2A97A

Crystal structure of catalytic domain of clostridium botulinum neurotoxin serotype f
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
414
structure length
392
Chain Sequence
PVAINSFNYNDPVNDDTILYMQIPYEEKSKKYYKAFEIMRNVWIIPERNTIGTNPSDFDPPASLKNGSSAYYDPNYLTTDAEKDRYLKTTIKLFKRINSNPAGKVLLQEISYAKPYLGNDHTPIDEFSPVTRTTSVNIKLSTNVESSMLLNLLVLGAGPDIFESCCYPVRKLIDPDVVYDPSNYGFGSINIVTFSPEYEYTFNESFIADPAISLAHELIHALHGLYGARGVTYEETIPIRLEEFLTFGGQDLNIITSAMKEKIYNNLLANYEKIATRLSEVNSAPPEYDINEYKDYFQWKYGLDKNADGSYTVNENKFNEIYKKLYSFTESDLANKFKVKCRNTYFIKYEFLKVPNLLDDDIYTVSEGFNIGNLAVNNRGQSIKLNPKIIDS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of botulinum neurotoxin serotype f light chain: implications on substrate binding and inhibitor design
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type F
total genus 134
structure length 392
sequence length 414
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2005-07-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2a97A00
1G9CA 2G7PA 3BOKA 2QN0A 4EJ5A 3QJ0A 2FPQA 3C8AA 3FIIA 1XTGA 3V0BA 1S0GA 1YVGA 1ZB7A 1ZKWA 2G7NA 1S0CA 1EPWA 1G9DA 3C8BA 3C88A 1ZKXA 2IMBA 1ZN3A 1G9AA 1F82A 3DEBA 2A8AA 2IMCA 1S0EA 3K3QB 4KTXA 3FFZA 1ZL5A 3QIZA 3QW6A 3DSEA 3DS9A 3C89A 3ZUQA 2ILPA 2G7QA 3FIEA 5BQNA 1I1EA 3QW7A 2IMAA 3QW5A 3ZUSA 3QIXA 3QIYA 3BTAA 2ISEA 5BQMA 4J1LA 2NP0A 1Z7HA 1S0BA 1ZL6A 4KUFA 3V0AB 4ZJXA 2A97A 4ELCA 1S0FA 2ISGA 3QW8A 2NYYA 3DDAA 3DDBA 3VUOA 3BOOA 2NZ9A 1T3CA 2XHLA 3ZURA 1E1HA 2G7KA 1F31A 2ISHA 4ZKTB 3D3XA 3V0AA 1G9BA 3NF3A 3BONA 4KS6A 3V0BB 3BWIA 4EL4A 1S0DA 2W2DA 4HEVA 1T3AA 1XTFA 2ETFA
chains in the Genus database with same CATH superfamily
1G9CA 2G7PA 3BOKA 2QN0A 4EJ5A 3QJ0A 2FPQA 3C8AA 3FIIA 1XTGA 3V0BA 1S0GA 1YVGA 1ZB7A 1ZKWA 2G7NA 1S0CA 1EPWA 1G9DA 3C8BA 3C88A 1ZKXA 2IMBA 1ZN3A 1G9AA 1F82A 3DEBA 2A8AA 2IMCA 1S0EA 3K3QB 4KTXA 3FFZA 1ZL5A 3QIZA 3QW6A 3DSEA 3DS9A 3C89A 4JIXA 4IL3A 4JIUA 3ZUQA 2EJQA 2ILPA 2G7QA 3FIEA 5BQNA 1I1EA 3QW7A 2IMAA 3QW5A 3ZUSA 3QIXA 3QIYA 2YPTA 3BTAA 2ISEA 5BQMA 4J1LA 2NP0A 1Z7HA 1S0BA 1ZL6A 4KUFA 3V0AB 4ZJXA 2A97A 4ELCA 1S0FA 3QW8A 2ISGA 3CQBA 2NYYA 3DDAA 3DDBA 4QHFA 3VUOA 3BOOA 2NZ9A 1T3CA 4AW6A 2XHLA 3ZURA 1E1HA 2G7KA 1F31A 2ISHA 4ZKTB 3D3XA 3V0AA 1G9BA 3NF3A 3BONA 4KS6A 3V0BB 3BWIA 4EL4A 3E11A 1S0DA 2W2DA 4HEVA 1T3AA 1XTFA 2ETFA
chains in the Genus database with same CATH topology
1G9CA 2G7PA 3BOKA 2QN0A 4EJ5A 3QJ0A 2FPQA 3C8AA 3FIIA 1XTGA 3V0BA 1S0GA 1YVGA 1ZB7A 1ZKWA 2G7NA 1S0CA 1EPWA 1G9DA 3C8BA 3C88A 1ZKXA 2IMBA 1ZN3A 1G9AA 1F82A 3DEBA 2A8AA 2IMCA 1S0EA 3K3QB 4KTXA 3FFZA 1ZL5A 3QIZA 3QW6A 3DSEA 3DS9A 3C89A 3ZUQA 2ILPA 2G7QA 3FIEA 5BQNA 1I1EA 3QW7A 2IMAA 3QW5A 3ZUSA 3QIXA 3QIYA 3BTAA 2ISEA 5BQMA 4J1LA 2NP0A 1Z7HA 1S0BA 1ZL6A 4KUFA 3V0AB 4ZJXA 2A97A 4ELCA 1S0FA 2ISGA 3QW8A 2NYYA 3DDAA 3DDBA 3VUOA 3BOOA 2NZ9A 1T3CA 2XHLA 3ZURA 1E1HA 2G7KA 1F31A 2ISHA 4ZKTB 3D3XA 3V0AA 1G9BA 3NF3A 3BONA 4KS6A 3V0BB 3BWIA 4EL4A 1S0DA 2W2DA 4HEVA 1T3AA 1XTFA 2ETFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1G9C A;  2G7P A;  3BOK A;  2QN0 A;  4EJ5 A;  3QJ0 A;  2FPQ A;  3C8A A;  3FII A;  1XTG A;  3V0B A;  1S0G A;  1YVG A;  1ZB7 A;  1ZKW A;  2G7N A;  1S0C A;  1EPW A;  1G9D A;  3C8B A;  3C88 A;  1ZKX A;  2IMB A;  1ZN3 A;  1G9A A;  1F82 A;  3DEB A;  2A8A A;  2IMC A;  1S0E A;  3K3Q B;  4KTX A;  3FFZ A;  1ZL5 A;  3QIZ A;  3QW6 A;  3DSE A;  3DS9 A;  3C89 A;  3ZUQ A;  2ILP A;  2G7Q A;  3FIE A;  5BQN A;  1I1E A;  3QW7 A;  2IMA A;  3QW5 A;  3ZUS A;  3QIX A;  3QIY A;  3BTA A;  2ISE A;  5BQM A;  4J1L A;  2NP0 A;  1Z7H A;  1S0B A;  1ZL6 A;  4KUF A;  3V0A B;  4ZJX A;  2A97 A;  4ELC A;  1S0F A;  2ISG A;  3QW8 A;  2NYY A;  3DDA A;  3DDB A;  3VUO A;  3BOO A;  2NZ9 A;  1T3C A;  2XHL A;  3ZUR A;  1E1H A;  2G7K A;  1F31 A;  2ISH A;  4ZKT B;  3D3X A;  3V0A A;  1G9B A;  3NF3 A;  3BON A;  4KS6 A;  3V0B B;  3BWI A;  4EL4 A;  1S0D A;  2W2D A;  4HEV A;  1T3A A;  1XTF A;  2ETF A; 
#chains in the Genus database with same CATH topology
 1G9C A;  2G7P A;  3BOK A;  2QN0 A;  4EJ5 A;  3QJ0 A;  2FPQ A;  3C8A A;  3FII A;  1XTG A;  3V0B A;  1S0G A;  1YVG A;  1ZB7 A;  1ZKW A;  2G7N A;  1S0C A;  1EPW A;  1G9D A;  3C8B A;  3C88 A;  1ZKX A;  2IMB A;  1ZN3 A;  1G9A A;  1F82 A;  3DEB A;  2A8A A;  2IMC A;  1S0E A;  3K3Q B;  4KTX A;  3FFZ A;  1ZL5 A;  3QIZ A;  3QW6 A;  3DSE A;  3DS9 A;  3C89 A;  4JIX A;  4IL3 A;  4JIU A;  3ZUQ A;  2EJQ A;  2ILP A;  2G7Q A;  3FIE A;  5BQN A;  1I1E A;  3QW7 A;  2IMA A;  3QW5 A;  3ZUS A;  3QIX A;  3QIY A;  2YPT A;  3BTA A;  2ISE A;  5BQM A;  4J1L A;  2NP0 A;  1Z7H A;  1S0B A;  1ZL6 A;  4KUF A;  3V0A B;  4ZJX A;  2A97 A;  4ELC A;  1S0F A;  3QW8 A;  2ISG A;  3CQB A;  2NYY A;  3DDA A;  3DDB A;  4QHF A;  3VUO A;  3BOO A;  2NZ9 A;  1T3C A;  4AW6 A;  2XHL A;  3ZUR A;  1E1H A;  2G7K A;  1F31 A;  2ISH A;  4ZKT B;  3D3X A;  3V0A A;  1G9B A;  3NF3 A;  3BON A;  4KS6 A;  3V0B B;  3BWI A;  4EL4 A;  3E11 A;  1S0D A;  2W2D A;  4HEV A;  1T3A A;  1XTF A;  2ETF A; 
#chains in the Genus database with same CATH homology
 1G9C A;  2G7P A;  3BOK A;  2QN0 A;  4EJ5 A;  3QJ0 A;  2FPQ A;  3C8A A;  3FII A;  1XTG A;  3V0B A;  1S0G A;  1YVG A;  1ZB7 A;  1ZKW A;  2G7N A;  1S0C A;  1EPW A;  1G9D A;  3C8B A;  3C88 A;  1ZKX A;  2IMB A;  1ZN3 A;  1G9A A;  1F82 A;  3DEB A;  2A8A A;  2IMC A;  1S0E A;  3K3Q B;  4KTX A;  3FFZ A;  1ZL5 A;  3QIZ A;  3QW6 A;  3DSE A;  3DS9 A;  3C89 A;  3ZUQ A;  2ILP A;  2G7Q A;  3FIE A;  5BQN A;  1I1E A;  3QW7 A;  2IMA A;  3QW5 A;  3ZUS A;  3QIX A;  3QIY A;  3BTA A;  2ISE A;  5BQM A;  4J1L A;  2NP0 A;  1Z7H A;  1S0B A;  1ZL6 A;  4KUF A;  3V0A B;  4ZJX A;  2A97 A;  4ELC A;  1S0F A;  2ISG A;  3QW8 A;  2NYY A;  3DDA A;  3DDB A;  3VUO A;  3BOO A;  2NZ9 A;  1T3C A;  2XHL A;  3ZUR A;  1E1H A;  2G7K A;  1F31 A;  2ISH A;  4ZKT B;  3D3X A;  3V0A A;  1G9B A;  3NF3 A;  3BON A;  4KS6 A;  3V0B B;  3BWI A;  4EL4 A;  1S0D A;  2W2D A;  4HEV A;  1T3A A;  1XTF A;  2ETF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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