1ZL6A

Crystal structure of tyr350ala mutant of clostridium botulinum neurotoxin e catalytic domain
Total Genus 136
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
136
sequence length
411
structure length
400
Chain Sequence
PKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGTTPQDFHPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGGILLEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQDILLPNVIIMGAEPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSMNEFIQDPALTLMHELIHSLHGLYGAKGITTKYTITGTNIEEFLTFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVFEAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQTAIGQYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPITGRGLVKKIIRFC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords botulinum neurotoxin type E
total genus 136
structure length 400
sequence length 411
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2005-05-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 1zl6A00
2ISEA 3V0AA 2G7PA 3DS9A 5BQNA 1S0CA 2IMAA 1ZB7A 1G9BA 3DDAA 3DDBA 2A8AA 2NYYA 1S0BA 1ZL5A 3QIZA 3VUOA 1YVGA 1S0FA 4KS6A 1G9AA 1F31A 3BWIA 1ZL6A 1S0DA 3C89A 3ZURA 3QW5A 1E1HA 5BQMA 2ILPA 1G9CA 1S0GA 4KTXA 3BTAA 3QW7A 2ISGA 3QW6A 1G9DA 1EPWA 4J1LA 4KUFA 1T3CA 4ELCA 3DEBA 3C8AA 3QIYA 3QIXA 2ISHA 3QJ0A 4HEVA 3BONA 3FFZA 2W2DA 2G7KA 2A97A 4EJ5A 2IMBA 3K3QB 2IMCA 3D3XA 2G7NA 1I1EA 1XTFA 3BOOA 3V0BB 4ZKTB 1ZKWA 4ZJXA 3FIEA 2NZ9A 2ETFA 1T3AA 1Z7HA 3C8BA 4EL4A 1ZKXA 2G7QA 1ZN3A 1XTGA 2QN0A 1F82A 3ZUSA 1S0EA 2NP0A 3BOKA 2XHLA 3DSEA 3QW8A 2FPQA 3FIIA 3ZUQA 3NF3A 3C88A 3V0AB 3V0BA
chains in the Genus database with same CATH superfamily
2ISEA 3V0AA 2G7PA 4JIUA 3DS9A 5BQNA 1S0CA 2IMAA 1ZB7A 1G9BA 3DDAA 4QHFA 3DDBA 2A8AA 2NYYA 1S0BA 1ZL5A 3QIZA 3VUOA 1YVGA 1S0FA 4KS6A 1G9AA 1F31A 3BWIA 3E11A 1ZL6A 1S0DA 3C89A 3ZURA 3QW5A 1E1HA 5BQMA 3CQBA 2ILPA 1G9CA 1S0GA 4KTXA 3BTAA 3QW7A 2ISGA 3QW6A 1G9DA 1EPWA 2EJQA 4J1LA 4KUFA 1T3CA 4ELCA 3DEBA 3C8AA 3QIYA 3QIXA 4IL3A 2ISHA 3QJ0A 4HEVA 3BONA 3FFZA 2W2DA 2G7KA 2A97A 4EJ5A 2IMBA 3K3QB 2IMCA 3D3XA 2G7NA 1I1EA 1XTFA 4JIXA 3BOOA 3V0BB 4ZKTB 1ZKWA 4ZJXA 3FIEA 2NZ9A 2ETFA 1T3AA 1Z7HA 3C8BA 4EL4A 1ZKXA 2G7QA 1ZN3A 1XTGA 2QN0A 1F82A 3ZUSA 1S0EA 2NP0A 3BOKA 2XHLA 3DSEA 3QW8A 2FPQA 3FIIA 3ZUQA 3NF3A 3C88A 4AW6A 2YPTA 3V0AB 3V0BA
chains in the Genus database with same CATH topology
2ISEA 3V0AA 2G7PA 3DS9A 5BQNA 1S0CA 2IMAA 1ZB7A 1G9BA 3DDAA 3DDBA 2A8AA 2NYYA 1S0BA 1ZL5A 3QIZA 3VUOA 1YVGA 1S0FA 4KS6A 1G9AA 1F31A 3BWIA 1ZL6A 1S0DA 3C89A 3ZURA 3QW5A 1E1HA 5BQMA 2ILPA 1G9CA 1S0GA 4KTXA 3BTAA 3QW7A 2ISGA 3QW6A 1G9DA 1EPWA 4J1LA 4KUFA 1T3CA 4ELCA 3DEBA 3C8AA 3QIYA 3QIXA 2ISHA 3QJ0A 4HEVA 3BONA 3FFZA 2W2DA 2G7KA 2A97A 4EJ5A 2IMBA 3K3QB 2IMCA 3D3XA 2G7NA 1I1EA 1XTFA 3BOOA 3V0BB 4ZKTB 1ZKWA 4ZJXA 3FIEA 2NZ9A 2ETFA 1T3AA 1Z7HA 3C8BA 4EL4A 1ZKXA 2G7QA 1ZN3A 1XTGA 2QN0A 1F82A 3ZUSA 1S0EA 2NP0A 3BOKA 2XHLA 3DSEA 3QW8A 2FPQA 3FIIA 3ZUQA 3NF3A 3C88A 3V0AB 3V0BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ISE A;  3V0A A;  2G7P A;  3DS9 A;  5BQN A;  1S0C A;  2IMA A;  1ZB7 A;  1G9B A;  3DDA A;  3DDB A;  2A8A A;  2NYY A;  1S0B A;  1ZL5 A;  3QIZ A;  3VUO A;  1YVG A;  1S0F A;  4KS6 A;  1G9A A;  1F31 A;  3BWI A;  1ZL6 A;  1S0D A;  3C89 A;  3ZUR A;  3QW5 A;  1E1H A;  5BQM A;  2ILP A;  1G9C A;  1S0G A;  4KTX A;  3BTA A;  3QW7 A;  2ISG A;  3QW6 A;  1G9D A;  1EPW A;  4J1L A;  4KUF A;  1T3C A;  4ELC A;  3DEB A;  3C8A A;  3QIY A;  3QIX A;  2ISH A;  3QJ0 A;  4HEV A;  3BON A;  3FFZ A;  2W2D A;  2G7K A;  2A97 A;  4EJ5 A;  2IMB A;  3K3Q B;  2IMC A;  3D3X A;  2G7N A;  1I1E A;  1XTF A;  3BOO A;  3V0B B;  4ZKT B;  1ZKW A;  4ZJX A;  3FIE A;  2NZ9 A;  2ETF A;  1T3A A;  1Z7H A;  3C8B A;  4EL4 A;  1ZKX A;  2G7Q A;  1ZN3 A;  1XTG A;  2QN0 A;  1F82 A;  3ZUS A;  1S0E A;  2NP0 A;  3BOK A;  2XHL A;  3DSE A;  3QW8 A;  2FPQ A;  3FII A;  3ZUQ A;  3NF3 A;  3C88 A;  3V0A B;  3V0B A; 
#chains in the Genus database with same CATH topology
 2ISE A;  3V0A A;  2G7P A;  4JIU A;  3DS9 A;  5BQN A;  1S0C A;  2IMA A;  1ZB7 A;  1G9B A;  3DDA A;  4QHF A;  3DDB A;  2A8A A;  2NYY A;  1S0B A;  1ZL5 A;  3QIZ A;  3VUO A;  1YVG A;  1S0F A;  4KS6 A;  1G9A A;  1F31 A;  3BWI A;  3E11 A;  1ZL6 A;  1S0D A;  3C89 A;  3ZUR A;  3QW5 A;  1E1H A;  5BQM A;  3CQB A;  2ILP A;  1G9C A;  1S0G A;  4KTX A;  3BTA A;  3QW7 A;  2ISG A;  3QW6 A;  1G9D A;  1EPW A;  2EJQ A;  4J1L A;  4KUF A;  1T3C A;  4ELC A;  3DEB A;  3C8A A;  3QIY A;  3QIX A;  4IL3 A;  2ISH A;  3QJ0 A;  4HEV A;  3BON A;  3FFZ A;  2W2D A;  2G7K A;  2A97 A;  4EJ5 A;  2IMB A;  3K3Q B;  2IMC A;  3D3X A;  2G7N A;  1I1E A;  1XTF A;  4JIX A;  3BOO A;  3V0B B;  4ZKT B;  1ZKW A;  4ZJX A;  3FIE A;  2NZ9 A;  2ETF A;  1T3A A;  1Z7H A;  3C8B A;  4EL4 A;  1ZKX A;  2G7Q A;  1ZN3 A;  1XTG A;  2QN0 A;  1F82 A;  3ZUS A;  1S0E A;  2NP0 A;  3BOK A;  2XHL A;  3DSE A;  3QW8 A;  2FPQ A;  3FII A;  3ZUQ A;  3NF3 A;  3C88 A;  4AW6 A;  2YPT A;  3V0A B;  3V0B A; 
#chains in the Genus database with same CATH homology
 2ISE A;  3V0A A;  2G7P A;  3DS9 A;  5BQN A;  1S0C A;  2IMA A;  1ZB7 A;  1G9B A;  3DDA A;  3DDB A;  2A8A A;  2NYY A;  1S0B A;  1ZL5 A;  3QIZ A;  3VUO A;  1YVG A;  1S0F A;  4KS6 A;  1G9A A;  1F31 A;  3BWI A;  1ZL6 A;  1S0D A;  3C89 A;  3ZUR A;  3QW5 A;  1E1H A;  5BQM A;  2ILP A;  1G9C A;  1S0G A;  4KTX A;  3BTA A;  3QW7 A;  2ISG A;  3QW6 A;  1G9D A;  1EPW A;  4J1L A;  4KUF A;  1T3C A;  4ELC A;  3DEB A;  3C8A A;  3QIY A;  3QIX A;  2ISH A;  3QJ0 A;  4HEV A;  3BON A;  3FFZ A;  2W2D A;  2G7K A;  2A97 A;  4EJ5 A;  2IMB A;  3K3Q B;  2IMC A;  3D3X A;  2G7N A;  1I1E A;  1XTF A;  3BOO A;  3V0B B;  4ZKT B;  1ZKW A;  4ZJX A;  3FIE A;  2NZ9 A;  2ETF A;  1T3A A;  1Z7H A;  3C8B A;  4EL4 A;  1ZKX A;  2G7Q A;  1ZN3 A;  1XTG A;  2QN0 A;  1F82 A;  3ZUS A;  1S0E A;  2NP0 A;  3BOK A;  2XHL A;  3DSE A;  3QW8 A;  2FPQ A;  3FII A;  3ZUQ A;  3NF3 A;  3C88 A;  3V0A B;  3V0B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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