1ZKW | Genus

Total Genus 134

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	134
sequence length	411
structure length	411
Chain Sequence	PKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGTTPQDFHPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGGILLEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQDILLPNVIIMGAEPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSMNEFIQDPALTLMHELIHSLHGLYGAKGITTKYTITQKQNPLITNIRGTNIEEFLTFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVFEAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCAQTYIGQYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPITGRGLVKKIIRFC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

loadScript /static/js/j2s/core/package.js

loadScript /static/js/j2s/core/corejmol.z.js

loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__0819616530808918__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet0__0819616530808918__)

vwrOptions:

{ "name":"jmolApplet0","applet":true,"documentBase":"https://genus.fuw.edu.pl/view/1ZKW/A/","platform":"J.awtjs2d.Platform","fullName":"jmolApplet0__0819616530808918__","codePath":"https:/static/js/j2s/","display":"jmolApplet0_canvas2d","signedApplet":"true","appletReadyCallback":"Jmol._readyCallback","statusListener":"[J.appletjs.Jmol object]","syncId":"0819616530808918","bgcolor":"white" }

setting document base to "https://genus.fuw.edu.pl/view/1ZKW/A/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

Jmol getValue DRAGDROPCallback null

Jmol getValue ECHOCallback null

Jmol getValue ERRORCallback null

Jmol getValue EVALCallback null

Jmol getValue HOVERCallback null

Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback null

Jmol getValue MEASURECallback null

Jmol getValue MESSAGECallback null

Jmol getValue MINIMIZATIONCallback null

Jmol getValue SERVICECallback null

Jmol getValue PICKCallback null

Jmol getValue RESIZECallback null

Jmol getValue SCRIPTCallback null

Jmol getValue SYNCCallback null

Jmol getValue STRUCTUREMODIFIEDCallback null

Jmol getValue doTranslate null

language=en_US

Jmol getValue popupMenu null

Jmol getValue script null

Jmol getValue loadInline null

Jmol getValue load null

Jmol applet jmolApplet0__0819616530808918__ ready

script 1 started

platformSpeed = 8

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme. pubmed doi rcsb
molecule keywords	botulinum neurotoxin type E
total genus	134
structure length	411
sequence length	411
chains with identical sequence	B
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2005-05-04

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	1zkwA00

2G7PA 3FIEA 4J1LA 4KTXA 1E1HA 3V0AA 2NZ9A 3C88A 1I1EA 2A97A 3DEBA 2ISEA 3V0BB 2IMBA 3BOOA 1S0DA 2NYYA 1ZL6A 2ETFA 3DSEA 2FPQA 4EJ5A 1XTFA 1ZL5A 5BQNA 3BTAA 4ZJXA 3FIIA 1S0GA 1T3CA 3QW6A 3ZURA 3V0BA 3BOKA 1F31A 3QIXA 1G9AA 1S0FA 4ELCA 3DS9A 3QW5A 3C89A 1G9CA 3QIZA 3QJ0A 1Z7HA 2G7KA 1T3AA 3K3QB 3BONA 2QN0A 2W2DA 4HEVA 3FFZA 1F82A 3DDBA 4KS6A 4KUFA 3NF3A 3C8BA 2IMAA 1ZB7A 3ZUSA 3QIYA 1S0BA 3BWIA 3DDAA 2IMCA 1ZN3A 3C8AA 1S0CA 1G9DA 2ISGA 2XHLA 3VUOA 4ZKTB 3QW8A 1YVGA 2NP0A 3V0AB 3QW7A 1S0EA 5BQMA 1EPWA 1ZKWA 1XTGA 2G7QA 2ISHA 3ZUQA 1G9BA 2ILPA 2A8AA 4EL4A 3D3XA 2G7NA 1ZKXA
chains in the Genus database with same CATH superfamily

2G7PA 3FIEA 4J1LA 4KTXA 1E1HA 3V0AA 2NZ9A 3C88A 1I1EA 2A97A 3DEBA 2ISEA 3V0BB 2IMBA 4JIXA 3BOOA 1S0DA 2NYYA 1ZL6A 2ETFA 3DSEA 2FPQA 4EJ5A 1XTFA 1ZL5A 5BQNA 2YPTA 3BTAA 4ZJXA 3E11A 3FIIA 4JIUA 1S0GA 1T3CA 3QW6A 3ZURA 3V0BA 3BOKA 1F31A 3QIXA 1G9AA 1S0FA 4ELCA 3DS9A 4QHFA 3QW5A 4AW6A 3C89A 1G9CA 3QIZA 3QJ0A 1Z7HA 2G7KA 1T3AA 3K3QB 3BONA 2QN0A 2W2DA 4HEVA 3FFZA 1F82A 3DDBA 4KS6A 4KUFA 3CQBA 3NF3A 2EJQA 3C8BA 2IMAA 1ZB7A 3ZUSA 3QIYA 1S0BA 3BWIA 3DDAA 2IMCA 1ZN3A 3C8AA 1S0CA 1G9DA 4IL3A 2ISGA 2XHLA 3VUOA 4ZKTB 3QW8A 1YVGA 2NP0A 3V0AB 3QW7A 1S0EA 5BQMA 1EPWA 1ZKWA 1XTGA 2G7QA 2ISHA 3ZUQA 1G9BA 2ILPA 2A8AA 4EL4A 3D3XA 2G7NA 1ZKXA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2G7P A;  3FIE A;  4J1L A;  4KTX A;  1E1H A;  3V0A A;  2NZ9 A;  3C88 A;  1I1E A;  2A97 A;  3DEB A;  2ISE A;  3V0B B;  2IMB A;  3BOO A;  1S0D A;  2NYY A;  1ZL6 A;  2ETF A;  3DSE A;  2FPQ A;  4EJ5 A;  1XTF A;  1ZL5 A;  5BQN A;  3BTA A;  4ZJX A;  3FII A;  1S0G A;  1T3C A;  3QW6 A;  3ZUR A;  3V0B A;  3BOK A;  1F31 A;  3QIX A;  1G9A A;  1S0F A;  4ELC A;  3DS9 A;  3QW5 A;  3C89 A;  1G9C A;  3QIZ A;  3QJ0 A;  1Z7H A;  2G7K A;  1T3A A;  3K3Q B;  3BON A;  2QN0 A;  2W2D A;  4HEV A;  3FFZ A;  1F82 A;  3DDB A;  4KS6 A;  4KUF A;  3NF3 A;  3C8B A;  2IMA A;  1ZB7 A;  3ZUS A;  3QIY A;  1S0B A;  3BWI A;  3DDA A;  2IMC A;  1ZN3 A;  3C8A A;  1S0C A;  1G9D A;  2ISG A;  2XHL A;  3VUO A;  4ZKT B;  3QW8 A;  1YVG A;  2NP0 A;  3V0A B;  3QW7 A;  1S0E A;  5BQM A;  1EPW A;  1ZKW A;  1XTG A;  2G7Q A;  2ISH A;  3ZUQ A;  1G9B A;  2ILP A;  2A8A A;  4EL4 A;  3D3X A;  2G7N A;  1ZKX A; 
#chains in the Genus database with same CATH topology
 2G7P A;  3FIE A;  4J1L A;  4KTX A;  1E1H A;  3V0A A;  2NZ9 A;  3C88 A;  1I1E A;  2A97 A;  3DEB A;  2ISE A;  3V0B B;  2IMB A;  4JIX A;  3BOO A;  1S0D A;  2NYY A;  1ZL6 A;  2ETF A;  3DSE A;  2FPQ A;  4EJ5 A;  1XTF A;  1ZL5 A;  5BQN A;  2YPT A;  3BTA A;  4ZJX A;  3E11 A;  3FII A;  4JIU A;  1S0G A;  1T3C A;  3QW6 A;  3ZUR A;  3V0B A;  3BOK A;  1F31 A;  3QIX A;  1G9A A;  1S0F A;  4ELC A;  3DS9 A;  4QHF A;  3QW5 A;  4AW6 A;  3C89 A;  1G9C A;  3QIZ A;  3QJ0 A;  1Z7H A;  2G7K A;  1T3A A;  3K3Q B;  3BON A;  2QN0 A;  2W2D A;  4HEV A;  3FFZ A;  1F82 A;  3DDB A;  4KS6 A;  4KUF A;  3CQB A;  3NF3 A;  2EJQ A;  3C8B A;  2IMA A;  1ZB7 A;  3ZUS A;  3QIY A;  1S0B A;  3BWI A;  3DDA A;  2IMC A;  1ZN3 A;  3C8A A;  1S0C A;  1G9D A;  4IL3 A;  2ISG A;  2XHL A;  3VUO A;  4ZKT B;  3QW8 A;  1YVG A;  2NP0 A;  3V0A B;  3QW7 A;  1S0E A;  5BQM A;  1EPW A;  1ZKW A;  1XTG A;  2G7Q A;  2ISH A;  3ZUQ A;  1G9B A;  2ILP A;  2A8A A;  4EL4 A;  3D3X A;  2G7N A;  1ZKX A; 
#chains in the Genus database with same CATH homology
 2G7P A;  3FIE A;  4J1L A;  4KTX A;  1E1H A;  3V0A A;  2NZ9 A;  3C88 A;  1I1E A;  2A97 A;  3DEB A;  2ISE A;  3V0B B;  2IMB A;  3BOO A;  1S0D A;  2NYY A;  1ZL6 A;  2ETF A;  3DSE A;  2FPQ A;  4EJ5 A;  1XTF A;  1ZL5 A;  5BQN A;  3BTA A;  4ZJX A;  3FII A;  1S0G A;  1T3C A;  3QW6 A;  3ZUR A;  3V0B A;  3BOK A;  1F31 A;  3QIX A;  1G9A A;  1S0F A;  4ELC A;  3DS9 A;  3QW5 A;  3C89 A;  1G9C A;  3QIZ A;  3QJ0 A;  1Z7H A;  2G7K A;  1T3A A;  3K3Q B;  3BON A;  2QN0 A;  2W2D A;  4HEV A;  3FFZ A;  1F82 A;  3DDB A;  4KS6 A;  4KUF A;  3NF3 A;  3C8B A;  2IMA A;  1ZB7 A;  3ZUS A;  3QIY A;  1S0B A;  3BWI A;  3DDA A;  2IMC A;  1ZN3 A;  3C8A A;  1S0C A;  1G9D A;  2ISG A;  2XHL A;  3VUO A;  4ZKT B;  3QW8 A;  1YVG A;  2NP0 A;  3V0A B;  3QW7 A;  1S0E A;  5BQM A;  1EPW A;  1ZKW A;  1XTG A;  2G7Q A;  2ISH A;  3ZUQ A;  1G9B A;  2ILP A;  2A8A A;  4EL4 A;  3D3X A;  2G7N A;  1ZKX A;

...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)

...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

1ZKWA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations