1XTGA

Crystal structure of neurotoxin bont/a complexed with synaptosomal-associated protein 25
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
424
structure length
424
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHQLIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTFLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTPLVPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Toxin
source organism Clostridium botulinum
publication title Substrate recognition strategy for botulinum neurotoxin serotype A
pubmed doi rcsb
molecule keywords NEUROTOXIN BONT/A
total genus 128
structure length 424
sequence length 424
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2004-10-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 1xtgA00
1S0CA 2NZ9A 2G7PA 3QJ0A 2IMCA 4ZJXA 1E1HA 3QW5A 2W2DA 3DDBA 3C8AA 2G7NA 5BQMA 3C8BA 3ZURA 2IMBA 1S0GA 3BWIA 3DSEA 3FIEA 1S0FA 1S0EA 3VUOA 3DEBA 3ZUQA 2IMAA 4KS6A 1G9CA 2G7QA 1ZKXA 2ILPA 4ELCA 2FPQA 1F82A 3BOKA 3QW6A 3FFZA 3ZUSA 3K3QB 3BONA 3V0BA 3V0AA 2ISHA 4HEVA 1ZL5A 2A97A 2ISEA 1ZKWA 2NYYA 3C88A 2ETFA 1G9AA 1G9BA 3QW8A 1F31A 3QIYA 5BQNA 1T3AA 3NF3A 1YVGA 1I1EA 3V0BB 3V0AB 4ZKTB 3DS9A 1ZL6A 1XTGA 3DDAA 2ISGA 2G7KA 1XTFA 2QN0A 3C89A 3QIXA 3D3XA 1S0BA 1T3CA 3FIIA 1S0DA 1ZB7A 1ZN3A 3BOOA 4KTXA 2NP0A 2XHLA 4EL4A 3QW7A 4KUFA 3BTAA 4J1LA 1Z7HA 1EPWA 4EJ5A 2A8AA 3QIZA 1G9DA
chains in the Genus database with same CATH superfamily
1S0CA 2NZ9A 3CQBA 2G7PA 3QJ0A 2IMCA 4ZJXA 1E1HA 3QW5A 2W2DA 3DDBA 3C8AA 2G7NA 5BQMA 4JIUA 3C8BA 3ZURA 2IMBA 1S0GA 3BWIA 3DSEA 3FIEA 1S0FA 4JIXA 1S0EA 3VUOA 3DEBA 3ZUQA 2IMAA 4KS6A 1G9CA 2G7QA 1ZKXA 2ILPA 4ELCA 2FPQA 2YPTA 1F82A 3BOKA 3QW6A 3FFZA 3ZUSA 3K3QB 3BONA 3V0BA 3V0AA 2ISHA 4HEVA 1ZL5A 2A97A 2ISEA 1ZKWA 2NYYA 3C88A 2ETFA 2EJQA 1G9AA 1G9BA 3QW8A 1F31A 3QIYA 4QHFA 4IL3A 5BQNA 1T3AA 3NF3A 1YVGA 1I1EA 3V0BB 3V0AB 4ZKTB 3DS9A 1ZL6A 1XTGA 3DDAA 2ISGA 2G7KA 1XTFA 2QN0A 3C89A 3QIXA 3D3XA 1S0BA 1T3CA 3FIIA 1S0DA 1ZB7A 1ZN3A 3BOOA 4KTXA 2NP0A 3E11A 2XHLA 4AW6A 4EL4A 3QW7A 4KUFA 3BTAA 4J1LA 1Z7HA 1EPWA 4EJ5A 2A8AA 3QIZA 1G9DA
chains in the Genus database with same CATH topology
1S0CA 2NZ9A 2G7PA 3QJ0A 2IMCA 4ZJXA 1E1HA 3QW5A 2W2DA 3DDBA 3C8AA 2G7NA 5BQMA 3C8BA 3ZURA 2IMBA 1S0GA 3BWIA 3DSEA 3FIEA 1S0FA 1S0EA 3VUOA 3DEBA 3ZUQA 2IMAA 4KS6A 1G9CA 2G7QA 1ZKXA 2ILPA 4ELCA 2FPQA 1F82A 3BOKA 3QW6A 3FFZA 3ZUSA 3K3QB 3BONA 3V0BA 3V0AA 2ISHA 4HEVA 1ZL5A 2A97A 2ISEA 1ZKWA 2NYYA 3C88A 2ETFA 1G9AA 1G9BA 3QW8A 1F31A 3QIYA 5BQNA 1T3AA 3NF3A 1YVGA 1I1EA 3V0BB 3V0AB 4ZKTB 3DS9A 1ZL6A 1XTGA 3DDAA 2ISGA 2G7KA 1XTFA 2QN0A 3C89A 3QIXA 3D3XA 1S0BA 1T3CA 3FIIA 1S0DA 1ZB7A 1ZN3A 3BOOA 4KTXA 2NP0A 2XHLA 4EL4A 3QW7A 4KUFA 3BTAA 4J1LA 1Z7HA 1EPWA 4EJ5A 2A8AA 3QIZA 1G9DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S0C A;  2NZ9 A;  2G7P A;  3QJ0 A;  2IMC A;  4ZJX A;  1E1H A;  3QW5 A;  2W2D A;  3DDB A;  3C8A A;  2G7N A;  5BQM A;  3C8B A;  3ZUR A;  2IMB A;  1S0G A;  3BWI A;  3DSE A;  3FIE A;  1S0F A;  1S0E A;  3VUO A;  3DEB A;  3ZUQ A;  2IMA A;  4KS6 A;  1G9C A;  2G7Q A;  1ZKX A;  2ILP A;  4ELC A;  2FPQ A;  1F82 A;  3BOK A;  3QW6 A;  3FFZ A;  3ZUS A;  3K3Q B;  3BON A;  3V0B A;  3V0A A;  2ISH A;  4HEV A;  1ZL5 A;  2A97 A;  2ISE A;  1ZKW A;  2NYY A;  3C88 A;  2ETF A;  1G9A A;  1G9B A;  3QW8 A;  1F31 A;  3QIY A;  5BQN A;  1T3A A;  3NF3 A;  1YVG A;  1I1E A;  3V0B B;  3V0A B;  4ZKT B;  3DS9 A;  1ZL6 A;  1XTG A;  3DDA A;  2ISG A;  2G7K A;  1XTF A;  2QN0 A;  3C89 A;  3QIX A;  3D3X A;  1S0B A;  1T3C A;  3FII A;  1S0D A;  1ZB7 A;  1ZN3 A;  3BOO A;  4KTX A;  2NP0 A;  2XHL A;  4EL4 A;  3QW7 A;  4KUF A;  3BTA A;  4J1L A;  1Z7H A;  1EPW A;  4EJ5 A;  2A8A A;  3QIZ A;  1G9D A; 
#chains in the Genus database with same CATH topology
 1S0C A;  2NZ9 A;  3CQB A;  2G7P A;  3QJ0 A;  2IMC A;  4ZJX A;  1E1H A;  3QW5 A;  2W2D A;  3DDB A;  3C8A A;  2G7N A;  5BQM A;  4JIU A;  3C8B A;  3ZUR A;  2IMB A;  1S0G A;  3BWI A;  3DSE A;  3FIE A;  1S0F A;  4JIX A;  1S0E A;  3VUO A;  3DEB A;  3ZUQ A;  2IMA A;  4KS6 A;  1G9C A;  2G7Q A;  1ZKX A;  2ILP A;  4ELC A;  2FPQ A;  2YPT A;  1F82 A;  3BOK A;  3QW6 A;  3FFZ A;  3ZUS A;  3K3Q B;  3BON A;  3V0B A;  3V0A A;  2ISH A;  4HEV A;  1ZL5 A;  2A97 A;  2ISE A;  1ZKW A;  2NYY A;  3C88 A;  2ETF A;  2EJQ A;  1G9A A;  1G9B A;  3QW8 A;  1F31 A;  3QIY A;  4QHF A;  4IL3 A;  5BQN A;  1T3A A;  3NF3 A;  1YVG A;  1I1E A;  3V0B B;  3V0A B;  4ZKT B;  3DS9 A;  1ZL6 A;  1XTG A;  3DDA A;  2ISG A;  2G7K A;  1XTF A;  2QN0 A;  3C89 A;  3QIX A;  3D3X A;  1S0B A;  1T3C A;  3FII A;  1S0D A;  1ZB7 A;  1ZN3 A;  3BOO A;  4KTX A;  2NP0 A;  3E11 A;  2XHL A;  4AW6 A;  4EL4 A;  3QW7 A;  4KUF A;  3BTA A;  4J1L A;  1Z7H A;  1EPW A;  4EJ5 A;  2A8A A;  3QIZ A;  1G9D A; 
#chains in the Genus database with same CATH homology
 1S0C A;  2NZ9 A;  2G7P A;  3QJ0 A;  2IMC A;  4ZJX A;  1E1H A;  3QW5 A;  2W2D A;  3DDB A;  3C8A A;  2G7N A;  5BQM A;  3C8B A;  3ZUR A;  2IMB A;  1S0G A;  3BWI A;  3DSE A;  3FIE A;  1S0F A;  1S0E A;  3VUO A;  3DEB A;  3ZUQ A;  2IMA A;  4KS6 A;  1G9C A;  2G7Q A;  1ZKX A;  2ILP A;  4ELC A;  2FPQ A;  1F82 A;  3BOK A;  3QW6 A;  3FFZ A;  3ZUS A;  3K3Q B;  3BON A;  3V0B A;  3V0A A;  2ISH A;  4HEV A;  1ZL5 A;  2A97 A;  2ISE A;  1ZKW A;  2NYY A;  3C88 A;  2ETF A;  1G9A A;  1G9B A;  3QW8 A;  1F31 A;  3QIY A;  5BQN A;  1T3A A;  3NF3 A;  1YVG A;  1I1E A;  3V0B B;  3V0A B;  4ZKT B;  3DS9 A;  1ZL6 A;  1XTG A;  3DDA A;  2ISG A;  2G7K A;  1XTF A;  2QN0 A;  3C89 A;  3QIX A;  3D3X A;  1S0B A;  1T3C A;  3FII A;  1S0D A;  1ZB7 A;  1ZN3 A;  3BOO A;  4KTX A;  2NP0 A;  2XHL A;  4EL4 A;  3QW7 A;  4KUF A;  3BTA A;  4J1L A;  1Z7H A;  1EPW A;  4EJ5 A;  2A8A A;  3QIZ A;  1G9D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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