2QN0A

Structure of botulinum neurotoxin serotype c1 light chain protease
Total Genus 141
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
141
sequence length
429
structure length
429
Chain Sequence
PITINNFNYSDPVDNKNILYLDTHLNTLANEPEKAFRITGNIWVIPDRFSRNSNPNLNKPPRVTSPKSGYYDPNYLSTDSDKDTFLKEIIKLFKRINSREIGEELIYRLSTDIPFPGNNNTPINTFDFDVDFNSVDVKTRQGNNWVKTGSINPSVIITGPRENIIDPETSTFKLTNNTFAAQEGFGALSIISISPRFMLTYSNATNDVGEGRFSKSEFCMDPILILMHELNHAMHNLYGIAIPNDQTISSVTSNIFYSQYNVKLEYAEIYAFGGPTIDLIPKSARKYFEEKALDYYRSIAKRLNSITTANPSSFNKYIGEYKQKLIRKYRFVVESSGEVTVNRNKFVELYNELTQIFTEFNYAKIYNVQNRKIYLSNVYTPVTANILDDNVYDIQNGFNIPKSNLNVLFMGQNLSRNPALRKVNPEPLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
pubmed doi rcsb
molecule tags Toxin
source organism Clostridium botulinum
molecule keywords Neurotoxin
total genus 141
structure length 429
sequence length 429
ec nomenclature ec 3.4.24.69: Bontoxilysin.
pdb deposition date 2007-07-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01742 Peptidase_M27 Clostridial neurotoxin zinc protease
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1240.10 Alpha Beta Alpha-Beta Complex Zincin-like Metalloproteases ("zincins"), catalytic domain like 2qn0A00
1XTGA 3DDAA 1S0GA 3VUOA 1G9AA 3FIEA 2ILPA 2NP0A 1XTFA 1S0FA 1ZB7A 3ZUQA 1S0EA 3NF3A 4J1LA 4EL4A 3QW8A 1Z7HA 3C8AA 2FPQA 4EJ5A 3QJ0A 3ZUSA 1ZKXA 1ZL6A 3DSEA 1S0BA 1ZN3A 2G7PA 4KTXA 3V0AA 3FFZA 1F82A 3V0AB 3QIZA 3K3QB 3C8BA 3C89A 2ETFA 2ISGA 2NZ9A 1G9BA 3BONA 1G9CA 1I1EA 3DDBA 3V0BB 2XHLA 2G7QA 4HEVA 2IMBA 3BTAA 1ZL5A 3QIYA 4KS6A 3QW6A 2ISEA 1G9DA 1S0DA 3QW7A 5BQNA 1T3AA 4ELCA 2QN0A 4KUFA 1T3CA 3V0BA 5BQMA 3BOOA 1EPWA 1ZKWA 3D3XA 2G7KA 3DEBA 4ZJXA 1F31A 1YVGA 2A97A 3FIIA 1S0CA 2A8AA 1E1HA 2NYYA 3DS9A 3ZURA 3BOKA 2IMCA 3QW5A 4ZKTB 2ISHA 2W2DA 3BWIA 3QIXA 2IMAA 3C88A 2G7NA
chains in the Genus database with same CATH superfamily
1XTGA 3DDAA 1S0GA 3VUOA 1G9AA 3FIEA 2ILPA 2NP0A 1XTFA 1S0FA 3CQBA 1ZB7A 3ZUQA 1S0EA 3NF3A 4J1LA 4EL4A 3QW8A 1Z7HA 3C8AA 2FPQA 4EJ5A 3QJ0A 3ZUSA 1ZKXA 1ZL6A 3DSEA 4JIUA 1S0BA 1ZN3A 2G7PA 4KTXA 4QHFA 3V0AA 3FFZA 1F82A 3V0AB 3QIZA 3K3QB 3C8BA 3C89A 2ETFA 2ISGA 2NZ9A 1G9BA 3BONA 1G9CA 1I1EA 3DDBA 3V0BB 2XHLA 2G7QA 4HEVA 2IMBA 3BTAA 1ZL5A 3QIYA 4KS6A 3QW6A 2ISEA 4JIXA 1G9DA 1S0DA 3QW7A 5BQNA 1T3AA 4ELCA 2QN0A 2EJQA 4KUFA 1T3CA 3V0BA 5BQMA 3E11A 3BOOA 1EPWA 1ZKWA 3D3XA 2G7KA 3DEBA 4ZJXA 1F31A 1YVGA 2A97A 3FIIA 1S0CA 2A8AA 1E1HA 2NYYA 3DS9A 3ZURA 3BOKA 2YPTA 2IMCA 3QW5A 4ZKTB 4AW6A 2ISHA 4IL3A 2W2DA 3BWIA 3QIXA 2IMAA 3C88A 2G7NA
chains in the Genus database with same CATH topology
1XTGA 3DDAA 1S0GA 3VUOA 1G9AA 3FIEA 2ILPA 2NP0A 1XTFA 1S0FA 1ZB7A 3ZUQA 1S0EA 3NF3A 4J1LA 4EL4A 3QW8A 1Z7HA 3C8AA 2FPQA 4EJ5A 3QJ0A 3ZUSA 1ZKXA 1ZL6A 3DSEA 1S0BA 1ZN3A 2G7PA 4KTXA 3V0AA 3FFZA 1F82A 3V0AB 3QIZA 3K3QB 3C8BA 3C89A 2ETFA 2ISGA 2NZ9A 1G9BA 3BONA 1G9CA 1I1EA 3DDBA 3V0BB 2XHLA 2G7QA 4HEVA 2IMBA 3BTAA 1ZL5A 3QIYA 4KS6A 3QW6A 2ISEA 1G9DA 1S0DA 3QW7A 5BQNA 1T3AA 4ELCA 2QN0A 4KUFA 1T3CA 3V0BA 5BQMA 3BOOA 1EPWA 1ZKWA 3D3XA 2G7KA 3DEBA 4ZJXA 1F31A 1YVGA 2A97A 3FIIA 1S0CA 2A8AA 1E1HA 2NYYA 3DS9A 3ZURA 3BOKA 2IMCA 3QW5A 4ZKTB 2ISHA 2W2DA 3BWIA 3QIXA 2IMAA 3C88A 2G7NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XTG A;  3DDA A;  1S0G A;  3VUO A;  1G9A A;  3FIE A;  2ILP A;  2NP0 A;  1XTF A;  1S0F A;  1ZB7 A;  3ZUQ A;  1S0E A;  3NF3 A;  4J1L A;  4EL4 A;  3QW8 A;  1Z7H A;  3C8A A;  2FPQ A;  4EJ5 A;  3QJ0 A;  3ZUS A;  1ZKX A;  1ZL6 A;  3DSE A;  1S0B A;  1ZN3 A;  2G7P A;  4KTX A;  3V0A A;  3FFZ A;  1F82 A;  3V0A B;  3QIZ A;  3K3Q B;  3C8B A;  3C89 A;  2ETF A;  2ISG A;  2NZ9 A;  1G9B A;  3BON A;  1G9C A;  1I1E A;  3DDB A;  3V0B B;  2XHL A;  2G7Q A;  4HEV A;  2IMB A;  3BTA A;  1ZL5 A;  3QIY A;  4KS6 A;  3QW6 A;  2ISE A;  1G9D A;  1S0D A;  3QW7 A;  5BQN A;  1T3A A;  4ELC A;  2QN0 A;  4KUF A;  1T3C A;  3V0B A;  5BQM A;  3BOO A;  1EPW A;  1ZKW A;  3D3X A;  2G7K A;  3DEB A;  4ZJX A;  1F31 A;  1YVG A;  2A97 A;  3FII A;  1S0C A;  2A8A A;  1E1H A;  2NYY A;  3DS9 A;  3ZUR A;  3BOK A;  2IMC A;  3QW5 A;  4ZKT B;  2ISH A;  2W2D A;  3BWI A;  3QIX A;  2IMA A;  3C88 A;  2G7N A; 
#chains in the Genus database with same CATH topology
 1XTG A;  3DDA A;  1S0G A;  3VUO A;  1G9A A;  3FIE A;  2ILP A;  2NP0 A;  1XTF A;  1S0F A;  3CQB A;  1ZB7 A;  3ZUQ A;  1S0E A;  3NF3 A;  4J1L A;  4EL4 A;  3QW8 A;  1Z7H A;  3C8A A;  2FPQ A;  4EJ5 A;  3QJ0 A;  3ZUS A;  1ZKX A;  1ZL6 A;  3DSE A;  4JIU A;  1S0B A;  1ZN3 A;  2G7P A;  4KTX A;  4QHF A;  3V0A A;  3FFZ A;  1F82 A;  3V0A B;  3QIZ A;  3K3Q B;  3C8B A;  3C89 A;  2ETF A;  2ISG A;  2NZ9 A;  1G9B A;  3BON A;  1G9C A;  1I1E A;  3DDB A;  3V0B B;  2XHL A;  2G7Q A;  4HEV A;  2IMB A;  3BTA A;  1ZL5 A;  3QIY A;  4KS6 A;  3QW6 A;  2ISE A;  4JIX A;  1G9D A;  1S0D A;  3QW7 A;  5BQN A;  1T3A A;  4ELC A;  2QN0 A;  2EJQ A;  4KUF A;  1T3C A;  3V0B A;  5BQM A;  3E11 A;  3BOO A;  1EPW A;  1ZKW A;  3D3X A;  2G7K A;  3DEB A;  4ZJX A;  1F31 A;  1YVG A;  2A97 A;  3FII A;  1S0C A;  2A8A A;  1E1H A;  2NYY A;  3DS9 A;  3ZUR A;  3BOK A;  2YPT A;  2IMC A;  3QW5 A;  4ZKT B;  4AW6 A;  2ISH A;  4IL3 A;  2W2D A;  3BWI A;  3QIX A;  2IMA A;  3C88 A;  2G7N A; 
#chains in the Genus database with same CATH homology
 1XTG A;  3DDA A;  1S0G A;  3VUO A;  1G9A A;  3FIE A;  2ILP A;  2NP0 A;  1XTF A;  1S0F A;  1ZB7 A;  3ZUQ A;  1S0E A;  3NF3 A;  4J1L A;  4EL4 A;  3QW8 A;  1Z7H A;  3C8A A;  2FPQ A;  4EJ5 A;  3QJ0 A;  3ZUS A;  1ZKX A;  1ZL6 A;  3DSE A;  1S0B A;  1ZN3 A;  2G7P A;  4KTX A;  3V0A A;  3FFZ A;  1F82 A;  3V0A B;  3QIZ A;  3K3Q B;  3C8B A;  3C89 A;  2ETF A;  2ISG A;  2NZ9 A;  1G9B A;  3BON A;  1G9C A;  1I1E A;  3DDB A;  3V0B B;  2XHL A;  2G7Q A;  4HEV A;  2IMB A;  3BTA A;  1ZL5 A;  3QIY A;  4KS6 A;  3QW6 A;  2ISE A;  1G9D A;  1S0D A;  3QW7 A;  5BQN A;  1T3A A;  4ELC A;  2QN0 A;  4KUF A;  1T3C A;  3V0B A;  5BQM A;  3BOO A;  1EPW A;  1ZKW A;  3D3X A;  2G7K A;  3DEB A;  4ZJX A;  1F31 A;  1YVG A;  2A97 A;  3FII A;  1S0C A;  2A8A A;  1E1H A;  2NYY A;  3DS9 A;  3ZUR A;  3BOK A;  2IMC A;  3QW5 A;  4ZKT B;  2ISH A;  2W2D A;  3BWI A;  3QIX A;  2IMA A;  3C88 A;  2G7N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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