4JC3A

14-3-3 protein interaction with estrogen receptor alpha provides a novel drug target interface
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
236
structure length
236
Chain Sequence
GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.
pubmed doi rcsb
molecule keywords 14-3-3 protein sigma
molecule tags Signaling protein/peptide
source organism Homo sapiens
total genus 101
structure length 236
sequence length 236
ec nomenclature
pdb deposition date 2013-02-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4jc3A00
5HF3A 4DATA 4Y3BA 4N84A 5LU1A 4DHQA 5D3EA 1O9FA 3CU8A 4WRQA 4Y32A 3UZDA 4DHNA 3P1QA 4JC3A 1O9DA 2C23A 1A38A 2C74A 4Y5IA 1A37A 4F7RA 4DX0A 5IQPA 3RDHA 4ZQ0A 3IQJA 3IQUA 4N7GA 4JDDA 1YWTA 2O8PA 3MHRA 2B05A 4DNKA 3P1SA 3SMLA 5BTVA 3U9XA 3P1NA 3SMOA 4DHUA 3UALA 5J31A 5F74A 5LX2A 2BR9A 1O9EA 3SP5A 1YZ5A 4E2EA 1QJAA 2NPMA 2BTPA 2WH0A 3LW1A 3IQVA 3SPRA 2C1NA 1A4OA 2C63A 1O9CA 5EXAA 3SMNA 4QLIA 3M50A 3P1RA 3T0LA 3UBWA 2O98A 3EFZA 4IEAA 4DHSA 1IB1A 5LVZA 4FJ3A 4DHTA 2BQ0A 4IHLA 5D2DA 4DHOA 3P1OA 3M51A 4FR3A 1QJBA 2O02A 3SMMA 4J6SA 4BG6A 3P1PA 3UX0A 4HKCA 3SMKA 3E6YA 2C1JA 2V7DA 4FL5A 5D3FA 4O46A 3NKXA 4N7YA 5LHOA 3AXYC 4ZDRA 4DHRA 3T0MA 5LU2A 3O8IA 5BY9A 4GNTA 4DHPA 5EWZA 4DAUA 4DHMA
chains in the Genus database with same CATH superfamily
5HF3A 2C9KA 4ARYA 4DATA 4Y3BA 4N84A 1W99A 4QX1A 5LU1A 4DHQA 5D3EA 4MOAA 1O9FA 3CU8A 4WRQA 4Y32A 4QX2A 3UZDA 4DHNA 3P1QA 4D8MA 3EB7A 4JC3A 1O9DA 2C23A 1A38A 4ARXA 2C74A 4Y5IA 1JI6A 1A37A 4F7RA 4DX0A 1I5PA 5IQPA 3CQGA 3RDHA 4ZQ0A 3IQJA 4QX3A 3IQUA 4N7GA 4JDDA 1YWTA 2O8PA 3MHRA 2B05A 4DNKA 1DLCA 1URJA 3P1SA 3SMLA 5BTVA 3U9XA 3P1NA 3SMOA 4DHUA 3UALA 5J31A 5F74A 5LX2A 2BR9A 1O9EA 3SP5A 1YZ5A 4E2EA 1QJAA 2NPMA 2BTPA 2WH0A 3LW1A 3IQVA 3SPRA 2C1NA 1A4OA 2C63A 1O9CA 5EXAA 3SMNA 4QLIA 3M50A 3P1RA 3T0LA 1CIYA 3UBWA 2O98A 3EFZA 4IEAA 4DHSA 1IB1A 5LVZA 4FJ3A 4DHTA 1S2XA 2BQ0A 3I4RA 4IHLA 5D2DA 4DHOA 3P1OA 3M51A 4FR3A 3CQCA 1QJBA 3X0UA 2O02A 3SMMA 4QX0A 3ZHEB 4J6SA 4BG6A 3P1PA 3UX0A 4HKCA 3SMKA 3E6YA 2C1JA 2V7DA 4FL5A 5D3FA 4O46A 3NKXA 4N7YA 5LHOA 3AXYC 4ZDRA 4DHRA 3T0MA 5LU2A 3O8IA 5BY9A 4GNTA 4DHPA 5EWZA 4DAUA 4DHMA 4W8JA
chains in the Genus database with same CATH topology
5HF3A 4DATA 4Y3BA 4N84A 5LU1A 4DHQA 5D3EA 1O9FA 3CU8A 4WRQA 4Y32A 3UZDA 4DHNA 3P1QA 4JC3A 1O9DA 2C23A 1A38A 2C74A 4Y5IA 1A37A 4F7RA 4DX0A 5IQPA 3RDHA 4ZQ0A 3IQJA 3IQUA 4N7GA 4JDDA 1YWTA 2O8PA 3MHRA 2B05A 4DNKA 3P1SA 3SMLA 5BTVA 3U9XA 3P1NA 3SMOA 4DHUA 3UALA 5J31A 5F74A 5LX2A 2BR9A 1O9EA 3SP5A 1YZ5A 4E2EA 1QJAA 2NPMA 2BTPA 2WH0A 3LW1A 3IQVA 3SPRA 2C1NA 1A4OA 2C63A 1O9CA 5EXAA 3SMNA 4QLIA 3M50A 3P1RA 3T0LA 3UBWA 2O98A 3EFZA 4IEAA 4DHSA 1IB1A 5LVZA 4FJ3A 4DHTA 2BQ0A 4IHLA 5D2DA 4DHOA 3P1OA 3M51A 4FR3A 1QJBA 2O02A 3SMMA 4J6SA 4BG6A 3P1PA 3UX0A 4HKCA 3SMKA 3E6YA 2C1JA 2V7DA 4FL5A 5D3FA 4O46A 3NKXA 4N7YA 5LHOA 3AXYC 4ZDRA 4DHRA 3T0MA 5LU2A 3O8IA 5BY9A 4GNTA 4DHPA 5EWZA 4DAUA 4DHMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HF3 A;  4DAT A;  4Y3B A;  4N84 A;  5LU1 A;  4DHQ A;  5D3E A;  1O9F A;  3CU8 A;  4WRQ A;  4Y32 A;  3UZD A;  4DHN A;  3P1Q A;  4JC3 A;  1O9D A;  2C23 A;  1A38 A;  2C74 A;  4Y5I A;  1A37 A;  4F7R A;  4DX0 A;  5IQP A;  3RDH A;  4ZQ0 A;  3IQJ A;  3IQU A;  4N7G A;  4JDD A;  1YWT A;  2O8P A;  3MHR A;  2B05 A;  4DNK A;  3P1S A;  3SML A;  5BTV A;  3U9X A;  3P1N A;  3SMO A;  4DHU A;  3UAL A;  5J31 A;  5F74 A;  5LX2 A;  2BR9 A;  1O9E A;  3SP5 A;  1YZ5 A;  4E2E A;  1QJA A;  2NPM A;  2BTP A;  2WH0 A;  3LW1 A;  3IQV A;  3SPR A;  2C1N A;  1A4O A;  2C63 A;  1O9C A;  5EXA A;  3SMN A;  4QLI A;  3M50 A;  3P1R A;  3T0L A;  3UBW A;  2O98 A;  3EFZ A;  4IEA A;  4DHS A;  1IB1 A;  5LVZ A;  4FJ3 A;  4DHT A;  2BQ0 A;  4IHL A;  5D2D A;  4DHO A;  3P1O A;  3M51 A;  4FR3 A;  1QJB A;  2O02 A;  3SMM A;  4J6S A;  4BG6 A;  3P1P A;  3UX0 A;  4HKC A;  3SMK A;  3E6Y A;  2C1J A;  2V7D A;  4FL5 A;  5D3F A;  4O46 A;  3NKX A;  4N7Y A;  5LHO A;  3AXY C;  4ZDR A;  4DHR A;  3T0M A;  5LU2 A;  3O8I A;  5BY9 A;  4GNT A;  4DHP A;  5EWZ A;  4DAU A;  4DHM A; 
#chains in the Genus database with same CATH topology
 5HF3 A;  2C9K A;  4ARY A;  4DAT A;  4Y3B A;  4N84 A;  1W99 A;  4QX1 A;  5LU1 A;  4DHQ A;  5D3E A;  4MOA A;  1O9F A;  3CU8 A;  4WRQ A;  4Y32 A;  4QX2 A;  3UZD A;  4DHN A;  3P1Q A;  4D8M A;  3EB7 A;  4JC3 A;  1O9D A;  2C23 A;  1A38 A;  4ARX A;  2C74 A;  4Y5I A;  1JI6 A;  1A37 A;  4F7R A;  4DX0 A;  1I5P A;  5IQP A;  3CQG A;  3RDH A;  4ZQ0 A;  3IQJ A;  4QX3 A;  3IQU A;  4N7G A;  4JDD A;  1YWT A;  2O8P A;  3MHR A;  2B05 A;  4DNK A;  1DLC A;  1URJ A;  3P1S A;  3SML A;  5BTV A;  3U9X A;  3P1N A;  3SMO A;  4DHU A;  3UAL A;  5J31 A;  5F74 A;  5LX2 A;  2BR9 A;  1O9E A;  3SP5 A;  1YZ5 A;  4E2E A;  1QJA A;  2NPM A;  2BTP A;  2WH0 A;  3LW1 A;  3IQV A;  3SPR A;  2C1N A;  1A4O A;  2C63 A;  1O9C A;  5EXA A;  3SMN A;  4QLI A;  3M50 A;  3P1R A;  3T0L A;  1CIY A;  3UBW A;  2O98 A;  3EFZ A;  4IEA A;  4DHS A;  1IB1 A;  5LVZ A;  4FJ3 A;  4DHT A;  1S2X A;  2BQ0 A;  3I4R A;  4IHL A;  5D2D A;  4DHO A;  3P1O A;  3M51 A;  4FR3 A;  3CQC A;  1QJB A;  3X0U A;  2O02 A;  3SMM A;  4QX0 A;  3ZHE B;  4J6S A;  4BG6 A;  3P1P A;  3UX0 A;  4HKC A;  3SMK A;  3E6Y A;  2C1J A;  2V7D A;  4FL5 A;  5D3F A;  4O46 A;  3NKX A;  4N7Y A;  5LHO A;  3AXY C;  4ZDR A;  4DHR A;  3T0M A;  5LU2 A;  3O8I A;  5BY9 A;  4GNT A;  4DHP A;  5EWZ A;  4DAU A;  4DHM A;  4W8J A; 
#chains in the Genus database with same CATH homology
 5HF3 A;  4DAT A;  4Y3B A;  4N84 A;  5LU1 A;  4DHQ A;  5D3E A;  1O9F A;  3CU8 A;  4WRQ A;  4Y32 A;  3UZD A;  4DHN A;  3P1Q A;  4JC3 A;  1O9D A;  2C23 A;  1A38 A;  2C74 A;  4Y5I A;  1A37 A;  4F7R A;  4DX0 A;  5IQP A;  3RDH A;  4ZQ0 A;  3IQJ A;  3IQU A;  4N7G A;  4JDD A;  1YWT A;  2O8P A;  3MHR A;  2B05 A;  4DNK A;  3P1S A;  3SML A;  5BTV A;  3U9X A;  3P1N A;  3SMO A;  4DHU A;  3UAL A;  5J31 A;  5F74 A;  5LX2 A;  2BR9 A;  1O9E A;  3SP5 A;  1YZ5 A;  4E2E A;  1QJA A;  2NPM A;  2BTP A;  2WH0 A;  3LW1 A;  3IQV A;  3SPR A;  2C1N A;  1A4O A;  2C63 A;  1O9C A;  5EXA A;  3SMN A;  4QLI A;  3M50 A;  3P1R A;  3T0L A;  3UBW A;  2O98 A;  3EFZ A;  4IEA A;  4DHS A;  1IB1 A;  5LVZ A;  4FJ3 A;  4DHT A;  2BQ0 A;  4IHL A;  5D2D A;  4DHO A;  3P1O A;  3M51 A;  4FR3 A;  1QJB A;  2O02 A;  3SMM A;  4J6S A;  4BG6 A;  3P1P A;  3UX0 A;  4HKC A;  3SMK A;  3E6Y A;  2C1J A;  2V7D A;  4FL5 A;  5D3F A;  4O46 A;  3NKX A;  4N7Y A;  5LHO A;  3AXY C;  4ZDR A;  4DHR A;  3T0M A;  5LU2 A;  3O8I A;  5BY9 A;  4GNT A;  4DHP A;  5EWZ A;  4DAU A;  4DHM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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