 4DHUA 4WRQA 3SMKA 3LW1A 3RDHA 2WH0A 2O02A 3SMNA 4JDDA 2BTPA 3NKXA 3P1SA 3IQVA 4DHQA 3IQUA 5BTVA 1O9FA 3T0MA 5BY9A 2V7DA 5IQPA 4FJ3A 2BQ0A 3M51A 4DATA 2B05A 1YZ5A 3UALA
chains in the Genus database with same CATH superfamily
2C63A 4ARXA 2C9KA 5J31A 3EFZA 3P1RA 5LHOA 1QJBA 2BR9A 4DHPA 4HKCA 2O98A 1YWTA 4DHMA 4W8JA 3MHRA 3EB7A 4QX3A 4BG6A 5D3FA 2C74A 3I4RA 1CIYA 3SMLA 1O9DA 4DHTA 5LX2A 4FL5A 4DX0A 2NPMA 4DHNA 4ZQ0A 4FR3A 3UZDA 4DHRA 4N7GA 3SPRA 2O8PA 4F7RA 4DHSA 4N84A 2C23A 3IQJA 1YZ5A 1O9CA 4E2EA 5D3EA 3CU8A 5F74A 4QX2A 4QLIA 3UX0A 3SP5A 3P1PA 3X0UA 3UBWA 1I5PA 4GNTA 4N7YA 3AXYC 4MOAA 1A4OA 4IEAA 5LVZA 1S2XA 4Y3BA 4Y5IA 2C1NA 1A37A 3M50A 3SMMA 4Y32A 5EXAA 5EWZA 4ARYA 1O9EA 3T0LA 5LU1A 3U9XA 3SMOA 4O46A 3P1NA 4DHOA 1A38A 5D2DA 5LU2A 3O8IA 1IB1A 4ZDRA 3CQCA 2C1JA 4J6SA 3P1QA 3P1OA 4DAUA 4JC3A 4IHLA 1QJAA 3CQGA 4DNKA 3E6YA 5HF3A 4DHUA 4WRQA 3SMKA 3LW1A 3RDHA 1JI6A 2WH0A 2O02A 3ZHEB 3SMNA 4JDDA 2BTPA 3NKXA 3P1SA 3IQVA 4DHQA 1URJA 3IQUA 5BTVA 1O9FA 3T0MA 5BY9A 1W99A 2V7DA 5IQPA 4FJ3A 1DLCA 2BQ0A 3M51A 4QX1A 4D8MA 4DATA 2B05A 4QX0A 3UALA
chains in the Genus database with same CATH topology
2C63A 5J31A 3EFZA 3P1RA 5LHOA 1QJBA 2BR9A 4DHPA 4HKCA 2O98A 1YWTA 4DHMA 3MHRA 4BG6A 5D3FA 2C74A 3SMLA 1O9DA 4DHTA 5LX2A 4FL5A 4DX0A 2NPMA 4DHNA 4ZQ0A 4FR3A 3UZDA 4DHRA 4N7GA 3SPRA 2O8PA 4F7RA 4DHSA 4N84A 2C23A 3IQJA 1O9CA 4E2EA 5D3EA 3CU8A 5F74A 4QLIA 3UX0A 3SP5A 3P1PA 3UBWA 4GNTA 4N7YA 3AXYC 1A4OA 4IEAA 5LVZA 4Y5IA 4Y3BA 2C1NA 1A37A 3M50A 3SMMA 4Y32A 5EXAA 5EWZA 1O9EA 3T0LA 5LU1A 3U9XA 3SMOA 4O46A 3P1NA 4DHOA 1A38A 5D2DA 5LU2A 3O8IA 1IB1A 4ZDRA 2C1JA 4J6SA 3P1QA 3P1OA 4DAUA 4JC3A 4IHLA 1QJAA 4DNKA 3E6YA 5HF3A 4DHUA 4WRQA 3SMKA 3LW1A 3RDHA 2WH0A 2O02A 3SMNA 4JDDA 2BTPA 3NKXA 3P1SA 3IQVA 4DHQA 3IQUA 5BTVA 1O9FA 3T0MA 5BY9A 2V7DA 5IQPA 4FJ3A 2BQ0A 3M51A 4DATA 2B05A 1YZ5A 3UALA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C63 A;  5J31 A;  3EFZ A;  3P1R A;  5LHO A;  1QJB A;  2BR9 A;  4DHP A;  4HKC A;  2O98 A;  1YWT A;  4DHM A;  3MHR A;  4BG6 A;  5D3F A;  2C74 A;  3SML A;  1O9D A;  4DHT A;  5LX2 A;  4FL5 A;  4DX0 A;  2NPM A;  4DHN A;  4ZQ0 A;  4FR3 A;  3UZD A;  4DHR A;  4N7G A;  3SPR A;  2O8P A;  4F7R A;  4DHS A;  4N84 A;  2C23 A;  3IQJ A;  1O9C A;  4E2E A;  5D3E A;  3CU8 A;  5F74 A;  4QLI A;  3UX0 A;  3SP5 A;  3P1P A;  3UBW A;  4GNT A;  4N7Y A;  3AXY C;  1A4O A;  4IEA A;  5LVZ A;  4Y5I A;  4Y3B A;  2C1N A;  1A37 A;  3M50 A;  3SMM A;  4Y32 A;  5EXA A;  5EWZ A;  1O9E A;  3T0L A;  5LU1 A;  3U9X A;  3SMO A;  4O46 A;  3P1N A;  4DHO A;  1A38 A;  5D2D A;  5LU2 A;  3O8I A;  1IB1 A;  4ZDR A;  2C1J A;  4J6S A;  3P1Q A;  3P1O A;  4DAU A;  4JC3 A;  4IHL A;  1QJA A;  4DNK A;  3E6Y A;  5HF3 A;  4DHU A;  4WRQ A;  3SMK A;  3LW1 A;  3RDH A;  2WH0 A;  2O02 A;  3SMN A;  4JDD A;  2BTP A;  3NKX A;  3P1S A;  3IQV A;  4DHQ A;  3IQU A;  5BTV A;  1O9F A;  3T0M A;  5BY9 A;  2V7D A;  5IQP A;  4FJ3 A;  2BQ0 A;  3M51 A;  4DAT A;  2B05 A;  1YZ5 A;  3UAL A; 
#chains in the Genus database with same CATH topology
 2C63 A;  4ARX A;  2C9K A;  5J31 A;  3EFZ A;  3P1R A;  5LHO A;  1QJB A;  2BR9 A;  4DHP A;  4HKC A;  2O98 A;  1YWT A;  4DHM A;  4W8J A;  3MHR A;  3EB7 A;  4QX3 A;  4BG6 A;  5D3F A;  2C74 A;  3I4R A;  1CIY A;  3SML A;  1O9D A;  4DHT A;  5LX2 A;  4FL5 A;  4DX0 A;  2NPM A;  4DHN A;  4ZQ0 A;  4FR3 A;  3UZD A;  4DHR A;  4N7G A;  3SPR A;  2O8P A;  4F7R A;  4DHS A;  4N84 A;  2C23 A;  3IQJ A;  1YZ5 A;  1O9C A;  4E2E A;  5D3E A;  3CU8 A;  5F74 A;  4QX2 A;  4QLI A;  3UX0 A;  3SP5 A;  3P1P A;  3X0U A;  3UBW A;  1I5P A;  4GNT A;  4N7Y A;  3AXY C;  4MOA A;  1A4O A;  4IEA A;  5LVZ A;  1S2X A;  4Y3B A;  4Y5I A;  2C1N A;  1A37 A;  3M50 A;  3SMM A;  4Y32 A;  5EXA A;  5EWZ A;  4ARY A;  1O9E A;  3T0L A;  5LU1 A;  3U9X A;  3SMO A;  4O46 A;  3P1N A;  4DHO A;  1A38 A;  5D2D A;  5LU2 A;  3O8I A;  1IB1 A;  4ZDR A;  3CQC A;  2C1J A;  4J6S A;  3P1Q A;  3P1O A;  4DAU A;  4JC3 A;  4IHL A;  1QJA A;  3CQG A;  4DNK A;  3E6Y A;  5HF3 A;  4DHU A;  4WRQ A;  3SMK A;  3LW1 A;  3RDH A;  1JI6 A;  2WH0 A;  2O02 A;  3ZHE B;  3SMN A;  4JDD A;  2BTP A;  3NKX A;  3P1S A;  3IQV A;  4DHQ A;  1URJ A;  3IQU A;  5BTV A;  1O9F A;  3T0M A;  5BY9 A;  1W99 A;  2V7D A;  5IQP A;  4FJ3 A;  1DLC A;  2BQ0 A;  3M51 A;  4QX1 A;  4D8M A;  4DAT A;  2B05 A;  4QX0 A;  3UAL A; 
#chains in the Genus database with same CATH homology
 2C63 A;  5J31 A;  3EFZ A;  3P1R A;  5LHO A;  1QJB A;  2BR9 A;  4DHP A;  4HKC A;  2O98 A;  1YWT A;  4DHM A;  3MHR A;  4BG6 A;  5D3F A;  2C74 A;  3SML A;  1O9D A;  4DHT A;  5LX2 A;  4FL5 A;  4DX0 A;  2NPM A;  4DHN A;  4ZQ0 A;  4FR3 A;  3UZD A;  4DHR A;  4N7G A;  3SPR A;  2O8P A;  4F7R A;  4DHS A;  4N84 A;  2C23 A;  3IQJ A;  1O9C A;  4E2E A;  5D3E A;  3CU8 A;  5F74 A;  4QLI A;  3UX0 A;  3SP5 A;  3P1P A;  3UBW A;  4GNT A;  4N7Y A;  3AXY C;  1A4O A;  4IEA A;  5LVZ A;  4Y5I A;  4Y3B A;  2C1N A;  1A37 A;  3M50 A;  3SMM A;  4Y32 A;  5EXA A;  5EWZ A;  1O9E A;  3T0L A;  5LU1 A;  3U9X A;  3SMO A;  4O46 A;  3P1N A;  4DHO A;  1A38 A;  5D2D A;  5LU2 A;  3O8I A;  1IB1 A;  4ZDR A;  2C1J A;  4J6S A;  3P1Q A;  3P1O A;  4DAU A;  4JC3 A;  4IHL A;  1QJA A;  4DNK A;  3E6Y A;  5HF3 A;  4DHU A;  4WRQ A;  3SMK A;  3LW1 A;  3RDH A;  2WH0 A;  2O02 A;  3SMN A;  4JDD A;  2BTP A;  3NKX A;  3P1S A;  3IQV A;  4DHQ A;  3IQU A;  5BTV A;  1O9F A;  3T0M A;  5BY9 A;  2V7D A;  5IQP A;  4FJ3 A;  2BQ0 A;  3M51 A;  4DAT A;  2B05 A;  1YZ5 A;  3UAL A; 
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