2ISHA

Botulinum neurotoxin a light chain wt crystal form c
Total Genus 123
50100150200250300350400020406080100120
Genus TraceResidueGenus

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
123
sequence length
416
structure length
416
Chain Sequence
PFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
50100150200250300350400400300200100
020406080100120Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (81-100)TI1 (9-12)TIV1 (15-18)S6 (144-148)S2 (33-39)S1 (19-23)EMPTYS3 (42-48)TII1 (39-42)TI5 (74-77)S9 (184-187)TIV4 (49-52)TI2 (53-56)TIV6 (54-57)TI3 (63-66)TI4 (64-67)TIV7 (68-71)TII2 (76-79)TIV13 (189-192)TI12 (380-383)AH2 (102-113)AH3 (217-233)AH8 (335-348)O2 (113-115)AH7 (310-321)TIV12 (176-179)S14 (302-303)S4 (126-127)S5 (134-138)S7 (151-155)TIV9 (156-159)TVIII3 (157-160)TI7 (159-162)S8 (164-167)TI8 (174-177)TIV10 (170-173)TIV11 (175-178)S17 (372-375)S10 (192-198)TI11 (365-368)TVIII6 (363-366)TIV14 (206-209)S11 (211-214)TIV18 (405-408)3H3 (402-404)S13 (258-259)TI9 (238-241)S12 (242-243)TVIII5 (246-249)AH4 (260-266)AH6 (276-299)AH9 (351-358)AH5 (268-272)S16 (331-333)S15 (323-325)S18 (414-415)TI14 (385-388)TII'1 (388-391)TIV16 (389-392)TII3 (392-395)TIV17 (398-401)3H2 (396-398)3H4 (410-412)TIV19 (406-409)3H1 (131-133)TI6 (139-142)TIV15 (305-308)TI10 (326-329)TI13 (381-384)TIV8 (123-126)Updating...
connected with : NaN
molecule tags Toxin
source organism Clostridium botulinum
publication title Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons.
pubmed doi rcsb
molecule keywords Neurotoxin BoNT/A
total genus 123
structure length 416
sequence length 416
chains with identical sequence B
ec nomenclature
pdb deposition date 2006-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2ishA00
1ZN3A 3QIZA 1G9AA 4ZJXA 1ZKXA 3FIIA 3DDBA 1F82A 4ELCA 1S0BA 3K3QB 2ISEA 4ZKTB 1E1HA 3QIYA 1G9CA 4J1LA 3C89A 3FFZA 3V0BA 1S0CA 2IMAA 3NF3A 4EJ5A 4KTXA 3C88A 3BOOA 4KS6A 3DS9A 3C8BA 2ISGA 3DDAA 5BQMA 2FPQA 3QIXA 1ZL5A 1Z7HA 3D3XA 1EPWA 2ILPA 1G9BA 3QW8A 1I1EA 3ZUQA 2G7PA 2G7NA 1XTFA 1S0DA 2NZ9A 3QW5A 2G7QA 3BOKA 4KUFA 1G9DA 1ZB7A 3BONA 3DSEA 2A8AA 2A97A 2IMCA 3QJ0A 2W2DA 1S0EA 2ISHA 1ZL6A 2NYYA 3QW7A 3V0AB 3BWIA 3V0BB 2XHLA 3FIEA 4EL4A 1T3CA 1ZKWA 3DEBA 3VUOA 3ZURA 2G7KA 1XTGA 2ETFA 5BQNA 3QW6A 3V0AA 4HEVA 1T3AA 3BTAA 1S0FA 1S0GA 1F31A 1YVGA 2IMBA 2QN0A 3ZUSA 3C8AA 2NP0A
chains in the Genus database with same CATH superfamily
1ZN3A 3QIZA 1G9AA 4ZJXA 1ZKXA 3FIIA 3DDBA 1F82A 4ELCA 1S0BA 3K3QB 2ISEA 4ZKTB 1E1HA 3QIYA 1G9CA 4J1LA 3C89A 3FFZA 3V0BA 1S0CA 2EJQA 2IMAA 3NF3A 4EJ5A 4KTXA 3C88A 3BOOA 3E11A 4KS6A 3DS9A 3C8BA 2ISGA 3DDAA 5BQMA 2FPQA 3QIXA 1ZL5A 1Z7HA 3D3XA 1EPWA 2ILPA 1G9BA 3QW8A 1I1EA 3ZUQA 2G7PA 2G7NA 1XTFA 1S0DA 2NZ9A 3QW5A 2G7QA 3BOKA 4KUFA 1G9DA 4JIXA 1ZB7A 3BONA 3DSEA 2A8AA 2A97A 2IMCA 3QJ0A 2W2DA 1S0EA 2ISHA 1ZL6A 2NYYA 3QW7A 3V0AB 3BWIA 3V0BB 2XHLA 3FIEA 4EL4A 1T3CA 1ZKWA 3DEBA 3VUOA 4IL3A 3ZURA 2G7KA 3CQBA 4QHFA 1XTGA 4AW6A 2ETFA 5BQNA 3QW6A 3V0AA 4HEVA 1T3AA 4JIUA 3BTAA 2YPTA 1S0FA 1S0GA 1F31A 1YVGA 2IMBA 2QN0A 3ZUSA 3C8AA 2NP0A
chains in the Genus database with same CATH topology
1ZN3A 3QIZA 1G9AA 4ZJXA 1ZKXA 3FIIA 3DDBA 1F82A 4ELCA 1S0BA 3K3QB 2ISEA 4ZKTB 1E1HA 3QIYA 1G9CA 4J1LA 3C89A 3FFZA 3V0BA 1S0CA 2IMAA 3NF3A 4EJ5A 4KTXA 3C88A 3BOOA 4KS6A 3DS9A 3C8BA 2ISGA 3DDAA 5BQMA 2FPQA 3QIXA 1ZL5A 1Z7HA 3D3XA 1EPWA 2ILPA 1G9BA 3QW8A 1I1EA 3ZUQA 2G7PA 2G7NA 1XTFA 1S0DA 2NZ9A 3QW5A 2G7QA 3BOKA 4KUFA 1G9DA 1ZB7A 3BONA 3DSEA 2A8AA 2A97A 2IMCA 3QJ0A 2W2DA 1S0EA 2ISHA 1ZL6A 2NYYA 3QW7A 3V0AB 3BWIA 3V0BB 2XHLA 3FIEA 4EL4A 1T3CA 1ZKWA 3DEBA 3VUOA 3ZURA 2G7KA 1XTGA 2ETFA 5BQNA 3QW6A 3V0AA 4HEVA 1T3AA 3BTAA 1S0FA 1S0GA 1F31A 1YVGA 2IMBA 2QN0A 3ZUSA 3C8AA 2NP0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZN3 A;  3QIZ A;  1G9A A;  4ZJX A;  1ZKX A;  3FII A;  3DDB A;  1F82 A;  4ELC A;  1S0B A;  3K3Q B;  2ISE A;  4ZKT B;  1E1H A;  3QIY A;  1G9C A;  4J1L A;  3C89 A;  3FFZ A;  3V0B A;  1S0C A;  2IMA A;  3NF3 A;  4EJ5 A;  4KTX A;  3C88 A;  3BOO A;  4KS6 A;  3DS9 A;  3C8B A;  2ISG A;  3DDA A;  5BQM A;  2FPQ A;  3QIX A;  1ZL5 A;  1Z7H A;  3D3X A;  1EPW A;  2ILP A;  1G9B A;  3QW8 A;  1I1E A;  3ZUQ A;  2G7P A;  2G7N A;  1XTF A;  1S0D A;  2NZ9 A;  3QW5 A;  2G7Q A;  3BOK A;  4KUF A;  1G9D A;  1ZB7 A;  3BON A;  3DSE A;  2A8A A;  2A97 A;  2IMC A;  3QJ0 A;  2W2D A;  1S0E A;  2ISH A;  1ZL6 A;  2NYY A;  3QW7 A;  3V0A B;  3BWI A;  3V0B B;  2XHL A;  3FIE A;  4EL4 A;  1T3C A;  1ZKW A;  3DEB A;  3VUO A;  3ZUR A;  2G7K A;  1XTG A;  2ETF A;  5BQN A;  3QW6 A;  3V0A A;  4HEV A;  1T3A A;  3BTA A;  1S0F A;  1S0G A;  1F31 A;  1YVG A;  2IMB A;  2QN0 A;  3ZUS A;  3C8A A;  2NP0 A; 
#chains in the Genus database with same CATH topology
 1ZN3 A;  3QIZ A;  1G9A A;  4ZJX A;  1ZKX A;  3FII A;  3DDB A;  1F82 A;  4ELC A;  1S0B A;  3K3Q B;  2ISE A;  4ZKT B;  1E1H A;  3QIY A;  1G9C A;  4J1L A;  3C89 A;  3FFZ A;  3V0B A;  1S0C A;  2EJQ A;  2IMA A;  3NF3 A;  4EJ5 A;  4KTX A;  3C88 A;  3BOO A;  3E11 A;  4KS6 A;  3DS9 A;  3C8B A;  2ISG A;  3DDA A;  5BQM A;  2FPQ A;  3QIX A;  1ZL5 A;  1Z7H A;  3D3X A;  1EPW A;  2ILP A;  1G9B A;  3QW8 A;  1I1E A;  3ZUQ A;  2G7P A;  2G7N A;  1XTF A;  1S0D A;  2NZ9 A;  3QW5 A;  2G7Q A;  3BOK A;  4KUF A;  1G9D A;  4JIX A;  1ZB7 A;  3BON A;  3DSE A;  2A8A A;  2A97 A;  2IMC A;  3QJ0 A;  2W2D A;  1S0E A;  2ISH A;  1ZL6 A;  2NYY A;  3QW7 A;  3V0A B;  3BWI A;  3V0B B;  2XHL A;  3FIE A;  4EL4 A;  1T3C A;  1ZKW A;  3DEB A;  3VUO A;  4IL3 A;  3ZUR A;  2G7K A;  3CQB A;  4QHF A;  1XTG A;  4AW6 A;  2ETF A;  5BQN A;  3QW6 A;  3V0A A;  4HEV A;  1T3A A;  4JIU A;  3BTA A;  2YPT A;  1S0F A;  1S0G A;  1F31 A;  1YVG A;  2IMB A;  2QN0 A;  3ZUS A;  3C8A A;  2NP0 A; 
#chains in the Genus database with same CATH homology
 1ZN3 A;  3QIZ A;  1G9A A;  4ZJX A;  1ZKX A;  3FII A;  3DDB A;  1F82 A;  4ELC A;  1S0B A;  3K3Q B;  2ISE A;  4ZKT B;  1E1H A;  3QIY A;  1G9C A;  4J1L A;  3C89 A;  3FFZ A;  3V0B A;  1S0C A;  2IMA A;  3NF3 A;  4EJ5 A;  4KTX A;  3C88 A;  3BOO A;  4KS6 A;  3DS9 A;  3C8B A;  2ISG A;  3DDA A;  5BQM A;  2FPQ A;  3QIX A;  1ZL5 A;  1Z7H A;  3D3X A;  1EPW A;  2ILP A;  1G9B A;  3QW8 A;  1I1E A;  3ZUQ A;  2G7P A;  2G7N A;  1XTF A;  1S0D A;  2NZ9 A;  3QW5 A;  2G7Q A;  3BOK A;  4KUF A;  1G9D A;  1ZB7 A;  3BON A;  3DSE A;  2A8A A;  2A97 A;  2IMC A;  3QJ0 A;  2W2D A;  1S0E A;  2ISH A;  1ZL6 A;  2NYY A;  3QW7 A;  3V0A B;  3BWI A;  3V0B B;  2XHL A;  3FIE A;  4EL4 A;  1T3C A;  1ZKW A;  3DEB A;  3VUO A;  3ZUR A;  2G7K A;  1XTG A;  2ETF A;  5BQN A;  3QW6 A;  3V0A A;  4HEV A;  1T3A A;  3BTA A;  1S0F A;  1S0G A;  1F31 A;  1YVG A;  2IMB A;  2QN0 A;  3ZUS A;  3C8A A;  2NP0 A; 
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