2A97A

Crystal structure of catalytic domain of clostridium botulinum neurotoxin serotype f
Total Genus 134
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
134
sequence length
414
structure length
392
Chain Sequence
PVAINSFNYNDPVNDDTILYMQIPYEEKSKKYYKAFEIMRNVWIIPERNTIGTNPSDFDPPASLKNGSSAYYDPNYLTTDAEKDRYLKTTIKLFKRINSNPAGKVLLQEISYAKPYLGNDHTPIDEFSPVTRTTSVNIKLSTNVESSMLLNLLVLGAGPDIFESCCYPVRKLIDPDVVYDPSNYGFGSINIVTFSPEYEYTFNESFIADPAISLAHELIHALHGLYGARGVTYEETIPIRLEEFLTFGGQDLNIITSAMKEKIYNNLLANYEKIATRLSEVNSAPPEYDINEYKDYFQWKYGLDKNADGSYTVNENKFNEIYKKLYSFTESDLANKFKVKCRNTYFIKYEFLKVPNLLDDDIYTVSEGFNIGNLAVNNRGQSIKLNPKIIDS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of botulinum neurotoxin serotype f light chain: implications on substrate binding and inhibitor design
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type F
total genus 134
structure length 392
sequence length 414
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2005-07-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2a97A00
1G9DA 3C89A 2IMAA 2NYYA 3K3QB 1ZB7A 1T3AA 3QIYA 3V0AB 2ISHA 3ZUSA 3QJ0A 2A8AA 2A97A 3BWIA 1F31A 4KTXA 1ZL6A 1ZN3A 5BQNA 1G9AA 2XHLA 2IMCA 3C88A 1Z7HA 4EL4A 3QW5A 3DDAA 3QIZA 4KS6A 4J1LA 1S0BA 2ILPA 3BOOA 2ETFA 1YVGA 3QW6A 1EPWA 3DS9A 3QIXA 2IMBA 1S0GA 2FPQA 1T3CA 1G9CA 4EJ5A 1ZKXA 1E1HA 2G7PA 3FFZA 2NP0A 1S0EA 3C8BA 2G7KA 3DSEA 2G7NA 3V0BB 3ZURA 1ZL5A 3FIEA 1S0CA 3NF3A 4HEVA 3QW8A 4ZJXA 3V0BA 3D3XA 5BQMA 1G9BA 2ISEA 3DEBA 3C8AA 3BOKA 3ZUQA 4KUFA 1S0FA 2ISGA 1XTGA 1S0DA 4ELCA 1I1EA 2NZ9A 1F82A 3BTAA 2G7QA 3DDBA 1XTFA 3FIIA 3QW7A 4ZKTB 2QN0A 3V0AA 3BONA 1ZKWA 3VUOA 2W2DA
chains in the Genus database with same CATH superfamily
1G9DA 3C89A 2IMAA 2NYYA 3K3QB 1ZB7A 1T3AA 3QIYA 3V0AB 2ISHA 3ZUSA 3QJ0A 2A8AA 2YPTA 2A97A 3BWIA 1F31A 1ZL6A 4KTXA 1ZN3A 4JIXA 5BQNA 1G9AA 2XHLA 2IMCA 3C88A 1Z7HA 4EL4A 3E11A 3QW5A 3DDAA 3QIZA 4KS6A 3CQBA 4IL3A 4J1LA 1S0BA 2ILPA 3BOOA 2ETFA 1YVGA 3QW6A 1EPWA 3DS9A 3QIXA 2IMBA 1S0GA 4JIUA 2FPQA 1T3CA 1G9CA 4EJ5A 1ZKXA 2EJQA 1E1HA 2G7PA 3FFZA 2NP0A 1S0EA 3C8BA 2G7KA 3DSEA 2G7NA 3V0BB 3ZURA 4AW6A 1ZL5A 3FIEA 1S0CA 3NF3A 4HEVA 3QW8A 4ZJXA 3V0BA 3D3XA 5BQMA 4QHFA 1G9BA 2ISEA 3DEBA 3C8AA 3BOKA 3ZUQA 4KUFA 1S0FA 2ISGA 1XTGA 1S0DA 4ELCA 1I1EA 2NZ9A 1F82A 3BTAA 2G7QA 3DDBA 1XTFA 3FIIA 3QW7A 4ZKTB 2QN0A 3V0AA 3BONA 1ZKWA 3VUOA 2W2DA
chains in the Genus database with same CATH topology
1G9DA 3C89A 2IMAA 2NYYA 3K3QB 1ZB7A 1T3AA 3QIYA 3V0AB 2ISHA 3ZUSA 3QJ0A 2A8AA 2A97A 3BWIA 1F31A 4KTXA 1ZL6A 1ZN3A 5BQNA 1G9AA 2XHLA 2IMCA 3C88A 1Z7HA 4EL4A 3QW5A 3DDAA 3QIZA 4KS6A 4J1LA 1S0BA 2ILPA 3BOOA 2ETFA 1YVGA 3QW6A 1EPWA 3DS9A 3QIXA 2IMBA 1S0GA 2FPQA 1T3CA 1G9CA 4EJ5A 1ZKXA 1E1HA 2G7PA 3FFZA 2NP0A 1S0EA 3C8BA 2G7KA 3DSEA 2G7NA 3V0BB 3ZURA 1ZL5A 3FIEA 1S0CA 3NF3A 4HEVA 3QW8A 4ZJXA 3V0BA 3D3XA 5BQMA 1G9BA 2ISEA 3DEBA 3C8AA 3BOKA 3ZUQA 4KUFA 1S0FA 2ISGA 1XTGA 1S0DA 4ELCA 1I1EA 2NZ9A 1F82A 3BTAA 2G7QA 3DDBA 1XTFA 3FIIA 3QW7A 4ZKTB 2QN0A 3V0AA 3BONA 1ZKWA 3VUOA 2W2DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1G9D A;  3C89 A;  2IMA A;  2NYY A;  3K3Q B;  1ZB7 A;  1T3A A;  3QIY A;  3V0A B;  2ISH A;  3ZUS A;  3QJ0 A;  2A8A A;  2A97 A;  3BWI A;  1F31 A;  4KTX A;  1ZL6 A;  1ZN3 A;  5BQN A;  1G9A A;  2XHL A;  2IMC A;  3C88 A;  1Z7H A;  4EL4 A;  3QW5 A;  3DDA A;  3QIZ A;  4KS6 A;  4J1L A;  1S0B A;  2ILP A;  3BOO A;  2ETF A;  1YVG A;  3QW6 A;  1EPW A;  3DS9 A;  3QIX A;  2IMB A;  1S0G A;  2FPQ A;  1T3C A;  1G9C A;  4EJ5 A;  1ZKX A;  1E1H A;  2G7P A;  3FFZ A;  2NP0 A;  1S0E A;  3C8B A;  2G7K A;  3DSE A;  2G7N A;  3V0B B;  3ZUR A;  1ZL5 A;  3FIE A;  1S0C A;  3NF3 A;  4HEV A;  3QW8 A;  4ZJX A;  3V0B A;  3D3X A;  5BQM A;  1G9B A;  2ISE A;  3DEB A;  3C8A A;  3BOK A;  3ZUQ A;  4KUF A;  1S0F A;  2ISG A;  1XTG A;  1S0D A;  4ELC A;  1I1E A;  2NZ9 A;  1F82 A;  3BTA A;  2G7Q A;  3DDB A;  1XTF A;  3FII A;  3QW7 A;  4ZKT B;  2QN0 A;  3V0A A;  3BON A;  1ZKW A;  3VUO A;  2W2D A; 
#chains in the Genus database with same CATH topology
 1G9D A;  3C89 A;  2IMA A;  2NYY A;  3K3Q B;  1ZB7 A;  1T3A A;  3QIY A;  3V0A B;  2ISH A;  3ZUS A;  3QJ0 A;  2A8A A;  2YPT A;  2A97 A;  3BWI A;  1F31 A;  1ZL6 A;  4KTX A;  1ZN3 A;  4JIX A;  5BQN A;  1G9A A;  2XHL A;  2IMC A;  3C88 A;  1Z7H A;  4EL4 A;  3E11 A;  3QW5 A;  3DDA A;  3QIZ A;  4KS6 A;  3CQB A;  4IL3 A;  4J1L A;  1S0B A;  2ILP A;  3BOO A;  2ETF A;  1YVG A;  3QW6 A;  1EPW A;  3DS9 A;  3QIX A;  2IMB A;  1S0G A;  4JIU A;  2FPQ A;  1T3C A;  1G9C A;  4EJ5 A;  1ZKX A;  2EJQ A;  1E1H A;  2G7P A;  3FFZ A;  2NP0 A;  1S0E A;  3C8B A;  2G7K A;  3DSE A;  2G7N A;  3V0B B;  3ZUR A;  4AW6 A;  1ZL5 A;  3FIE A;  1S0C A;  3NF3 A;  4HEV A;  3QW8 A;  4ZJX A;  3V0B A;  3D3X A;  5BQM A;  4QHF A;  1G9B A;  2ISE A;  3DEB A;  3C8A A;  3BOK A;  3ZUQ A;  4KUF A;  1S0F A;  2ISG A;  1XTG A;  1S0D A;  4ELC A;  1I1E A;  2NZ9 A;  1F82 A;  3BTA A;  2G7Q A;  3DDB A;  1XTF A;  3FII A;  3QW7 A;  4ZKT B;  2QN0 A;  3V0A A;  3BON A;  1ZKW A;  3VUO A;  2W2D A; 
#chains in the Genus database with same CATH homology
 1G9D A;  3C89 A;  2IMA A;  2NYY A;  3K3Q B;  1ZB7 A;  1T3A A;  3QIY A;  3V0A B;  2ISH A;  3ZUS A;  3QJ0 A;  2A8A A;  2A97 A;  3BWI A;  1F31 A;  4KTX A;  1ZL6 A;  1ZN3 A;  5BQN A;  1G9A A;  2XHL A;  2IMC A;  3C88 A;  1Z7H A;  4EL4 A;  3QW5 A;  3DDA A;  3QIZ A;  4KS6 A;  4J1L A;  1S0B A;  2ILP A;  3BOO A;  2ETF A;  1YVG A;  3QW6 A;  1EPW A;  3DS9 A;  3QIX A;  2IMB A;  1S0G A;  2FPQ A;  1T3C A;  1G9C A;  4EJ5 A;  1ZKX A;  1E1H A;  2G7P A;  3FFZ A;  2NP0 A;  1S0E A;  3C8B A;  2G7K A;  3DSE A;  2G7N A;  3V0B B;  3ZUR A;  1ZL5 A;  3FIE A;  1S0C A;  3NF3 A;  4HEV A;  3QW8 A;  4ZJX A;  3V0B A;  3D3X A;  5BQM A;  1G9B A;  2ISE A;  3DEB A;  3C8A A;  3BOK A;  3ZUQ A;  4KUF A;  1S0F A;  2ISG A;  1XTG A;  1S0D A;  4ELC A;  1I1E A;  2NZ9 A;  1F82 A;  3BTA A;  2G7Q A;  3DDB A;  1XTF A;  3FII A;  3QW7 A;  4ZKT B;  2QN0 A;  3V0A A;  3BON A;  1ZKW A;  3VUO A;  2W2D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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