4Y32A

Crystal structure of c-terminal modified tau peptide-hybrid 109b with 14-3-3sigma
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
236
structure length
235
Chain Sequence
GAMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Stabilizer-Guided Inhibition of Protein-Protein Interactions.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords 14-3-3 protein sigma
total genus 102
structure length 235
sequence length 236
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4y32A00
5J31A 4FL5A 4DNKA 3SMKA 4DHUA 4JC3A 1O9FA 4WRQA 3P1OA 1O9EA 4DHRA 3P1NA 4N84A 5HF3A 3P1SA 4DHQA 3E6YA 2NPMA 3UALA 3EFZA 4N7GA 2O98A 1A38A 1A37A 3CU8A 4DX0A 5F74A 3SMOA 5BY9A 5IQPA 4DHMA 5LHOA 1YWTA 1O9CA 4E2EA 3SPRA 3O8IA 2B05A 5LU1A 4JDDA 5BTVA 1QJAA 2BQ0A 4DHSA 3SMLA 4Y5IA 4IHLA 5D3FA 3U9XA 3LW1A 3AXYC 3T0LA 3UX0A 3SMMA 3SMNA 3SP5A 1A4OA 2C63A 2O02A 4DHPA 1YZ5A 4Y3BA 3M51A 4QLIA 3IQJA 1O9DA 2WH0A 4FR3A 4IEAA 3UZDA 4F7RA 5LX2A 3IQUA 5D3EA 5EWZA 4DHNA 1QJBA 1IB1A 2O8PA 3P1QA 4ZQ0A 4O46A 2C74A 3P1PA 3P1RA 4J6SA 5LU2A 2C1JA 3RDHA 3M50A 4DHTA 4ZDRA 4HKCA 4FJ3A 4DAUA 2BR9A 4DATA 3MHRA 3UBWA 3T0MA 4N7YA 2C23A 2C1NA 5EXAA 4DHOA 3IQVA 2BTPA 3NKXA 2V7DA 4GNTA 5D2DA 5LVZA 4BG6A 4Y32A
chains in the Genus database with same CATH superfamily
5J31A 4FL5A 4DNKA 1DLCA 3SMKA 3ZHEB 4DHUA 4JC3A 1O9FA 4WRQA 4QX3A 3P1OA 1O9EA 4DHRA 3P1NA 4N84A 5HF3A 3P1SA 4DHQA 3E6YA 2NPMA 4D8MA 1URJA 3UALA 3EFZA 4N7GA 2O98A 1A38A 1A37A 3CU8A 4DX0A 5F74A 3SMOA 1W99A 5BY9A 5IQPA 4DHMA 5LHOA 1S2XA 4QX1A 1YWTA 3CQCA 2C9KA 1O9CA 4E2EA 3SPRA 3O8IA 2B05A 5LU1A 4JDDA 5BTVA 1QJAA 2BQ0A 4MOAA 1CIYA 4DHSA 3SMLA 4Y5IA 4IHLA 3X0UA 5D3FA 4QX2A 3U9XA 3LW1A 3AXYC 3T0LA 3UX0A 3SMMA 3SMNA 3SP5A 1A4OA 2C63A 2O02A 4DHPA 1YZ5A 4Y3BA 3M51A 4QLIA 3IQJA 1O9DA 2WH0A 4FR3A 4IEAA 3UZDA 4QX0A 4F7RA 5LX2A 3IQUA 5D3EA 5EWZA 4DHNA 1QJBA 1IB1A 2O8PA 3P1QA 4ZQ0A 3I4RA 4O46A 2C74A 3P1PA 3P1RA 4J6SA 5LU2A 2C1JA 3RDHA 3M50A 4DHTA 1I5PA 4ZDRA 4HKCA 4FJ3A 4DAUA 2BR9A 3CQGA 4DATA 3MHRA 3UBWA 3T0MA 4W8JA 4N7YA 2C23A 2C1NA 4ARYA 5EXAA 4DHOA 3EB7A 3IQVA 2BTPA 3NKXA 2V7DA 4GNTA 5D2DA 4ARXA 5LVZA 4BG6A 1JI6A 4Y32A
chains in the Genus database with same CATH topology
5J31A 4FL5A 4DNKA 3SMKA 4DHUA 4JC3A 1O9FA 4WRQA 3P1OA 1O9EA 4DHRA 3P1NA 4N84A 5HF3A 3P1SA 4DHQA 3E6YA 2NPMA 3UALA 3EFZA 4N7GA 2O98A 1A38A 1A37A 3CU8A 4DX0A 5F74A 3SMOA 5BY9A 5IQPA 4DHMA 5LHOA 1YWTA 1O9CA 4E2EA 3SPRA 3O8IA 2B05A 5LU1A 4JDDA 5BTVA 1QJAA 2BQ0A 4DHSA 3SMLA 4Y5IA 4IHLA 5D3FA 3U9XA 3LW1A 3AXYC 3T0LA 3UX0A 3SMMA 3SMNA 3SP5A 1A4OA 2C63A 2O02A 4DHPA 1YZ5A 4Y3BA 3M51A 4QLIA 3IQJA 1O9DA 2WH0A 4FR3A 4IEAA 3UZDA 4F7RA 5LX2A 3IQUA 5D3EA 5EWZA 4DHNA 1QJBA 1IB1A 2O8PA 3P1QA 4ZQ0A 4O46A 2C74A 3P1PA 3P1RA 4J6SA 5LU2A 2C1JA 3RDHA 3M50A 4DHTA 4ZDRA 4HKCA 4FJ3A 4DAUA 2BR9A 4DATA 3MHRA 3UBWA 3T0MA 4N7YA 2C23A 2C1NA 5EXAA 4DHOA 3IQVA 2BTPA 3NKXA 2V7DA 4GNTA 5D2DA 5LVZA 4BG6A 4Y32A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5J31 A;  4FL5 A;  4DNK A;  3SMK A;  4DHU A;  4JC3 A;  1O9F A;  4WRQ A;  3P1O A;  1O9E A;  4DHR A;  3P1N A;  4N84 A;  5HF3 A;  3P1S A;  4DHQ A;  3E6Y A;  2NPM A;  3UAL A;  3EFZ A;  4N7G A;  2O98 A;  1A38 A;  1A37 A;  3CU8 A;  4DX0 A;  5F74 A;  3SMO A;  5BY9 A;  5IQP A;  4DHM A;  5LHO A;  1YWT A;  1O9C A;  4E2E A;  3SPR A;  3O8I A;  2B05 A;  5LU1 A;  4JDD A;  5BTV A;  1QJA A;  2BQ0 A;  4DHS A;  3SML A;  4Y5I A;  4IHL A;  5D3F A;  3U9X A;  3LW1 A;  3AXY C;  3T0L A;  3UX0 A;  3SMM A;  3SMN A;  3SP5 A;  1A4O A;  2C63 A;  2O02 A;  4DHP A;  1YZ5 A;  4Y3B A;  3M51 A;  4QLI A;  3IQJ A;  1O9D A;  2WH0 A;  4FR3 A;  4IEA A;  3UZD A;  4F7R A;  5LX2 A;  3IQU A;  5D3E A;  5EWZ A;  4DHN A;  1QJB A;  1IB1 A;  2O8P A;  3P1Q A;  4ZQ0 A;  4O46 A;  2C74 A;  3P1P A;  3P1R A;  4J6S A;  5LU2 A;  2C1J A;  3RDH A;  3M50 A;  4DHT A;  4ZDR A;  4HKC A;  4FJ3 A;  4DAU A;  2BR9 A;  4DAT A;  3MHR A;  3UBW A;  3T0M A;  4N7Y A;  2C23 A;  2C1N A;  5EXA A;  4DHO A;  3IQV A;  2BTP A;  3NKX A;  2V7D A;  4GNT A;  5D2D A;  5LVZ A;  4BG6 A;  4Y32 A; 
#chains in the Genus database with same CATH topology
 5J31 A;  4FL5 A;  4DNK A;  1DLC A;  3SMK A;  3ZHE B;  4DHU A;  4JC3 A;  1O9F A;  4WRQ A;  4QX3 A;  3P1O A;  1O9E A;  4DHR A;  3P1N A;  4N84 A;  5HF3 A;  3P1S A;  4DHQ A;  3E6Y A;  2NPM A;  4D8M A;  1URJ A;  3UAL A;  3EFZ A;  4N7G A;  2O98 A;  1A38 A;  1A37 A;  3CU8 A;  4DX0 A;  5F74 A;  3SMO A;  1W99 A;  5BY9 A;  5IQP A;  4DHM A;  5LHO A;  1S2X A;  4QX1 A;  1YWT A;  3CQC A;  2C9K A;  1O9C A;  4E2E A;  3SPR A;  3O8I A;  2B05 A;  5LU1 A;  4JDD A;  5BTV A;  1QJA A;  2BQ0 A;  4MOA A;  1CIY A;  4DHS A;  3SML A;  4Y5I A;  4IHL A;  3X0U A;  5D3F A;  4QX2 A;  3U9X A;  3LW1 A;  3AXY C;  3T0L A;  3UX0 A;  3SMM A;  3SMN A;  3SP5 A;  1A4O A;  2C63 A;  2O02 A;  4DHP A;  1YZ5 A;  4Y3B A;  3M51 A;  4QLI A;  3IQJ A;  1O9D A;  2WH0 A;  4FR3 A;  4IEA A;  3UZD A;  4QX0 A;  4F7R A;  5LX2 A;  3IQU A;  5D3E A;  5EWZ A;  4DHN A;  1QJB A;  1IB1 A;  2O8P A;  3P1Q A;  4ZQ0 A;  3I4R A;  4O46 A;  2C74 A;  3P1P A;  3P1R A;  4J6S A;  5LU2 A;  2C1J A;  3RDH A;  3M50 A;  4DHT A;  1I5P A;  4ZDR A;  4HKC A;  4FJ3 A;  4DAU A;  2BR9 A;  3CQG A;  4DAT A;  3MHR A;  3UBW A;  3T0M A;  4W8J A;  4N7Y A;  2C23 A;  2C1N A;  4ARY A;  5EXA A;  4DHO A;  3EB7 A;  3IQV A;  2BTP A;  3NKX A;  2V7D A;  4GNT A;  5D2D A;  4ARX A;  5LVZ A;  4BG6 A;  1JI6 A;  4Y32 A; 
#chains in the Genus database with same CATH homology
 5J31 A;  4FL5 A;  4DNK A;  3SMK A;  4DHU A;  4JC3 A;  1O9F A;  4WRQ A;  3P1O A;  1O9E A;  4DHR A;  3P1N A;  4N84 A;  5HF3 A;  3P1S A;  4DHQ A;  3E6Y A;  2NPM A;  3UAL A;  3EFZ A;  4N7G A;  2O98 A;  1A38 A;  1A37 A;  3CU8 A;  4DX0 A;  5F74 A;  3SMO A;  5BY9 A;  5IQP A;  4DHM A;  5LHO A;  1YWT A;  1O9C A;  4E2E A;  3SPR A;  3O8I A;  2B05 A;  5LU1 A;  4JDD A;  5BTV A;  1QJA A;  2BQ0 A;  4DHS A;  3SML A;  4Y5I A;  4IHL A;  5D3F A;  3U9X A;  3LW1 A;  3AXY C;  3T0L A;  3UX0 A;  3SMM A;  3SMN A;  3SP5 A;  1A4O A;  2C63 A;  2O02 A;  4DHP A;  1YZ5 A;  4Y3B A;  3M51 A;  4QLI A;  3IQJ A;  1O9D A;  2WH0 A;  4FR3 A;  4IEA A;  3UZD A;  4F7R A;  5LX2 A;  3IQU A;  5D3E A;  5EWZ A;  4DHN A;  1QJB A;  1IB1 A;  2O8P A;  3P1Q A;  4ZQ0 A;  4O46 A;  2C74 A;  3P1P A;  3P1R A;  4J6S A;  5LU2 A;  2C1J A;  3RDH A;  3M50 A;  4DHT A;  4ZDR A;  4HKC A;  4FJ3 A;  4DAU A;  2BR9 A;  4DAT A;  3MHR A;  3UBW A;  3T0M A;  4N7Y A;  2C23 A;  2C1N A;  5EXA A;  4DHO A;  3IQV A;  2BTP A;  3NKX A;  2V7D A;  4GNT A;  5D2D A;  5LVZ A;  4BG6 A;  4Y32 A; 
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similar chains in the Genus database (?% sequence similarity)
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