4IHL | Genus

Total Genus 102

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	102
sequence length	230
structure length	230
Chain Sequence	MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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reading 230 atoms

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230 atoms created

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Peptide binding protein
source organism	Homo sapiens
publication title	Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. pubmed doi rcsb
molecule keywords	14-3-3 protein zeta/delta
total genus	102
structure length	230
sequence length	230
chains with identical sequence	B
ec nomenclature
pdb deposition date	2012-12-19

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00244	14-3-3	14-3-3 protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.190.20	Mainly Alpha	Up-down Bundle	Delta-Endotoxin; domain 1	14-3-3 domain	4ihlA00

4FL5A 2BR9A 4ZQ0A 3IQUA 3SMNA 2BTPA 3NKXA 4IEAA 4Y5IA 5BY9A 1A38A 3MHRA 4GNTA 4O46A 2C74A 4JDDA 3SMKA 5EXAA 4DHOA 5BTVA 3UALA 3LW1A 1QJBA 1O9DA 1O9EA 3AXYC 3SMOA 3RDHA 3P1OA 4DHTA 2NPMA 1IB1A 3P1QA 3U9XA 4FR3A 4DHRA 2C1NA 2O02A 4FJ3A 4WRQA 3CU8A 3SMLA 3P1RA 5J31A 1YWTA 3T0LA 2BQ0A 3IQVA 3SP5A 4DATA 3UZDA 4N7YA 2B05A 2O8PA 4E2EA 5F74A 4DHNA 5LVZA 4N7GA 4BG6A 5EWZA 3P1NA 2V7DA 2C23A 4Y3BA 4DNKA 5IQPA 3M50A 2C1JA 1O9CA 4QLIA 5D3EA 4DHPA 1O9FA 4DX0A 4N84A 3IQJA 3SPRA 1QJAA 4J6SA 3M51A 2C63A 4DHSA 3T0MA 4HKCA 4DHQA 5LU2A 4DHUA 1YZ5A 5LU1A 4JC3A 3UX0A 4DHMA 4Y32A 3P1PA 3SMMA 5HF3A 4F7RA 3O8IA 3EFZA 2O98A 2WH0A 3UBWA 4IHLA 5D3FA 1A4OA 3E6YA 3P1SA 4ZDRA 5LX2A 1A37A 5D2DA 4DAUA 5LHOA
chains in the Genus database with same CATH superfamily

1I5PA 2BR9A 4FL5A 4ZQ0A 3IQUA 3SMNA 2BTPA 3NKXA 4IEAA 4Y5IA 5BY9A 3I4RA 1CIYA 1A38A 3MHRA 4MOAA 4GNTA 4O46A 2C74A 4JDDA 3SMKA 5EXAA 4DHOA 5BTVA 3UALA 3LW1A 1QJBA 1O9DA 3CQCA 1O9EA 1DLCA 3AXYC 3SMOA 3P1OA 3RDHA 4DHTA 2NPMA 1IB1A 1URJA 3P1QA 3U9XA 4FR3A 4QX2A 2C1NA 2O02A 4DHRA 4FJ3A 4QX3A 4WRQA 3CU8A 3SMLA 3CQGA 3P1RA 5J31A 1YWTA 3T0LA 2BQ0A 3IQVA 3SP5A 4DATA 3UZDA 4N7YA 2B05A 2O8PA 4E2EA 3X0UA 5F74A 4DHNA 5LVZA 4N7GA 4QX0A 4BG6A 5EWZA 4ARYA 3P1NA 2V7DA 2C23A 4Y3BA 4DNKA 5IQPA 1S2XA 1W99A 4ARXA 3M50A 2C1JA 1O9CA 4QLIA 5D3EA 4DHPA 1O9FA 4DX0A 4N84A 3IQJA 3SPRA 4QX1A 1QJAA 4J6SA 3M51A 1JI6A 2C63A 4DHSA 3T0MA 4HKCA 4DHQA 5LU2A 4DHUA 1YZ5A 5LU1A 4JC3A 3UX0A 4DHMA 3P1PA 4Y32A 3SMMA 5HF3A 4F7RA 3O8IA 3EFZA 2O98A 2WH0A 3ZHEB 3UBWA 4IHLA 5D3FA 1A4OA 3EB7A 3E6YA 3P1SA 4ZDRA 4D8MA 5LX2A 1A37A 5D2DA 4DAUA 4W8JA 2C9KA 5LHOA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4FL5 A;  2BR9 A;  4ZQ0 A;  3IQU A;  3SMN A;  2BTP A;  3NKX A;  4IEA A;  4Y5I A;  5BY9 A;  1A38 A;  3MHR A;  4GNT A;  4O46 A;  2C74 A;  4JDD A;  3SMK A;  5EXA A;  4DHO A;  5BTV A;  3UAL A;  3LW1 A;  1QJB A;  1O9D A;  1O9E A;  3AXY C;  3SMO A;  3RDH A;  3P1O A;  4DHT A;  2NPM A;  1IB1 A;  3P1Q A;  3U9X A;  4FR3 A;  4DHR A;  2C1N A;  2O02 A;  4FJ3 A;  4WRQ A;  3CU8 A;  3SML A;  3P1R A;  5J31 A;  1YWT A;  3T0L A;  2BQ0 A;  3IQV A;  3SP5 A;  4DAT A;  3UZD A;  4N7Y A;  2B05 A;  2O8P A;  4E2E A;  5F74 A;  4DHN A;  5LVZ A;  4N7G A;  4BG6 A;  5EWZ A;  3P1N A;  2V7D A;  2C23 A;  4Y3B A;  4DNK A;  5IQP A;  3M50 A;  2C1J A;  1O9C A;  4QLI A;  5D3E A;  4DHP A;  1O9F A;  4DX0 A;  4N84 A;  3IQJ A;  3SPR A;  1QJA A;  4J6S A;  3M51 A;  2C63 A;  4DHS A;  3T0M A;  4HKC A;  4DHQ A;  5LU2 A;  4DHU A;  1YZ5 A;  5LU1 A;  4JC3 A;  3UX0 A;  4DHM A;  4Y32 A;  3P1P A;  3SMM A;  5HF3 A;  4F7R A;  3O8I A;  3EFZ A;  2O98 A;  2WH0 A;  3UBW A;  4IHL A;  5D3F A;  1A4O A;  3E6Y A;  3P1S A;  4ZDR A;  5LX2 A;  1A37 A;  5D2D A;  4DAU A;  5LHO A; 
#chains in the Genus database with same CATH topology
 1I5P A;  2BR9 A;  4FL5 A;  4ZQ0 A;  3IQU A;  3SMN A;  2BTP A;  3NKX A;  4IEA A;  4Y5I A;  5BY9 A;  3I4R A;  1CIY A;  1A38 A;  3MHR A;  4MOA A;  4GNT A;  4O46 A;  2C74 A;  4JDD A;  3SMK A;  5EXA A;  4DHO A;  5BTV A;  3UAL A;  3LW1 A;  1QJB A;  1O9D A;  3CQC A;  1O9E A;  1DLC A;  3AXY C;  3SMO A;  3P1O A;  3RDH A;  4DHT A;  2NPM A;  1IB1 A;  1URJ A;  3P1Q A;  3U9X A;  4FR3 A;  4QX2 A;  2C1N A;  2O02 A;  4DHR A;  4FJ3 A;  4QX3 A;  4WRQ A;  3CU8 A;  3SML A;  3CQG A;  3P1R A;  5J31 A;  1YWT A;  3T0L A;  2BQ0 A;  3IQV A;  3SP5 A;  4DAT A;  3UZD A;  4N7Y A;  2B05 A;  2O8P A;  4E2E A;  3X0U A;  5F74 A;  4DHN A;  5LVZ A;  4N7G A;  4QX0 A;  4BG6 A;  5EWZ A;  4ARY A;  3P1N A;  2V7D A;  2C23 A;  4Y3B A;  4DNK A;  5IQP A;  1S2X A;  1W99 A;  4ARX A;  3M50 A;  2C1J A;  1O9C A;  4QLI A;  5D3E A;  4DHP A;  1O9F A;  4DX0 A;  4N84 A;  3IQJ A;  3SPR A;  4QX1 A;  1QJA A;  4J6S A;  3M51 A;  1JI6 A;  2C63 A;  4DHS A;  3T0M A;  4HKC A;  4DHQ A;  5LU2 A;  4DHU A;  1YZ5 A;  5LU1 A;  4JC3 A;  3UX0 A;  4DHM A;  3P1P A;  4Y32 A;  3SMM A;  5HF3 A;  4F7R A;  3O8I A;  3EFZ A;  2O98 A;  2WH0 A;  3ZHE B;  3UBW A;  4IHL A;  5D3F A;  1A4O A;  3EB7 A;  3E6Y A;  3P1S A;  4ZDR A;  4D8M A;  5LX2 A;  1A37 A;  5D2D A;  4DAU A;  4W8J A;  2C9K A;  5LHO A; 
#chains in the Genus database with same CATH homology
 4FL5 A;  2BR9 A;  4ZQ0 A;  3IQU A;  3SMN A;  2BTP A;  3NKX A;  4IEA A;  4Y5I A;  5BY9 A;  1A38 A;  3MHR A;  4GNT A;  4O46 A;  2C74 A;  4JDD A;  3SMK A;  5EXA A;  4DHO A;  5BTV A;  3UAL A;  3LW1 A;  1QJB A;  1O9D A;  1O9E A;  3AXY C;  3SMO A;  3RDH A;  3P1O A;  4DHT A;  2NPM A;  1IB1 A;  3P1Q A;  3U9X A;  4FR3 A;  4DHR A;  2C1N A;  2O02 A;  4FJ3 A;  4WRQ A;  3CU8 A;  3SML A;  3P1R A;  5J31 A;  1YWT A;  3T0L A;  2BQ0 A;  3IQV A;  3SP5 A;  4DAT A;  3UZD A;  4N7Y A;  2B05 A;  2O8P A;  4E2E A;  5F74 A;  4DHN A;  5LVZ A;  4N7G A;  4BG6 A;  5EWZ A;  3P1N A;  2V7D A;  2C23 A;  4Y3B A;  4DNK A;  5IQP A;  3M50 A;  2C1J A;  1O9C A;  4QLI A;  5D3E A;  4DHP A;  1O9F A;  4DX0 A;  4N84 A;  3IQJ A;  3SPR A;  1QJA A;  4J6S A;  3M51 A;  2C63 A;  4DHS A;  3T0M A;  4HKC A;  4DHQ A;  5LU2 A;  4DHU A;  1YZ5 A;  5LU1 A;  4JC3 A;  3UX0 A;  4DHM A;  4Y32 A;  3P1P A;  3SMM A;  5HF3 A;  4F7R A;  3O8I A;  3EFZ A;  2O98 A;  2WH0 A;  3UBW A;  4IHL A;  5D3F A;  1A4O A;  3E6Y A;  3P1S A;  4ZDR A;  5LX2 A;  1A37 A;  5D2D A;  4DAU A;  5LHO A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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4IHLA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations