3NF3A

Crystal structure of bont/a lc with jth-nb-7239 peptide
Total Genus 127
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
127
sequence length
417
structure length
392
Chain Sequence
MPFVNKQFNYKDPVNGVDIAYIKIPNQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEEGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Clostridium botulinum
molecule keywords BoNT/A
total genus 127
structure length 392
sequence length 417
ec nomenclature
pdb deposition date 2010-06-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 3nf3A00
4EJ5A 1S0DA 3C89A 3BWIA 1S0FA 2G7PA 3QIZA 1G9DA 2FPQA 1E1HA 2G7KA 3QIXA 3QW7A 2IMBA 1ZKXA 1XTGA 2ISHA 3QW5A 3ZUSA 3V0AB 3FIIA 3ZUQA 1G9CA 3DSEA 2NP0A 3QW6A 3QW8A 5BQMA 4KUFA 1T3AA 2QN0A 1EPWA 4J1LA 3FFZA 3C8BA 1S0EA 2A8AA 4ZJXA 1Z7HA 1G9AA 3VUOA 1S0CA 1ZL6A 2ETFA 4ELCA 3BOOA 2ISGA 3K3QB 4KS6A 2IMCA 1F31A 1ZB7A 3DEBA 1XTFA 1ZKWA 2W2DA 3C88A 1ZL5A 4EL4A 2G7QA 3NF3A 3V0BB 4ZKTB 3ZURA 3FIEA 2ILPA 3DS9A 3BTAA 2NYYA 3DDAA 1I1EA 1G9BA 1F82A 3DDBA 1ZN3A 3C8AA 3BONA 2G7NA 3QJ0A 2IMAA 3V0AA 2ISEA 3D3XA 1S0BA 5BQNA 4KTXA 2A97A 3BOKA 2XHLA 2NZ9A 1T3CA 4HEVA 1YVGA 3QIYA 3V0BA 1S0GA
chains in the Genus database with same CATH superfamily
4EJ5A 1S0DA 3C89A 3BWIA 1S0FA 2G7PA 3QIZA 1G9DA 2FPQA 1E1HA 2G7KA 3QIXA 3QW7A 2IMBA 1ZKXA 1XTGA 2ISHA 3QW5A 3ZUSA 3V0AB 3FIIA 3ZUQA 1G9CA 4JIUA 3DSEA 2NP0A 3QW6A 3QW8A 5BQMA 4KUFA 1T3AA 2QN0A 1EPWA 4J1LA 3FFZA 3C8BA 1S0EA 2A8AA 4AW6A 4ZJXA 1Z7HA 1G9AA 3VUOA 1S0CA 1ZL6A 2ETFA 4ELCA 3BOOA 2ISGA 3K3QB 4KS6A 2IMCA 2YPTA 1F31A 1ZB7A 3DEBA 1XTFA 1ZKWA 2W2DA 3C88A 1ZL5A 4EL4A 2G7QA 3NF3A 3V0BB 4ZKTB 3ZURA 3FIEA 2ILPA 4JIXA 3DS9A 3BTAA 2NYYA 3DDAA 1I1EA 4QHFA 1F82A 1G9BA 3DDBA 1ZN3A 3C8AA 3BONA 2G7NA 3QJ0A 2IMAA 3V0AA 2ISEA 3D3XA 1S0BA 5BQNA 4KTXA 2A97A 3BOKA 2XHLA 3E11A 2NZ9A 3CQBA 2EJQA 1T3CA 4HEVA 1YVGA 3QIYA 3V0BA 4IL3A 1S0GA
chains in the Genus database with same CATH topology
4EJ5A 1S0DA 3C89A 3BWIA 1S0FA 2G7PA 3QIZA 1G9DA 2FPQA 1E1HA 2G7KA 3QIXA 3QW7A 2IMBA 1ZKXA 1XTGA 2ISHA 3QW5A 3ZUSA 3V0AB 3FIIA 3ZUQA 1G9CA 3DSEA 2NP0A 3QW6A 3QW8A 5BQMA 4KUFA 1T3AA 2QN0A 1EPWA 4J1LA 3FFZA 3C8BA 1S0EA 2A8AA 4ZJXA 1Z7HA 1G9AA 3VUOA 1S0CA 1ZL6A 2ETFA 4ELCA 3BOOA 2ISGA 3K3QB 4KS6A 2IMCA 1F31A 1ZB7A 3DEBA 1XTFA 1ZKWA 2W2DA 3C88A 1ZL5A 4EL4A 2G7QA 3NF3A 3V0BB 4ZKTB 3ZURA 3FIEA 2ILPA 3DS9A 3BTAA 2NYYA 3DDAA 1I1EA 1G9BA 1F82A 3DDBA 1ZN3A 3C8AA 3BONA 2G7NA 3QJ0A 2IMAA 3V0AA 2ISEA 3D3XA 1S0BA 5BQNA 4KTXA 2A97A 3BOKA 2XHLA 2NZ9A 1T3CA 4HEVA 1YVGA 3QIYA 3V0BA 1S0GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EJ5 A;  1S0D A;  3C89 A;  3BWI A;  1S0F A;  2G7P A;  3QIZ A;  1G9D A;  2FPQ A;  1E1H A;  2G7K A;  3QIX A;  3QW7 A;  2IMB A;  1ZKX A;  1XTG A;  2ISH A;  3QW5 A;  3ZUS A;  3V0A B;  3FII A;  3ZUQ A;  1G9C A;  3DSE A;  2NP0 A;  3QW6 A;  3QW8 A;  5BQM A;  4KUF A;  1T3A A;  2QN0 A;  1EPW A;  4J1L A;  3FFZ A;  3C8B A;  1S0E A;  2A8A A;  4ZJX A;  1Z7H A;  1G9A A;  3VUO A;  1S0C A;  1ZL6 A;  2ETF A;  4ELC A;  3BOO A;  2ISG A;  3K3Q B;  4KS6 A;  2IMC A;  1F31 A;  1ZB7 A;  3DEB A;  1XTF A;  1ZKW A;  2W2D A;  3C88 A;  1ZL5 A;  4EL4 A;  2G7Q A;  3NF3 A;  3V0B B;  4ZKT B;  3ZUR A;  3FIE A;  2ILP A;  3DS9 A;  3BTA A;  2NYY A;  3DDA A;  1I1E A;  1G9B A;  1F82 A;  3DDB A;  1ZN3 A;  3C8A A;  3BON A;  2G7N A;  3QJ0 A;  2IMA A;  3V0A A;  2ISE A;  3D3X A;  1S0B A;  5BQN A;  4KTX A;  2A97 A;  3BOK A;  2XHL A;  2NZ9 A;  1T3C A;  4HEV A;  1YVG A;  3QIY A;  3V0B A;  1S0G A; 
#chains in the Genus database with same CATH topology
 4EJ5 A;  1S0D A;  3C89 A;  3BWI A;  1S0F A;  2G7P A;  3QIZ A;  1G9D A;  2FPQ A;  1E1H A;  2G7K A;  3QIX A;  3QW7 A;  2IMB A;  1ZKX A;  1XTG A;  2ISH A;  3QW5 A;  3ZUS A;  3V0A B;  3FII A;  3ZUQ A;  1G9C A;  4JIU A;  3DSE A;  2NP0 A;  3QW6 A;  3QW8 A;  5BQM A;  4KUF A;  1T3A A;  2QN0 A;  1EPW A;  4J1L A;  3FFZ A;  3C8B A;  1S0E A;  2A8A A;  4AW6 A;  4ZJX A;  1Z7H A;  1G9A A;  3VUO A;  1S0C A;  1ZL6 A;  2ETF A;  4ELC A;  3BOO A;  2ISG A;  3K3Q B;  4KS6 A;  2IMC A;  2YPT A;  1F31 A;  1ZB7 A;  3DEB A;  1XTF A;  1ZKW A;  2W2D A;  3C88 A;  1ZL5 A;  4EL4 A;  2G7Q A;  3NF3 A;  3V0B B;  4ZKT B;  3ZUR A;  3FIE A;  2ILP A;  4JIX A;  3DS9 A;  3BTA A;  2NYY A;  3DDA A;  1I1E A;  4QHF A;  1F82 A;  1G9B A;  3DDB A;  1ZN3 A;  3C8A A;  3BON A;  2G7N A;  3QJ0 A;  2IMA A;  3V0A A;  2ISE A;  3D3X A;  1S0B A;  5BQN A;  4KTX A;  2A97 A;  3BOK A;  2XHL A;  3E11 A;  2NZ9 A;  3CQB A;  2EJQ A;  1T3C A;  4HEV A;  1YVG A;  3QIY A;  3V0B A;  4IL3 A;  1S0G A; 
#chains in the Genus database with same CATH homology
 4EJ5 A;  1S0D A;  3C89 A;  3BWI A;  1S0F A;  2G7P A;  3QIZ A;  1G9D A;  2FPQ A;  1E1H A;  2G7K A;  3QIX A;  3QW7 A;  2IMB A;  1ZKX A;  1XTG A;  2ISH A;  3QW5 A;  3ZUS A;  3V0A B;  3FII A;  3ZUQ A;  1G9C A;  3DSE A;  2NP0 A;  3QW6 A;  3QW8 A;  5BQM A;  4KUF A;  1T3A A;  2QN0 A;  1EPW A;  4J1L A;  3FFZ A;  3C8B A;  1S0E A;  2A8A A;  4ZJX A;  1Z7H A;  1G9A A;  3VUO A;  1S0C A;  1ZL6 A;  2ETF A;  4ELC A;  3BOO A;  2ISG A;  3K3Q B;  4KS6 A;  2IMC A;  1F31 A;  1ZB7 A;  3DEB A;  1XTF A;  1ZKW A;  2W2D A;  3C88 A;  1ZL5 A;  4EL4 A;  2G7Q A;  3NF3 A;  3V0B B;  4ZKT B;  3ZUR A;  3FIE A;  2ILP A;  3DS9 A;  3BTA A;  2NYY A;  3DDA A;  1I1E A;  1G9B A;  1F82 A;  3DDB A;  1ZN3 A;  3C8A A;  3BON A;  2G7N A;  3QJ0 A;  2IMA A;  3V0A A;  2ISE A;  3D3X A;  1S0B A;  5BQN A;  4KTX A;  2A97 A;  3BOK A;  2XHL A;  2NZ9 A;  1T3C A;  4HEV A;  1YVG A;  3QIY A;  3V0B A;  1S0G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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