1ZKXA

Crystal structure of glu158ala/thr159ala/asn160ala- a triple mutant of clostridium botulinum neurotoxin e catalytic domain
Total Genus 125
50100150200250300350020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
125
sequence length
411
structure length
400
Chain Sequence
PKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGTTPQDFHPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGGILLEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQDILLPNVIIMGAEPDLFAAASSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSMNEFIQDPALTLMHELIHSLHGLYGAKGITTKYTITGTNIEEFLTFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVFEAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQTYIGQYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPITGRGLVKKIIRFC
50100150200250300350300200100
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTIV4 (92-95)TI1 (7-10)TI11 (135-138)TIV1 (13-16)S2 (29-35)S1 (17-21)AH2 (97-108)TII2 (35-38)S6 (147-151)S3 (38-44)AH1 (76-92)TII3 (46-49)TI2 (50-53)TI4 (52-55)TI5 (59-62)TVIII2 (56-59)TII4 (61-64)TIV3 (58-61)TI6 (63-66)TI22 (387-390)TVIII4 (153-156)TI7 (69-72)TII5 (71-74)TI13 (186-189)AH7 (320-331)TIV5 (93-96)O3 (112-114)TIV8 (175-178)TI8 (115-118)AH5 (264-287)TI9 (119-122)TI10 (126-129)TIV6 (127-130)S5 (140-143)S8 (181-184)3H1 (167-169)3H2 (172-174)TIV9 (224-227)S9 (189-194)S10 (200-202)3H5 (377-386)TII'1 (372-375)3H4 (293-295)AH3 (205-221)TI15 (225-228)TI16 (226-229)TIV10 (227-230)TIV11 (231-245)3H3 (257-261)S11 (231-232)AH4 (248-254)TI17 (311-314)AH6 (296-306)TVIII5 (290-293)S13 (308-311)S14 (315-318)TVIII6 (331-334)TI18 (361-364)TIV13 (365-368)TI19 (364-367)TI20 (369-372)TI21 (370-373)TIV14 (373-376)TIV16 (389-392)S16 (395-396)TIV15 (388-391)TII6 (398-401)S4 (131-134)TIV7 (152-155)S15 (356-359)TI12 (155-158)S7 (160-163)TI14 (195-198)S12 (246-247)AH8 (335-342)Updating...
connected with : NaN
publication title Analysis of Active Site Residues of Botulinum Neurotoxin E by Mutational, Functional, and Structural Studies: Glu335Gln Is an Apoenzyme.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords botulinum neurotoxin type E
total genus 125
structure length 400
sequence length 411
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2005-05-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 1zkxA00
2ISGA 3C89A 3BOOA 4KS6A 1G9AA 3C8BA 1ZKWA 3QIZA 3ZUSA 4HEVA 2ISEA 2XHLA 3D3XA 1EPWA 1ZN3A 1ZL5A 1G9CA 1XTFA 3ZURA 1T3AA 1I1EA 2FPQA 3DDAA 1S0FA 4J1LA 2W2DA 3DS9A 1YVGA 3FFZA 1XTGA 2NZ9A 1ZB7A 3V0BA 3DEBA 1Z7HA 3BTAA 1G9BA 1F31A 3C88A 3QJ0A 3QW8A 3ZUQA 3V0AB 3DDBA 3FIIA 2A8AA 2QN0A 4EJ5A 4ZJXA 1G9DA 4KTXA 4KUFA 2ETFA 2A97A 2ISHA 4EL4A 2G7NA 2G7KA 3NF3A 1F82A 4ZKTB 3VUOA 1ZKXA 3BOKA 5BQNA 3DSEA 3K3QB 2IMCA 1S0BA 3V0AA 1S0DA 3BWIA 2ILPA 1E1HA 1S0GA 3QIYA 2IMAA 3QIXA 1ZL6A 2IMBA 4ELCA 2G7QA 2NYYA 3FIEA 3QW6A 3C8AA 1T3CA 5BQMA 1S0EA 3BONA 2G7PA 2NP0A 1S0CA 3QW5A 3V0BB 3QW7A
chains in the Genus database with same CATH superfamily
2ISGA 3C89A 3BOOA 4KS6A 1G9AA 3C8BA 1ZKWA 3QIZA 3ZUSA 4HEVA 2ISEA 2XHLA 3D3XA 1EPWA 1ZN3A 1ZL5A 1G9CA 1XTFA 3ZURA 1T3AA 1I1EA 2FPQA 3DDAA 1S0FA 4J1LA 2W2DA 3DS9A 1YVGA 3FFZA 1XTGA 2NZ9A 1ZB7A 3V0BA 3DEBA 1Z7HA 3BTAA 4QHFA 1G9BA 1F31A 3C88A 3QJ0A 3QW8A 3ZUQA 3V0AB 3DDBA 3E11A 4IL3A 3FIIA 2A8AA 2QN0A 4EJ5A 4ZJXA 1G9DA 4KTXA 4KUFA 2ETFA 2A97A 2ISHA 4EL4A 4AW6A 2G7NA 2YPTA 2G7KA 3NF3A 1F82A 4ZKTB 3VUOA 1ZKXA 3BOKA 5BQNA 3DSEA 3K3QB 2IMCA 3CQBA 1S0BA 3V0AA 1S0DA 3BWIA 2ILPA 1E1HA 1S0GA 3QIYA 2IMAA 3QIXA 1ZL6A 4JIUA 2IMBA 4ELCA 2G7QA 4JIXA 2NYYA 3FIEA 3QW6A 3C8AA 1T3CA 5BQMA 2EJQA 1S0EA 3BONA 2G7PA 2NP0A 1S0CA 3QW5A 3V0BB 3QW7A
chains in the Genus database with same CATH topology
2ISGA 3C89A 3BOOA 4KS6A 1G9AA 3C8BA 1ZKWA 3QIZA 3ZUSA 4HEVA 2ISEA 2XHLA 3D3XA 1EPWA 1ZN3A 1ZL5A 1G9CA 1XTFA 3ZURA 1T3AA 1I1EA 2FPQA 3DDAA 1S0FA 4J1LA 2W2DA 3DS9A 1YVGA 3FFZA 1XTGA 2NZ9A 1ZB7A 3V0BA 3DEBA 1Z7HA 3BTAA 1G9BA 1F31A 3C88A 3QJ0A 3QW8A 3ZUQA 3V0AB 3DDBA 3FIIA 2A8AA 2QN0A 4EJ5A 4ZJXA 1G9DA 4KTXA 4KUFA 2ETFA 2A97A 2ISHA 4EL4A 2G7NA 2G7KA 3NF3A 1F82A 4ZKTB 3VUOA 1ZKXA 3BOKA 5BQNA 3DSEA 3K3QB 2IMCA 1S0BA 3V0AA 1S0DA 3BWIA 2ILPA 1E1HA 1S0GA 3QIYA 2IMAA 3QIXA 1ZL6A 2IMBA 4ELCA 2G7QA 2NYYA 3FIEA 3QW6A 3C8AA 1T3CA 5BQMA 1S0EA 3BONA 2G7PA 2NP0A 1S0CA 3QW5A 3V0BB 3QW7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ISG A;  3C89 A;  3BOO A;  4KS6 A;  1G9A A;  3C8B A;  1ZKW A;  3QIZ A;  3ZUS A;  4HEV A;  2ISE A;  2XHL A;  3D3X A;  1EPW A;  1ZN3 A;  1ZL5 A;  1G9C A;  1XTF A;  3ZUR A;  1T3A A;  1I1E A;  2FPQ A;  3DDA A;  1S0F A;  4J1L A;  2W2D A;  3DS9 A;  1YVG A;  3FFZ A;  1XTG A;  2NZ9 A;  1ZB7 A;  3V0B A;  3DEB A;  1Z7H A;  3BTA A;  1G9B A;  1F31 A;  3C88 A;  3QJ0 A;  3QW8 A;  3ZUQ A;  3V0A B;  3DDB A;  3FII A;  2A8A A;  2QN0 A;  4EJ5 A;  4ZJX A;  1G9D A;  4KTX A;  4KUF A;  2ETF A;  2A97 A;  2ISH A;  4EL4 A;  2G7N A;  2G7K A;  3NF3 A;  1F82 A;  4ZKT B;  3VUO A;  1ZKX A;  3BOK A;  5BQN A;  3DSE A;  3K3Q B;  2IMC A;  1S0B A;  3V0A A;  1S0D A;  3BWI A;  2ILP A;  1E1H A;  1S0G A;  3QIY A;  2IMA A;  3QIX A;  1ZL6 A;  2IMB A;  4ELC A;  2G7Q A;  2NYY A;  3FIE A;  3QW6 A;  3C8A A;  1T3C A;  5BQM A;  1S0E A;  3BON A;  2G7P A;  2NP0 A;  1S0C A;  3QW5 A;  3V0B B;  3QW7 A; 
#chains in the Genus database with same CATH topology
 2ISG A;  3C89 A;  3BOO A;  4KS6 A;  1G9A A;  3C8B A;  1ZKW A;  3QIZ A;  3ZUS A;  4HEV A;  2ISE A;  2XHL A;  3D3X A;  1EPW A;  1ZN3 A;  1ZL5 A;  1G9C A;  1XTF A;  3ZUR A;  1T3A A;  1I1E A;  2FPQ A;  3DDA A;  1S0F A;  4J1L A;  2W2D A;  3DS9 A;  1YVG A;  3FFZ A;  1XTG A;  2NZ9 A;  1ZB7 A;  3V0B A;  3DEB A;  1Z7H A;  3BTA A;  4QHF A;  1G9B A;  1F31 A;  3C88 A;  3QJ0 A;  3QW8 A;  3ZUQ A;  3V0A B;  3DDB A;  3E11 A;  4IL3 A;  3FII A;  2A8A A;  2QN0 A;  4EJ5 A;  4ZJX A;  1G9D A;  4KTX A;  4KUF A;  2ETF A;  2A97 A;  2ISH A;  4EL4 A;  4AW6 A;  2G7N A;  2YPT A;  2G7K A;  3NF3 A;  1F82 A;  4ZKT B;  3VUO A;  1ZKX A;  3BOK A;  5BQN A;  3DSE A;  3K3Q B;  2IMC A;  3CQB A;  1S0B A;  3V0A A;  1S0D A;  3BWI A;  2ILP A;  1E1H A;  1S0G A;  3QIY A;  2IMA A;  3QIX A;  1ZL6 A;  4JIU A;  2IMB A;  4ELC A;  2G7Q A;  4JIX A;  2NYY A;  3FIE A;  3QW6 A;  3C8A A;  1T3C A;  5BQM A;  2EJQ A;  1S0E A;  3BON A;  2G7P A;  2NP0 A;  1S0C A;  3QW5 A;  3V0B B;  3QW7 A; 
#chains in the Genus database with same CATH homology
 2ISG A;  3C89 A;  3BOO A;  4KS6 A;  1G9A A;  3C8B A;  1ZKW A;  3QIZ A;  3ZUS A;  4HEV A;  2ISE A;  2XHL A;  3D3X A;  1EPW A;  1ZN3 A;  1ZL5 A;  1G9C A;  1XTF A;  3ZUR A;  1T3A A;  1I1E A;  2FPQ A;  3DDA A;  1S0F A;  4J1L A;  2W2D A;  3DS9 A;  1YVG A;  3FFZ A;  1XTG A;  2NZ9 A;  1ZB7 A;  3V0B A;  3DEB A;  1Z7H A;  3BTA A;  1G9B A;  1F31 A;  3C88 A;  3QJ0 A;  3QW8 A;  3ZUQ A;  3V0A B;  3DDB A;  3FII A;  2A8A A;  2QN0 A;  4EJ5 A;  4ZJX A;  1G9D A;  4KTX A;  4KUF A;  2ETF A;  2A97 A;  2ISH A;  4EL4 A;  2G7N A;  2G7K A;  3NF3 A;  1F82 A;  4ZKT B;  3VUO A;  1ZKX A;  3BOK A;  5BQN A;  3DSE A;  3K3Q B;  2IMC A;  1S0B A;  3V0A A;  1S0D A;  3BWI A;  2ILP A;  1E1H A;  1S0G A;  3QIY A;  2IMA A;  3QIX A;  1ZL6 A;  2IMB A;  4ELC A;  2G7Q A;  2NYY A;  3FIE A;  3QW6 A;  3C8A A;  1T3C A;  5BQM A;  1S0E A;  3BON A;  2G7P A;  2NP0 A;  1S0C A;  3QW5 A;  3V0B B;  3QW7 A; 
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