1XTGA

Crystal structure of neurotoxin bont/a complexed with synaptosomal-associated protein 25
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
424
structure length
424
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHQLIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTFLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTPLVPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substrate recognition strategy for botulinum neurotoxin serotype A
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords NEUROTOXIN BONT/A
total genus 128
structure length 424
sequence length 424
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2004-10-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 1xtgA00
3BONA 3DDAA 2G7NA 2IMBA 1ZB7A 1YVGA 1E1HA 1S0BA 2NYYA 2ISGA 3QW6A 1ZL5A 1S0DA 3V0AA 1G9AA 4ELCA 3V0BB 2G7KA 4KTXA 3FIEA 4ZJXA 3BTAA 1F31A 3C8BA 3K3QB 2A8AA 1Z7HA 1EPWA 2NP0A 1ZKXA 2IMCA 3ZUQA 3BWIA 3D3XA 3C89A 3DS9A 3QIZA 4KUFA 1F82A 2G7PA 2ISEA 4HEVA 3DEBA 2ISHA 2A97A 3V0AB 3FFZA 4ZKTB 1XTFA 3QJ0A 3BOKA 1G9DA 2QN0A 3BOOA 1ZN3A 5BQMA 3QW8A 2IMAA 1ZKWA 5BQNA 3ZUSA 1G9BA 2G7QA 1T3AA 3QIXA 1S0EA 4EJ5A 1S0CA 3C8AA 2FPQA 2ETFA 2XHLA 3QIYA 3FIIA 1XTGA 3QW7A 1ZL6A 3VUOA 3DSEA 1S0FA 3ZURA 1T3CA 1G9CA 3QW5A 4KS6A 4J1LA 3V0BA 3DDBA 4EL4A 1S0GA 2W2DA 1I1EA 3NF3A 3C88A 2ILPA 2NZ9A
chains in the Genus database with same CATH superfamily
3BONA 3DDAA 2G7NA 2IMBA 1ZB7A 3CQBA 4QHFA 1YVGA 1E1HA 1S0BA 2NYYA 2ISGA 3QW6A 1ZL5A 1S0DA 3V0AA 1G9AA 4ELCA 3V0BB 2YPTA 2G7KA 4KTXA 3FIEA 4ZJXA 3BTAA 1F31A 3C8BA 3K3QB 2A8AA 1Z7HA 1EPWA 2NP0A 4AW6A 1ZKXA 2IMCA 3ZUQA 3BWIA 3D3XA 3C89A 4JIUA 3DS9A 3QIZA 4KUFA 1F82A 2G7PA 2ISEA 4HEVA 3DEBA 3E11A 2ISHA 2A97A 3V0AB 3FFZA 4ZKTB 1XTFA 3QJ0A 3BOKA 1G9DA 2QN0A 3BOOA 1ZN3A 5BQMA 3QW8A 2IMAA 1ZKWA 5BQNA 3ZUSA 1G9BA 2G7QA 1T3AA 3QIXA 1S0EA 4EJ5A 1S0CA 3C8AA 2FPQA 2ETFA 2XHLA 3QIYA 4JIXA 3FIIA 1XTGA 3QW7A 1ZL6A 3VUOA 3DSEA 1S0FA 3ZURA 1T3CA 1G9CA 3QW5A 4KS6A 4J1LA 3V0BA 3DDBA 2EJQA 4EL4A 1S0GA 2W2DA 1I1EA 3NF3A 3C88A 4IL3A 2ILPA 2NZ9A
chains in the Genus database with same CATH topology
3BONA 3DDAA 2G7NA 2IMBA 1ZB7A 1YVGA 1E1HA 1S0BA 2NYYA 2ISGA 3QW6A 1ZL5A 1S0DA 3V0AA 1G9AA 4ELCA 3V0BB 2G7KA 4KTXA 3FIEA 4ZJXA 3BTAA 1F31A 3C8BA 3K3QB 2A8AA 1Z7HA 1EPWA 2NP0A 1ZKXA 2IMCA 3ZUQA 3BWIA 3D3XA 3C89A 3DS9A 3QIZA 4KUFA 1F82A 2G7PA 2ISEA 4HEVA 3DEBA 2ISHA 2A97A 3V0AB 3FFZA 4ZKTB 1XTFA 3QJ0A 3BOKA 1G9DA 2QN0A 3BOOA 1ZN3A 5BQMA 3QW8A 2IMAA 1ZKWA 5BQNA 3ZUSA 1G9BA 2G7QA 1T3AA 3QIXA 1S0EA 4EJ5A 1S0CA 3C8AA 2FPQA 2ETFA 2XHLA 3QIYA 3FIIA 1XTGA 3QW7A 1ZL6A 3VUOA 3DSEA 1S0FA 3ZURA 1T3CA 1G9CA 3QW5A 4KS6A 4J1LA 3V0BA 3DDBA 4EL4A 1S0GA 2W2DA 1I1EA 3NF3A 3C88A 2ILPA 2NZ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BON A;  3DDA A;  2G7N A;  2IMB A;  1ZB7 A;  1YVG A;  1E1H A;  1S0B A;  2NYY A;  2ISG A;  3QW6 A;  1ZL5 A;  1S0D A;  3V0A A;  1G9A A;  4ELC A;  3V0B B;  2G7K A;  4KTX A;  3FIE A;  4ZJX A;  3BTA A;  1F31 A;  3C8B A;  3K3Q B;  2A8A A;  1Z7H A;  1EPW A;  2NP0 A;  1ZKX A;  2IMC A;  3ZUQ A;  3BWI A;  3D3X A;  3C89 A;  3DS9 A;  3QIZ A;  4KUF A;  1F82 A;  2G7P A;  2ISE A;  4HEV A;  3DEB A;  2ISH A;  2A97 A;  3V0A B;  3FFZ A;  4ZKT B;  1XTF A;  3QJ0 A;  3BOK A;  1G9D A;  2QN0 A;  3BOO A;  1ZN3 A;  5BQM A;  3QW8 A;  2IMA A;  1ZKW A;  5BQN A;  3ZUS A;  1G9B A;  2G7Q A;  1T3A A;  3QIX A;  1S0E A;  4EJ5 A;  1S0C A;  3C8A A;  2FPQ A;  2ETF A;  2XHL A;  3QIY A;  3FII A;  1XTG A;  3QW7 A;  1ZL6 A;  3VUO A;  3DSE A;  1S0F A;  3ZUR A;  1T3C A;  1G9C A;  3QW5 A;  4KS6 A;  4J1L A;  3V0B A;  3DDB A;  4EL4 A;  1S0G A;  2W2D A;  1I1E A;  3NF3 A;  3C88 A;  2ILP A;  2NZ9 A; 
#chains in the Genus database with same CATH topology
 3BON A;  3DDA A;  2G7N A;  2IMB A;  1ZB7 A;  3CQB A;  4QHF A;  1YVG A;  1E1H A;  1S0B A;  2NYY A;  2ISG A;  3QW6 A;  1ZL5 A;  1S0D A;  3V0A A;  1G9A A;  4ELC A;  3V0B B;  2YPT A;  2G7K A;  4KTX A;  3FIE A;  4ZJX A;  3BTA A;  1F31 A;  3C8B A;  3K3Q B;  2A8A A;  1Z7H A;  1EPW A;  2NP0 A;  4AW6 A;  1ZKX A;  2IMC A;  3ZUQ A;  3BWI A;  3D3X A;  3C89 A;  4JIU A;  3DS9 A;  3QIZ A;  4KUF A;  1F82 A;  2G7P A;  2ISE A;  4HEV A;  3DEB A;  3E11 A;  2ISH A;  2A97 A;  3V0A B;  3FFZ A;  4ZKT B;  1XTF A;  3QJ0 A;  3BOK A;  1G9D A;  2QN0 A;  3BOO A;  1ZN3 A;  5BQM A;  3QW8 A;  2IMA A;  1ZKW A;  5BQN A;  3ZUS A;  1G9B A;  2G7Q A;  1T3A A;  3QIX A;  1S0E A;  4EJ5 A;  1S0C A;  3C8A A;  2FPQ A;  2ETF A;  2XHL A;  3QIY A;  4JIX A;  3FII A;  1XTG A;  3QW7 A;  1ZL6 A;  3VUO A;  3DSE A;  1S0F A;  3ZUR A;  1T3C A;  1G9C A;  3QW5 A;  4KS6 A;  4J1L A;  3V0B A;  3DDB A;  2EJQ A;  4EL4 A;  1S0G A;  2W2D A;  1I1E A;  3NF3 A;  3C88 A;  4IL3 A;  2ILP A;  2NZ9 A; 
#chains in the Genus database with same CATH homology
 3BON A;  3DDA A;  2G7N A;  2IMB A;  1ZB7 A;  1YVG A;  1E1H A;  1S0B A;  2NYY A;  2ISG A;  3QW6 A;  1ZL5 A;  1S0D A;  3V0A A;  1G9A A;  4ELC A;  3V0B B;  2G7K A;  4KTX A;  3FIE A;  4ZJX A;  3BTA A;  1F31 A;  3C8B A;  3K3Q B;  2A8A A;  1Z7H A;  1EPW A;  2NP0 A;  1ZKX A;  2IMC A;  3ZUQ A;  3BWI A;  3D3X A;  3C89 A;  3DS9 A;  3QIZ A;  4KUF A;  1F82 A;  2G7P A;  2ISE A;  4HEV A;  3DEB A;  2ISH A;  2A97 A;  3V0A B;  3FFZ A;  4ZKT B;  1XTF A;  3QJ0 A;  3BOK A;  1G9D A;  2QN0 A;  3BOO A;  1ZN3 A;  5BQM A;  3QW8 A;  2IMA A;  1ZKW A;  5BQN A;  3ZUS A;  1G9B A;  2G7Q A;  1T3A A;  3QIX A;  1S0E A;  4EJ5 A;  1S0C A;  3C8A A;  2FPQ A;  2ETF A;  2XHL A;  3QIY A;  3FII A;  1XTG A;  3QW7 A;  1ZL6 A;  3VUO A;  3DSE A;  1S0F A;  3ZUR A;  1T3C A;  1G9C A;  3QW5 A;  4KS6 A;  4J1L A;  3V0B A;  3DDB A;  4EL4 A;  1S0G A;  2W2D A;  1I1E A;  3NF3 A;  3C88 A;  2ILP A;  2NZ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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