4J6SA

14-3-3gamma complexed with the n-terminal sequence of tyrosine hydroxylase (residues 1-43)
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
237
structure length
237
Chain Sequence
GLVDREQLVQKARLAEQAERYDDMAAAMKNVTELNEPLSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTSADGNEKKIEMVRAYREKIEKELEAVCQDVLSLLDNYLIKNCSETQYESKVFYLKMKGDYYRYLAEVATGEKRATVVESSEKAYSEAHEISKEHMQPTHPIRLGLALNYSVFYYEIQNAPEQACHLAKTAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords 14-3-3 protein gamma
total genus 100
structure length 237
sequence length 237
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2013-02-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4j6sA00
2O98A 2O02A 2WH0A 3SMNA 3U9XA 4Y5IA 4N7GA 4DHNA 1O9DA 2C63A 5LX2A 3P1NA 5LU1A 3RDHA 3IQJA 3UZDA 3P1QA 3M50A 3O8IA 4IHLA 3SPRA 5LHOA 5EWZA 3T0MA 3UX0A 4DNKA 3UALA 3AXYC 4DATA 4DHUA 5D3FA 3P1RA 4HKCA 4J6SA 4DHQA 1O9CA 5F74A 4ZQ0A 4Y3BA 3EFZA 3UBWA 4JC3A 1QJBA 4DAUA 4JDDA 4GNTA 4DHMA 3SMKA 4ZDRA 5D3EA 4DX0A 5LVZA 3M51A 4WRQA 4DHOA 5IQPA 3P1PA 4N84A 4DHPA 3P1OA 4QLIA 2BTPA 5D2DA 1A37A 2B05A 4DHSA 5J31A 3SMOA 4BG6A 2BQ0A 4IEAA 2C74A 2BR9A 4DHRA 1O9EA 1A4OA 3IQUA 1IB1A 4N7YA 3SMMA 5BY9A 3IQVA 5HF3A 3T0LA 3E6YA 3NKXA 3LW1A 2C1NA 3CU8A 1A38A 4FR3A 2C23A 5BTVA 4F7RA 1QJAA 1YWTA 3MHRA 3P1SA 4Y32A 4FL5A 2O8PA 4DHTA 2C1JA 1O9FA 3SMLA 2V7DA 4FJ3A 4O46A 2NPMA 5LU2A 3SP5A 1YZ5A 5EXAA 4E2EA
chains in the Genus database with same CATH superfamily
4ARXA 1JI6A 2O98A 2O02A 2WH0A 3SMNA 3U9XA 4Y5IA 4N7GA 4DHNA 1O9DA 2C63A 5LX2A 3P1NA 4MOAA 5LU1A 3RDHA 3IQJA 3UZDA 3P1QA 3M50A 3O8IA 4IHLA 3SPRA 4QX3A 5LHOA 1W99A 1S2XA 5EWZA 3T0MA 3UX0A 4DNKA 3UALA 3AXYC 4DATA 4DHUA 1DLCA 5D3FA 3P1RA 4HKCA 3CQGA 4J6SA 3I4RA 4DHQA 1O9CA 5F74A 4W8JA 4ZQ0A 4Y3BA 3EFZA 3UBWA 3CQCA 3ZHEB 4JC3A 1QJBA 4DAUA 4QX2A 4JDDA 4GNTA 4DHMA 4ZDRA 3SMKA 5D3EA 4DX0A 5LVZA 3M51A 4WRQA 4DHOA 2C9KA 5IQPA 3P1PA 4N84A 4DHPA 3P1OA 4QLIA 2BTPA 5D2DA 1A37A 2B05A 4D8MA 4DHSA 5J31A 3SMOA 4BG6A 2BQ0A 4QX0A 3EB7A 4IEAA 2C74A 2BR9A 4DHRA 1O9EA 1A4OA 3IQUA 1IB1A 4N7YA 3SMMA 5BY9A 3IQVA 5HF3A 3T0LA 3E6YA 3NKXA 3LW1A 2C1NA 1CIYA 3CU8A 1A38A 4FR3A 2C23A 5BTVA 4F7RA 1QJAA 1YWTA 3MHRA 3P1SA 4Y32A 4FL5A 1I5PA 3X0UA 2O8PA 4DHTA 2C1JA 1O9FA 3SMLA 2V7DA 4ARYA 4FJ3A 4O46A 2NPMA 1URJA 5LU2A 3SP5A 1YZ5A 4QX1A 5EXAA 4E2EA
chains in the Genus database with same CATH topology
2O98A 2O02A 2WH0A 3SMNA 3U9XA 4Y5IA 4N7GA 4DHNA 1O9DA 2C63A 5LX2A 3P1NA 5LU1A 3RDHA 3IQJA 3UZDA 3P1QA 3M50A 3O8IA 4IHLA 3SPRA 5LHOA 5EWZA 3T0MA 3UX0A 4DNKA 3UALA 3AXYC 4DATA 4DHUA 5D3FA 3P1RA 4HKCA 4J6SA 4DHQA 1O9CA 5F74A 4ZQ0A 4Y3BA 3EFZA 3UBWA 4JC3A 1QJBA 4DAUA 4JDDA 4GNTA 4DHMA 3SMKA 4ZDRA 5D3EA 4DX0A 5LVZA 3M51A 4WRQA 4DHOA 5IQPA 3P1PA 4N84A 4DHPA 3P1OA 4QLIA 2BTPA 5D2DA 1A37A 2B05A 4DHSA 5J31A 3SMOA 4BG6A 2BQ0A 4IEAA 2C74A 2BR9A 4DHRA 1O9EA 1A4OA 3IQUA 1IB1A 4N7YA 3SMMA 5BY9A 3IQVA 5HF3A 3T0LA 3E6YA 3NKXA 3LW1A 2C1NA 3CU8A 1A38A 4FR3A 2C23A 5BTVA 4F7RA 1QJAA 1YWTA 3MHRA 3P1SA 4Y32A 4FL5A 2O8PA 4DHTA 2C1JA 1O9FA 3SMLA 2V7DA 4FJ3A 4O46A 2NPMA 5LU2A 3SP5A 1YZ5A 5EXAA 4E2EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O98 A;  2O02 A;  2WH0 A;  3SMN A;  3U9X A;  4Y5I A;  4N7G A;  4DHN A;  1O9D A;  2C63 A;  5LX2 A;  3P1N A;  5LU1 A;  3RDH A;  3IQJ A;  3UZD A;  3P1Q A;  3M50 A;  3O8I A;  4IHL A;  3SPR A;  5LHO A;  5EWZ A;  3T0M A;  3UX0 A;  4DNK A;  3UAL A;  3AXY C;  4DAT A;  4DHU A;  5D3F A;  3P1R A;  4HKC A;  4J6S A;  4DHQ A;  1O9C A;  5F74 A;  4ZQ0 A;  4Y3B A;  3EFZ A;  3UBW A;  4JC3 A;  1QJB A;  4DAU A;  4JDD A;  4GNT A;  4DHM A;  3SMK A;  4ZDR A;  5D3E A;  4DX0 A;  5LVZ A;  3M51 A;  4WRQ A;  4DHO A;  5IQP A;  3P1P A;  4N84 A;  4DHP A;  3P1O A;  4QLI A;  2BTP A;  5D2D A;  1A37 A;  2B05 A;  4DHS A;  5J31 A;  3SMO A;  4BG6 A;  2BQ0 A;  4IEA A;  2C74 A;  2BR9 A;  4DHR A;  1O9E A;  1A4O A;  3IQU A;  1IB1 A;  4N7Y A;  3SMM A;  5BY9 A;  3IQV A;  5HF3 A;  3T0L A;  3E6Y A;  3NKX A;  3LW1 A;  2C1N A;  3CU8 A;  1A38 A;  4FR3 A;  2C23 A;  5BTV A;  4F7R A;  1QJA A;  1YWT A;  3MHR A;  3P1S A;  4Y32 A;  4FL5 A;  2O8P A;  4DHT A;  2C1J A;  1O9F A;  3SML A;  2V7D A;  4FJ3 A;  4O46 A;  2NPM A;  5LU2 A;  3SP5 A;  1YZ5 A;  5EXA A;  4E2E A; 
#chains in the Genus database with same CATH topology
 4ARX A;  1JI6 A;  2O98 A;  2O02 A;  2WH0 A;  3SMN A;  3U9X A;  4Y5I A;  4N7G A;  4DHN A;  1O9D A;  2C63 A;  5LX2 A;  3P1N A;  4MOA A;  5LU1 A;  3RDH A;  3IQJ A;  3UZD A;  3P1Q A;  3M50 A;  3O8I A;  4IHL A;  3SPR A;  4QX3 A;  5LHO A;  1W99 A;  1S2X A;  5EWZ A;  3T0M A;  3UX0 A;  4DNK A;  3UAL A;  3AXY C;  4DAT A;  4DHU A;  1DLC A;  5D3F A;  3P1R A;  4HKC A;  3CQG A;  4J6S A;  3I4R A;  4DHQ A;  1O9C A;  5F74 A;  4W8J A;  4ZQ0 A;  4Y3B A;  3EFZ A;  3UBW A;  3CQC A;  3ZHE B;  4JC3 A;  1QJB A;  4DAU A;  4QX2 A;  4JDD A;  4GNT A;  4DHM A;  4ZDR A;  3SMK A;  5D3E A;  4DX0 A;  5LVZ A;  3M51 A;  4WRQ A;  4DHO A;  2C9K A;  5IQP A;  3P1P A;  4N84 A;  4DHP A;  3P1O A;  4QLI A;  2BTP A;  5D2D A;  1A37 A;  2B05 A;  4D8M A;  4DHS A;  5J31 A;  3SMO A;  4BG6 A;  2BQ0 A;  4QX0 A;  3EB7 A;  4IEA A;  2C74 A;  2BR9 A;  4DHR A;  1O9E A;  1A4O A;  3IQU A;  1IB1 A;  4N7Y A;  3SMM A;  5BY9 A;  3IQV A;  5HF3 A;  3T0L A;  3E6Y A;  3NKX A;  3LW1 A;  2C1N A;  1CIY A;  3CU8 A;  1A38 A;  4FR3 A;  2C23 A;  5BTV A;  4F7R A;  1QJA A;  1YWT A;  3MHR A;  3P1S A;  4Y32 A;  4FL5 A;  1I5P A;  3X0U A;  2O8P A;  4DHT A;  2C1J A;  1O9F A;  3SML A;  2V7D A;  4ARY A;  4FJ3 A;  4O46 A;  2NPM A;  1URJ A;  5LU2 A;  3SP5 A;  1YZ5 A;  4QX1 A;  5EXA A;  4E2E A; 
#chains in the Genus database with same CATH homology
 2O98 A;  2O02 A;  2WH0 A;  3SMN A;  3U9X A;  4Y5I A;  4N7G A;  4DHN A;  1O9D A;  2C63 A;  5LX2 A;  3P1N A;  5LU1 A;  3RDH A;  3IQJ A;  3UZD A;  3P1Q A;  3M50 A;  3O8I A;  4IHL A;  3SPR A;  5LHO A;  5EWZ A;  3T0M A;  3UX0 A;  4DNK A;  3UAL A;  3AXY C;  4DAT A;  4DHU A;  5D3F A;  3P1R A;  4HKC A;  4J6S A;  4DHQ A;  1O9C A;  5F74 A;  4ZQ0 A;  4Y3B A;  3EFZ A;  3UBW A;  4JC3 A;  1QJB A;  4DAU A;  4JDD A;  4GNT A;  4DHM A;  3SMK A;  4ZDR A;  5D3E A;  4DX0 A;  5LVZ A;  3M51 A;  4WRQ A;  4DHO A;  5IQP A;  3P1P A;  4N84 A;  4DHP A;  3P1O A;  4QLI A;  2BTP A;  5D2D A;  1A37 A;  2B05 A;  4DHS A;  5J31 A;  3SMO A;  4BG6 A;  2BQ0 A;  4IEA A;  2C74 A;  2BR9 A;  4DHR A;  1O9E A;  1A4O A;  3IQU A;  1IB1 A;  4N7Y A;  3SMM A;  5BY9 A;  3IQV A;  5HF3 A;  3T0L A;  3E6Y A;  3NKX A;  3LW1 A;  2C1N A;  3CU8 A;  1A38 A;  4FR3 A;  2C23 A;  5BTV A;  4F7R A;  1QJA A;  1YWT A;  3MHR A;  3P1S A;  4Y32 A;  4FL5 A;  2O8P A;  4DHT A;  2C1J A;  1O9F A;  3SML A;  2V7D A;  4FJ3 A;  4O46 A;  2NPM A;  5LU2 A;  3SP5 A;  1YZ5 A;  5EXA A;  4E2E A; 
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similar chains in the Genus database (?% sequence similarity)
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