3BOKA

Structure of the c. botulinum neurotoxin serotype a apo-enzyme
Total Genus 148
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
148
sequence length
423
structure length
416
Chain Sequence
MQFVNKQFNYKDPVNGVDIAYIKIPQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Toxin
molecule keywords Neurotoxin A
publication title Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex.
pubmed doi rcsb
source organism Clostridium botulinum
total genus 148
structure length 416
sequence length 423
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2007-12-17
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3bokA00
3C88A 3QW7A 3C8AA 2G7QA 2IMCA 4KS6A 2IMBA 3QIYA 3V0AA 3QIXA 1ZB7A 3FFZA 1G9DA 1S0EA 3QW8A 1G9CA 1G9AA 3V0BA 1S0DA 2G7NA 1XTFA 3ZUQA 4ELCA 1S0BA 3V0BB 3DSEA 3DDAA 1ZKXA 1S0FA 2QN0A 1ZN3A 2ETFA 2NP0A 2A97A 2ILPA 1ZL6A 3QJ0A 1F31A 3K3QB 3NF3A 4EL4A 3V0AB 5BQNA 4EJ5A 4KUFA 2ISHA 1G9BA 4HEVA 3ZUSA 4ZKTB 1ZL5A 1YVGA 2G7KA 1S0CA 3QW5A 3BTAA 3BWIA 4ZJXA 2G7PA 1XTGA 2FPQA 3QIZA 5BQMA 3BOOA 1ZKWA 3FIEA 2W2DA 4J1LA 1I1EA 1T3AA 3C89A 3DS9A 3BOKA 3VUOA 4KTXA 1EPWA 1E1HA 3FIIA 3C8BA 2IMAA 3DEBA 3D3XA 2A8AA 1Z7HA 2ISEA 1T3CA 2XHLA 2NYYA 3BONA 2ISGA 1F82A 3ZURA 3DDBA 2NZ9A 1S0GA 3QW6A
chains in the Genus database with same CATH superfamily
3C88A 3QW7A 3C8AA 2G7QA 2IMCA 4KS6A 4AW6A 2IMBA 3QIYA 3V0AA 3QIXA 1ZB7A 3FFZA 1G9DA 1S0EA 3QW8A 1G9CA 1G9AA 3V0BA 1S0DA 2G7NA 1XTFA 3ZUQA 4JIUA 2EJQA 4ELCA 1S0BA 3V0BB 3DSEA 3DDAA 1ZKXA 1S0FA 2QN0A 1ZN3A 2ETFA 2NP0A 2A97A 4QHFA 2ILPA 3CQBA 1ZL6A 3QJ0A 1F31A 3K3QB 2YPTA 3NF3A 4EL4A 3V0AB 5BQNA 4EJ5A 4IL3A 4KUFA 2ISHA 1G9BA 4HEVA 3ZUSA 4ZKTB 1ZL5A 1YVGA 2G7KA 1S0CA 3QW5A 3BTAA 3BWIA 4ZJXA 2G7PA 4JIXA 1XTGA 2FPQA 3QIZA 5BQMA 3BOOA 1ZKWA 3FIEA 2W2DA 4J1LA 1I1EA 1T3AA 3C89A 3DS9A 3BOKA 3VUOA 4KTXA 1EPWA 1E1HA 3FIIA 3C8BA 2IMAA 3DEBA 3D3XA 2A8AA 1Z7HA 2ISEA 1T3CA 2XHLA 2NYYA 3BONA 2ISGA 1F82A 3ZURA 3DDBA 2NZ9A 1S0GA 3E11A 3QW6A
chains in the Genus database with same CATH topology
3C88A 3QW7A 3C8AA 2G7QA 2IMCA 4KS6A 2IMBA 3QIYA 3V0AA 3QIXA 1ZB7A 3FFZA 1G9DA 1S0EA 3QW8A 1G9CA 1G9AA 3V0BA 1S0DA 2G7NA 1XTFA 3ZUQA 4ELCA 1S0BA 3V0BB 3DSEA 3DDAA 1ZKXA 1S0FA 2QN0A 1ZN3A 2ETFA 2NP0A 2A97A 2ILPA 1ZL6A 3QJ0A 1F31A 3K3QB 3NF3A 4EL4A 3V0AB 5BQNA 4EJ5A 4KUFA 2ISHA 1G9BA 4HEVA 3ZUSA 4ZKTB 1ZL5A 1YVGA 2G7KA 1S0CA 3QW5A 3BTAA 3BWIA 4ZJXA 2G7PA 1XTGA 2FPQA 3QIZA 5BQMA 3BOOA 1ZKWA 3FIEA 2W2DA 4J1LA 1I1EA 1T3AA 3C89A 3DS9A 3BOKA 3VUOA 4KTXA 1EPWA 1E1HA 3FIIA 3C8BA 2IMAA 3DEBA 3D3XA 2A8AA 1Z7HA 2ISEA 1T3CA 2XHLA 2NYYA 3BONA 2ISGA 1F82A 3ZURA 3DDBA 2NZ9A 1S0GA 3QW6A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3C88 A;  3QW7 A;  3C8A A;  2G7Q A;  2IMC A;  4KS6 A;  2IMB A;  3QIY A;  3V0A A;  3QIX A;  1ZB7 A;  3FFZ A;  1G9D A;  1S0E A;  3QW8 A;  1G9C A;  1G9A A;  3V0B A;  1S0D A;  2G7N A;  1XTF A;  3ZUQ A;  4ELC A;  1S0B A;  3V0B B;  3DSE A;  3DDA A;  1ZKX A;  1S0F A;  2QN0 A;  1ZN3 A;  2ETF A;  2NP0 A;  2A97 A;  2ILP A;  1ZL6 A;  3QJ0 A;  1F31 A;  3K3Q B;  3NF3 A;  4EL4 A;  3V0A B;  5BQN A;  4EJ5 A;  4KUF A;  2ISH A;  1G9B A;  4HEV A;  3ZUS A;  4ZKT B;  1ZL5 A;  1YVG A;  2G7K A;  1S0C A;  3QW5 A;  3BTA A;  3BWI A;  4ZJX A;  2G7P A;  1XTG A;  2FPQ A;  3QIZ A;  5BQM A;  3BOO A;  1ZKW A;  3FIE A;  2W2D A;  4J1L A;  1I1E A;  1T3A A;  3C89 A;  3DS9 A;  3BOK A;  3VUO A;  4KTX A;  1EPW A;  1E1H A;  3FII A;  3C8B A;  2IMA A;  3DEB A;  3D3X A;  2A8A A;  1Z7H A;  2ISE A;  1T3C A;  2XHL A;  2NYY A;  3BON A;  2ISG A;  1F82 A;  3ZUR A;  3DDB A;  2NZ9 A;  1S0G A;  3QW6 A; 
#chains in the Genus database with same CATH topology
 3C88 A;  3QW7 A;  3C8A A;  2G7Q A;  2IMC A;  4KS6 A;  4AW6 A;  2IMB A;  3QIY A;  3V0A A;  3QIX A;  1ZB7 A;  3FFZ A;  1G9D A;  1S0E A;  3QW8 A;  1G9C A;  1G9A A;  3V0B A;  1S0D A;  2G7N A;  1XTF A;  3ZUQ A;  4JIU A;  2EJQ A;  4ELC A;  1S0B A;  3V0B B;  3DSE A;  3DDA A;  1ZKX A;  1S0F A;  2QN0 A;  1ZN3 A;  2ETF A;  2NP0 A;  2A97 A;  4QHF A;  2ILP A;  3CQB A;  1ZL6 A;  3QJ0 A;  1F31 A;  3K3Q B;  2YPT A;  3NF3 A;  4EL4 A;  3V0A B;  5BQN A;  4EJ5 A;  4IL3 A;  4KUF A;  2ISH A;  1G9B A;  4HEV A;  3ZUS A;  4ZKT B;  1ZL5 A;  1YVG A;  2G7K A;  1S0C A;  3QW5 A;  3BTA A;  3BWI A;  4ZJX A;  2G7P A;  4JIX A;  1XTG A;  2FPQ A;  3QIZ A;  5BQM A;  3BOO A;  1ZKW A;  3FIE A;  2W2D A;  4J1L A;  1I1E A;  1T3A A;  3C89 A;  3DS9 A;  3BOK A;  3VUO A;  4KTX A;  1EPW A;  1E1H A;  3FII A;  3C8B A;  2IMA A;  3DEB A;  3D3X A;  2A8A A;  1Z7H A;  2ISE A;  1T3C A;  2XHL A;  2NYY A;  3BON A;  2ISG A;  1F82 A;  3ZUR A;  3DDB A;  2NZ9 A;  1S0G A;  3E11 A;  3QW6 A; 
#chains in the Genus database with same CATH homology
 3C88 A;  3QW7 A;  3C8A A;  2G7Q A;  2IMC A;  4KS6 A;  2IMB A;  3QIY A;  3V0A A;  3QIX A;  1ZB7 A;  3FFZ A;  1G9D A;  1S0E A;  3QW8 A;  1G9C A;  1G9A A;  3V0B A;  1S0D A;  2G7N A;  1XTF A;  3ZUQ A;  4ELC A;  1S0B A;  3V0B B;  3DSE A;  3DDA A;  1ZKX A;  1S0F A;  2QN0 A;  1ZN3 A;  2ETF A;  2NP0 A;  2A97 A;  2ILP A;  1ZL6 A;  3QJ0 A;  1F31 A;  3K3Q B;  3NF3 A;  4EL4 A;  3V0A B;  5BQN A;  4EJ5 A;  4KUF A;  2ISH A;  1G9B A;  4HEV A;  3ZUS A;  4ZKT B;  1ZL5 A;  1YVG A;  2G7K A;  1S0C A;  3QW5 A;  3BTA A;  3BWI A;  4ZJX A;  2G7P A;  1XTG A;  2FPQ A;  3QIZ A;  5BQM A;  3BOO A;  1ZKW A;  3FIE A;  2W2D A;  4J1L A;  1I1E A;  1T3A A;  3C89 A;  3DS9 A;  3BOK A;  3VUO A;  4KTX A;  1EPW A;  1E1H A;  3FII A;  3C8B A;  2IMA A;  3DEB A;  3D3X A;  2A8A A;  1Z7H A;  2ISE A;  1T3C A;  2XHL A;  2NYY A;  3BON A;  2ISG A;  1F82 A;  3ZUR A;  3DDB A;  2NZ9 A;  1S0G A;  3QW6 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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