2V0RA

Crystal structure of a hairpin exchange variant (ltx) of the targeting line-1 retrotransposon endonuclease
Total Genus 70
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
70
sequence length
235
structure length
235
Chain Sequence
SHITILTLNINGLNSAIKRHRLASWIKSQDPSVCCIQETHLTCRDTHRLKIKGWRKIYQANGKQKKAGVAILVSDKTDFKPTKIKRDKEGHYIMVKGSIQQEELTILNIYAPNTGAPRFIKQVLSDLQRDLDSHTLIMGDFNTPLSTLDRSTRQKVNKDTQELNSALHQADLIDIYRTLHPKSTEYTYVRVRDGHVSQSKIDHIVGSKALLSKCKRTEIITNYLSDHSAIKLELR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Determinants for DNA Target Structure Selectivity of the Human Line-1 Retrotransposon Endonuclease
pubmed doi rcsb
molecule tags Transcription
source organism Homo sapiens
molecule keywords LTX
total genus 70
structure length 235
sequence length 235
chains with identical sequence B
ec nomenclature ec 2.7.7.49: RNA-directed DNA polymerase.
pdb deposition date 2007-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 2v0rA00
3W2YA 3MTCA 1VYBA 4RUWA 4GZ1A 2XSWA 3G00A 4C1RA 4FPVA 2O3CA 4QHEA 5INNA 4LNDA 1ATND 4F1RA 3FZIA 3U8UA 1YJHA 4L1YA 1I9ZA 5DV2A 3NR8A 3I46A 5CFGA 4B5HA 4L1ZA 1DE8A 2F2FB 3G2CA 2DDRA 3G4TA 3G0AA 3CJCD 1SI6X 5EWTA 3TEBA 2VOAA 3W2XA 1DEWA 3WCXA 2O3HA 5HT2A 4IEMA 5INOA 2DDSA 5DG0A 4F1IA 4CMNA 4QH9A 4CMLA 4L20A 2A3ZB 3L1WA 4B5GA 4AWNA 3I48A 3G2DA 3N9VA 5A7JA 2ISIA 5J3ZA 3MPRA 5J3SA 5J42A 1ZWXA 2A40B 3G91A 4PUQA 2V0RA 3G3YA 4B5IA 5DFJA 3G8VA 3I5VA 5DFHA 5INLA 4JG3A 5INKA 3G38A 1Y21A 4GYZA 3NGQA 3G3CA 5CFEA 4F1HB 5INPA 2UYRX 3G0RA 5DV4A 1WDUA 2EI9A 2JC5A 1E9NA 2A41B 4QHDA 4K6LF 1DE9A 1I9YA 4GEWA 3G6SA 5INQA 2F1NA 4B5MA 4A9CA 5J3PA 2A42B 5DFIA 4GZ2A 3G1KA 4B5JA 3NGNA 2DNJA 3NGOA 3GA6A 2DDTA 4B5FA 1DNKA 2IMQX 4GZ0A 5INMA 3W3DB 5J8NA 2J63A 3I41A 4FVAA 5DFFA 5A7IA 1BIXA 1AKOA 2D1KB 1HD7A 2JC4A 4F1HA 1NTFA 3DNIA 4L21A 2V0SA 1SR4B 3K55A
chains in the Genus database with same CATH superfamily
3W2YA 3MTCA 1VYBA 4RUWA 4GZ1A 2XSWA 3G00A 4C1RA 4FPVA 2O3CA 4QHEA 5INNA 4LNDA 1ATND 4F1RA 3FZIA 3U8UA 1YJHA 4L1YA 1I9ZA 5DV2A 3NR8A 3I46A 5CFGA 4B5HA 4L1ZA 1DE8A 2F2FB 3G2CA 2DDRA 3G4TA 3G0AA 3CJCD 1SI6X 5EWTA 3TEBA 2VOAA 3W2XA 1DEWA 3WCXA 2O3HA 5HT2A 4IEMA 5INOA 2DDSA 5DG0A 4F1IA 4CMNA 4QH9A 4CMLA 4L20A 2A3ZB 3L1WA 4B5GA 4AWNA 3I48A 3G2DA 3N9VA 5A7JA 2ISIA 5J3ZA 3MPRA 5J3SA 5J42A 1ZWXA 2A40B 3G91A 4PUQA 2V0RA 3G3YA 4B5IA 5DFJA 3G8VA 3I5VA 5DFHA 5INLA 4JG3A 5INKA 3G38A 1Y21A 4GYZA 3NGQA 3G3CA 5CFEA 4F1HB 5INPA 2UYRX 3G0RA 5DV4A 1WDUA 2EI9A 2JC5A 1E9NA 2A41B 4QHDA 4K6LF 1DE9A 1I9YA 4GEWA 3G6SA 5INQA 2F1NA 4B5MA 4A9CA 5J3PA 2A42B 5DFIA 4GZ2A 3G1KA 4B5JA 3NGNA 2DNJA 3NGOA 3GA6A 2DDTA 4B5FA 1DNKA 2IMQX 4GZ0A 5INMA 3W3DB 5J8NA 2J63A 3I41A 4FVAA 5DFFA 5A7IA 1BIXA 1AKOA 2D1KB 1HD7A 2JC4A 4F1HA 1NTFA 3DNIA 4L21A 2V0SA 1SR4B 3K55A
chains in the Genus database with same CATH topology
3W2YA 3MTCA 1VYBA 4RUWA 4GZ1A 2XSWA 3G00A 4C1RA 4FPVA 2O3CA 4QHEA 5INNA 4LNDA 1ATND 4F1RA 3FZIA 3U8UA 1YJHA 4L1YA 1I9ZA 5DV2A 3NR8A 3I46A 5CFGA 4B5HA 4L1ZA 1DE8A 2F2FB 3G2CA 2DDRA 3G4TA 3G0AA 3CJCD 1SI6X 5EWTA 3TEBA 2VOAA 3W2XA 1DEWA 3WCXA 2O3HA 5HT2A 4IEMA 5INOA 2DDSA 5DG0A 4F1IA 4CMNA 4QH9A 4CMLA 4L20A 2A3ZB 3L1WA 4B5GA 4AWNA 3I48A 3G2DA 3N9VA 5A7JA 2ISIA 5J3ZA 3MPRA 5J3SA 5J42A 1ZWXA 2A40B 3G91A 4PUQA 2V0RA 3G3YA 4B5IA 5DFJA 3G8VA 3I5VA 5DFHA 5INLA 4JG3A 5INKA 3G38A 1Y21A 4GYZA 3NGQA 3G3CA 5CFEA 4F1HB 5INPA 2UYRX 3G0RA 5DV4A 1WDUA 2EI9A 2JC5A 1E9NA 2A41B 4QHDA 4K6LF 1DE9A 1I9YA 4GEWA 3G6SA 5INQA 2F1NA 4B5MA 4A9CA 5J3PA 2A42B 5DFIA 4GZ2A 3G1KA 4B5JA 3NGNA 2DNJA 3NGOA 3GA6A 2DDTA 4B5FA 1DNKA 2IMQX 4GZ0A 5INMA 3W3DB 5J8NA 2J63A 3I41A 4FVAA 5DFFA 5A7IA 1BIXA 1AKOA 2D1KB 1HD7A 2JC4A 4F1HA 1NTFA 3DNIA 4L21A 2V0SA 1SR4B 3K55A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3W2Y A;  3MTC A;  1VYB A;  4RUW A;  4GZ1 A;  2XSW A;  3G00 A;  4C1R A;  4FPV A;  2O3C A;  4QHE A;  5INN A;  4LND A;  1ATN D;  4F1R A;  3FZI A;  3U8U A;  1YJH A;  4L1Y A;  1I9Z A;  5DV2 A;  3NR8 A;  3I46 A;  5CFG A;  4B5H A;  4L1Z A;  1DE8 A;  2F2F B;  3G2C A;  2DDR A;  3G4T A;  3G0A A;  3CJC D;  1SI6 X;  5EWT A;  3TEB A;  2VOA A;  3W2X A;  1DEW A;  3WCX A;  2O3H A;  5HT2 A;  4IEM A;  5INO A;  2DDS A;  5DG0 A;  4F1I A;  4CMN A;  4QH9 A;  4CML A;  4L20 A;  2A3Z B;  3L1W A;  4B5G A;  4AWN A;  3I48 A;  3G2D A;  3N9V A;  5A7J A;  2ISI A;  5J3Z A;  3MPR A;  5J3S A;  5J42 A;  1ZWX A;  2A40 B;  3G91 A;  4PUQ A;  2V0R A;  3G3Y A;  4B5I A;  5DFJ A;  3G8V A;  3I5V A;  5DFH A;  5INL A;  4JG3 A;  5INK A;  3G38 A;  1Y21 A;  4GYZ A;  3NGQ A;  3G3C A;  5CFE A;  4F1H B;  5INP A;  2UYR X;  3G0R A;  5DV4 A;  1WDU A;  2EI9 A;  2JC5 A;  1E9N A;  2A41 B;  4QHD A;  4K6L F;  1DE9 A;  1I9Y A;  4GEW A;  3G6S A;  5INQ A;  2F1N A;  4B5M A;  4A9C A;  5J3P A;  2A42 B;  5DFI A;  4GZ2 A;  3G1K A;  4B5J A;  3NGN A;  2DNJ A;  3NGO A;  3GA6 A;  2DDT A;  4B5F A;  1DNK A;  2IMQ X;  4GZ0 A;  5INM A;  3W3D B;  5J8N A;  2J63 A;  3I41 A;  4FVA A;  5DFF A;  5A7I A;  1BIX A;  1AKO A;  2D1K B;  1HD7 A;  2JC4 A;  4F1H A;  1NTF A;  3DNI A;  4L21 A;  2V0S A;  1SR4 B;  3K55 A; 
#chains in the Genus database with same CATH topology
 3W2Y A;  3MTC A;  1VYB A;  4RUW A;  4GZ1 A;  2XSW A;  3G00 A;  4C1R A;  4FPV A;  2O3C A;  4QHE A;  5INN A;  4LND A;  1ATN D;  4F1R A;  3FZI A;  3U8U A;  1YJH A;  4L1Y A;  1I9Z A;  5DV2 A;  3NR8 A;  3I46 A;  5CFG A;  4B5H A;  4L1Z A;  1DE8 A;  2F2F B;  3G2C A;  2DDR A;  3G4T A;  3G0A A;  3CJC D;  1SI6 X;  5EWT A;  3TEB A;  2VOA A;  3W2X A;  1DEW A;  3WCX A;  2O3H A;  5HT2 A;  4IEM A;  5INO A;  2DDS A;  5DG0 A;  4F1I A;  4CMN A;  4QH9 A;  4CML A;  4L20 A;  2A3Z B;  3L1W A;  4B5G A;  4AWN A;  3I48 A;  3G2D A;  3N9V A;  5A7J A;  2ISI A;  5J3Z A;  3MPR A;  5J3S A;  5J42 A;  1ZWX A;  2A40 B;  3G91 A;  4PUQ A;  2V0R A;  3G3Y A;  4B5I A;  5DFJ A;  3G8V A;  3I5V A;  5DFH A;  5INL A;  4JG3 A;  5INK A;  3G38 A;  1Y21 A;  4GYZ A;  3NGQ A;  3G3C A;  5CFE A;  4F1H B;  5INP A;  2UYR X;  3G0R A;  5DV4 A;  1WDU A;  2EI9 A;  2JC5 A;  1E9N A;  2A41 B;  4QHD A;  4K6L F;  1DE9 A;  1I9Y A;  4GEW A;  3G6S A;  5INQ A;  2F1N A;  4B5M A;  4A9C A;  5J3P A;  2A42 B;  5DFI A;  4GZ2 A;  3G1K A;  4B5J A;  3NGN A;  2DNJ A;  3NGO A;  3GA6 A;  2DDT A;  4B5F A;  1DNK A;  2IMQ X;  4GZ0 A;  5INM A;  3W3D B;  5J8N A;  2J63 A;  3I41 A;  4FVA A;  5DFF A;  5A7I A;  1BIX A;  1AKO A;  2D1K B;  1HD7 A;  2JC4 A;  4F1H A;  1NTF A;  3DNI A;  4L21 A;  2V0S A;  1SR4 B;  3K55 A; 
#chains in the Genus database with same CATH homology
 3W2Y A;  3MTC A;  1VYB A;  4RUW A;  4GZ1 A;  2XSW A;  3G00 A;  4C1R A;  4FPV A;  2O3C A;  4QHE A;  5INN A;  4LND A;  1ATN D;  4F1R A;  3FZI A;  3U8U A;  1YJH A;  4L1Y A;  1I9Z A;  5DV2 A;  3NR8 A;  3I46 A;  5CFG A;  4B5H A;  4L1Z A;  1DE8 A;  2F2F B;  3G2C A;  2DDR A;  3G4T A;  3G0A A;  3CJC D;  1SI6 X;  5EWT A;  3TEB A;  2VOA A;  3W2X A;  1DEW A;  3WCX A;  2O3H A;  5HT2 A;  4IEM A;  5INO A;  2DDS A;  5DG0 A;  4F1I A;  4CMN A;  4QH9 A;  4CML A;  4L20 A;  2A3Z B;  3L1W A;  4B5G A;  4AWN A;  3I48 A;  3G2D A;  3N9V A;  5A7J A;  2ISI A;  5J3Z A;  3MPR A;  5J3S A;  5J42 A;  1ZWX A;  2A40 B;  3G91 A;  4PUQ A;  2V0R A;  3G3Y A;  4B5I A;  5DFJ A;  3G8V A;  3I5V A;  5DFH A;  5INL A;  4JG3 A;  5INK A;  3G38 A;  1Y21 A;  4GYZ A;  3NGQ A;  3G3C A;  5CFE A;  4F1H B;  5INP A;  2UYR X;  3G0R A;  5DV4 A;  1WDU A;  2EI9 A;  2JC5 A;  1E9N A;  2A41 B;  4QHD A;  4K6L F;  1DE9 A;  1I9Y A;  4GEW A;  3G6S A;  5INQ A;  2F1N A;  4B5M A;  4A9C A;  5J3P A;  2A42 B;  5DFI A;  4GZ2 A;  3G1K A;  4B5J A;  3NGN A;  2DNJ A;  3NGO A;  3GA6 A;  2DDT A;  4B5F A;  1DNK A;  2IMQ X;  4GZ0 A;  5INM A;  3W3D B;  5J8N A;  2J63 A;  3I41 A;  4FVA A;  5DFF A;  5A7I A;  1BIX A;  1AKO A;  2D1K B;  1HD7 A;  2JC4 A;  4F1H A;  1NTF A;  3DNI A;  4L21 A;  2V0S A;  1SR4 B;  3K55 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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