2A97 | Genus

Total Genus 134

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	134
sequence length	414
structure length	392
Chain Sequence	PVAINSFNYNDPVNDDTILYMQIPYEEKSKKYYKAFEIMRNVWIIPERNTIGTNPSDFDPPASLKNGSSAYYDPNYLTTDAEKDRYLKTTIKLFKRINSNPAGKVLLQEISYAKPYLGNDHTPIDEFSPVTRTTSVNIKLSTNVESSMLLNLLVLGAGPDIFESCCYPVRKLIDPDVVYDPSNYGFGSINIVTFSPEYEYTFNESFIADPAISLAHELIHALHGLYGARGVTYEETIPIRLEEFLTFGGQDLNIITSAMKEKIYNNLLANYEKIATRLSEVNSAPPEYDINEYKDYFQWKYGLDKNADGSYTVNENKFNEIYKKLYSFTESDLANKFKVKCRNTYFIKYEFLKVPNLLDDDIYTVSEGFNIGNLAVNNRGQSIKLNPKIIDS

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Structural analysis of botulinum neurotoxin serotype f light chain: implications on substrate binding and inhibitor design pubmed doi rcsb
molecule keywords	Botulinum neurotoxin type F
total genus	134
structure length	392
sequence length	414
chains with identical sequence	B
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2005-07-11

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	2a97A00

3NF3A 1ZKXA 1G9CA 3DEBA 3BOOA 1E1HA 3BWIA 3BTAA 1G9DA 3C8BA 2ETFA 1G9AA 2IMCA 3FIIA 1G9BA 2A8AA 3QW8A 3V0BA 4KS6A 2ISHA 2ISGA 4KTXA 3BONA 2G7KA 4HEVA 3DSEA 5BQMA 3QIYA 1ZN3A 1XTFA 3DDBA 3ZUQA 3QIXA 1Z7HA 1T3CA 1S0FA 4EJ5A 4ZJXA 3C88A 2QN0A 2G7NA 2FPQA 4J1LA 3V0AA 1YVGA 1F31A 1EPWA 3QW7A 2NP0A 4KUFA 1ZL6A 3DS9A 4ELCA 3QJ0A 3ZURA 3V0BB 3FFZA 1S0DA 2G7PA 1F82A 3FIEA 3D3XA 1S0CA 3QW5A 1S0BA 1S0EA 2G7QA 3C89A 3ZUSA 2IMAA 3V0AB 1ZKWA 2NYYA 2IMBA 3C8AA 1XTGA 2W2DA 2ISEA 3QIZA 4ZKTB 1ZB7A 3DDAA 5BQNA 2NZ9A 3VUOA 4EL4A 1I1EA 1T3AA 3K3QB 2ILPA 3QW6A 2A97A 1ZL5A 3BOKA 1S0GA 2XHLA
chains in the Genus database with same CATH superfamily

3NF3A 1ZKXA 1G9CA 3DEBA 3BOOA 1E1HA 3BWIA 3BTAA 1G9DA 3C8BA 2ETFA 3E11A 1G9AA 2IMCA 3FIIA 1G9BA 2A8AA 3QW8A 3V0BA 4KS6A 2ISHA 2ISGA 4KTXA 4JIXA 3BONA 2G7KA 4HEVA 3DSEA 5BQMA 3QIYA 1ZN3A 2EJQA 1XTFA 3DDBA 3ZUQA 3QIXA 1Z7HA 1T3CA 1S0FA 4EJ5A 4ZJXA 3C88A 2QN0A 2G7NA 2FPQA 4J1LA 3V0AA 1YVGA 1F31A 1EPWA 3QW7A 2NP0A 4KUFA 1ZL6A 3DS9A 4ELCA 3QJ0A 4JIUA 4AW6A 3ZURA 3V0BB 3FFZA 1S0DA 2G7PA 4IL3A 1F82A 3FIEA 3D3XA 1S0CA 3QW5A 1S0BA 1S0EA 2G7QA 3C89A 3ZUSA 2IMAA 3V0AB 1ZKWA 2NYYA 4QHFA 2IMBA 3C8AA 1XTGA 2W2DA 2ISEA 3QIZA 4ZKTB 1ZB7A 3DDAA 5BQNA 2NZ9A 3VUOA 4EL4A 1I1EA 1T3AA 3K3QB 2ILPA 3CQBA 2YPTA 3QW6A 2A97A 1ZL5A 3BOKA 1S0GA 2XHLA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3NF3 A;  1ZKX A;  1G9C A;  3DEB A;  3BOO A;  1E1H A;  3BWI A;  3BTA A;  1G9D A;  3C8B A;  2ETF A;  1G9A A;  2IMC A;  3FII A;  1G9B A;  2A8A A;  3QW8 A;  3V0B A;  4KS6 A;  2ISH A;  2ISG A;  4KTX A;  3BON A;  2G7K A;  4HEV A;  3DSE A;  5BQM A;  3QIY A;  1ZN3 A;  1XTF A;  3DDB A;  3ZUQ A;  3QIX A;  1Z7H A;  1T3C A;  1S0F A;  4EJ5 A;  4ZJX A;  3C88 A;  2QN0 A;  2G7N A;  2FPQ A;  4J1L A;  3V0A A;  1YVG A;  1F31 A;  1EPW A;  3QW7 A;  2NP0 A;  4KUF A;  1ZL6 A;  3DS9 A;  4ELC A;  3QJ0 A;  3ZUR A;  3V0B B;  3FFZ A;  1S0D A;  2G7P A;  1F82 A;  3FIE A;  3D3X A;  1S0C A;  3QW5 A;  1S0B A;  1S0E A;  2G7Q A;  3C89 A;  3ZUS A;  2IMA A;  3V0A B;  1ZKW A;  2NYY A;  2IMB A;  3C8A A;  1XTG A;  2W2D A;  2ISE A;  3QIZ A;  4ZKT B;  1ZB7 A;  3DDA A;  5BQN A;  2NZ9 A;  3VUO A;  4EL4 A;  1I1E A;  1T3A A;  3K3Q B;  2ILP A;  3QW6 A;  2A97 A;  1ZL5 A;  3BOK A;  1S0G A;  2XHL A; 
#chains in the Genus database with same CATH topology
 3NF3 A;  1ZKX A;  1G9C A;  3DEB A;  3BOO A;  1E1H A;  3BWI A;  3BTA A;  1G9D A;  3C8B A;  2ETF A;  3E11 A;  1G9A A;  2IMC A;  3FII A;  1G9B A;  2A8A A;  3QW8 A;  3V0B A;  4KS6 A;  2ISH A;  2ISG A;  4KTX A;  4JIX A;  3BON A;  2G7K A;  4HEV A;  3DSE A;  5BQM A;  3QIY A;  1ZN3 A;  2EJQ A;  1XTF A;  3DDB A;  3ZUQ A;  3QIX A;  1Z7H A;  1T3C A;  1S0F A;  4EJ5 A;  4ZJX A;  3C88 A;  2QN0 A;  2G7N A;  2FPQ A;  4J1L A;  3V0A A;  1YVG A;  1F31 A;  1EPW A;  3QW7 A;  2NP0 A;  4KUF A;  1ZL6 A;  3DS9 A;  4ELC A;  3QJ0 A;  4JIU A;  4AW6 A;  3ZUR A;  3V0B B;  3FFZ A;  1S0D A;  2G7P A;  4IL3 A;  1F82 A;  3FIE A;  3D3X A;  1S0C A;  3QW5 A;  1S0B A;  1S0E A;  2G7Q A;  3C89 A;  3ZUS A;  2IMA A;  3V0A B;  1ZKW A;  2NYY A;  4QHF A;  2IMB A;  3C8A A;  1XTG A;  2W2D A;  2ISE A;  3QIZ A;  4ZKT B;  1ZB7 A;  3DDA A;  5BQN A;  2NZ9 A;  3VUO A;  4EL4 A;  1I1E A;  1T3A A;  3K3Q B;  2ILP A;  3CQB A;  2YPT A;  3QW6 A;  2A97 A;  1ZL5 A;  3BOK A;  1S0G A;  2XHL A; 
#chains in the Genus database with same CATH homology
 3NF3 A;  1ZKX A;  1G9C A;  3DEB A;  3BOO A;  1E1H A;  3BWI A;  3BTA A;  1G9D A;  3C8B A;  2ETF A;  1G9A A;  2IMC A;  3FII A;  1G9B A;  2A8A A;  3QW8 A;  3V0B A;  4KS6 A;  2ISH A;  2ISG A;  4KTX A;  3BON A;  2G7K A;  4HEV A;  3DSE A;  5BQM A;  3QIY A;  1ZN3 A;  1XTF A;  3DDB A;  3ZUQ A;  3QIX A;  1Z7H A;  1T3C A;  1S0F A;  4EJ5 A;  4ZJX A;  3C88 A;  2QN0 A;  2G7N A;  2FPQ A;  4J1L A;  3V0A A;  1YVG A;  1F31 A;  1EPW A;  3QW7 A;  2NP0 A;  4KUF A;  1ZL6 A;  3DS9 A;  4ELC A;  3QJ0 A;  3ZUR A;  3V0B B;  3FFZ A;  1S0D A;  2G7P A;  1F82 A;  3FIE A;  3D3X A;  1S0C A;  3QW5 A;  1S0B A;  1S0E A;  2G7Q A;  3C89 A;  3ZUS A;  2IMA A;  3V0A B;  1ZKW A;  2NYY A;  2IMB A;  3C8A A;  1XTG A;  2W2D A;  2ISE A;  3QIZ A;  4ZKT B;  1ZB7 A;  3DDA A;  5BQN A;  2NZ9 A;  3VUO A;  4EL4 A;  1I1E A;  1T3A A;  3K3Q B;  2ILP A;  3QW6 A;  2A97 A;  1ZL5 A;  3BOK A;  1S0G A;  2XHL A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2A97A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations