4DX0A

Structure of the 14-3-3/pma2 complex stabilized by a pyrazole derivative
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
235
structure length
229
Chain Sequence
STREENVYMAKLAEQAERYEEMVEFMEKVAKTVDVEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESRGNEDHVSSIKEYRGKIEAELSKICDGILNLLESHLIPVASTAESKVFYLKMKGDYHRYLAEFKTGAERKEAAENTLLAYKSAQDIALAELAPTHPIRLGLALNFSVFYYEILNSSDRACNLAKQAFDDAIAELDYKDSTLIMQLLRDNLTLWTSD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title An Optimised Small-Molecule Stabiliser of the 14-3-3-PMA2 Protein-Protein Interaction.
pubmed doi rcsb
molecule tags Protein binding/hydrolase
source organism Nicotiana tabacum
molecule keywords 14-3-3-like protein E
total genus 84
structure length 229
sequence length 235
ec nomenclature
pdb deposition date 2012-02-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4dx0A00
1O9CA 2V7DA 3M51A 1QJBA 3M50A 3SP5A 3U9XA 3SMKA 1QJAA 2WH0A 4FJ3A 4WRQA 3SMLA 4BG6A 4DAUA 2O98A 5LHOA 4F7RA 3P1PA 2C1JA 4Y3BA 4DHPA 4J6SA 1O9EA 2C63A 4DHRA 5F74A 5D3EA 3O8IA 1O9DA 1A37A 4HKCA 3UALA 4N7YA 4DX0A 1YZ5A 3P1RA 5LU1A 2C1NA 3IQVA 3RDHA 2BQ0A 5BTVA 3IQUA 4FR3A 4Y32A 4IHLA 3CU8A 4DHMA 5D2DA 4N84A 3E6YA 4Y5IA 5HF3A 5D3FA 3T0MA 5EXAA 1IB1A 5BY9A 4JDDA 3SPRA 4O46A 3AXYC 2O8PA 3NKXA 5EWZA 4DHUA 3IQJA 5IQPA 3SMOA 5LX2A 2C23A 2C74A 5LVZA 2BTPA 4GNTA 3P1NA 4DHSA 2O02A 2B05A 1A4OA 4E2EA 2BR9A 5J31A 4DHNA 4JC3A 3MHRA 4DNKA 3T0LA 4N7GA 1YWTA 3UX0A 4IEAA 3EFZA 2NPMA 3LW1A 3UZDA 4DHOA 4DHQA 3P1OA 4QLIA 3P1QA 4ZQ0A 3P1SA 4DATA 4DHTA 1O9FA 3SMMA 4FL5A 3UBWA 3SMNA 5LU2A 1A38A 4ZDRA
chains in the Genus database with same CATH superfamily
1O9CA 2V7DA 3M51A 1QJBA 3M50A 3SP5A 3U9XA 3SMKA 4QX0A 1QJAA 2WH0A 4FJ3A 4WRQA 3CQGA 3SMLA 4BG6A 4DAUA 2O98A 5LHOA 4W8JA 4F7RA 4D8MA 3EB7A 3P1PA 1I5PA 2C1JA 4Y3BA 4J6SA 4DHPA 1CIYA 1O9EA 2C63A 4DHRA 5F74A 5D3EA 3O8IA 1O9DA 1A37A 4HKCA 3UALA 4N7YA 3ZHEB 4DX0A 1S2XA 1YZ5A 3P1RA 5LU1A 2C1NA 3IQVA 3RDHA 2BQ0A 5BTVA 3IQUA 4FR3A 4Y32A 4IHLA 3CU8A 4DHMA 3CQCA 4QX2A 2C9KA 5D2DA 1W99A 4ARYA 4N84A 3E6YA 4Y5IA 5HF3A 5D3FA 3T0MA 5EXAA 1IB1A 5BY9A 4JDDA 3I4RA 3SPRA 4O46A 3X0UA 3AXYC 2O8PA 3NKXA 5EWZA 1URJA 4DHUA 3IQJA 5IQPA 4ARXA 3SMOA 5LX2A 1DLCA 2C23A 2C74A 5LVZA 2BTPA 4GNTA 3P1NA 4DHSA 2O02A 2B05A 1A4OA 4QX3A 2BR9A 4E2EA 5J31A 4DHNA 4JC3A 3MHRA 4DNKA 4QX1A 3T0LA 4N7GA 4MOAA 1YWTA 3UX0A 1JI6A 4IEAA 3EFZA 2NPMA 3LW1A 3UZDA 4DHOA 4DHQA 3P1OA 4QLIA 3P1QA 4ZQ0A 3P1SA 4DATA 4DHTA 1O9FA 3SMMA 4FL5A 3UBWA 3SMNA 5LU2A 1A38A 4ZDRA
chains in the Genus database with same CATH topology
1O9CA 2V7DA 3M51A 1QJBA 3M50A 3SP5A 3U9XA 3SMKA 1QJAA 2WH0A 4FJ3A 4WRQA 3SMLA 4BG6A 4DAUA 2O98A 5LHOA 4F7RA 3P1PA 2C1JA 4Y3BA 4DHPA 4J6SA 1O9EA 2C63A 4DHRA 5F74A 5D3EA 3O8IA 1O9DA 1A37A 4HKCA 3UALA 4N7YA 4DX0A 1YZ5A 3P1RA 5LU1A 2C1NA 3IQVA 3RDHA 2BQ0A 5BTVA 3IQUA 4FR3A 4Y32A 4IHLA 3CU8A 4DHMA 5D2DA 4N84A 3E6YA 4Y5IA 5HF3A 5D3FA 3T0MA 5EXAA 1IB1A 5BY9A 4JDDA 3SPRA 4O46A 3AXYC 2O8PA 3NKXA 5EWZA 4DHUA 3IQJA 5IQPA 3SMOA 5LX2A 2C23A 2C74A 5LVZA 2BTPA 4GNTA 3P1NA 4DHSA 2O02A 2B05A 1A4OA 4E2EA 2BR9A 5J31A 4DHNA 4JC3A 3MHRA 4DNKA 3T0LA 4N7GA 1YWTA 3UX0A 4IEAA 3EFZA 2NPMA 3LW1A 3UZDA 4DHOA 4DHQA 3P1OA 4QLIA 3P1QA 4ZQ0A 3P1SA 4DATA 4DHTA 1O9FA 3SMMA 4FL5A 3UBWA 3SMNA 5LU2A 1A38A 4ZDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O9C A;  2V7D A;  3M51 A;  1QJB A;  3M50 A;  3SP5 A;  3U9X A;  3SMK A;  1QJA A;  2WH0 A;  4FJ3 A;  4WRQ A;  3SML A;  4BG6 A;  4DAU A;  2O98 A;  5LHO A;  4F7R A;  3P1P A;  2C1J A;  4Y3B A;  4DHP A;  4J6S A;  1O9E A;  2C63 A;  4DHR A;  5F74 A;  5D3E A;  3O8I A;  1O9D A;  1A37 A;  4HKC A;  3UAL A;  4N7Y A;  4DX0 A;  1YZ5 A;  3P1R A;  5LU1 A;  2C1N A;  3IQV A;  3RDH A;  2BQ0 A;  5BTV A;  3IQU A;  4FR3 A;  4Y32 A;  4IHL A;  3CU8 A;  4DHM A;  5D2D A;  4N84 A;  3E6Y A;  4Y5I A;  5HF3 A;  5D3F A;  3T0M A;  5EXA A;  1IB1 A;  5BY9 A;  4JDD A;  3SPR A;  4O46 A;  3AXY C;  2O8P A;  3NKX A;  5EWZ A;  4DHU A;  3IQJ A;  5IQP A;  3SMO A;  5LX2 A;  2C23 A;  2C74 A;  5LVZ A;  2BTP A;  4GNT A;  3P1N A;  4DHS A;  2O02 A;  2B05 A;  1A4O A;  4E2E A;  2BR9 A;  5J31 A;  4DHN A;  4JC3 A;  3MHR A;  4DNK A;  3T0L A;  4N7G A;  1YWT A;  3UX0 A;  4IEA A;  3EFZ A;  2NPM A;  3LW1 A;  3UZD A;  4DHO A;  4DHQ A;  3P1O A;  4QLI A;  3P1Q A;  4ZQ0 A;  3P1S A;  4DAT A;  4DHT A;  1O9F A;  3SMM A;  4FL5 A;  3UBW A;  3SMN A;  5LU2 A;  1A38 A;  4ZDR A; 
#chains in the Genus database with same CATH topology
 1O9C A;  2V7D A;  3M51 A;  1QJB A;  3M50 A;  3SP5 A;  3U9X A;  3SMK A;  4QX0 A;  1QJA A;  2WH0 A;  4FJ3 A;  4WRQ A;  3CQG A;  3SML A;  4BG6 A;  4DAU A;  2O98 A;  5LHO A;  4W8J A;  4F7R A;  4D8M A;  3EB7 A;  3P1P A;  1I5P A;  2C1J A;  4Y3B A;  4J6S A;  4DHP A;  1CIY A;  1O9E A;  2C63 A;  4DHR A;  5F74 A;  5D3E A;  3O8I A;  1O9D A;  1A37 A;  4HKC A;  3UAL A;  4N7Y A;  3ZHE B;  4DX0 A;  1S2X A;  1YZ5 A;  3P1R A;  5LU1 A;  2C1N A;  3IQV A;  3RDH A;  2BQ0 A;  5BTV A;  3IQU A;  4FR3 A;  4Y32 A;  4IHL A;  3CU8 A;  4DHM A;  3CQC A;  4QX2 A;  2C9K A;  5D2D A;  1W99 A;  4ARY A;  4N84 A;  3E6Y A;  4Y5I A;  5HF3 A;  5D3F A;  3T0M A;  5EXA A;  1IB1 A;  5BY9 A;  4JDD A;  3I4R A;  3SPR A;  4O46 A;  3X0U A;  3AXY C;  2O8P A;  3NKX A;  5EWZ A;  1URJ A;  4DHU A;  3IQJ A;  5IQP A;  4ARX A;  3SMO A;  5LX2 A;  1DLC A;  2C23 A;  2C74 A;  5LVZ A;  2BTP A;  4GNT A;  3P1N A;  4DHS A;  2O02 A;  2B05 A;  1A4O A;  4QX3 A;  2BR9 A;  4E2E A;  5J31 A;  4DHN A;  4JC3 A;  3MHR A;  4DNK A;  4QX1 A;  3T0L A;  4N7G A;  4MOA A;  1YWT A;  3UX0 A;  1JI6 A;  4IEA A;  3EFZ A;  2NPM A;  3LW1 A;  3UZD A;  4DHO A;  4DHQ A;  3P1O A;  4QLI A;  3P1Q A;  4ZQ0 A;  3P1S A;  4DAT A;  4DHT A;  1O9F A;  3SMM A;  4FL5 A;  3UBW A;  3SMN A;  5LU2 A;  1A38 A;  4ZDR A; 
#chains in the Genus database with same CATH homology
 1O9C A;  2V7D A;  3M51 A;  1QJB A;  3M50 A;  3SP5 A;  3U9X A;  3SMK A;  1QJA A;  2WH0 A;  4FJ3 A;  4WRQ A;  3SML A;  4BG6 A;  4DAU A;  2O98 A;  5LHO A;  4F7R A;  3P1P A;  2C1J A;  4Y3B A;  4DHP A;  4J6S A;  1O9E A;  2C63 A;  4DHR A;  5F74 A;  5D3E A;  3O8I A;  1O9D A;  1A37 A;  4HKC A;  3UAL A;  4N7Y A;  4DX0 A;  1YZ5 A;  3P1R A;  5LU1 A;  2C1N A;  3IQV A;  3RDH A;  2BQ0 A;  5BTV A;  3IQU A;  4FR3 A;  4Y32 A;  4IHL A;  3CU8 A;  4DHM A;  5D2D A;  4N84 A;  3E6Y A;  4Y5I A;  5HF3 A;  5D3F A;  3T0M A;  5EXA A;  1IB1 A;  5BY9 A;  4JDD A;  3SPR A;  4O46 A;  3AXY C;  2O8P A;  3NKX A;  5EWZ A;  4DHU A;  3IQJ A;  5IQP A;  3SMO A;  5LX2 A;  2C23 A;  2C74 A;  5LVZ A;  2BTP A;  4GNT A;  3P1N A;  4DHS A;  2O02 A;  2B05 A;  1A4O A;  4E2E A;  2BR9 A;  5J31 A;  4DHN A;  4JC3 A;  3MHR A;  4DNK A;  3T0L A;  4N7G A;  1YWT A;  3UX0 A;  4IEA A;  3EFZ A;  2NPM A;  3LW1 A;  3UZD A;  4DHO A;  4DHQ A;  3P1O A;  4QLI A;  3P1Q A;  4ZQ0 A;  3P1S A;  4DAT A;  4DHT A;  1O9F A;  3SMM A;  4FL5 A;  3UBW A;  3SMN A;  5LU2 A;  1A38 A;  4ZDR A; 
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similar chains in the Genus database (?% sequence similarity)
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