2IMA | Genus

Total Genus 132

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	132
sequence length	428
structure length	402
Chain Sequence	SSGLVPRGSHMQFVNKQFNYKDPVNGVDIAYIKIPMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLENPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKN

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Clostridium botulinum
publication title	Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain Complexed with Small-Molecule Inhibitors Highlight Active-Site Flexibility. pubmed doi rcsb
molecule keywords	Botulinum neurotoxin A light-chain
total genus	132
structure length	402
sequence length	428
chains with identical sequence	B
ec nomenclature	ec 3.4.24.69: Bontoxilysin.
pdb deposition date	2006-10-04

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF01742	Peptidase_M27	Clostridial neurotoxin zinc protease

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.90.1240.10	Alpha Beta	Alpha-Beta Complex	Zincin-like	Metalloproteases ("zincins"), catalytic domain like	2imaA01

2NYYA 2NP0A 1ZKWA 3C8BA 1ZL5A 1T3CA 3V0AB 3ZUSA 1EPWA 3NF3A 1S0DA 1ZN3A 3QW6A 3DDBA 3FIEA 4KS6A 3DEBA 1Z7HA 1ZB7A 1F31A 1ZL6A 3V0AA 3QJ0A 1E1HA 5BQNA 3BOOA 2A97A 3K3QB 2G7NA 1G9AA 1XTGA 3DSEA 2ISHA 3C89A 1T3AA 3DS9A 2G7KA 3QW5A 4ELCA 3ZUQA 1G9CA 3DDAA 3V0BA 2G7PA 2IMBA 3FIIA 4KUFA 4ZKTB 4KTXA 3QW7A 3FFZA 3QW8A 4ZJXA 1XTFA 1S0BA 2ISEA 3V0BB 1ZKXA 3BOKA 1YVGA 3QIZA 2IMCA 1I1EA 2G7QA 2ISGA 3C88A 4EL4A 3QIYA 1S0EA 3ZURA 3BWIA 2IMAA 4HEVA 1F82A 3C8AA 2FPQA 2W2DA 1S0CA 3D3XA 2NZ9A 3VUOA 2XHLA 2QN0A 5BQMA 2A8AA 3QIXA 1S0FA 2ILPA 1G9DA 2ETFA 4EJ5A 1G9BA 3BTAA 1S0GA 3BONA 4J1LA
chains in the Genus database with same CATH superfamily

2NYYA 2NP0A 1ZKWA 3C8BA 1ZL5A 1T3CA 2YPTA 3V0AB 3ZUSA 1EPWA 3NF3A 1S0DA 1ZN3A 4IL3A 3QW6A 3DDBA 3FIEA 4KS6A 3DEBA 1Z7HA 1ZB7A 1F31A 1ZL6A 3V0AA 3QJ0A 1E1HA 5BQNA 3BOOA 4AW6A 2EJQA 2A97A 3K3QB 2G7NA 1G9AA 1XTGA 3DSEA 2ISHA 3C89A 1T3AA 3CQBA 3DS9A 2G7KA 3QW5A 4ELCA 3ZUQA 1G9CA 3DDAA 3V0BA 2G7PA 2IMBA 4JIUA 3FIIA 4KUFA 4ZKTB 4KTXA 3QW7A 3FFZA 3E11A 3QW8A 4ZJXA 1XTFA 1S0BA 2ISEA 3V0BB 1ZKXA 3BOKA 1YVGA 4JIXA 3QIZA 2IMCA 1I1EA 2G7QA 2ISGA 3C88A 4EL4A 3QIYA 1S0EA 3ZURA 3BWIA 2IMAA 4HEVA 1F82A 3C8AA 2FPQA 4QHFA 2W2DA 1S0CA 3D3XA 2NZ9A 3VUOA 2XHLA 2QN0A 5BQMA 2A8AA 3QIXA 1S0FA 2ILPA 1G9DA 2ETFA 4EJ5A 1G9BA 3BTAA 1S0GA 3BONA 4J1LA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2NYY A;  2NP0 A;  1ZKW A;  3C8B A;  1ZL5 A;  1T3C A;  3V0A B;  3ZUS A;  1EPW A;  3NF3 A;  1S0D A;  1ZN3 A;  3QW6 A;  3DDB A;  3FIE A;  4KS6 A;  3DEB A;  1Z7H A;  1ZB7 A;  1F31 A;  1ZL6 A;  3V0A A;  3QJ0 A;  1E1H A;  5BQN A;  3BOO A;  2A97 A;  3K3Q B;  2G7N A;  1G9A A;  1XTG A;  3DSE A;  2ISH A;  3C89 A;  1T3A A;  3DS9 A;  2G7K A;  3QW5 A;  4ELC A;  3ZUQ A;  1G9C A;  3DDA A;  3V0B A;  2G7P A;  2IMB A;  3FII A;  4KUF A;  4ZKT B;  4KTX A;  3QW7 A;  3FFZ A;  3QW8 A;  4ZJX A;  1XTF A;  1S0B A;  2ISE A;  3V0B B;  1ZKX A;  3BOK A;  1YVG A;  3QIZ A;  2IMC A;  1I1E A;  2G7Q A;  2ISG A;  3C88 A;  4EL4 A;  3QIY A;  1S0E A;  3ZUR A;  3BWI A;  2IMA A;  4HEV A;  1F82 A;  3C8A A;  2FPQ A;  2W2D A;  1S0C A;  3D3X A;  2NZ9 A;  3VUO A;  2XHL A;  2QN0 A;  5BQM A;  2A8A A;  3QIX A;  1S0F A;  2ILP A;  1G9D A;  2ETF A;  4EJ5 A;  1G9B A;  3BTA A;  1S0G A;  3BON A;  4J1L A; 
#chains in the Genus database with same CATH topology
 2NYY A;  2NP0 A;  1ZKW A;  3C8B A;  1ZL5 A;  1T3C A;  2YPT A;  3V0A B;  3ZUS A;  1EPW A;  3NF3 A;  1S0D A;  1ZN3 A;  4IL3 A;  3QW6 A;  3DDB A;  3FIE A;  4KS6 A;  3DEB A;  1Z7H A;  1ZB7 A;  1F31 A;  1ZL6 A;  3V0A A;  3QJ0 A;  1E1H A;  5BQN A;  3BOO A;  4AW6 A;  2EJQ A;  2A97 A;  3K3Q B;  2G7N A;  1G9A A;  1XTG A;  3DSE A;  2ISH A;  3C89 A;  1T3A A;  3CQB A;  3DS9 A;  2G7K A;  3QW5 A;  4ELC A;  3ZUQ A;  1G9C A;  3DDA A;  3V0B A;  2G7P A;  2IMB A;  4JIU A;  3FII A;  4KUF A;  4ZKT B;  4KTX A;  3QW7 A;  3FFZ A;  3E11 A;  3QW8 A;  4ZJX A;  1XTF A;  1S0B A;  2ISE A;  3V0B B;  1ZKX A;  3BOK A;  1YVG A;  4JIX A;  3QIZ A;  2IMC A;  1I1E A;  2G7Q A;  2ISG A;  3C88 A;  4EL4 A;  3QIY A;  1S0E A;  3ZUR A;  3BWI A;  2IMA A;  4HEV A;  1F82 A;  3C8A A;  2FPQ A;  4QHF A;  2W2D A;  1S0C A;  3D3X A;  2NZ9 A;  3VUO A;  2XHL A;  2QN0 A;  5BQM A;  2A8A A;  3QIX A;  1S0F A;  2ILP A;  1G9D A;  2ETF A;  4EJ5 A;  1G9B A;  3BTA A;  1S0G A;  3BON A;  4J1L A; 
#chains in the Genus database with same CATH homology
 2NYY A;  2NP0 A;  1ZKW A;  3C8B A;  1ZL5 A;  1T3C A;  3V0A B;  3ZUS A;  1EPW A;  3NF3 A;  1S0D A;  1ZN3 A;  3QW6 A;  3DDB A;  3FIE A;  4KS6 A;  3DEB A;  1Z7H A;  1ZB7 A;  1F31 A;  1ZL6 A;  3V0A A;  3QJ0 A;  1E1H A;  5BQN A;  3BOO A;  2A97 A;  3K3Q B;  2G7N A;  1G9A A;  1XTG A;  3DSE A;  2ISH A;  3C89 A;  1T3A A;  3DS9 A;  2G7K A;  3QW5 A;  4ELC A;  3ZUQ A;  1G9C A;  3DDA A;  3V0B A;  2G7P A;  2IMB A;  3FII A;  4KUF A;  4ZKT B;  4KTX A;  3QW7 A;  3FFZ A;  3QW8 A;  4ZJX A;  1XTF A;  1S0B A;  2ISE A;  3V0B B;  1ZKX A;  3BOK A;  1YVG A;  3QIZ A;  2IMC A;  1I1E A;  2G7Q A;  2ISG A;  3C88 A;  4EL4 A;  3QIY A;  1S0E A;  3ZUR A;  3BWI A;  2IMA A;  4HEV A;  1F82 A;  3C8A A;  2FPQ A;  2W2D A;  1S0C A;  3D3X A;  2NZ9 A;  3VUO A;  2XHL A;  2QN0 A;  5BQM A;  2A8A A;  3QIX A;  1S0F A;  2ILP A;  1G9D A;  2ETF A;  4EJ5 A;  1G9B A;  3BTA A;  1S0G A;  3BON A;  4J1L A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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2IMAA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations