2G7QA

Structure of the light chain of botulinum neurotoxin serotype a bound to small molecule inhibitors
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
417
structure length
411
Chain Sequence
MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAYYEGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINAKTFLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Clostridium botulinum
molecule keywords Botulinum neurotoxin type A
total genus 131
structure length 411
sequence length 417
chains with identical sequence B
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2006-02-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2g7qA00
2A8AA 3QW7A 1S0GA 2ETFA 3QJ0A 1G9BA 5BQMA 3QW6A 2ISEA 3V0AA 2G7KA 2NZ9A 5BQNA 2NYYA 1S0CA 3FIEA 1E1HA 3FFZA 1Z7HA 1YVGA 3QIZA 3ZURA 1XTGA 3DS9A 3ZUQA 1ZN3A 2IMBA 3DSEA 2ISGA 4J1LA 1T3AA 3FIIA 4KS6A 4KUFA 1ZKWA 2FPQA 3ZUSA 3C8BA 3C89A 1F82A 1S0BA 3VUOA 1ZL5A 3V0AB 3BWIA 4ELCA 3DDAA 4ZKTB 2G7NA 2A97A 1T3CA 3BOKA 2ILPA 1F31A 1ZL6A 3DDBA 3BONA 1G9AA 3C8AA 3NF3A 1ZKXA 3QW8A 2G7QA 4KTXA 1I1EA 3V0BA 2W2DA 3DEBA 1ZB7A 2G7PA 3V0BB 1XTFA 4ZJXA 1S0FA 3QW5A 2NP0A 3BOOA 3QIXA 2XHLA 1G9DA 2QN0A 1EPWA 3K3QB 2IMCA 1G9CA 2IMAA 4HEVA 1S0DA 4EJ5A 4EL4A 3C88A 3BTAA 1S0EA 3D3XA 2ISHA 3QIYA
chains in the Genus database with same CATH superfamily
2A8AA 3QW7A 1S0GA 2ETFA 3QJ0A 1G9BA 5BQMA 3QW6A 2ISEA 3V0AA 2G7KA 2NZ9A 5BQNA 2NYYA 4QHFA 1S0CA 4JIXA 3FIEA 2YPTA 1E1HA 3FFZA 1Z7HA 1YVGA 3QIZA 3ZURA 1XTGA 3DS9A 3ZUQA 3CQBA 1ZN3A 2IMBA 3DSEA 2ISGA 4J1LA 1T3AA 3FIIA 4KS6A 4KUFA 1ZKWA 2FPQA 3ZUSA 3C8BA 3C89A 1F82A 1S0BA 3VUOA 1ZL5A 3V0AB 4JIUA 3BWIA 4ELCA 3DDAA 4ZKTB 2G7NA 2A97A 1T3CA 3BOKA 2ILPA 1F31A 1ZL6A 3DDBA 3BONA 1G9AA 3C8AA 3NF3A 1ZKXA 3QW8A 2G7QA 3E11A 4KTXA 1I1EA 3V0BA 2W2DA 3DEBA 1ZB7A 4IL3A 2G7PA 3V0BB 1XTFA 4ZJXA 1S0FA 3QW5A 2NP0A 3BOOA 3QIXA 2XHLA 1G9DA 2QN0A 1EPWA 3K3QB 2IMCA 1G9CA 2IMAA 4HEVA 1S0DA 4EJ5A 4EL4A 3C88A 3BTAA 4AW6A 1S0EA 3D3XA 2ISHA 2EJQA 3QIYA
chains in the Genus database with same CATH topology
2A8AA 3QW7A 1S0GA 2ETFA 3QJ0A 1G9BA 5BQMA 3QW6A 2ISEA 3V0AA 2G7KA 2NZ9A 5BQNA 2NYYA 1S0CA 3FIEA 1E1HA 3FFZA 1Z7HA 1YVGA 3QIZA 3ZURA 1XTGA 3DS9A 3ZUQA 1ZN3A 2IMBA 3DSEA 2ISGA 4J1LA 1T3AA 3FIIA 4KS6A 4KUFA 1ZKWA 2FPQA 3ZUSA 3C8BA 3C89A 1F82A 1S0BA 3VUOA 1ZL5A 3V0AB 3BWIA 4ELCA 3DDAA 4ZKTB 2G7NA 2A97A 1T3CA 3BOKA 2ILPA 1F31A 1ZL6A 3DDBA 3BONA 1G9AA 3C8AA 3NF3A 1ZKXA 3QW8A 2G7QA 4KTXA 1I1EA 3V0BA 2W2DA 3DEBA 1ZB7A 2G7PA 3V0BB 1XTFA 4ZJXA 1S0FA 3QW5A 2NP0A 3BOOA 3QIXA 2XHLA 1G9DA 2QN0A 1EPWA 3K3QB 2IMCA 1G9CA 2IMAA 4HEVA 1S0DA 4EJ5A 4EL4A 3C88A 3BTAA 1S0EA 3D3XA 2ISHA 3QIYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A8A A;  3QW7 A;  1S0G A;  2ETF A;  3QJ0 A;  1G9B A;  5BQM A;  3QW6 A;  2ISE A;  3V0A A;  2G7K A;  2NZ9 A;  5BQN A;  2NYY A;  1S0C A;  3FIE A;  1E1H A;  3FFZ A;  1Z7H A;  1YVG A;  3QIZ A;  3ZUR A;  1XTG A;  3DS9 A;  3ZUQ A;  1ZN3 A;  2IMB A;  3DSE A;  2ISG A;  4J1L A;  1T3A A;  3FII A;  4KS6 A;  4KUF A;  1ZKW A;  2FPQ A;  3ZUS A;  3C8B A;  3C89 A;  1F82 A;  1S0B A;  3VUO A;  1ZL5 A;  3V0A B;  3BWI A;  4ELC A;  3DDA A;  4ZKT B;  2G7N A;  2A97 A;  1T3C A;  3BOK A;  2ILP A;  1F31 A;  1ZL6 A;  3DDB A;  3BON A;  1G9A A;  3C8A A;  3NF3 A;  1ZKX A;  3QW8 A;  2G7Q A;  4KTX A;  1I1E A;  3V0B A;  2W2D A;  3DEB A;  1ZB7 A;  2G7P A;  3V0B B;  1XTF A;  4ZJX A;  1S0F A;  3QW5 A;  2NP0 A;  3BOO A;  3QIX A;  2XHL A;  1G9D A;  2QN0 A;  1EPW A;  3K3Q B;  2IMC A;  1G9C A;  2IMA A;  4HEV A;  1S0D A;  4EJ5 A;  4EL4 A;  3C88 A;  3BTA A;  1S0E A;  3D3X A;  2ISH A;  3QIY A; 
#chains in the Genus database with same CATH topology
 2A8A A;  3QW7 A;  1S0G A;  2ETF A;  3QJ0 A;  1G9B A;  5BQM A;  3QW6 A;  2ISE A;  3V0A A;  2G7K A;  2NZ9 A;  5BQN A;  2NYY A;  4QHF A;  1S0C A;  4JIX A;  3FIE A;  2YPT A;  1E1H A;  3FFZ A;  1Z7H A;  1YVG A;  3QIZ A;  3ZUR A;  1XTG A;  3DS9 A;  3ZUQ A;  3CQB A;  1ZN3 A;  2IMB A;  3DSE A;  2ISG A;  4J1L A;  1T3A A;  3FII A;  4KS6 A;  4KUF A;  1ZKW A;  2FPQ A;  3ZUS A;  3C8B A;  3C89 A;  1F82 A;  1S0B A;  3VUO A;  1ZL5 A;  3V0A B;  4JIU A;  3BWI A;  4ELC A;  3DDA A;  4ZKT B;  2G7N A;  2A97 A;  1T3C A;  3BOK A;  2ILP A;  1F31 A;  1ZL6 A;  3DDB A;  3BON A;  1G9A A;  3C8A A;  3NF3 A;  1ZKX A;  3QW8 A;  2G7Q A;  3E11 A;  4KTX A;  1I1E A;  3V0B A;  2W2D A;  3DEB A;  1ZB7 A;  4IL3 A;  2G7P A;  3V0B B;  1XTF A;  4ZJX A;  1S0F A;  3QW5 A;  2NP0 A;  3BOO A;  3QIX A;  2XHL A;  1G9D A;  2QN0 A;  1EPW A;  3K3Q B;  2IMC A;  1G9C A;  2IMA A;  4HEV A;  1S0D A;  4EJ5 A;  4EL4 A;  3C88 A;  3BTA A;  4AW6 A;  1S0E A;  3D3X A;  2ISH A;  2EJQ A;  3QIY A; 
#chains in the Genus database with same CATH homology
 2A8A A;  3QW7 A;  1S0G A;  2ETF A;  3QJ0 A;  1G9B A;  5BQM A;  3QW6 A;  2ISE A;  3V0A A;  2G7K A;  2NZ9 A;  5BQN A;  2NYY A;  1S0C A;  3FIE A;  1E1H A;  3FFZ A;  1Z7H A;  1YVG A;  3QIZ A;  3ZUR A;  1XTG A;  3DS9 A;  3ZUQ A;  1ZN3 A;  2IMB A;  3DSE A;  2ISG A;  4J1L A;  1T3A A;  3FII A;  4KS6 A;  4KUF A;  1ZKW A;  2FPQ A;  3ZUS A;  3C8B A;  3C89 A;  1F82 A;  1S0B A;  3VUO A;  1ZL5 A;  3V0A B;  3BWI A;  4ELC A;  3DDA A;  4ZKT B;  2G7N A;  2A97 A;  1T3C A;  3BOK A;  2ILP A;  1F31 A;  1ZL6 A;  3DDB A;  3BON A;  1G9A A;  3C8A A;  3NF3 A;  1ZKX A;  3QW8 A;  2G7Q A;  4KTX A;  1I1E A;  3V0B A;  2W2D A;  3DEB A;  1ZB7 A;  2G7P A;  3V0B B;  1XTF A;  4ZJX A;  1S0F A;  3QW5 A;  2NP0 A;  3BOO A;  3QIX A;  2XHL A;  1G9D A;  2QN0 A;  1EPW A;  3K3Q B;  2IMC A;  1G9C A;  2IMA A;  4HEV A;  1S0D A;  4EJ5 A;  4EL4 A;  3C88 A;  3BTA A;  1S0E A;  3D3X A;  2ISH A;  3QIY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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