2ETF | Genus

Total Genus 132

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	132
sequence length	437
structure length	431
Chain Sequence	PVTINNFNYNDPIDNNNIIMMEPPFARGTGRYYKAFKITDRIWIIPERYTFGYKPEDFNKSSGIFNRDVEYYDPDYLNTNDKKNIFLQTMIKLFNRIKSKPLGEKLLEMIINGIPYLGDRRVPLEEFNTNIASVTVNKLISNPGEVERKKGIFANLIIFGPGPVLNENETIDIGIQNHFASREGFGGIMQMKFCPEYVSVFNNVQENKGASIFNRRGYFSDPALILMHELIHVLHGLYGIKVDDLPIVPFMQSTDAIQAEELYTFGGQDPSIITPSTDKSIYDKVLQNFRGIVDRLNKVLVCISDPNININIYKNKFKDKYKFVEDSEGKYSIDVESFDKLYKSLMFGFTETNIAENYKIKTRASYFSDSLPPVKIKNLLDNEIYTIEEGFNISDKDMEKEYRGQNKAINKQAYEEISKEHLAVYKIQMCK

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Crystal structure of full length botulinum neurotoxin (Type B) light chain rcsb
molecule keywords	Botulinum neurotoxin B light chain
total genus	132
structure length	431
sequence length	437
chains with identical sequence	B
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2005-10-27

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	2etfA00

2A8AA 2ILPA 2XHLA 3C88A 3BOOA 3BWIA 3QIZA 3C8AA 4ELCA 2IMAA 2QN0A 1F31A 2IMBA 3NF3A 3V0AA 3ZUQA 3FIIA 2FPQA 1S0DA 1S0FA 2ISHA 3FFZA 2W2DA 1XTFA 3QIYA 2NYYA 3ZURA 1ZKWA 2G7NA 3QIXA 3DEBA 2G7PA 3V0AB 2ETFA 2NP0A 3QW7A 3DS9A 1T3AA 3QJ0A 1S0GA 2ISGA 3FIEA 4EJ5A 2A97A 3D3XA 1E1HA 1ZL5A 1YVGA 5BQMA 3BOKA 2NZ9A 1S0CA 1G9AA 4EL4A 4KUFA 4ZKTB 3C89A 1T3CA 1XTGA 3BTAA 3VUOA 3DSEA 3BONA 1ZKXA 1G9CA 3QW8A 4ZJXA 3DDAA 2ISEA 4HEVA 1ZB7A 1Z7HA 2G7KA 2IMCA 1S0EA 1G9DA 1ZN3A 1F82A 1ZL6A 1S0BA 3QW5A 2G7QA 4KTXA 3ZUSA 1I1EA 3V0BB 3C8BA 5BQNA 4J1LA 1EPWA 1G9BA 4KS6A 3QW6A 3DDBA 3K3QB 3V0BA
chains in the Genus database with same CATH superfamily

2A8AA 2ILPA 2XHLA 3C88A 3BOOA 3BWIA 3QIZA 3C8AA 4ELCA 2IMAA 2QN0A 1F31A 2IMBA 3NF3A 3V0AA 3ZUQA 3FIIA 2FPQA 1S0DA 1S0FA 2ISHA 3FFZA 2W2DA 1XTFA 3QIYA 2NYYA 4AW6A 3ZURA 1ZKWA 2G7NA 3QIXA 3DEBA 2G7PA 3V0AB 2YPTA 2ETFA 2NP0A 2EJQA 3QW7A 3DS9A 1T3AA 3QJ0A 1S0GA 2ISGA 3FIEA 4EJ5A 2A97A 3D3XA 1E1HA 1ZL5A 1YVGA 5BQMA 3BOKA 2NZ9A 1S0CA 1G9AA 4IL3A 4EL4A 4KUFA 4ZKTB 3C89A 1T3CA 1XTGA 3BTAA 3VUOA 3DSEA 3BONA 1ZKXA 1G9CA 3QW8A 4ZJXA 3DDAA 2ISEA 4HEVA 1ZB7A 1Z7HA 2G7KA 2IMCA 1S0EA 1G9DA 1ZN3A 1F82A 1ZL6A 1S0BA 3QW5A 2G7QA 4KTXA 4QHFA 3ZUSA 4JIXA 3CQBA 1I1EA 3V0BB 3C8BA 4JIUA 5BQNA 4J1LA 1EPWA 1G9BA 4KS6A 3QW6A 3DDBA 3K3QB 3V0BA 3E11A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2A8A A;  2ILP A;  2XHL A;  3C88 A;  3BOO A;  3BWI A;  3QIZ A;  3C8A A;  4ELC A;  2IMA A;  2QN0 A;  1F31 A;  2IMB A;  3NF3 A;  3V0A A;  3ZUQ A;  3FII A;  2FPQ A;  1S0D A;  1S0F A;  2ISH A;  3FFZ A;  2W2D A;  1XTF A;  3QIY A;  2NYY A;  3ZUR A;  1ZKW A;  2G7N A;  3QIX A;  3DEB A;  2G7P A;  3V0A B;  2ETF A;  2NP0 A;  3QW7 A;  3DS9 A;  1T3A A;  3QJ0 A;  1S0G A;  2ISG A;  3FIE A;  4EJ5 A;  2A97 A;  3D3X A;  1E1H A;  1ZL5 A;  1YVG A;  5BQM A;  3BOK A;  2NZ9 A;  1S0C A;  1G9A A;  4EL4 A;  4KUF A;  4ZKT B;  3C89 A;  1T3C A;  1XTG A;  3BTA A;  3VUO A;  3DSE A;  3BON A;  1ZKX A;  1G9C A;  3QW8 A;  4ZJX A;  3DDA A;  2ISE A;  4HEV A;  1ZB7 A;  1Z7H A;  2G7K A;  2IMC A;  1S0E A;  1G9D A;  1ZN3 A;  1F82 A;  1ZL6 A;  1S0B A;  3QW5 A;  2G7Q A;  4KTX A;  3ZUS A;  1I1E A;  3V0B B;  3C8B A;  5BQN A;  4J1L A;  1EPW A;  1G9B A;  4KS6 A;  3QW6 A;  3DDB A;  3K3Q B;  3V0B A; 
#chains in the Genus database with same CATH topology
 2A8A A;  2ILP A;  2XHL A;  3C88 A;  3BOO A;  3BWI A;  3QIZ A;  3C8A A;  4ELC A;  2IMA A;  2QN0 A;  1F31 A;  2IMB A;  3NF3 A;  3V0A A;  3ZUQ A;  3FII A;  2FPQ A;  1S0D A;  1S0F A;  2ISH A;  3FFZ A;  2W2D A;  1XTF A;  3QIY A;  2NYY A;  4AW6 A;  3ZUR A;  1ZKW A;  2G7N A;  3QIX A;  3DEB A;  2G7P A;  3V0A B;  2YPT A;  2ETF A;  2NP0 A;  2EJQ A;  3QW7 A;  3DS9 A;  1T3A A;  3QJ0 A;  1S0G A;  2ISG A;  3FIE A;  4EJ5 A;  2A97 A;  3D3X A;  1E1H A;  1ZL5 A;  1YVG A;  5BQM A;  3BOK A;  2NZ9 A;  1S0C A;  1G9A A;  4IL3 A;  4EL4 A;  4KUF A;  4ZKT B;  3C89 A;  1T3C A;  1XTG A;  3BTA A;  3VUO A;  3DSE A;  3BON A;  1ZKX A;  1G9C A;  3QW8 A;  4ZJX A;  3DDA A;  2ISE A;  4HEV A;  1ZB7 A;  1Z7H A;  2G7K A;  2IMC A;  1S0E A;  1G9D A;  1ZN3 A;  1F82 A;  1ZL6 A;  1S0B A;  3QW5 A;  2G7Q A;  4KTX A;  4QHF A;  3ZUS A;  4JIX A;  3CQB A;  1I1E A;  3V0B B;  3C8B A;  4JIU A;  5BQN A;  4J1L A;  1EPW A;  1G9B A;  4KS6 A;  3QW6 A;  3DDB A;  3K3Q B;  3V0B A;  3E11 A; 
#chains in the Genus database with same CATH homology
 2A8A A;  2ILP A;  2XHL A;  3C88 A;  3BOO A;  3BWI A;  3QIZ A;  3C8A A;  4ELC A;  2IMA A;  2QN0 A;  1F31 A;  2IMB A;  3NF3 A;  3V0A A;  3ZUQ A;  3FII A;  2FPQ A;  1S0D A;  1S0F A;  2ISH A;  3FFZ A;  2W2D A;  1XTF A;  3QIY A;  2NYY A;  3ZUR A;  1ZKW A;  2G7N A;  3QIX A;  3DEB A;  2G7P A;  3V0A B;  2ETF A;  2NP0 A;  3QW7 A;  3DS9 A;  1T3A A;  3QJ0 A;  1S0G A;  2ISG A;  3FIE A;  4EJ5 A;  2A97 A;  3D3X A;  1E1H A;  1ZL5 A;  1YVG A;  5BQM A;  3BOK A;  2NZ9 A;  1S0C A;  1G9A A;  4EL4 A;  4KUF A;  4ZKT B;  3C89 A;  1T3C A;  1XTG A;  3BTA A;  3VUO A;  3DSE A;  3BON A;  1ZKX A;  1G9C A;  3QW8 A;  4ZJX A;  3DDA A;  2ISE A;  4HEV A;  1ZB7 A;  1Z7H A;  2G7K A;  2IMC A;  1S0E A;  1G9D A;  1ZN3 A;  1F82 A;  1ZL6 A;  1S0B A;  3QW5 A;  2G7Q A;  4KTX A;  3ZUS A;  1I1E A;  3V0B B;  3C8B A;  5BQN A;  4J1L A;  1EPW A;  1G9B A;  4KS6 A;  3QW6 A;  3DDB A;  3K3Q B;  3V0B A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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2ETFA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations