2G7KA

Structure of the light chain of botulinum neurotoxin, serotype a bound to small molecule inhibitors
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
416
structure length
401
Chain Sequence
MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINRKTYLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 129
structure length 401
sequence length 416
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2g7kA00
2ISEA 3NF3A 5BQMA 3C88A 1EPWA 2G7QA 1G9BA 1T3AA 1XTFA 2A97A 3V0BB 3VUOA 2NZ9A 2W2DA 2G7PA 3BWIA 3DSEA 3FFZA 4J1LA 1E1HA 3C89A 1ZKXA 4EJ5A 3QW5A 3BONA 3FIIA 3V0AB 3QJ0A 3V0BA 1G9CA 3DEBA 2ETFA 3DDAA 2IMAA 4EL4A 1I1EA 1ZL5A 1ZL6A 3D3XA 4KTXA 1S0CA 2G7NA 3DS9A 3QW7A 1F82A 4ZKTB 4ZJXA 2FPQA 1S0GA 3ZUSA 1F31A 2NP0A 4KUFA 1S0BA 3ZUQA 1T3CA 5BQNA 1ZB7A 1XTGA 1S0DA 1S0EA 2XHLA 4ELCA 3QW8A 2G7KA 1G9AA 2IMBA 1G9DA 1Z7HA 3FIEA 2ISHA 3C8AA 1ZN3A 3K3QB 4HEVA 4KS6A 3BOKA 1ZKWA 2ILPA 1S0FA 3V0AA 3DDBA 2QN0A 3BOOA 3ZURA 2IMCA 3QW6A 2ISGA 3QIZA 3QIYA 2NYYA 1YVGA 2A8AA 3C8BA 3QIXA 3BTAA
chains in the Genus database with same CATH superfamily
2ISEA 3NF3A 5BQMA 3C88A 1EPWA 2G7QA 1G9BA 3E11A 1T3AA 1XTFA 2A97A 3V0BB 3VUOA 2NZ9A 2W2DA 2G7PA 3BWIA 3DSEA 3FFZA 4J1LA 1E1HA 4JIXA 3C89A 1ZKXA 4EJ5A 3QW5A 4QHFA 3BONA 4IL3A 3FIIA 3V0AB 3QJ0A 3V0BA 1G9CA 3DEBA 2ETFA 3DDAA 2IMAA 4EL4A 1I1EA 1ZL5A 1ZL6A 3D3XA 4KTXA 1S0CA 2G7NA 3DS9A 4AW6A 3QW7A 1F82A 4ZKTB 3CQBA 4ZJXA 2FPQA 1S0GA 3ZUSA 1F31A 2NP0A 4KUFA 1S0BA 3ZUQA 1T3CA 5BQNA 2YPTA 1ZB7A 1XTGA 1S0DA 1S0EA 2XHLA 4ELCA 3QW8A 2G7KA 1G9AA 2IMBA 1G9DA 4JIUA 1Z7HA 3FIEA 2ISHA 3C8AA 1ZN3A 3K3QB 4HEVA 4KS6A 3BOKA 1ZKWA 2ILPA 1S0FA 3V0AA 3DDBA 2QN0A 3BOOA 3ZURA 2IMCA 3QW6A 2ISGA 3QIZA 3QIYA 2NYYA 1YVGA 2A8AA 3C8BA 2EJQA 3QIXA 3BTAA
chains in the Genus database with same CATH topology
2ISEA 3NF3A 5BQMA 3C88A 1EPWA 2G7QA 1G9BA 1T3AA 1XTFA 2A97A 3V0BB 3VUOA 2NZ9A 2W2DA 2G7PA 3BWIA 3DSEA 3FFZA 4J1LA 1E1HA 3C89A 1ZKXA 4EJ5A 3QW5A 3BONA 3FIIA 3V0AB 3QJ0A 3V0BA 1G9CA 3DEBA 2ETFA 3DDAA 2IMAA 4EL4A 1I1EA 1ZL5A 1ZL6A 3D3XA 4KTXA 1S0CA 2G7NA 3DS9A 3QW7A 1F82A 4ZKTB 4ZJXA 2FPQA 1S0GA 3ZUSA 1F31A 2NP0A 4KUFA 1S0BA 3ZUQA 1T3CA 5BQNA 1ZB7A 1XTGA 1S0DA 1S0EA 2XHLA 4ELCA 3QW8A 2G7KA 1G9AA 2IMBA 1G9DA 1Z7HA 3FIEA 2ISHA 3C8AA 1ZN3A 3K3QB 4HEVA 4KS6A 3BOKA 1ZKWA 2ILPA 1S0FA 3V0AA 3DDBA 2QN0A 3BOOA 3ZURA 2IMCA 3QW6A 2ISGA 3QIZA 3QIYA 2NYYA 1YVGA 2A8AA 3C8BA 3QIXA 3BTAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ISE A;  3NF3 A;  5BQM A;  3C88 A;  1EPW A;  2G7Q A;  1G9B A;  1T3A A;  1XTF A;  2A97 A;  3V0B B;  3VUO A;  2NZ9 A;  2W2D A;  2G7P A;  3BWI A;  3DSE A;  3FFZ A;  4J1L A;  1E1H A;  3C89 A;  1ZKX A;  4EJ5 A;  3QW5 A;  3BON A;  3FII A;  3V0A B;  3QJ0 A;  3V0B A;  1G9C A;  3DEB A;  2ETF A;  3DDA A;  2IMA A;  4EL4 A;  1I1E A;  1ZL5 A;  1ZL6 A;  3D3X A;  4KTX A;  1S0C A;  2G7N A;  3DS9 A;  3QW7 A;  1F82 A;  4ZKT B;  4ZJX A;  2FPQ A;  1S0G A;  3ZUS A;  1F31 A;  2NP0 A;  4KUF A;  1S0B A;  3ZUQ A;  1T3C A;  5BQN A;  1ZB7 A;  1XTG A;  1S0D A;  1S0E A;  2XHL A;  4ELC A;  3QW8 A;  2G7K A;  1G9A A;  2IMB A;  1G9D A;  1Z7H A;  3FIE A;  2ISH A;  3C8A A;  1ZN3 A;  3K3Q B;  4HEV A;  4KS6 A;  3BOK A;  1ZKW A;  2ILP A;  1S0F A;  3V0A A;  3DDB A;  2QN0 A;  3BOO A;  3ZUR A;  2IMC A;  3QW6 A;  2ISG A;  3QIZ A;  3QIY A;  2NYY A;  1YVG A;  2A8A A;  3C8B A;  3QIX A;  3BTA A; 
#chains in the Genus database with same CATH topology
 2ISE A;  3NF3 A;  5BQM A;  3C88 A;  1EPW A;  2G7Q A;  1G9B A;  3E11 A;  1T3A A;  1XTF A;  2A97 A;  3V0B B;  3VUO A;  2NZ9 A;  2W2D A;  2G7P A;  3BWI A;  3DSE A;  3FFZ A;  4J1L A;  1E1H A;  4JIX A;  3C89 A;  1ZKX A;  4EJ5 A;  3QW5 A;  4QHF A;  3BON A;  4IL3 A;  3FII A;  3V0A B;  3QJ0 A;  3V0B A;  1G9C A;  3DEB A;  2ETF A;  3DDA A;  2IMA A;  4EL4 A;  1I1E A;  1ZL5 A;  1ZL6 A;  3D3X A;  4KTX A;  1S0C A;  2G7N A;  3DS9 A;  4AW6 A;  3QW7 A;  1F82 A;  4ZKT B;  3CQB A;  4ZJX A;  2FPQ A;  1S0G A;  3ZUS A;  1F31 A;  2NP0 A;  4KUF A;  1S0B A;  3ZUQ A;  1T3C A;  5BQN A;  2YPT A;  1ZB7 A;  1XTG A;  1S0D A;  1S0E A;  2XHL A;  4ELC A;  3QW8 A;  2G7K A;  1G9A A;  2IMB A;  1G9D A;  4JIU A;  1Z7H A;  3FIE A;  2ISH A;  3C8A A;  1ZN3 A;  3K3Q B;  4HEV A;  4KS6 A;  3BOK A;  1ZKW A;  2ILP A;  1S0F A;  3V0A A;  3DDB A;  2QN0 A;  3BOO A;  3ZUR A;  2IMC A;  3QW6 A;  2ISG A;  3QIZ A;  3QIY A;  2NYY A;  1YVG A;  2A8A A;  3C8B A;  2EJQ A;  3QIX A;  3BTA A; 
#chains in the Genus database with same CATH homology
 2ISE A;  3NF3 A;  5BQM A;  3C88 A;  1EPW A;  2G7Q A;  1G9B A;  1T3A A;  1XTF A;  2A97 A;  3V0B B;  3VUO A;  2NZ9 A;  2W2D A;  2G7P A;  3BWI A;  3DSE A;  3FFZ A;  4J1L A;  1E1H A;  3C89 A;  1ZKX A;  4EJ5 A;  3QW5 A;  3BON A;  3FII A;  3V0A B;  3QJ0 A;  3V0B A;  1G9C A;  3DEB A;  2ETF A;  3DDA A;  2IMA A;  4EL4 A;  1I1E A;  1ZL5 A;  1ZL6 A;  3D3X A;  4KTX A;  1S0C A;  2G7N A;  3DS9 A;  3QW7 A;  1F82 A;  4ZKT B;  4ZJX A;  2FPQ A;  1S0G A;  3ZUS A;  1F31 A;  2NP0 A;  4KUF A;  1S0B A;  3ZUQ A;  1T3C A;  5BQN A;  1ZB7 A;  1XTG A;  1S0D A;  1S0E A;  2XHL A;  4ELC A;  3QW8 A;  2G7K A;  1G9A A;  2IMB A;  1G9D A;  1Z7H A;  3FIE A;  2ISH A;  3C8A A;  1ZN3 A;  3K3Q B;  4HEV A;  4KS6 A;  3BOK A;  1ZKW A;  2ILP A;  1S0F A;  3V0A A;  3DDB A;  2QN0 A;  3BOO A;  3ZUR A;  2IMC A;  3QW6 A;  2ISG A;  3QIZ A;  3QIY A;  2NYY A;  1YVG A;  2A8A A;  3C8B A;  3QIX A;  3BTA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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