The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
135
|
sequence length |
411
|
structure length |
400
|
Chain Sequence |
PKINSFNYNDPVNDRTILYIKPGGCQEFYKSFNIMKNIWIIPERNVIGTTPQDFHPPTSLKNGDSSYYDPNYLQSDEEKDRFLKIVTKIFNRINNNLSGGILLEELSKANPYLGNDNTPDNQFHIGDASAVEIKFSNGSQDILLPNVIIMGAEPDLFETNSSNISLRNNYMPSNHGFGSIAIVTFSPEYSFRFNDNSMNEFIQDPALTLMHELIHSLHGLYGAKGITTKYTITGTNIEEFLTFGGTDLNIITSAQSNDIYTNLLADYKKIASKLSKVQVSNPLLNPYKDVFEAKYGLDKDASGIYSVNINKFNDIFKKLYSFTEFDLATKFQVKCRQTYIGQYKYFKLSNLLNDSIYNISEGYNINNLKVNFRGQNANLNPRIITPITGRGLVKKIIRFC
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structural analysis of botulinum neurotoxin type E catalytic domain and its mutant Glu212-->Gln reveals the pivotal role of the Glu212 carboxylate in the catalytic pathway
pubmed doi rcsb |
| molecule keywords |
neurotoxin type E
|
| molecule tags |
Hydrolase, toxin
|
| source organism |
Clostridium botulinum
|
| total genus |
135
|
| structure length |
400
|
| sequence length |
411
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
3.4.24.69: Bontoxilysin. |
| pdb deposition date | 2004-04-26 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01742 | Peptidase_M27 | Clostridial neurotoxin zinc protease |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Alpha-Beta Complex | Zincin-like | Metalloproteases ("zincins"), catalytic domain like |
#chains in the Genus database with same CATH superfamily 3FIE A; 1S0C A; 2IMC A; 1ZN3 A; 3C88 A; 3QW8 A; 2ILP A; 3DEB A; 5BQN A; 2ISG A; 2A97 A; 1ZL5 A; 4KUF A; 1S0B A; 3QIY A; 1G9B A; 1XTG A; 1F31 A; 1YVG A; 2FPQ A; 2IMB A; 3C8A A; 1G9A A; 2A8A A; 2ISH A; 4ZJX A; 1T3A A; 4KTX A; 1T3C A; 3C8B A; 3QIZ A; 3QJ0 A; 2W2D A; 4ZKT B; 3BOO A; 4EJ5 A; 3NF3 A; 3BON A; 4EL4 A; 3D3X A; 1I1E A; 1ZL6 A; 2G7K A; 1ZKX A; 3BTA A; 3V0B B; 1E1H A; 4HEV A; 4KS6 A; 3ZUR A; 1G9C A; 3V0A B; 5BQM A; 1XTF A; 1S0E A; 4J1L A; 3QW7 A; 1ZB7 A; 4ELC A; 3C89 A; 3DSE A; 3DDA A; 3QW6 A; 2XHL A; 1Z7H A; 1ZKW A; 2G7N A; 2G7P A; 3ZUS A; 2NP0 A; 3QW5 A; 2ETF A; 1S0G A; 2QN0 A; 3BWI A; 3DDB A; 2NYY A; 2ISE A; 3K3Q B; 3V0B A; 3VUO A; 2G7Q A; 1S0F A; 3ZUQ A; 1F82 A; 1EPW A; 2IMA A; 3V0A A; 3QIX A; 3BOK A; 3FFZ A; 1G9D A; 3DS9 A; 3FII A; 1S0D A; 2NZ9 A; #chains in the Genus database with same CATH topology 3FIE A; 1S0C A; 2IMC A; 1ZN3 A; 4JIX A; 3C88 A; 3QW8 A; 2ILP A; 3DEB A; 5BQN A; 2ISG A; 2A97 A; 1ZL5 A; 4KUF A; 1S0B A; 3QIY A; 1G9B A; 1XTG A; 1F31 A; 1YVG A; 2FPQ A; 2IMB A; 3CQB A; 3C8A A; 1G9A A; 2A8A A; 2ISH A; 4ZJX A; 1T3A A; 4KTX A; 1T3C A; 3C8B A; 3QIZ A; 3QJ0 A; 4QHF A; 2W2D A; 4ZKT B; 3BOO A; 4EJ5 A; 3NF3 A; 3BON A; 4EL4 A; 3D3X A; 1I1E A; 1ZL6 A; 2G7K A; 1ZKX A; 3BTA A; 3V0B B; 1E1H A; 4HEV A; 4AW6 A; 4KS6 A; 3ZUR A; 1G9C A; 3V0A B; 5BQM A; 1XTF A; 1S0E A; 4J1L A; 3QW7 A; 1ZB7 A; 4ELC A; 2YPT A; 3C89 A; 3DSE A; 3DDA A; 3QW6 A; 2XHL A; 1Z7H A; 4JIU A; 1ZKW A; 2G7N A; 2G7P A; 3ZUS A; 2NP0 A; 3QW5 A; 2ETF A; 1S0G A; 2QN0 A; 3BWI A; 3DDB A; 2NYY A; 2ISE A; 3K3Q B; 2EJQ A; 3V0B A; 3VUO A; 4IL3 A; 2G7Q A; 1S0F A; 3ZUQ A; 1F82 A; 1EPW A; 2IMA A; 3V0A A; 3QIX A; 3BOK A; 3FFZ A; 3E11 A; 1G9D A; 3DS9 A; 3FII A; 1S0D A; 2NZ9 A; #chains in the Genus database with same CATH homology 3FIE A; 1S0C A; 2IMC A; 1ZN3 A; 3C88 A; 3QW8 A; 2ILP A; 3DEB A; 5BQN A; 2ISG A; 2A97 A; 1ZL5 A; 4KUF A; 1S0B A; 3QIY A; 1G9B A; 1XTG A; 1F31 A; 1YVG A; 2FPQ A; 2IMB A; 3C8A A; 1G9A A; 2A8A A; 2ISH A; 4ZJX A; 1T3A A; 4KTX A; 1T3C A; 3C8B A; 3QIZ A; 3QJ0 A; 2W2D A; 4ZKT B; 3BOO A; 4EJ5 A; 3NF3 A; 3BON A; 4EL4 A; 3D3X A; 1I1E A; 1ZL6 A; 2G7K A; 1ZKX A; 3BTA A; 3V0B B; 1E1H A; 4HEV A; 4KS6 A; 3ZUR A; 1G9C A; 3V0A B; 5BQM A; 1XTF A; 1S0E A; 4J1L A; 3QW7 A; 1ZB7 A; 4ELC A; 3C89 A; 3DSE A; 3DDA A; 3QW6 A; 2XHL A; 1Z7H A; 1ZKW A; 2G7N A; 2G7P A; 3ZUS A; 2NP0 A; 3QW5 A; 2ETF A; 1S0G A; 2QN0 A; 3BWI A; 3DDB A; 2NYY A; 2ISE A; 3K3Q B; 3V0B A; 3VUO A; 2G7Q A; 1S0F A; 3ZUQ A; 1F82 A; 1EPW A; 2IMA A; 3V0A A; 3QIX A; 3BOK A; 3FFZ A; 1G9D A; 3DS9 A; 3FII A; 1S0D A; 2NZ9 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
