2FPQ | Genus

Total Genus 128

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	128
sequence length	426
structure length	413
Chain Sequence	EFMTWPVKDFNYSDPVNDNDILYLRIPQNKLITTPVKAFMITQNIWVIPERFSSDTNPSLSKPPRPTSKYQSYYDPSYLSTDEQKDTFLKGIIKLFKRINERDIGKKLINYLVVGSPFMGDSSTPEDTFDFTRHTTNIAVEKFENGSWKVTNIITPSVLIFGPLPNILDYTASLTQSNPSFEGFGTLSILKVAPEFLLTFSDVGKSIFCMDPVIALMHELTHSLHQLYGINIPSDKRIRPQVSEGFFSQDGPNVQFEELYTFGGLDVEIIPQIERSQLREKALGHYKDIAKRLNNINKTIPSSWISNIDKYKKIFSEKYNFDKDNTGNFVVNIDKFNSLYSDLTNVMSEVVYSSQYNVKNRTHYFSRHYLPVFANILDDNIYTIRDGFNLTNKGFNIENSGQNIERNPALQKL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Toxin
source organism	Clostridium botulinum
publication title	Structure of Botulinum Neurotoxin Type D Light Chain at 1.65 A Resolution: Repercussions for VAMP-2 Substrate Specificity(,). pubmed doi rcsb
molecule keywords	BOTULINUM NEUROTOXIN D LIGHT CHAIN
total genus	128
structure length	413
sequence length	426
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2006-01-16

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	2fpqA00

1T3CA 1G9DA 3NF3A 2ETFA 5BQNA 1S0FA 1S0BA 2FPQA 3BONA 1YVGA 1ZB7A 1F82A 2W2DA 3DDAA 3V0BB 3D3XA 1ZKXA 1ZN3A 3QW5A 2XHLA 1E1HA 2G7PA 2NYYA 3VUOA 5BQMA 1XTFA 3QIYA 1ZL6A 4ZKTB 2ILPA 3ZUQA 4KUFA 4ELCA 2ISGA 3QJ0A 3QIZA 3ZURA 1S0EA 3DS9A 4KS6A 2A8AA 3QW8A 2IMAA 3FIEA 3FFZA 2G7NA 1S0CA 1EPWA 2G7KA 2ISHA 1Z7HA 2G7QA 3K3QB 3QW7A 1S0DA 3DEBA 3C8BA 2QN0A 3QW6A 2IMBA 2A97A 3C89A 3QIXA 4ZJXA 3DDBA 3BOKA 3ZUSA 4EL4A 3C8AA 1ZL5A 2ISEA 1G9CA 1G9AA 1XTGA 1G9BA 3V0AA 3C88A 3BOOA 2IMCA 3V0BA 3V0AB 1T3AA 1F31A 1ZKWA 4KTXA 3BWIA 1I1EA 1S0GA 3BTAA 2NP0A 4EJ5A 2NZ9A 3FIIA 4HEVA 3DSEA 4J1LA
chains in the Genus database with same CATH superfamily

1T3CA 4JIXA 1G9DA 3NF3A 2EJQA 2ETFA 5BQNA 1S0FA 1S0BA 2FPQA 3BONA 1YVGA 1ZB7A 1F82A 2W2DA 3DDAA 3V0BB 3D3XA 4QHFA 1ZKXA 1ZN3A 3QW5A 2XHLA 4JIUA 3CQBA 1E1HA 2G7PA 2NYYA 3VUOA 5BQMA 1XTFA 3QIYA 1ZL6A 4ZKTB 2ILPA 3ZUQA 4KUFA 4ELCA 2ISGA 3QJ0A 4IL3A 3QIZA 3ZURA 1S0EA 3DS9A 4KS6A 2A8AA 3QW8A 2IMAA 3FIEA 3FFZA 2G7NA 1S0CA 1EPWA 2G7KA 2ISHA 1Z7HA 2G7QA 3K3QB 3E11A 3QW7A 1S0DA 3DEBA 3C8BA 2QN0A 3QW6A 2IMBA 2A97A 3C89A 3QIXA 4ZJXA 3DDBA 3BOKA 3ZUSA 4EL4A 3C8AA 1ZL5A 2ISEA 1G9CA 1G9AA 1XTGA 1G9BA 3V0AA 3C88A 3BOOA 2IMCA 3V0BA 3V0AB 1T3AA 1F31A 1ZKWA 4KTXA 3BWIA 2YPTA 1I1EA 1S0GA 3BTAA 2NP0A 4EJ5A 4AW6A 2NZ9A 3FIIA 4HEVA 3DSEA 4J1LA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1T3C A;  1G9D A;  3NF3 A;  2ETF A;  5BQN A;  1S0F A;  1S0B A;  2FPQ A;  3BON A;  1YVG A;  1ZB7 A;  1F82 A;  2W2D A;  3DDA A;  3V0B B;  3D3X A;  1ZKX A;  1ZN3 A;  3QW5 A;  2XHL A;  1E1H A;  2G7P A;  2NYY A;  3VUO A;  5BQM A;  1XTF A;  3QIY A;  1ZL6 A;  4ZKT B;  2ILP A;  3ZUQ A;  4KUF A;  4ELC A;  2ISG A;  3QJ0 A;  3QIZ A;  3ZUR A;  1S0E A;  3DS9 A;  4KS6 A;  2A8A A;  3QW8 A;  2IMA A;  3FIE A;  3FFZ A;  2G7N A;  1S0C A;  1EPW A;  2G7K A;  2ISH A;  1Z7H A;  2G7Q A;  3K3Q B;  3QW7 A;  1S0D A;  3DEB A;  3C8B A;  2QN0 A;  3QW6 A;  2IMB A;  2A97 A;  3C89 A;  3QIX A;  4ZJX A;  3DDB A;  3BOK A;  3ZUS A;  4EL4 A;  3C8A A;  1ZL5 A;  2ISE A;  1G9C A;  1G9A A;  1XTG A;  1G9B A;  3V0A A;  3C88 A;  3BOO A;  2IMC A;  3V0B A;  3V0A B;  1T3A A;  1F31 A;  1ZKW A;  4KTX A;  3BWI A;  1I1E A;  1S0G A;  3BTA A;  2NP0 A;  4EJ5 A;  2NZ9 A;  3FII A;  4HEV A;  3DSE A;  4J1L A; 
#chains in the Genus database with same CATH topology
 1T3C A;  4JIX A;  1G9D A;  3NF3 A;  2EJQ A;  2ETF A;  5BQN A;  1S0F A;  1S0B A;  2FPQ A;  3BON A;  1YVG A;  1ZB7 A;  1F82 A;  2W2D A;  3DDA A;  3V0B B;  3D3X A;  4QHF A;  1ZKX A;  1ZN3 A;  3QW5 A;  2XHL A;  4JIU A;  3CQB A;  1E1H A;  2G7P A;  2NYY A;  3VUO A;  5BQM A;  1XTF A;  3QIY A;  1ZL6 A;  4ZKT B;  2ILP A;  3ZUQ A;  4KUF A;  4ELC A;  2ISG A;  3QJ0 A;  4IL3 A;  3QIZ A;  3ZUR A;  1S0E A;  3DS9 A;  4KS6 A;  2A8A A;  3QW8 A;  2IMA A;  3FIE A;  3FFZ A;  2G7N A;  1S0C A;  1EPW A;  2G7K A;  2ISH A;  1Z7H A;  2G7Q A;  3K3Q B;  3E11 A;  3QW7 A;  1S0D A;  3DEB A;  3C8B A;  2QN0 A;  3QW6 A;  2IMB A;  2A97 A;  3C89 A;  3QIX A;  4ZJX A;  3DDB A;  3BOK A;  3ZUS A;  4EL4 A;  3C8A A;  1ZL5 A;  2ISE A;  1G9C A;  1G9A A;  1XTG A;  1G9B A;  3V0A A;  3C88 A;  3BOO A;  2IMC A;  3V0B A;  3V0A B;  1T3A A;  1F31 A;  1ZKW A;  4KTX A;  3BWI A;  2YPT A;  1I1E A;  1S0G A;  3BTA A;  2NP0 A;  4EJ5 A;  4AW6 A;  2NZ9 A;  3FII A;  4HEV A;  3DSE A;  4J1L A; 
#chains in the Genus database with same CATH homology
 1T3C A;  1G9D A;  3NF3 A;  2ETF A;  5BQN A;  1S0F A;  1S0B A;  2FPQ A;  3BON A;  1YVG A;  1ZB7 A;  1F82 A;  2W2D A;  3DDA A;  3V0B B;  3D3X A;  1ZKX A;  1ZN3 A;  3QW5 A;  2XHL A;  1E1H A;  2G7P A;  2NYY A;  3VUO A;  5BQM A;  1XTF A;  3QIY A;  1ZL6 A;  4ZKT B;  2ILP A;  3ZUQ A;  4KUF A;  4ELC A;  2ISG A;  3QJ0 A;  3QIZ A;  3ZUR A;  1S0E A;  3DS9 A;  4KS6 A;  2A8A A;  3QW8 A;  2IMA A;  3FIE A;  3FFZ A;  2G7N A;  1S0C A;  1EPW A;  2G7K A;  2ISH A;  1Z7H A;  2G7Q A;  3K3Q B;  3QW7 A;  1S0D A;  3DEB A;  3C8B A;  2QN0 A;  3QW6 A;  2IMB A;  2A97 A;  3C89 A;  3QIX A;  4ZJX A;  3DDB A;  3BOK A;  3ZUS A;  4EL4 A;  3C8A A;  1ZL5 A;  2ISE A;  1G9C A;  1G9A A;  1XTG A;  1G9B A;  3V0A A;  3C88 A;  3BOO A;  2IMC A;  3V0B A;  3V0A B;  1T3A A;  1F31 A;  1ZKW A;  4KTX A;  3BWI A;  1I1E A;  1S0G A;  3BTA A;  2NP0 A;  4EJ5 A;  2NZ9 A;  3FII A;  4HEV A;  3DSE A;  4J1L A;

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similar chains in the Genus database (?% sequence similarity)

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#similar chains, but unknotted
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2FPQA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations