4D3CA

Crystal structure of the nk1 domain of hgf in complex with anti-hgf monoclonal antibody sfn68.
Total Genus 27
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
172
structure length
137
Chain Sequence
NTIHEFKKSAKTADQCANRCTRNKGLPFTCKAFVFCLWFPFNSMSDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist.
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords HEPATOCYTE GROWTH FACTOR
total genus 27
structure length 137
sequence length 172
ec nomenclature
pdb deposition date 2014-10-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4d3cA02
1KDUA 4HZHA 4BV7A 4BVVA 1URKA 1NK1A 1KI0A 1GP9A 5CSQA 1PK2A 2PF1A 5CT1A 4A5TS 2I9BA 2PF2A 1HPJA 4KIVA 1PMKA 2FD6A 3HN4A 4BVWA 2I9AA 2DOIA 1PMLA 5CT2A 3U73A 2KNFA 1CEAA 5COEA 1TPKA 1CEBA 1BHTA 5CT3A 2L0SA 2QJ4A 3BT2A 3E6PL 2FEBA 1JFNA 4DURA 2SPTA 3KIVA 2K4RA 1I5KA 4O03A 5HPGA 4BVCA 5CS1A 2KJ4A 1HPKA 5CS9A 4CIKA 1KRNA 1PK4A 1NL1A 3BT1A 3NXPA 3SP8A 1GMNA 1KIVA 1NL2A 1I71A 3LAQA 1B2IA 2PK4A 2K51A 3MKPA 2QJ2A 5CS3A 1GMOA 2DOHX 4D3CA 2HPPP 3K65A 2HPQP 5CP9A 1PKRA 4BVDA 5CS5A 4BV5A 4IUAA 1A0HA 4NZQA
chains in the Genus database with same CATH superfamily
1KDUA 4HZHA 4BV7A 4BVVA 1URKA 1NK1A 1KI0A 1GP9A 5CSQA 1PK2A 2PF1A 5CT1A 4A5TS 2I9BA 2PF2A 1HPJA 4KIVA 1PMKA 2FD6A 3HN4A 4BVWA 2I9AA 2DOIA 1PMLA 5CT2A 3U73A 2KNFA 1CEAA 5COEA 1TPKA 1CEBA 1BHTA 5CT3A 2L0SA 2QJ4A 3BT2A 3E6PL 2FEBA 1JFNA 4DURA 2SPTA 3KIVA 2K4RA 1I5KA 4O03A 5HPGA 4BVCA 5CS1A 2KJ4A 1HPKA 5CS9A 4CIKA 1KRNA 1PK4A 1NL1A 3BT1A 3NXPA 3SP8A 1GMNA 1KIVA 1NL2A 1I71A 3LAQA 1B2IA 2PK4A 2K51A 3MKPA 2QJ2A 5CS3A 1GMOA 2DOHX 4D3CA 2HPPP 3K65A 2HPQP 5CP9A 1PKRA 4BVDA 5CS5A 4BV5A 4IUAA 1A0HA 4NZQA
chains in the Genus database with same CATH topology
1KDUA 4HZHA 4BV7A 4BVVA 1URKA 1NK1A 1KI0A 1GP9A 5CSQA 1PK2A 2PF1A 5CT1A 4A5TS 2I9BA 2PF2A 1HPJA 4KIVA 1PMKA 2FD6A 3HN4A 4BVWA 2I9AA 2DOIA 1PMLA 5CT2A 3U73A 2KNFA 1CEAA 5COEA 1TPKA 1CEBA 1BHTA 5CT3A 2L0SA 2QJ4A 3BT2A 3E6PL 2FEBA 1JFNA 4DURA 2SPTA 3KIVA 2K4RA 1I5KA 4O03A 5HPGA 4BVCA 5CS1A 2KJ4A 1HPKA 5CS9A 4CIKA 1KRNA 1PK4A 1NL1A 3BT1A 3NXPA 3SP8A 1GMNA 1KIVA 1NL2A 1I71A 3LAQA 1B2IA 2PK4A 2K51A 3MKPA 2QJ2A 5CS3A 1GMOA 2DOHX 4D3CA 2HPPP 3K65A 2HPQP 5CP9A 1PKRA 4BVDA 5CS5A 4BV5A 4IUAA 1A0HA 4NZQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KDU A;  4HZH A;  4BV7 A;  4BVV A;  1URK A;  1NK1 A;  1KI0 A;  1GP9 A;  5CSQ A;  1PK2 A;  2PF1 A;  5CT1 A;  4A5T S;  2I9B A;  2PF2 A;  1HPJ A;  4KIV A;  1PMK A;  2FD6 A;  3HN4 A;  4BVW A;  2I9A A;  2DOI A;  1PML A;  5CT2 A;  3U73 A;  2KNF A;  1CEA A;  5COE A;  1TPK A;  1CEB A;  1BHT A;  5CT3 A;  2L0S A;  2QJ4 A;  3BT2 A;  3E6P L;  2FEB A;  1JFN A;  4DUR A;  2SPT A;  3KIV A;  2K4R A;  1I5K A;  4O03 A;  5HPG A;  4BVC A;  5CS1 A;  2KJ4 A;  1HPK A;  5CS9 A;  4CIK A;  1KRN A;  1PK4 A;  1NL1 A;  3BT1 A;  3NXP A;  3SP8 A;  1GMN A;  1KIV A;  1NL2 A;  1I71 A;  3LAQ A;  1B2I A;  2PK4 A;  2K51 A;  3MKP A;  2QJ2 A;  5CS3 A;  1GMO A;  2DOH X;  4D3C A;  2HPP P;  3K65 A;  2HPQ P;  5CP9 A;  1PKR A;  4BVD A;  5CS5 A;  4BV5 A;  4IUA A;  1A0H A;  4NZQ A; 
#chains in the Genus database with same CATH topology
 1KDU A;  4HZH A;  4BV7 A;  4BVV A;  1URK A;  1NK1 A;  1KI0 A;  1GP9 A;  5CSQ A;  1PK2 A;  2PF1 A;  5CT1 A;  4A5T S;  2I9B A;  2PF2 A;  1HPJ A;  4KIV A;  1PMK A;  2FD6 A;  3HN4 A;  4BVW A;  2I9A A;  2DOI A;  1PML A;  5CT2 A;  3U73 A;  2KNF A;  1CEA A;  5COE A;  1TPK A;  1CEB A;  1BHT A;  5CT3 A;  2L0S A;  2QJ4 A;  3BT2 A;  3E6P L;  2FEB A;  1JFN A;  4DUR A;  2SPT A;  3KIV A;  2K4R A;  1I5K A;  4O03 A;  5HPG A;  4BVC A;  5CS1 A;  2KJ4 A;  1HPK A;  5CS9 A;  4CIK A;  1KRN A;  1PK4 A;  1NL1 A;  3BT1 A;  3NXP A;  3SP8 A;  1GMN A;  1KIV A;  1NL2 A;  1I71 A;  3LAQ A;  1B2I A;  2PK4 A;  2K51 A;  3MKP A;  2QJ2 A;  5CS3 A;  1GMO A;  2DOH X;  4D3C A;  2HPP P;  3K65 A;  2HPQ P;  5CP9 A;  1PKR A;  4BVD A;  5CS5 A;  4BV5 A;  4IUA A;  1A0H A;  4NZQ A; 
#chains in the Genus database with same CATH homology
 1KDU A;  4HZH A;  4BV7 A;  4BVV A;  1URK A;  1NK1 A;  1KI0 A;  1GP9 A;  5CSQ A;  1PK2 A;  2PF1 A;  5CT1 A;  4A5T S;  2I9B A;  2PF2 A;  1HPJ A;  4KIV A;  1PMK A;  2FD6 A;  3HN4 A;  4BVW A;  2I9A A;  2DOI A;  1PML A;  5CT2 A;  3U73 A;  2KNF A;  1CEA A;  5COE A;  1TPK A;  1CEB A;  1BHT A;  5CT3 A;  2L0S A;  2QJ4 A;  3BT2 A;  3E6P L;  2FEB A;  1JFN A;  4DUR A;  2SPT A;  3KIV A;  2K4R A;  1I5K A;  4O03 A;  5HPG A;  4BVC A;  5CS1 A;  2KJ4 A;  1HPK A;  5CS9 A;  4CIK A;  1KRN A;  1PK4 A;  1NL1 A;  3BT1 A;  3NXP A;  3SP8 A;  1GMN A;  1KIV A;  1NL2 A;  1I71 A;  3LAQ A;  1B2I A;  2PK4 A;  2K51 A;  3MKP A;  2QJ2 A;  5CS3 A;  1GMO A;  2DOH X;  4D3C A;  2HPP P;  3K65 A;  2HPQ P;  5CP9 A;  1PKR A;  4BVD A;  5CS5 A;  4BV5 A;  4IUA A;  1A0H A;  4NZQ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...