1YVGA

Structural analysis of the catalytic domain of tetanus neurotoxin
Total Genus 125
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
426
structure length
397
Chain Sequence
PITINNFRYSDPVNNDTIIMMEPPYCKGLDIYYKAFKITDRIWIVPERYEFGTKPEDFNPPSSASEYYDPNYLRTDSDKDRFLQTMVKLFNRIKNNVAGEALLDKIINAIPYLGNSYSLLDKFDTNSNSVSFNLLEQDPSGATTKSAMLTNLIIFGPGPVLNKNEVRGIVLRVDNKNYFPCRDGFGSIMQMAFCPEYVPTFDNSKYFQDPALLLMHELIHVLHGLYGMQVSSHEIPISAEELFTFGGQDANLISIDIKNDLYEKTLNDYKAIANKLSQVTSCNDPNIDIDSYKQIYQQKYQFDKDSNGQYIVNEDKFQILYNSIMYGFTEIELGKKFNIKTRLSYFSMNHDPVKIPNLLDDTIYNDTEGFNIESKDLKSEYKGQNMRVNTNAFRNVD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural analysis of the catalytic domain of tetanus neurotoxin.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium tetani
molecule keywords Tetanus toxin, light chain
total genus 125
structure length 397
sequence length 426
ec nomenclature ec 3.4.24.68: Tentoxilysin.
pdb deposition date 2005-02-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 1yvgA00
1S0DA 2XHLA 1YVGA 2W2DA 3QIZA 3QIXA 2G7KA 3FFZA 4EL4A 1G9CA 4KS6A 4EJ5A 1ZKWA 2G7NA 3DDAA 3BOKA 1S0BA 2IMAA 1XTGA 1S0FA 2A8AA 1G9AA 3BOOA 2ISGA 3ZUSA 3K3QB 3V0AA 3V0BA 3FIEA 1T3CA 2QN0A 3QW5A 3FIIA 2ETFA 1ZKXA 1S0EA 1G9DA 3VUOA 2NZ9A 3C8BA 3BWIA 2A97A 2IMBA 4ELCA 4HEVA 5BQNA 3DSEA 2NP0A 1T3AA 3QW6A 3QW8A 3ZURA 1ZN3A 3DEBA 1ZL5A 1S0CA 2G7QA 3QJ0A 1Z7HA 2IMCA 3C8AA 4ZJXA 3QIYA 1G9BA 2FPQA 2ISHA 3BTAA 3NF3A 5BQMA 3V0BB 2ISEA 3C88A 3DDBA 2NYYA 3D3XA 3QW7A 4ZKTB 1S0GA 1E1HA 3C89A 1I1EA 1F31A 3DS9A 4J1LA 1EPWA 3BONA 4KTXA 1XTFA 1ZB7A 4KUFA 1F82A 3ZUQA 3V0AB 1ZL6A 2G7PA 2ILPA
chains in the Genus database with same CATH superfamily
1S0DA 2XHLA 1YVGA 2W2DA 3QIZA 3QIXA 2G7KA 3FFZA 4EL4A 1G9CA 4KS6A 4EJ5A 1ZKWA 3CQBA 2G7NA 3DDAA 3BOKA 1S0BA 2IMAA 1XTGA 1S0FA 2A8AA 1G9AA 3BOOA 2ISGA 4AW6A 3K3QB 3ZUSA 3V0AA 3V0BA 3FIEA 1T3CA 2QN0A 3QW5A 3FIIA 4JIUA 2ETFA 1ZKXA 1S0EA 1G9DA 3VUOA 2NZ9A 3C8BA 3BWIA 2A97A 2IMBA 4IL3A 4ELCA 3E11A 4HEVA 5BQNA 3DSEA 2NP0A 1T3AA 3QW6A 2YPTA 3QW8A 3ZURA 1ZN3A 3DEBA 1ZL5A 1S0CA 2G7QA 3QJ0A 1Z7HA 2IMCA 2EJQA 3C8AA 4ZJXA 3QIYA 1G9BA 2FPQA 2ISHA 3BTAA 3NF3A 4QHFA 5BQMA 3V0BB 2ISEA 3C88A 3DDBA 4JIXA 2NYYA 3D3XA 3QW7A 4ZKTB 1S0GA 1E1HA 3C89A 1I1EA 1F31A 3DS9A 4J1LA 1EPWA 3BONA 4KTXA 1XTFA 1ZB7A 4KUFA 1F82A 3ZUQA 3V0AB 1ZL6A 2G7PA 2ILPA
chains in the Genus database with same CATH topology
1S0DA 2XHLA 1YVGA 2W2DA 3QIZA 3QIXA 2G7KA 3FFZA 4EL4A 1G9CA 4KS6A 4EJ5A 1ZKWA 2G7NA 3DDAA 3BOKA 1S0BA 2IMAA 1XTGA 1S0FA 2A8AA 1G9AA 3BOOA 2ISGA 3ZUSA 3K3QB 3V0AA 3V0BA 3FIEA 1T3CA 2QN0A 3QW5A 3FIIA 2ETFA 1ZKXA 1S0EA 1G9DA 3VUOA 2NZ9A 3C8BA 3BWIA 2A97A 2IMBA 4ELCA 4HEVA 5BQNA 3DSEA 2NP0A 1T3AA 3QW6A 3QW8A 3ZURA 1ZN3A 3DEBA 1ZL5A 1S0CA 2G7QA 3QJ0A 1Z7HA 2IMCA 3C8AA 4ZJXA 3QIYA 1G9BA 2FPQA 2ISHA 3BTAA 3NF3A 5BQMA 3V0BB 2ISEA 3C88A 3DDBA 2NYYA 3D3XA 3QW7A 4ZKTB 1S0GA 1E1HA 3C89A 1I1EA 1F31A 3DS9A 4J1LA 1EPWA 3BONA 4KTXA 1XTFA 1ZB7A 4KUFA 1F82A 3ZUQA 3V0AB 1ZL6A 2G7PA 2ILPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S0D A;  2XHL A;  1YVG A;  2W2D A;  3QIZ A;  3QIX A;  2G7K A;  3FFZ A;  4EL4 A;  1G9C A;  4KS6 A;  4EJ5 A;  1ZKW A;  2G7N A;  3DDA A;  3BOK A;  1S0B A;  2IMA A;  1XTG A;  1S0F A;  2A8A A;  1G9A A;  3BOO A;  2ISG A;  3ZUS A;  3K3Q B;  3V0A A;  3V0B A;  3FIE A;  1T3C A;  2QN0 A;  3QW5 A;  3FII A;  2ETF A;  1ZKX A;  1S0E A;  1G9D A;  3VUO A;  2NZ9 A;  3C8B A;  3BWI A;  2A97 A;  2IMB A;  4ELC A;  4HEV A;  5BQN A;  3DSE A;  2NP0 A;  1T3A A;  3QW6 A;  3QW8 A;  3ZUR A;  1ZN3 A;  3DEB A;  1ZL5 A;  1S0C A;  2G7Q A;  3QJ0 A;  1Z7H A;  2IMC A;  3C8A A;  4ZJX A;  3QIY A;  1G9B A;  2FPQ A;  2ISH A;  3BTA A;  3NF3 A;  5BQM A;  3V0B B;  2ISE A;  3C88 A;  3DDB A;  2NYY A;  3D3X A;  3QW7 A;  4ZKT B;  1S0G A;  1E1H A;  3C89 A;  1I1E A;  1F31 A;  3DS9 A;  4J1L A;  1EPW A;  3BON A;  4KTX A;  1XTF A;  1ZB7 A;  4KUF A;  1F82 A;  3ZUQ A;  3V0A B;  1ZL6 A;  2G7P A;  2ILP A; 
#chains in the Genus database with same CATH topology
 1S0D A;  2XHL A;  1YVG A;  2W2D A;  3QIZ A;  3QIX A;  2G7K A;  3FFZ A;  4EL4 A;  1G9C A;  4KS6 A;  4EJ5 A;  1ZKW A;  3CQB A;  2G7N A;  3DDA A;  3BOK A;  1S0B A;  2IMA A;  1XTG A;  1S0F A;  2A8A A;  1G9A A;  3BOO A;  2ISG A;  4AW6 A;  3K3Q B;  3ZUS A;  3V0A A;  3V0B A;  3FIE A;  1T3C A;  2QN0 A;  3QW5 A;  3FII A;  4JIU A;  2ETF A;  1ZKX A;  1S0E A;  1G9D A;  3VUO A;  2NZ9 A;  3C8B A;  3BWI A;  2A97 A;  2IMB A;  4IL3 A;  4ELC A;  3E11 A;  4HEV A;  5BQN A;  3DSE A;  2NP0 A;  1T3A A;  3QW6 A;  2YPT A;  3QW8 A;  3ZUR A;  1ZN3 A;  3DEB A;  1ZL5 A;  1S0C A;  2G7Q A;  3QJ0 A;  1Z7H A;  2IMC A;  2EJQ A;  3C8A A;  4ZJX A;  3QIY A;  1G9B A;  2FPQ A;  2ISH A;  3BTA A;  3NF3 A;  4QHF A;  5BQM A;  3V0B B;  2ISE A;  3C88 A;  3DDB A;  4JIX A;  2NYY A;  3D3X A;  3QW7 A;  4ZKT B;  1S0G A;  1E1H A;  3C89 A;  1I1E A;  1F31 A;  3DS9 A;  4J1L A;  1EPW A;  3BON A;  4KTX A;  1XTF A;  1ZB7 A;  4KUF A;  1F82 A;  3ZUQ A;  3V0A B;  1ZL6 A;  2G7P A;  2ILP A; 
#chains in the Genus database with same CATH homology
 1S0D A;  2XHL A;  1YVG A;  2W2D A;  3QIZ A;  3QIX A;  2G7K A;  3FFZ A;  4EL4 A;  1G9C A;  4KS6 A;  4EJ5 A;  1ZKW A;  2G7N A;  3DDA A;  3BOK A;  1S0B A;  2IMA A;  1XTG A;  1S0F A;  2A8A A;  1G9A A;  3BOO A;  2ISG A;  3ZUS A;  3K3Q B;  3V0A A;  3V0B A;  3FIE A;  1T3C A;  2QN0 A;  3QW5 A;  3FII A;  2ETF A;  1ZKX A;  1S0E A;  1G9D A;  3VUO A;  2NZ9 A;  3C8B A;  3BWI A;  2A97 A;  2IMB A;  4ELC A;  4HEV A;  5BQN A;  3DSE A;  2NP0 A;  1T3A A;  3QW6 A;  3QW8 A;  3ZUR A;  1ZN3 A;  3DEB A;  1ZL5 A;  1S0C A;  2G7Q A;  3QJ0 A;  1Z7H A;  2IMC A;  3C8A A;  4ZJX A;  3QIY A;  1G9B A;  2FPQ A;  2ISH A;  3BTA A;  3NF3 A;  5BQM A;  3V0B B;  2ISE A;  3C88 A;  3DDB A;  2NYY A;  3D3X A;  3QW7 A;  4ZKT B;  1S0G A;  1E1H A;  3C89 A;  1I1E A;  1F31 A;  3DS9 A;  4J1L A;  1EPW A;  3BON A;  4KTX A;  1XTF A;  1ZB7 A;  4KUF A;  1F82 A;  3ZUQ A;  3V0A B;  1ZL6 A;  2G7P A;  2ILP A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...