3BOKA

Structure of the c. botulinum neurotoxin serotype a apo-enzyme
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
423
structure length
416
Chain Sequence
MQFVNKQFNYKDPVNGVDIAYIKIPQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords Neurotoxin A
total genus 148
structure length 416
sequence length 423
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2007-12-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3bokA00
1XTFA 1EPWA 3DDBA 2IMBA 1ZL6A 2QN0A 3ZUQA 2G7PA 2ISHA 2IMCA 3NF3A 4EL4A 1ZL5A 3FIEA 2ISEA 3C89A 3FFZA 1S0DA 4ZJXA 2NYYA 4HEVA 3DDAA 4EJ5A 1S0CA 1T3CA 1F31A 3FIIA 2IMAA 3K3QB 3QIYA 1T3AA 1ZN3A 4KTXA 2NZ9A 1XTGA 2FPQA 3V0AB 3C8BA 1I1EA 1S0BA 3QW7A 1S0EA 2ETFA 2A8AA 3QW5A 1G9DA 3V0BA 3DEBA 3BOOA 1ZKWA 4ZKTB 3BONA 1S0GA 3BWIA 2NP0A 1ZKXA 2XHLA 3BTAA 2W2DA 1G9CA 3ZURA 1S0FA 3VUOA 4KUFA 1F82A 3DS9A 1YVGA 3QJ0A 4ELCA 3DSEA 2G7KA 1G9AA 3QW8A 2G7QA 1Z7HA 3QIXA 2ILPA 5BQNA 4KS6A 1E1HA 2G7NA 3BOKA 2ISGA 3D3XA 3ZUSA 3C88A 3V0BB 5BQMA 3QW6A 1G9BA 4J1LA 3C8AA 3V0AA 3QIZA 1ZB7A 2A97A
chains in the Genus database with same CATH superfamily
1XTFA 1EPWA 3DDBA 2IMBA 3CQBA 1ZL6A 2QN0A 3ZUQA 2G7PA 4IL3A 2ISHA 2IMCA 3NF3A 4EL4A 1ZL5A 3FIEA 2ISEA 3C89A 3FFZA 1S0DA 4ZJXA 2NYYA 4HEVA 3DDAA 4EJ5A 1S0CA 1T3CA 1F31A 3FIIA 2IMAA 3K3QB 3QIYA 1T3AA 1ZN3A 4KTXA 2NZ9A 1XTGA 2FPQA 3V0AB 3C8BA 1I1EA 1S0BA 3QW7A 1S0EA 2ETFA 2A8AA 3QW5A 1G9DA 3V0BA 3DEBA 3BOOA 1ZKWA 4ZKTB 3BONA 1S0GA 3BWIA 2NP0A 1ZKXA 2XHLA 3BTAA 2W2DA 1G9CA 3ZURA 1S0FA 3VUOA 4KUFA 1F82A 3DS9A 4QHFA 1YVGA 3QJ0A 4ELCA 3DSEA 2G7KA 1G9AA 3QW8A 2G7QA 1Z7HA 3QIXA 2ILPA 2EJQA 5BQNA 4KS6A 4JIUA 1E1HA 2G7NA 3BOKA 2ISGA 3E11A 2YPTA 3D3XA 4JIXA 3ZUSA 3C88A 3V0BB 5BQMA 3QW6A 1G9BA 4J1LA 3C8AA 3V0AA 3QIZA 1ZB7A 2A97A 4AW6A
chains in the Genus database with same CATH topology
1XTFA 1EPWA 3DDBA 2IMBA 1ZL6A 2QN0A 3ZUQA 2G7PA 2ISHA 2IMCA 3NF3A 4EL4A 1ZL5A 3FIEA 2ISEA 3C89A 3FFZA 1S0DA 4ZJXA 2NYYA 4HEVA 3DDAA 4EJ5A 1S0CA 1T3CA 1F31A 3FIIA 2IMAA 3K3QB 3QIYA 1T3AA 1ZN3A 4KTXA 2NZ9A 1XTGA 2FPQA 3V0AB 3C8BA 1I1EA 1S0BA 3QW7A 1S0EA 2ETFA 2A8AA 3QW5A 1G9DA 3V0BA 3DEBA 3BOOA 1ZKWA 4ZKTB 3BONA 1S0GA 3BWIA 2NP0A 1ZKXA 2XHLA 3BTAA 2W2DA 1G9CA 3ZURA 1S0FA 3VUOA 4KUFA 1F82A 3DS9A 1YVGA 3QJ0A 4ELCA 3DSEA 2G7KA 1G9AA 3QW8A 2G7QA 1Z7HA 3QIXA 2ILPA 5BQNA 4KS6A 1E1HA 2G7NA 3BOKA 2ISGA 3D3XA 3ZUSA 3C88A 3V0BB 5BQMA 3QW6A 1G9BA 4J1LA 3C8AA 3V0AA 3QIZA 1ZB7A 2A97A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XTF A;  1EPW A;  3DDB A;  2IMB A;  1ZL6 A;  2QN0 A;  3ZUQ A;  2G7P A;  2ISH A;  2IMC A;  3NF3 A;  4EL4 A;  1ZL5 A;  3FIE A;  2ISE A;  3C89 A;  3FFZ A;  1S0D A;  4ZJX A;  2NYY A;  4HEV A;  3DDA A;  4EJ5 A;  1S0C A;  1T3C A;  1F31 A;  3FII A;  2IMA A;  3K3Q B;  3QIY A;  1T3A A;  1ZN3 A;  4KTX A;  2NZ9 A;  1XTG A;  2FPQ A;  3V0A B;  3C8B A;  1I1E A;  1S0B A;  3QW7 A;  1S0E A;  2ETF A;  2A8A A;  3QW5 A;  1G9D A;  3V0B A;  3DEB A;  3BOO A;  1ZKW A;  4ZKT B;  3BON A;  1S0G A;  3BWI A;  2NP0 A;  1ZKX A;  2XHL A;  3BTA A;  2W2D A;  1G9C A;  3ZUR A;  1S0F A;  3VUO A;  4KUF A;  1F82 A;  3DS9 A;  1YVG A;  3QJ0 A;  4ELC A;  3DSE A;  2G7K A;  1G9A A;  3QW8 A;  2G7Q A;  1Z7H A;  3QIX A;  2ILP A;  5BQN A;  4KS6 A;  1E1H A;  2G7N A;  3BOK A;  2ISG A;  3D3X A;  3ZUS A;  3C88 A;  3V0B B;  5BQM A;  3QW6 A;  1G9B A;  4J1L A;  3C8A A;  3V0A A;  3QIZ A;  1ZB7 A;  2A97 A; 
#chains in the Genus database with same CATH topology
 1XTF A;  1EPW A;  3DDB A;  2IMB A;  3CQB A;  1ZL6 A;  2QN0 A;  3ZUQ A;  2G7P A;  4IL3 A;  2ISH A;  2IMC A;  3NF3 A;  4EL4 A;  1ZL5 A;  3FIE A;  2ISE A;  3C89 A;  3FFZ A;  1S0D A;  4ZJX A;  2NYY A;  4HEV A;  3DDA A;  4EJ5 A;  1S0C A;  1T3C A;  1F31 A;  3FII A;  2IMA A;  3K3Q B;  3QIY A;  1T3A A;  1ZN3 A;  4KTX A;  2NZ9 A;  1XTG A;  2FPQ A;  3V0A B;  3C8B A;  1I1E A;  1S0B A;  3QW7 A;  1S0E A;  2ETF A;  2A8A A;  3QW5 A;  1G9D A;  3V0B A;  3DEB A;  3BOO A;  1ZKW A;  4ZKT B;  3BON A;  1S0G A;  3BWI A;  2NP0 A;  1ZKX A;  2XHL A;  3BTA A;  2W2D A;  1G9C A;  3ZUR A;  1S0F A;  3VUO A;  4KUF A;  1F82 A;  3DS9 A;  4QHF A;  1YVG A;  3QJ0 A;  4ELC A;  3DSE A;  2G7K A;  1G9A A;  3QW8 A;  2G7Q A;  1Z7H A;  3QIX A;  2ILP A;  2EJQ A;  5BQN A;  4KS6 A;  4JIU A;  1E1H A;  2G7N A;  3BOK A;  2ISG A;  3E11 A;  2YPT A;  3D3X A;  4JIX A;  3ZUS A;  3C88 A;  3V0B B;  5BQM A;  3QW6 A;  1G9B A;  4J1L A;  3C8A A;  3V0A A;  3QIZ A;  1ZB7 A;  2A97 A;  4AW6 A; 
#chains in the Genus database with same CATH homology
 1XTF A;  1EPW A;  3DDB A;  2IMB A;  1ZL6 A;  2QN0 A;  3ZUQ A;  2G7P A;  2ISH A;  2IMC A;  3NF3 A;  4EL4 A;  1ZL5 A;  3FIE A;  2ISE A;  3C89 A;  3FFZ A;  1S0D A;  4ZJX A;  2NYY A;  4HEV A;  3DDA A;  4EJ5 A;  1S0C A;  1T3C A;  1F31 A;  3FII A;  2IMA A;  3K3Q B;  3QIY A;  1T3A A;  1ZN3 A;  4KTX A;  2NZ9 A;  1XTG A;  2FPQ A;  3V0A B;  3C8B A;  1I1E A;  1S0B A;  3QW7 A;  1S0E A;  2ETF A;  2A8A A;  3QW5 A;  1G9D A;  3V0B A;  3DEB A;  3BOO A;  1ZKW A;  4ZKT B;  3BON A;  1S0G A;  3BWI A;  2NP0 A;  1ZKX A;  2XHL A;  3BTA A;  2W2D A;  1G9C A;  3ZUR A;  1S0F A;  3VUO A;  4KUF A;  1F82 A;  3DS9 A;  1YVG A;  3QJ0 A;  4ELC A;  3DSE A;  2G7K A;  1G9A A;  3QW8 A;  2G7Q A;  1Z7H A;  3QIX A;  2ILP A;  5BQN A;  4KS6 A;  1E1H A;  2G7N A;  3BOK A;  2ISG A;  3D3X A;  3ZUS A;  3C88 A;  3V0B B;  5BQM A;  3QW6 A;  1G9B A;  4J1L A;  3C8A A;  3V0A A;  3QIZ A;  1ZB7 A;  2A97 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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