2G7Q | Genus

Total Genus 131

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	131
sequence length	417
structure length	411
Chain Sequence	MFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHDVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAEHRLYGIAINPNRVFKVNTNAYYEGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDVASTLNKAKSIIGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVNFFKVINAKTFLNFDKAVFRINIVPDENYTIKDGFNLKGANLSTNFNGQNTEINSRNFTRLKN

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Light chain of botulinum neurotoxin serotype A: structural resolution of a catalytic intermediate. pubmed doi rcsb
molecule keywords	Botulinum neurotoxin type A
total genus	131
structure length	411
sequence length	417
chains with identical sequence	B
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2006-02-28

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	2g7qA00

3QW5A 5BQNA 3V0AB 1YVGA 3QIXA 2W2DA 1G9CA 3QJ0A 4ZJXA 1ZL5A 3K3QB 1ZN3A 3V0AA 1T3CA 1S0BA 1ZB7A 1F31A 3DSEA 1S0DA 1XTGA 3QIZA 2ISGA 5BQMA 3FIIA 1S0CA 3QW6A 3V0BB 1EPWA 3BOOA 2G7NA 3DEBA 3QW8A 3VUOA 4EL4A 2NZ9A 4EJ5A 3NF3A 3ZURA 4J1LA 4KS6A 3DDAA 3V0BA 2ILPA 2A8AA 1ZL6A 1ZKWA 3FIEA 2ISEA 1G9BA 2IMBA 2ISHA 3C8AA 2QN0A 3QIYA 1Z7HA 1S0FA 3DS9A 2A97A 3QW7A 4ELCA 2XHLA 1E1HA 1XTFA 4HEVA 2NP0A 3FFZA 2G7KA 1G9AA 2G7PA 3D3XA 1S0GA 4ZKTB 3BONA 3C88A 3ZUSA 3BOKA 1S0EA 2FPQA 3BWIA 1G9DA 3DDBA 1T3AA 2NYYA 1ZKXA 4KUFA 3ZUQA 3C8BA 1F82A 2ETFA 2IMAA 2IMCA 3BTAA 1I1EA 2G7QA 4KTXA 3C89A
chains in the Genus database with same CATH superfamily

3QW5A 5BQNA 4IL3A 3V0AB 1YVGA 3QIXA 2W2DA 1G9CA 3QJ0A 4ZJXA 3CQBA 4AW6A 1ZL5A 3K3QB 1ZN3A 3V0AA 1T3CA 1S0BA 1ZB7A 1F31A 3DSEA 1S0DA 1XTGA 3QIZA 2ISGA 5BQMA 3FIIA 1S0CA 3QW6A 3V0BB 1EPWA 3BOOA 2G7NA 3DEBA 4JIUA 3QW8A 3VUOA 4EL4A 2NZ9A 4EJ5A 3NF3A 3ZURA 4J1LA 4KS6A 3DDAA 3V0BA 2ILPA 2A8AA 1ZL6A 1ZKWA 3FIEA 2ISEA 4QHFA 1G9BA 2IMBA 4JIXA 2ISHA 3C8AA 3E11A 2QN0A 3QIYA 1Z7HA 1S0FA 3DS9A 2A97A 3QW7A 4ELCA 2XHLA 1E1HA 1XTFA 4HEVA 2NP0A 3FFZA 2G7KA 1G9AA 2G7PA 3D3XA 1S0GA 4ZKTB 3BONA 2EJQA 3C88A 3ZUSA 3BOKA 1S0EA 2FPQA 3BWIA 1G9DA 3DDBA 1T3AA 2NYYA 1ZKXA 4KUFA 3ZUQA 3C8BA 1F82A 2YPTA 2ETFA 2IMAA 2IMCA 3BTAA 1I1EA 2G7QA 4KTXA 3C89A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 3QW5 A;  5BQN A;  3V0A B;  1YVG A;  3QIX A;  2W2D A;  1G9C A;  3QJ0 A;  4ZJX A;  1ZL5 A;  3K3Q B;  1ZN3 A;  3V0A A;  1T3C A;  1S0B A;  1ZB7 A;  1F31 A;  3DSE A;  1S0D A;  1XTG A;  3QIZ A;  2ISG A;  5BQM A;  3FII A;  1S0C A;  3QW6 A;  3V0B B;  1EPW A;  3BOO A;  2G7N A;  3DEB A;  3QW8 A;  3VUO A;  4EL4 A;  2NZ9 A;  4EJ5 A;  3NF3 A;  3ZUR A;  4J1L A;  4KS6 A;  3DDA A;  3V0B A;  2ILP A;  2A8A A;  1ZL6 A;  1ZKW A;  3FIE A;  2ISE A;  1G9B A;  2IMB A;  2ISH A;  3C8A A;  2QN0 A;  3QIY A;  1Z7H A;  1S0F A;  3DS9 A;  2A97 A;  3QW7 A;  4ELC A;  2XHL A;  1E1H A;  1XTF A;  4HEV A;  2NP0 A;  3FFZ A;  2G7K A;  1G9A A;  2G7P A;  3D3X A;  1S0G A;  4ZKT B;  3BON A;  3C88 A;  3ZUS A;  3BOK A;  1S0E A;  2FPQ A;  3BWI A;  1G9D A;  3DDB A;  1T3A A;  2NYY A;  1ZKX A;  4KUF A;  3ZUQ A;  3C8B A;  1F82 A;  2ETF A;  2IMA A;  2IMC A;  3BTA A;  1I1E A;  2G7Q A;  4KTX A;  3C89 A; 
#chains in the Genus database with same CATH topology
 3QW5 A;  5BQN A;  4IL3 A;  3V0A B;  1YVG A;  3QIX A;  2W2D A;  1G9C A;  3QJ0 A;  4ZJX A;  3CQB A;  4AW6 A;  1ZL5 A;  3K3Q B;  1ZN3 A;  3V0A A;  1T3C A;  1S0B A;  1ZB7 A;  1F31 A;  3DSE A;  1S0D A;  1XTG A;  3QIZ A;  2ISG A;  5BQM A;  3FII A;  1S0C A;  3QW6 A;  3V0B B;  1EPW A;  3BOO A;  2G7N A;  3DEB A;  4JIU A;  3QW8 A;  3VUO A;  4EL4 A;  2NZ9 A;  4EJ5 A;  3NF3 A;  3ZUR A;  4J1L A;  4KS6 A;  3DDA A;  3V0B A;  2ILP A;  2A8A A;  1ZL6 A;  1ZKW A;  3FIE A;  2ISE A;  4QHF A;  1G9B A;  2IMB A;  4JIX A;  2ISH A;  3C8A A;  3E11 A;  2QN0 A;  3QIY A;  1Z7H A;  1S0F A;  3DS9 A;  2A97 A;  3QW7 A;  4ELC A;  2XHL A;  1E1H A;  1XTF A;  4HEV A;  2NP0 A;  3FFZ A;  2G7K A;  1G9A A;  2G7P A;  3D3X A;  1S0G A;  4ZKT B;  3BON A;  2EJQ A;  3C88 A;  3ZUS A;  3BOK A;  1S0E A;  2FPQ A;  3BWI A;  1G9D A;  3DDB A;  1T3A A;  2NYY A;  1ZKX A;  4KUF A;  3ZUQ A;  3C8B A;  1F82 A;  2YPT A;  2ETF A;  2IMA A;  2IMC A;  3BTA A;  1I1E A;  2G7Q A;  4KTX A;  3C89 A; 
#chains in the Genus database with same CATH homology
 3QW5 A;  5BQN A;  3V0A B;  1YVG A;  3QIX A;  2W2D A;  1G9C A;  3QJ0 A;  4ZJX A;  1ZL5 A;  3K3Q B;  1ZN3 A;  3V0A A;  1T3C A;  1S0B A;  1ZB7 A;  1F31 A;  3DSE A;  1S0D A;  1XTG A;  3QIZ A;  2ISG A;  5BQM A;  3FII A;  1S0C A;  3QW6 A;  3V0B B;  1EPW A;  3BOO A;  2G7N A;  3DEB A;  3QW8 A;  3VUO A;  4EL4 A;  2NZ9 A;  4EJ5 A;  3NF3 A;  3ZUR A;  4J1L A;  4KS6 A;  3DDA A;  3V0B A;  2ILP A;  2A8A A;  1ZL6 A;  1ZKW A;  3FIE A;  2ISE A;  1G9B A;  2IMB A;  2ISH A;  3C8A A;  2QN0 A;  3QIY A;  1Z7H A;  1S0F A;  3DS9 A;  2A97 A;  3QW7 A;  4ELC A;  2XHL A;  1E1H A;  1XTF A;  4HEV A;  2NP0 A;  3FFZ A;  2G7K A;  1G9A A;  2G7P A;  3D3X A;  1S0G A;  4ZKT B;  3BON A;  3C88 A;  3ZUS A;  3BOK A;  1S0E A;  2FPQ A;  3BWI A;  1G9D A;  3DDB A;  1T3A A;  2NYY A;  1ZKX A;  4KUF A;  3ZUQ A;  3C8B A;  1F82 A;  2ETF A;  2IMA A;  2IMC A;  3BTA A;  1I1E A;  2G7Q A;  4KTX A;  3C89 A;

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similar chains in the Genus database (?% sequence similarity)

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#similar chains, but unknotted
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2G7QA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations