1XTGA

Crystal structure of neurotoxin bont/a complexed with synaptosomal-associated protein 25
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
424
structure length
424
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHQLIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTFLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTPLVPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substrate recognition strategy for botulinum neurotoxin serotype A
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords NEUROTOXIN BONT/A
total genus 128
structure length 424
sequence length 424
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2004-10-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 1xtgA00
3DEBA 1ZB7A 3ZUQA 1S0CA 1I1EA 2ISEA 2ISGA 4EJ5A 2G7KA 3QIYA 4KUFA 4KS6A 3BWIA 4KTXA 3QIXA 1YVGA 2IMBA 2ISHA 3C88A 2NP0A 2FPQA 2NYYA 3K3QB 1S0FA 2IMAA 2ETFA 3FIEA 3FFZA 3C8AA 1F31A 1G9CA 4ELCA 3ZURA 2A97A 2QN0A 2XHLA 1F82A 4J1LA 3V0AA 1ZN3A 1ZL6A 3V0BA 3C8BA 3QW5A 2G7QA 3BONA 1E1HA 1T3CA 1T3AA 3D3XA 3QW6A 3BOKA 3BTAA 5BQMA 3NF3A 2W2DA 3VUOA 1Z7HA 1ZKWA 3DSEA 1EPWA 2IMCA 1S0EA 1XTFA 4ZKTB 1ZKXA 3ZUSA 4HEVA 5BQNA 2G7NA 2ILPA 1G9DA 3DDBA 3DDAA 1S0GA 1G9BA 1G9AA 1XTGA 3QJ0A 1S0BA 1S0DA 2NZ9A 3C89A 2G7PA 3DS9A 2A8AA 3BOOA 3QW7A 3V0AB 3QIZA 3QW8A 3V0BB 4ZJXA 1ZL5A 4EL4A 3FIIA
chains in the Genus database with same CATH superfamily
3DEBA 1ZB7A 4JIXA 3ZUQA 4AW6A 1S0CA 1I1EA 2ISEA 2ISGA 4EJ5A 2G7KA 3QIYA 4KUFA 4KS6A 3BWIA 4KTXA 3QIXA 1YVGA 2IMBA 2ISHA 3C88A 2NP0A 2FPQA 2NYYA 3K3QB 1S0FA 2IMAA 2ETFA 3FIEA 3FFZA 3C8AA 4JIUA 1F31A 4IL3A 1G9CA 4ELCA 3ZURA 2A97A 2QN0A 2XHLA 4QHFA 1F82A 4J1LA 3V0AA 2EJQA 1ZN3A 1ZL6A 3V0BA 3C8BA 3QW5A 2G7QA 3BONA 1E1HA 1T3CA 1T3AA 3D3XA 3QW6A 3BOKA 3BTAA 5BQMA 3NF3A 2W2DA 3VUOA 3CQBA 1Z7HA 1ZKWA 3DSEA 1EPWA 2IMCA 1S0EA 1XTFA 4ZKTB 1ZKXA 3ZUSA 4HEVA 5BQNA 2G7NA 2ILPA 1G9DA 3DDBA 3DDAA 1S0GA 1G9BA 1G9AA 1XTGA 3QJ0A 1S0BA 1S0DA 2NZ9A 3C89A 2YPTA 2G7PA 3DS9A 2A8AA 3BOOA 3QW7A 3V0AB 3E11A 3QIZA 3QW8A 3V0BB 4ZJXA 1ZL5A 4EL4A 3FIIA
chains in the Genus database with same CATH topology
3DEBA 1ZB7A 3ZUQA 1S0CA 1I1EA 2ISEA 2ISGA 4EJ5A 2G7KA 3QIYA 4KUFA 4KS6A 3BWIA 4KTXA 3QIXA 1YVGA 2IMBA 2ISHA 3C88A 2NP0A 2FPQA 2NYYA 3K3QB 1S0FA 2IMAA 2ETFA 3FIEA 3FFZA 3C8AA 1F31A 1G9CA 4ELCA 3ZURA 2A97A 2QN0A 2XHLA 1F82A 4J1LA 3V0AA 1ZN3A 1ZL6A 3V0BA 3C8BA 3QW5A 2G7QA 3BONA 1E1HA 1T3CA 1T3AA 3D3XA 3QW6A 3BOKA 3BTAA 5BQMA 3NF3A 2W2DA 3VUOA 1Z7HA 1ZKWA 3DSEA 1EPWA 2IMCA 1S0EA 1XTFA 4ZKTB 1ZKXA 3ZUSA 4HEVA 5BQNA 2G7NA 2ILPA 1G9DA 3DDBA 3DDAA 1S0GA 1G9BA 1G9AA 1XTGA 3QJ0A 1S0BA 1S0DA 2NZ9A 3C89A 2G7PA 3DS9A 2A8AA 3BOOA 3QW7A 3V0AB 3QIZA 3QW8A 3V0BB 4ZJXA 1ZL5A 4EL4A 3FIIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3DEB A;  1ZB7 A;  3ZUQ A;  1S0C A;  1I1E A;  2ISE A;  2ISG A;  4EJ5 A;  2G7K A;  3QIY A;  4KUF A;  4KS6 A;  3BWI A;  4KTX A;  3QIX A;  1YVG A;  2IMB A;  2ISH A;  3C88 A;  2NP0 A;  2FPQ A;  2NYY A;  3K3Q B;  1S0F A;  2IMA A;  2ETF A;  3FIE A;  3FFZ A;  3C8A A;  1F31 A;  1G9C A;  4ELC A;  3ZUR A;  2A97 A;  2QN0 A;  2XHL A;  1F82 A;  4J1L A;  3V0A A;  1ZN3 A;  1ZL6 A;  3V0B A;  3C8B A;  3QW5 A;  2G7Q A;  3BON A;  1E1H A;  1T3C A;  1T3A A;  3D3X A;  3QW6 A;  3BOK A;  3BTA A;  5BQM A;  3NF3 A;  2W2D A;  3VUO A;  1Z7H A;  1ZKW A;  3DSE A;  1EPW A;  2IMC A;  1S0E A;  1XTF A;  4ZKT B;  1ZKX A;  3ZUS A;  4HEV A;  5BQN A;  2G7N A;  2ILP A;  1G9D A;  3DDB A;  3DDA A;  1S0G A;  1G9B A;  1G9A A;  1XTG A;  3QJ0 A;  1S0B A;  1S0D A;  2NZ9 A;  3C89 A;  2G7P A;  3DS9 A;  2A8A A;  3BOO A;  3QW7 A;  3V0A B;  3QIZ A;  3QW8 A;  3V0B B;  4ZJX A;  1ZL5 A;  4EL4 A;  3FII A; 
#chains in the Genus database with same CATH topology
 3DEB A;  1ZB7 A;  4JIX A;  3ZUQ A;  4AW6 A;  1S0C A;  1I1E A;  2ISE A;  2ISG A;  4EJ5 A;  2G7K A;  3QIY A;  4KUF A;  4KS6 A;  3BWI A;  4KTX A;  3QIX A;  1YVG A;  2IMB A;  2ISH A;  3C88 A;  2NP0 A;  2FPQ A;  2NYY A;  3K3Q B;  1S0F A;  2IMA A;  2ETF A;  3FIE A;  3FFZ A;  3C8A A;  4JIU A;  1F31 A;  4IL3 A;  1G9C A;  4ELC A;  3ZUR A;  2A97 A;  2QN0 A;  2XHL A;  4QHF A;  1F82 A;  4J1L A;  3V0A A;  2EJQ A;  1ZN3 A;  1ZL6 A;  3V0B A;  3C8B A;  3QW5 A;  2G7Q A;  3BON A;  1E1H A;  1T3C A;  1T3A A;  3D3X A;  3QW6 A;  3BOK A;  3BTA A;  5BQM A;  3NF3 A;  2W2D A;  3VUO A;  3CQB A;  1Z7H A;  1ZKW A;  3DSE A;  1EPW A;  2IMC A;  1S0E A;  1XTF A;  4ZKT B;  1ZKX A;  3ZUS A;  4HEV A;  5BQN A;  2G7N A;  2ILP A;  1G9D A;  3DDB A;  3DDA A;  1S0G A;  1G9B A;  1G9A A;  1XTG A;  3QJ0 A;  1S0B A;  1S0D A;  2NZ9 A;  3C89 A;  2YPT A;  2G7P A;  3DS9 A;  2A8A A;  3BOO A;  3QW7 A;  3V0A B;  3E11 A;  3QIZ A;  3QW8 A;  3V0B B;  4ZJX A;  1ZL5 A;  4EL4 A;  3FII A; 
#chains in the Genus database with same CATH homology
 3DEB A;  1ZB7 A;  3ZUQ A;  1S0C A;  1I1E A;  2ISE A;  2ISG A;  4EJ5 A;  2G7K A;  3QIY A;  4KUF A;  4KS6 A;  3BWI A;  4KTX A;  3QIX A;  1YVG A;  2IMB A;  2ISH A;  3C88 A;  2NP0 A;  2FPQ A;  2NYY A;  3K3Q B;  1S0F A;  2IMA A;  2ETF A;  3FIE A;  3FFZ A;  3C8A A;  1F31 A;  1G9C A;  4ELC A;  3ZUR A;  2A97 A;  2QN0 A;  2XHL A;  1F82 A;  4J1L A;  3V0A A;  1ZN3 A;  1ZL6 A;  3V0B A;  3C8B A;  3QW5 A;  2G7Q A;  3BON A;  1E1H A;  1T3C A;  1T3A A;  3D3X A;  3QW6 A;  3BOK A;  3BTA A;  5BQM A;  3NF3 A;  2W2D A;  3VUO A;  1Z7H A;  1ZKW A;  3DSE A;  1EPW A;  2IMC A;  1S0E A;  1XTF A;  4ZKT B;  1ZKX A;  3ZUS A;  4HEV A;  5BQN A;  2G7N A;  2ILP A;  1G9D A;  3DDB A;  3DDA A;  1S0G A;  1G9B A;  1G9A A;  1XTG A;  3QJ0 A;  1S0B A;  1S0D A;  2NZ9 A;  3C89 A;  2G7P A;  3DS9 A;  2A8A A;  3BOO A;  3QW7 A;  3V0A B;  3QIZ A;  3QW8 A;  3V0B B;  4ZJX A;  1ZL5 A;  4EL4 A;  3FII A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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