4AWNA

Structure of recombinant human dnase i (rhdnasei) in complex with magnesium and phosphate.
Total Genus 78
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
78
sequence length
260
structure length
260
Chain Sequence
LKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-Like Superfamily.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords DEOXYRIBONUCLEASE-1
total genus 78
structure length 260
sequence length 260
ec nomenclature ec 3.1.21.1: Deoxyribonuclease I.
pdb deposition date 2012-06-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.10.10 Alpha Beta 4-Layer Sandwich Deoxyribonuclease I; Chain A Endonuclease/exonuclease/phosphatase 4awnA00
5DFHA 3G00A 5CFEA 2DDRA 3WCXA 3NGOA 3U8UA 4LNDA 1WDUA 4GZ0A 2A42B 3G0AA 2DDTA 5INMA 5INKA 4L1YA 4L1ZA 1SR4B 3DNIA 1I9YA 2IMQX 5INQA 4GZ1A 1NTFA 5EWTA 5INLA 3K55A 2F2FB 3G6SA 2VOAA 2O3HA 2ISIA 3G1KA 3MTCA 5DFIA 4F1HA 2F1NA 4F1IA 4B5MA 1DE8A 2DDSA 4FVAA 4AWNA 3G3CA 4B5HA 5CFGA 5A7JA 3I46A 4PUQA 2JC4A 4GEWA 4C1RA 3G4TA 2DNJA 4K6LF 5INOA 5J42A 1ZWXA 2EI9A 5J3SA 3G0RA 4GYZA 4QH9A 3CJCD 3N9VA 2A40B 5J8NA 5INNA 2V0RA 3TEBA 3G38A 1DEWA 3FZIA 2O3CA 4RUWA 4GZ2A 1SI6X 4CMNA 5DG0A 3W2XA 5INPA 5A7IA 1E9NA 2XSWA 5HT2A 5DV2A 3MPRA 4L21A 4B5GA 4JG3A 3GA6A 3NGQA 2UYRX 2J63A 1DE9A 2JC5A 2D1KB 3G2DA 1HD7A 4B5FA 1ATND 4QHDA 3NR8A 4B5JA 4A9CA 3NGNA 5DFJA 2A3ZB 4L20A 3I5VA 3W2YA 4B5IA 5DFFA 1DNKA 3W3DB 1VYBA 1I9ZA 4F1RA 5DV4A 4FPVA 1Y21A 3G8VA 4F1HB 4CMLA 5J3PA 2V0SA 3I48A 1BIXA 2A41B 1YJHA 3G91A 1AKOA 3I41A 3G2CA 4QHEA 3G3YA 3L1WA 5J3ZA 4IEMA
chains in the Genus database with same CATH superfamily
5DFHA 3G00A 5CFEA 2DDRA 3WCXA 3NGOA 3U8UA 4LNDA 1WDUA 4GZ0A 2A42B 3G0AA 2DDTA 5INMA 5INKA 4L1YA 4L1ZA 1SR4B 3DNIA 1I9YA 2IMQX 5INQA 4GZ1A 1NTFA 5EWTA 5INLA 3K55A 2F2FB 3G6SA 2VOAA 2O3HA 2ISIA 3G1KA 3MTCA 5DFIA 4F1HA 2F1NA 4F1IA 4B5MA 1DE8A 2DDSA 4FVAA 4AWNA 3G3CA 4B5HA 5CFGA 5A7JA 3I46A 4PUQA 2JC4A 4GEWA 4C1RA 3G4TA 2DNJA 4K6LF 5INOA 5J42A 1ZWXA 2EI9A 5J3SA 3G0RA 4GYZA 4QH9A 3CJCD 3N9VA 2A40B 5J8NA 5INNA 2V0RA 3TEBA 3G38A 1DEWA 3FZIA 2O3CA 4RUWA 4GZ2A 1SI6X 4CMNA 5DG0A 3W2XA 5INPA 5A7IA 1E9NA 2XSWA 5HT2A 5DV2A 3MPRA 4L21A 4B5GA 4JG3A 3GA6A 3NGQA 2UYRX 2J63A 1DE9A 2JC5A 2D1KB 3G2DA 1HD7A 4B5FA 1ATND 4QHDA 3NR8A 4B5JA 4A9CA 3NGNA 5DFJA 2A3ZB 4L20A 3I5VA 3W2YA 4B5IA 5DFFA 1DNKA 3W3DB 1VYBA 1I9ZA 4F1RA 5DV4A 4FPVA 1Y21A 3G8VA 4F1HB 4CMLA 5J3PA 2V0SA 3I48A 1BIXA 2A41B 1YJHA 3G91A 1AKOA 3I41A 3G2CA 4QHEA 3G3YA 3L1WA 5J3ZA 4IEMA
chains in the Genus database with same CATH topology
5DFHA 3G00A 5CFEA 2DDRA 3WCXA 3NGOA 3U8UA 4LNDA 1WDUA 4GZ0A 2A42B 3G0AA 2DDTA 5INMA 5INKA 4L1YA 4L1ZA 1SR4B 3DNIA 1I9YA 2IMQX 5INQA 4GZ1A 1NTFA 5EWTA 5INLA 3K55A 2F2FB 3G6SA 2VOAA 2O3HA 2ISIA 3G1KA 3MTCA 5DFIA 4F1HA 2F1NA 4F1IA 4B5MA 1DE8A 2DDSA 4FVAA 4AWNA 3G3CA 4B5HA 5CFGA 5A7JA 3I46A 4PUQA 2JC4A 4GEWA 4C1RA 3G4TA 2DNJA 4K6LF 5INOA 5J42A 1ZWXA 2EI9A 5J3SA 3G0RA 4GYZA 4QH9A 3CJCD 3N9VA 2A40B 5J8NA 5INNA 2V0RA 3TEBA 3G38A 1DEWA 3FZIA 2O3CA 4RUWA 4GZ2A 1SI6X 4CMNA 5DG0A 3W2XA 5INPA 5A7IA 1E9NA 2XSWA 5HT2A 5DV2A 3MPRA 4L21A 4B5GA 4JG3A 3GA6A 3NGQA 2UYRX 2J63A 1DE9A 2JC5A 2D1KB 3G2DA 1HD7A 4B5FA 1ATND 4QHDA 3NR8A 4B5JA 4A9CA 3NGNA 5DFJA 2A3ZB 4L20A 3I5VA 3W2YA 4B5IA 5DFFA 1DNKA 3W3DB 1VYBA 1I9ZA 4F1RA 5DV4A 4FPVA 1Y21A 3G8VA 4F1HB 4CMLA 5J3PA 2V0SA 3I48A 1BIXA 2A41B 1YJHA 3G91A 1AKOA 3I41A 3G2CA 4QHEA 3G3YA 3L1WA 5J3ZA 4IEMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DFH A;  3G00 A;  5CFE A;  2DDR A;  3WCX A;  3NGO A;  3U8U A;  4LND A;  1WDU A;  4GZ0 A;  2A42 B;  3G0A A;  2DDT A;  5INM A;  5INK A;  4L1Y A;  4L1Z A;  1SR4 B;  3DNI A;  1I9Y A;  2IMQ X;  5INQ A;  4GZ1 A;  1NTF A;  5EWT A;  5INL A;  3K55 A;  2F2F B;  3G6S A;  2VOA A;  2O3H A;  2ISI A;  3G1K A;  3MTC A;  5DFI A;  4F1H A;  2F1N A;  4F1I A;  4B5M A;  1DE8 A;  2DDS A;  4FVA A;  4AWN A;  3G3C A;  4B5H A;  5CFG A;  5A7J A;  3I46 A;  4PUQ A;  2JC4 A;  4GEW A;  4C1R A;  3G4T A;  2DNJ A;  4K6L F;  5INO A;  5J42 A;  1ZWX A;  2EI9 A;  5J3S A;  3G0R A;  4GYZ A;  4QH9 A;  3CJC D;  3N9V A;  2A40 B;  5J8N A;  5INN A;  2V0R A;  3TEB A;  3G38 A;  1DEW A;  3FZI A;  2O3C A;  4RUW A;  4GZ2 A;  1SI6 X;  4CMN A;  5DG0 A;  3W2X A;  5INP A;  5A7I A;  1E9N A;  2XSW A;  5HT2 A;  5DV2 A;  3MPR A;  4L21 A;  4B5G A;  4JG3 A;  3GA6 A;  3NGQ A;  2UYR X;  2J63 A;  1DE9 A;  2JC5 A;  2D1K B;  3G2D A;  1HD7 A;  4B5F A;  1ATN D;  4QHD A;  3NR8 A;  4B5J A;  4A9C A;  3NGN A;  5DFJ A;  2A3Z B;  4L20 A;  3I5V A;  3W2Y A;  4B5I A;  5DFF A;  1DNK A;  3W3D B;  1VYB A;  1I9Z A;  4F1R A;  5DV4 A;  4FPV A;  1Y21 A;  3G8V A;  4F1H B;  4CML A;  5J3P A;  2V0S A;  3I48 A;  1BIX A;  2A41 B;  1YJH A;  3G91 A;  1AKO A;  3I41 A;  3G2C A;  4QHE A;  3G3Y A;  3L1W A;  5J3Z A;  4IEM A; 
#chains in the Genus database with same CATH topology
 5DFH A;  3G00 A;  5CFE A;  2DDR A;  3WCX A;  3NGO A;  3U8U A;  4LND A;  1WDU A;  4GZ0 A;  2A42 B;  3G0A A;  2DDT A;  5INM A;  5INK A;  4L1Y A;  4L1Z A;  1SR4 B;  3DNI A;  1I9Y A;  2IMQ X;  5INQ A;  4GZ1 A;  1NTF A;  5EWT A;  5INL A;  3K55 A;  2F2F B;  3G6S A;  2VOA A;  2O3H A;  2ISI A;  3G1K A;  3MTC A;  5DFI A;  4F1H A;  2F1N A;  4F1I A;  4B5M A;  1DE8 A;  2DDS A;  4FVA A;  4AWN A;  3G3C A;  4B5H A;  5CFG A;  5A7J A;  3I46 A;  4PUQ A;  2JC4 A;  4GEW A;  4C1R A;  3G4T A;  2DNJ A;  4K6L F;  5INO A;  5J42 A;  1ZWX A;  2EI9 A;  5J3S A;  3G0R A;  4GYZ A;  4QH9 A;  3CJC D;  3N9V A;  2A40 B;  5J8N A;  5INN A;  2V0R A;  3TEB A;  3G38 A;  1DEW A;  3FZI A;  2O3C A;  4RUW A;  4GZ2 A;  1SI6 X;  4CMN A;  5DG0 A;  3W2X A;  5INP A;  5A7I A;  1E9N A;  2XSW A;  5HT2 A;  5DV2 A;  3MPR A;  4L21 A;  4B5G A;  4JG3 A;  3GA6 A;  3NGQ A;  2UYR X;  2J63 A;  1DE9 A;  2JC5 A;  2D1K B;  3G2D A;  1HD7 A;  4B5F A;  1ATN D;  4QHD A;  3NR8 A;  4B5J A;  4A9C A;  3NGN A;  5DFJ A;  2A3Z B;  4L20 A;  3I5V A;  3W2Y A;  4B5I A;  5DFF A;  1DNK A;  3W3D B;  1VYB A;  1I9Z A;  4F1R A;  5DV4 A;  4FPV A;  1Y21 A;  3G8V A;  4F1H B;  4CML A;  5J3P A;  2V0S A;  3I48 A;  1BIX A;  2A41 B;  1YJH A;  3G91 A;  1AKO A;  3I41 A;  3G2C A;  4QHE A;  3G3Y A;  3L1W A;  5J3Z A;  4IEM A; 
#chains in the Genus database with same CATH homology
 5DFH A;  3G00 A;  5CFE A;  2DDR A;  3WCX A;  3NGO A;  3U8U A;  4LND A;  1WDU A;  4GZ0 A;  2A42 B;  3G0A A;  2DDT A;  5INM A;  5INK A;  4L1Y A;  4L1Z A;  1SR4 B;  3DNI A;  1I9Y A;  2IMQ X;  5INQ A;  4GZ1 A;  1NTF A;  5EWT A;  5INL A;  3K55 A;  2F2F B;  3G6S A;  2VOA A;  2O3H A;  2ISI A;  3G1K A;  3MTC A;  5DFI A;  4F1H A;  2F1N A;  4F1I A;  4B5M A;  1DE8 A;  2DDS A;  4FVA A;  4AWN A;  3G3C A;  4B5H A;  5CFG A;  5A7J A;  3I46 A;  4PUQ A;  2JC4 A;  4GEW A;  4C1R A;  3G4T A;  2DNJ A;  4K6L F;  5INO A;  5J42 A;  1ZWX A;  2EI9 A;  5J3S A;  3G0R A;  4GYZ A;  4QH9 A;  3CJC D;  3N9V A;  2A40 B;  5J8N A;  5INN A;  2V0R A;  3TEB A;  3G38 A;  1DEW A;  3FZI A;  2O3C A;  4RUW A;  4GZ2 A;  1SI6 X;  4CMN A;  5DG0 A;  3W2X A;  5INP A;  5A7I A;  1E9N A;  2XSW A;  5HT2 A;  5DV2 A;  3MPR A;  4L21 A;  4B5G A;  4JG3 A;  3GA6 A;  3NGQ A;  2UYR X;  2J63 A;  1DE9 A;  2JC5 A;  2D1K B;  3G2D A;  1HD7 A;  4B5F A;  1ATN D;  4QHD A;  3NR8 A;  4B5J A;  4A9C A;  3NGN A;  5DFJ A;  2A3Z B;  4L20 A;  3I5V A;  3W2Y A;  4B5I A;  5DFF A;  1DNK A;  3W3D B;  1VYB A;  1I9Z A;  4F1R A;  5DV4 A;  4FPV A;  1Y21 A;  3G8V A;  4F1H B;  4CML A;  5J3P A;  2V0S A;  3I48 A;  1BIX A;  2A41 B;  1YJH A;  3G91 A;  1AKO A;  3I41 A;  3G2C A;  4QHE A;  3G3Y A;  3L1W A;  5J3Z A;  4IEM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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